A 63-year-old male was admitted to our hospital for frequent fever. Abdominal magnetic resonance cholangiopancreatography showed diffuse narrowing of the common bile duct and post-stenotic dilatation of the right posterior bile duct. [ncbi.nlm.nih.gov]

[…] disease The diagnosis of primary sclerosing cholangitis should be suspected in a patient with ulcerative colitis who has abnormal LFTs, especially a raised alkaline phosphatase pruritus and fatigue are early symptoms - patients may also present with fevers [gpnotebook.co.uk]

Some patients present with pruritus (itching), jaundice (yellow skin caused by bilirubin retention), fatigue, fever, weight loss or signs of advanced liver disease. [texasliver.com]

For those who do, symptoms include: fatigue (the most common symptom of PSC) itchy skin unexpected weight loss abdominal pain unexplained fever As the condition progresses, a person with PSC may develop symptoms of liver failure, including: jaundice pain [childrenshospital.org]

As primary sclerosing cholangitis progresses, individuals typically develop right upper abdominal pain, fever, fatigue, pruritus, and jaundice. These individuals also are at risk of developing primary sclerosing cholangitis complications. [emedicinehealth.com]

Contrast-enhanced computed tomography showed diffuse swelling of the pancreas and thickening of the common bile duct (CBD) wall with delayed enhancement. Obvious diffuse wall thickening of the CBD was observed on endoscopic ultrasonography. [ncbi.nlm.nih.gov]

In primary sclerosing cholangitis, the swelling causes scaring that causes the bile ducts to narrow and harden which can cause serious liver damage. The most utilized treatment for primary sclerosing cholangitis is a liver transplant. [stlouischildrens.org]

These diseases typically cause swelling and scarring of the bile ducts in livers. Patients may not display any symptoms, but both conditions may be linked to pruritus, or itching all over the body. [atriumhealth.org]

Finally, in the advanced stages of cirrhosis, extensive swelling can occur in the abdomen and feet. Liver failure may take many years to develop. [gicare.com]

Sclerosing cholangitis refers to swelling (inflammation), scarring, and destruction of the bile ducts inside and outside of the liver. The cause of this condition is unknown in most cases. [medlineplus.gov]

KEYWORDS: Autoimmune pancreatitis; IgG4; IgG4-related disease; Inflammatory pseudotumor; Sclerosing cholangitis [ncbi.nlm.nih.gov]

Frequent findings include 2-4 : periductal fibrosis (onion skin lesions) periportal eosinophilic infiltrate paucity of ducts Associations ulcerative colitis Sjogren syndrome 6 retroperitoneal fibrosis 6 mediastinal fibrosis Riedel thyroiditis orbital pseudotumor [radiopaedia.org]

Other associated conditions include cirrhosis, chronic active hepatitis, pericholangitis, pancreatitis, retroperitoneal or mediastinal fibrosis, Peyronie disease, Riedel thyroiditis, hypothyroidism, or retro-orbital pseudotumor. [sonoworld.com]

Clinicians and pathologists should recognize this to avoid major surgery. Copyright 2014 Elsevier Inc. All rights reserved. KEYWORDS: Autoimmune pancreatitis; IgG4; IgG4-related disease; Inflammatory pseudotumor; Sclerosing cholangitis [ncbi.nlm.nih.gov]

This is analyzed under a microscope by a pathologist to make the diagnosis. [medicinenet.com]

former Chairman and Pathologist-in-Chief, Children's Hospital, Boston, MA, USA. Dr. [scielo.br]

The complementary use of FISH increased the sensitivity of hematoxylin-and-eosin (H&E) staining from 69.4% to 77.6%; the specificity was not reduced when either H&E or FISH was positive. [ncbi.nlm.nih.gov]

Red arrows represent assumes stable findings; CA 19-9: Carbohydrate antigen 19-9; CCA: Cholangiocarcinoma; ERC: Endoscopic retrograde cholangiography; GB: Gallbladder; GBC: Gallbladder cancer; FISH: Fluorescence in situ hybridization; HCC: Hepatocellular [wjgnet.com]

Biopsy can also be supplemented with a fluorescent-in-situ- hybridization (FISH) study to detect chromosome anomalies, if this technique is available ( 17 ). [aerzteblatt.de]

Prednisolone was reduced to 5 mg every other day without consultation with his doctor 1 year ago in May 2017, then he presented to our hospital again with recurrent abdominal pain and jaundice. [ncbi.nlm.nih.gov]

However, 3 months after his first admission, he had more severe abdominal pain and further elevated serum CA19-9. [ncbi.nlm.nih.gov]

Among the eight cases with diagnoses reported, six patients were misdiagnosed as intrahepatic cholangiocarcinoma; one was diagnosed as hepatic mass and one as IgG4-SC before biopsy or operation. [ncbi.nlm.nih.gov]

CT of hepatic masses: significance of prolonged and delayed enhancement. AJR Am J Roentgenol 1986 ; 146:729-733. Crossref, Medline, Google Scholar 39 Fulcher AS, Turner MA. HASTE MR cholangiography in the evaluation of hilar cholangiocarcinoma. [pubs.rsna.org]

pruritus, jaundice ). Laboratory abnormalities include elevated liver function tests and autoantibodies ( pANCA in up to 80% of cases). [amboss.com]

Symptoms of PSC include intermittent malaise, pruritus, fever, chills, night sweats, and right upper abdominal quadrant pain. [e-guide.ecco-ibd.eu]

Presentations of primary sclerosing cholangitis History: Fatigue Pruritus Weight loss Right upper quadrant (RUQ) pain Recurrent biliary infections Examination: Jaundice Hepatomegaly Features of chronic liver disease Dupuytren’s contracture; palmar erythema [oxfordmedicaleducation.com]

The hallmark clinical feature of intrahepatic cholestasis of pregnancy is pruritus. [clevelandclinicmeded.com]

[…] be asymptomatic at the time of diagnosis, although they may have advanced disease The diagnosis of primary sclerosing cholangitis should be suspected in a patient with ulcerative colitis who has abnormal LFTs, especially a raised alkaline phosphatase pruritus [gpnotebook.co.uk]

We report a male child with WAS, who had presented with recurrent pneumonia, eczema, thrombocytopenia, autoimmune hemolytic anemia, and vasculitic skin lesions. Genetic analysis revealed a classical genotype WAS 155C T; R41X. [ncbi.nlm.nih.gov]

Prednisolone was started from 40 mg daily, tapered gradually, and totally withdrawn after 22 months of treatment. A new-onset cholangitis was detected 2 months later. Prednisolone 10 mg daily was administered again. [ncbi.nlm.nih.gov]

The two patients that did not receive allocated treatment had withdrawn their consent. As expected, around 60%-70% of the patients in each group were male. [mdedge.com]

Several years after this diagnosis, a small liver lesion was found incidentally on computed tomography scan following a motorcycle accident. This lesion was shown to be stable by magnetic resonance imaging over the course of 2 years. [ncbi.nlm.nih.gov]