The clinical presentation was with fever, weight loss, cholestatic jaundice with hepatosplenomegaly and generalized lymphadenopathy. [ncbi.nlm.nih.gov]

The clinical presentation was with fever, weight loss, cholestatic jaundice with hepatosplenomegaly and generalized lymphadenopathy. [ncbi.nlm.nih.gov]

Characterized by progressive weight loss and fatigue, steatorrhea, splenomegaly and hepatomegaly. Accession portal hypertension and hepatic failure is observed in the late stage secondary biliary cirrhosis. [medicalformat.com]

loss, weakness, fatigue, and even osteoporosis as a result of vitamin D malabsorption and subsequent calcium deficiency. [aafp.org]

As the disease progresses, symptoms may include weakness, fatigue, loss of appetite, nausea, vomiting, weight loss, abdominal pain and bloating, itching, and spiderlike blood vessels on the skin. [surgery.ucsf.edu]

The most common initial symptoms are: Itchy skin Fatigue Jaundice symptoms like yellowing of the eyes and skin Other manifestations may include: Darkening of exposed areas of the skin Fever Bone pain Pale-colored, foul-smelling, bulky stools Easy bruising [digestion.ygoy.com]

Cirrhosis can lead to Easy bruising or bleeding, or nosebleeds Swelling of the abdomen or legs Extra sensitivity to medicines High blood pressure in the vein entering the liver Enlarged veins called varices in the esophagus and stomach. [icdlist.com]

Some of the signs and symptoms of liver disease include: jaundice (yellowing of the skin and eyes) pruritus (itching) dark, tea-colored urine weight loss muscle wasting ascites (swelling of the abdomen with fluid) fatigue easy bruising and bleeding (bleeding [surgery.uic.edu]

Easy bruising and bleeding. Periods may become heavier. Bleeding into the bowel and stomach may occur. Stomach ulcers are more common. There may be swelling of the stomach (ascites) due to fluid leak from the liver. [patient.info]

The indication for the procedure was recent acute pancreatitis and episodic abdominal pain. [acgcasereports.gi.org]

It has a lengthy latent period, usually followed by the sudden appearance of abdominal pain and swelling, hematemesis, dependent edema, or jaundice. [medical-dictionary.thefreedictionary.com]

According to her medical history, she had been referred to a clinic because of abdominal pain in the left lower quadrant and examined due to acute abdominal pain when she was 6 years old. [link.springer.com]

Some patients experience no symptoms, while others may experience symptoms such as: Fatigue Itchy skin Abdominal pain Dry eyes Dry mouth Yellowing of the skin and eyes (jaundice) Darkening of the skin Swollen feet and ankles Accumulation of abdominal [columbiasurgery.org]

As the disease progresses, symptoms may include weakness, fatigue, loss of appetite, nausea, vomiting, weight loss, abdominal pain and bloating, itching, and spiderlike blood vessels on the skin. [surgery.ucsf.edu]

Case presentation A 58-year-old female patient, who complained of icterus appearing in the last 6-7 months, along with the symptoms of fatigue and loss of appetite continued for 2-3 years, was referred to our clinic. [link.springer.com]

As the disease progresses, symptoms may include weakness, fatigue, loss of appetite, nausea, vomiting, weight loss, abdominal pain and bloating, itching, and spiderlike blood vessels on the skin. [surgery.ucsf.edu]

The patient was 34 years-old male who had been suffered from right upper quadrant pain with intermittent fluctuating jaundice for 4 months. [jpatholtm.org]

The diagnosis of cirrhosis should never be established without thorough visualization of the entire biliary tract in patients with biochemical or clinical jaundice of unknown origin. [ncbi.nlm.nih.gov]

In such a case presenting as persisting and fluctuating obstructive jaundice in HCC, an intrabile duct tumor growth should be suspected. [jpatholtm.org]

It has a lengthy latent period, usually followed by the sudden appearance of abdominal pain and swelling, hematemesis, dependent edema, or jaundice. [medical-dictionary.thefreedictionary.com]

Characterized by progressive weight loss and fatigue, steatorrhea, splenomegaly and hepatomegaly. Accession portal hypertension and hepatic failure is observed in the late stage secondary biliary cirrhosis. [medicalformat.com]

P hy sica l e x am i natio n : May be normal (no finding) Jaundice Melanosis Xanthomas Hepatomegaly Splenomegaly Clubbing Bone tenderness Sicca syndrome (drying up of mucus membranes) CREST syndrome. [medicscientist.com]

In her physical examination, icteric appearance, moderate hepatomegaly and kyphosis was detected. [link.springer.com]

In later phases of the disease, patients may develop hepatomegaly, xanthomas/xanthalasmas, melanotic patches, or evidence of portal hypertension (splenomegaly, ascites, edema, encephalopathy). [clinicaladvisor.com]

