Pyoderma gangrenosum is a neutrophilic dermatosis that presents as an ulcer with violaceous borders. [unboundmedicine.com]

Abstract We present a case of Scleredema Diabeticorum (SD) in a patient with diabetic neuropathy and restrictive respiratory disease with unusual skin lesion distribution. [ncbi.nlm.nih.gov]

However, this mechanism does not seem to be, at least solely, the cause of scleredema in the case that we present here. [hindawi.com]

• Cough

  At the same time, he experienced frequent shortening of breath with nonproductive coughing and he was admitted several times. [ncbi.nlm.nih.gov]

[Scleredema adultorum : Clinical presentation, diagnostic workup, differential diagnosis, treatment option]. Kreuter A. Kreuter A. Hautarzt. 2018 Nov;69(11):908-915. doi: 10.1007/s00105-018-4259-6. Hautarzt. 2018. PMID: 30128796 Review. German. [pubmed.ncbi.nlm.nih.gov]

Additional workup may be necessary that includes imaging studies and recruitment of subspecialists to treat affected organs. For example, scleredema involving the heart muscles may lead to cardiomyopathy resulting in congestive heart failure. [dermatologyadvisor.com]

There are no specific laboratory abnormalities, but the diagnostic workup of SAB should include analysis of anti-streptolysin O titre, haemoglobin A1c, sedimentation rate, blood count, and protein electrophoresis. [medicaljournals.se]

Treatment may improve movement and breathing. [ucsfhealth.org]

At the end of the treatment (fiftieth treatment), the 17-MHz probe ultrasound was repeated at the same site. [ncbi.nlm.nih.gov]

No effective treatment is known for SD. [jrheum.org]

Ultraviolet A-1 phototherapy and photochemotherapy with PUVA seem to be the most effective treatments for this pathology. [hindawi.com]

[…] exposed to ultraviolet light Glucocorticoid medications (topical or oral) Electron beam therapy (a type of radiation therapy) Medicines that suppress the immune system Physical therapy, if you find it hard to move your torso or breathe deeply Outlook (Prognosis [ucsfhealth.org]

Amyloidosis: Recognition, confirmation, prognosis, and therapy. Mayo Clin Proc. 1999;74:490–4. [PubMed] [Google Scholar] 12. Banker BQ, Engel AG. Myology. New York: McGraw-Hill; 1986. The polymyositis and dermatomyositis syndrome; pp. 1385–422. [ncbi.nlm.nih.gov]

The majority of childhood cases are postinfectious and self-resolving. [21, 22] Prognosis The course of scleredema is unpredictable. [emedicine.medscape.com]

Affiliations PMID: 33865279 Free article Case Reports Scleredema diabeticorum in a patient: un uncommon etiology of restrictive lung pattern Escleredema diabeticorum en un paciente: una etiología infrecuente de patrón restrictivo pulmonar Mónica García-Arpal [pubmed.ncbi.nlm.nih.gov]

ISSN 0304-4866, Vol. 78, Nº. 4 (Diciembre), 2017, págs. 165-167 Idioma: portugués Títulos paralelos: Buschke´s Scleredema - Case Report Enlaces Texto completo (pdf) Resumen English Scleredema of Buschke (EB) is a rare sclerotic disorder, of unknown etiology [dialnet.unirioja.es]

Other etiologic mechanism besides hyperglycemia probably takes place in some patients. There are different approaches for the treatment of scleredema adultorum. [hindawi.com]

This review describes characteristic skin findings of diabetes, general skin findings related to diabetes, and findings related to diabetes treatment with a focus on clinical presentation, diagnosis, pathophysiology, epidemiology, and treatment. [unboundmedicine.com]

[…] due to mechanical stress. [16] Drug reaction: In 2005, scleredema was reported in association with the use of infliximab; although rare, treating physicians should consider the possibility of an adverse drug reaction as the underlying etiology. [17] Epidemiology [emedicine.medscape.com]

FREE Publisher Full TextPMC Free Full TextPMC Free PDF Cutaneous Manifestations of Nutritional Excess: Pathophysiologic Effects of Hyperglycemia and Hyperinsulinemia on the Skin. [unboundmedicine.com]

Pathophysiology Increased deposition of collagen and mucin (hyaluronic acid, an acid mucopolysaccharide) is seen in this condition; however, the causative mechanism is unknown. [emedicine.medscape.com]

Etiology Pathophysiology The pathogenesis of scleredema is poorly understood. [dermatologyadvisor.com]

Keeping blood sugar levels within range helps prevent diabetes complications. [ucsfhealth.org]