Presentation
Usually, it presents with hypocalcemia. Even if there is no established therapeutic treatment, vitamin D or its analogues are required. [ncbi.nlm.nih.gov]
We present two such rare cases, one with PHPT presenting with choreoathetotic movements and the second with SHPT in ESRD presenting with a seizure disorder. [thejhs.org]
Presentation of a rare cause of hypocalcemia in childhood and the necessity of measuring serum electrolyte levels in patients presenting with afebrile seizures. a 7.5-year-old female child presented with afebrile seizures lasting 5 min with postictal [ruralneuropractice.com]
This presentation alone is enough to stratify the patient as a high risk for sudden cardiac death and to consider implantation of an automated internal defibrillator. [innovationsincrm.com]
Rather we present the case as an example of unusual manifestation of hypoparathyroidism. Conclusion Primary hypoparathyroidism leading to hypocalcemia may present with vague symptoms which often makes diagnosis difficult. [casereports.in]
Entire Body System
- Developmental Disorder
Isolated idiopathic hypoparathyroidism: PTH deficiency is present but no other associated endocrine or developmental disorders. Usually sporadic but can be familial. May possibly be a form of autoimmune hypoparathyroidism. [patient.info]
Developmental Disorders of the Parathyroid Gland Hypoparathyroidism may result from agenesis or dysgenesis of the parathyroid glands. [hypopara.org]
- Amyloidosis
Pathologic involvement of the parathyroid glands can also occur in metastatic neoplasia, miliary tuberculosis, amyloidosis, and sarcoid, but clinical hypoparathyroidism rarely occurs in these conditions. Magnesium deficiency and excess. [hypopara.org]
Respiratoric
- Stridor
Hypoparathyroidism has wide variety of presentations: from the asymptomatic patient with dramatically low serum calcium to the acutely symptomatic patient with neuromuscular irritability, tetany, painful muscle cramps, stridor, and even seizures with [bestpractice.bmj.com]
Stridor. Convulsions (usually grand mal). Syncope. Emotional lability, anxiety and depression, confusion. Memory impairment. Lethargy. Headaches. Brittle nails. Dry hair and skin. Painful menstruation. [patient.info]
However, acute hypocalcemia usually results in severe symptoms including laryngospasm, stridor, airway obstruction, neuromuscular irritability, cognitive impairment, prolonged QT interval, and cardiac arrhythmias. [ruralneuropractice.com]
- Dyspnea
Symptoms Associated with Hypercalcemia Organ system Most common symptoms and possible diagnoses Cardiovascular Angina, dyspnea, palpitations, syncope Possible diagnoses: diastolic dysfunction, dysrhythmias, hypertension, left ventricular hypertrophy, [aafp.org]
Gastrointestinal
- Abdominal Pain
Excess PTH causes GI symptoms like nausea, vomiting, abdominal pain, and loss of appetite. Finally, the psychic groans of the saying stem from hypercalcemia's effect on neurotransmitters. This can cause symptoms like depression and memory problems. [study.com]
Signs and symptoms include muscle cramps, abdominal pain, dry skin, brittle nails, cataracts, tetany, and convulsions. [icd10data.com]
[…] and insomnia. [1] Crampy abdominal pain may occur. [3] Physical examination of someone with hypocalcemia may show tetany, but it is also possible to provoke tetany of the facial muscles by tapping on the facial nerve (a phenomenon known as Chvostek's [en.wikipedia.org]
Bone pain: bone turnover is abnormally low and bone mineral density is typically increased. [ 12 ] Abdominal pain. Paraesthesiae (tingling, vibrating, burning and numbness) of the face, fingers and toes. Facial twitching. Carpopedal spasm. Stridor. [patient.info]
Hypoparathyroidism can cause hypocalcemia with consequent circumoral numbness, paresthesias of distal extremities (finger and toes), muscle pain, abdominal pain or muscle cramping which can progress to spasm or tetany. [jdas.in]
Skin
- Alopecia
Review of systems was negative for skin rash, photosensitivity, alopecia, mouth sores, sicca symptoms, Raynaud’s phenomenon, pleurisy, prolonged morning stiffness, joint swelling, swallowing problems, or shortness of breath. [casereports.in]
On the other hand, some patients will develop additional features, such as alopecia, keratoconjunctivitis, malabsorption and steatorrhea, gonadal failure, pernicious anemia, chronic active hepatitis, thyroid disease, and insulin-requiring diabetes mellitus [hypopara.org]
These disorders include alopecia, loss of axillary and pubic hair, coarsening of body hair, scaling of the skin, deformities of the nails. [38] Increased neuromuscular irritability (due to hypocalcemia) may be demonstrated by eliciting a Chvostek or Trousseau [jdas.in]
Psychiatrical
- Anxiety Disorder
Neuroimaging in social anxiety disorder: A systematic review of the literature. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34(4), pp.565-580. Journal Ibrahim, I. [citethisforme.com]