[…] osteoarthropathy Constitutional symptoms, including anorexia, fatigue, weakness, and weight loss Cruveilhier-Baumgarten murmur—a venous hum in patients with portal hypertension Dupuytren’s contracture Fetor hepaticus—a sweet, pungent breath odor Gynecomastia Hepatomegaly [aafp.org]

hepaticus—a sweet, pungent breath odor Gynecomastia Hepatomegaly Jaundice Kayser-Fleischer ring—brown-green ring of copper deposit around the cornea, pathognomonic for Wilson’s disease Nail changes: Muehrcke’s nails—paired horizontal white bands separated [aafp.org]

icterus Vascular spiders (spider telangiectasias, spider angiomata) Splenomegaly Testicular atrophy Most patients with cirrhosis severe enough to lead to ascites have additional stigmata of cirrhosis on physical examination. [aafp.org]

SECONDARY BILIARY CI RR H OS I S Symptoms Clinical features · Jaundice · Pruritus · Biliary colics. SECONDARY BILIARY CI RR H OS I S Diagnosis Invest i gatio n · Cholangiography · Liver biopsy. [medicscientist.com]

The secondary biliary cirrhosis is characterized by jaundice, pruritus, pyrexia, pain in the right upper quadrant. [medicalformat.com]

Affecting chiefly middle-aged women, it is characterized by chronic cholestasis with pruritus, jaundice, and hypercholesterolemia with xanthomas, and malabsorption. secondary biliary cirrhosis cirrhosis resulting from chronic bile obstruction due to congenital [medical-dictionary.thefreedictionary.com]

The typical patient is a middle-aged woman presenting with symptoms of fatigue and pruritus and laboratory test evidence of cholestasis. [radiopaedia.org]

The pruritus has a diurnal variation and tends to be worst in the evenings. [clinicaladvisor.com]

Patients will display the general clinical features of cholestasis such as pruritis, xanthomas, jaundice, steatorrhea, and deficiencies of the fat soluble vitamins A, D, E, and K. [pathwaymedicine.org]

P hy sica l e x am i natio n : May be normal (no finding) Jaundice Melanosis Xanthomas Hepatomegaly Splenomegaly Clubbing Bone tenderness Sicca syndrome (drying up of mucus membranes) CREST syndrome. [medicscientist.com]

Affecting chiefly middle-aged women, it is characterized by chronic cholestasis with pruritus, jaundice, and hypercholesterolemia with xanthomas, and malabsorption. secondary biliary cirrhosis cirrhosis resulting from chronic bile obstruction due to congenital [medical-dictionary.thefreedictionary.com]

[…] mouth Yellowing of the skin and eyes (jaundice) Darkening of the skin Swollen feet and ankles Accumulation of abdominal fluid (ascites) Fatty deposits on the skin around your eyes, your eyelids, or in the creases in your palms, soles, elbows or knees (xanthomas [columbiasurgery.org]

Affecting chiefly middle-aged women, it is characterized by chronic cholestasis (accumulation of bile in the liver) with pruritis, jaundice, and hypercholesterolemia with xanthomas, and malabsorption. [healthcentral.com]

Twelve days after the transplant, a diffuse, pruritic, maculopapular rash involving the entire body surface (including the palms and soles) developed. [ncbi.nlm.nih.gov]

[…] yellowing of the eyes and skin Other manifestations may include: Darkening of exposed areas of the skin Fever Bone pain Pale-colored, foul-smelling, bulky stools Easy bruising Night blindness Abdominal or stomach pain on the right side Bone thinning or osteoporosis [digestion.ygoy.com]

Liver transplantation Ursodiol – 13 to 15 mg/kg/day single dose Colchicine Methotrexate Cholestyramine orally helps to relieve pruritus For steatorrhoea-Iow fat diet Vitamin A, 0, E, K Zinc and calcium supplementation Biphosphonate (Alendronate) for osteoporosis [medicscientist.com]

Medications Medications are used to reduce cholestasis, improve liver function, relieve itching and fatigue, and to treat complications such as varices and osteoporosis. [columbiasurgery.org]

Weak bones (osteoporosis). Exercise most days of the week can help increase your bone density. If you have osteoporosis, your treatment may include calcium and vitamin D supplements. Vitamin deficiencies. [mayoclinic.org]

There are few studies on dietary management in primary biliary cirrhosis and most of them have focused on micronutrients specifically vitamin D intake to prevent osteoporosis, and lipid control to prevent hyperlipidemia, but few recommendations have been [clinicaltrials.gov]

A trial of corticosteroids in patients with idiopathic granulomatous hepatitis who are symptomatic, with fever, myalgias, and arthralgias, may be helpful. Empirical antituberculous therapy should be considered before instituting corticosteroids. [clevelandclinicmeded.com]

With an increase in the appearance of jaundice is observed dark urine and feces discolored. Often there is nausea, low-grade fever, episodic fever, pain in the right abdomen associated recurrent cholangitis or biliary colic. [medicalformat.com]

Clinical description Clinical signs of cholestasis (discolored stools, dark urine) appear within the first year of life in about one third of patients, or later with recurrent episodes of jaundice and mild pruritus. [orpha.net]

Jaundice, dark urine, and darkening of the skin exposed to the sun occur as the liver disease progresses. The slow progression results eventually in portal hypertension, the accumulation of fluids, and eventually liver failure and death. [healthcentral.com]