Ferri's popular "5 books in 1" format provides quick guidance on Acute Coronary Syndromes, Biceps Tendonitis, H1N1 Influenza, Infertility, Metastic Brain Tumors, Postpartum Follow-up, Small Bowel Obstruction, Social Anxiety Disorder, Stuttering and much [books.google.com]
Workup
Workup Laboratory Studies Parathyroid hormone Primary hypoparathyroidism is defined by a low concentration of PTH with a concomitant low calcium level. [emedicine.medscape.com]
Treatment
RESULTS: (1) In the treatment group, the levels of serum corrected calcium, phosphorus and calcium-phosphate product began to decline after 1 month and exhibited further decrease 3 months later. [ncbi.nlm.nih.gov]
However, early diagnosis and treatment of hypocalcemia reduces the progression of basal ganglia calcification. [ruralneuropractice.com]
Calcium and other relevant blood parameters will be measured before the treatment, at the end of treatment and 2 weeks after stopping treatment. [clinicaltrials.gov]
Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]
Prognosis
Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]
Support Groups: Expectations (prognosis): The outcome for secondary hyperparathyroidism depends on the underlying cause. When treated, rickets generally has a good prognosis. Other causes of secondary hyperparathyroidism have variable outcomes. [uclahealth.org]
Prognosis The regular monitoring required to ensure appropriate calcium levels means that the prognosis is challenging for many people. This may improve if synthetic PTH becomes widely available. [patient.info]
Prognosis Hypoparathyroidism can be a temporary condition that stops when its cause is treated, or a permanent condition. [healthand.com]
RISULTATI ESTETICI) DELLA CHIRURGIA MININVASIVA CHE VIENE EFFETTUATA SIA NELLA CHIRURGIA TIROIDEA CHE NELLA CHIRURGIA PARATIROIDEA UNA ULTERIORE LINEA DI RICERCA E' LO STUDIO SULLA UTILITA' DEGLI ONCOGENI BRAF E RAS NELLA PIANIFICAZIONE CHIRURGICA E NELLA PROGNOSI [aosp.bo.it]
Etiology
Thus, idiopathic hypoparathyroidism and resulting hypoparathyroid cataract are relatively rare, where the underlying etiologies and pathogenesis remain to be clarified. [omicsonline.org]
Etiology Postoperative : ( most common cause of hypoparathyroidism in adults): secondary to thyroidectomy, parathyroidectomy, or radical neck dissection Autoimmune : second most common cause Congenital : Parathyroid aplasia or hypoplasia ( DiGeorge syndrome [amboss.com]
In musculoskeletal disorders where a clear etiology is not to be found, it is worthwhile measuring the serum calcium, phosphate and magnesium levels and if necessary, following it up with a parathyroid hormone assay if initial investigations point that [casereports.in]
Note: Normal QTc interval in men is Discussion The present report describes a case of primary hypoparathyroidism as the unusual etiology of major depressive symptoms. [link.springer.com]
Epidemiology
Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. [bestpractice.bmj.com]
The Epidemiology of Hypoparathyroidism in Italy: An 8-Year Register-Based Study. Calcif Tissue Int. 2017 Mar. 100 (3):278-285. [Medline]. Bhadada SK, Bhansali A, Upreti V, Subbiah S, Khandelwal N. [emedicine.medscape.com]
"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research". J. Bone Miner. Res. 26 (10): 2317–37. doi : 10.1002/jbmr.483. PMC 3405491. [en.wikipedia.org]
The Epidemiological Study of Dystonia in Europe (ESDE) Collaborative Group. A prevalence study of primary dystonia in eight European countries. J Neurol 2000 ;247 : 787-792 2. Fahn S. Concept and classification of dystonia. [functionalneurology.com]
Epidemiology This is a rare disorder. Found equally in males and females. Age of onset depends on the aetiology. Aetiology Hypoparathyroidism may be transient, congenital/genetically inherited or acquired. [patient.info]
Pathophysiology
Pathophysiology is emphasized throughout, providing a sound basis for discussions of the diagnosis, treatment, and prognosis that follow. [books.google.com]
Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. [bestpractice.bmj.com]
Despite an ever-increasing understanding of the molecular mechanism of parathyroid hormone, its action on skeletal muscle and the pathophysiology of skeletal muscle disorders produced by hyper- and hypoparathyroidism is poorly understood. [medlink.com]
Pathophysiology This is a polypeptide hormone produced in the parathyroid gland. These 4 in number and present close to or on the posterior surface of the thyroid gland. [labpedia.net]
Prevention
Succinct, targeted coverage of normal childhood growth and development, as well as the diagnosis, management, and prevention of common pediatric diseases and disorders, make this an ideal medical reference book for students, pediatric residents, nurse [books.google.de]
[…] to prevent hypoparathyroidism. [mayoclinic.org]
In addition to this PTH increases the rate of phosphate excretion which is very important to prevent to formation of calcium phosphate kidney stones. [teachmephysiology.com]
The inherited forms tend to arise from abnormal genes that may: encode abnormal forms of PTH or its receptor prevent normal conduction of cell signals from the PTH receptor to the nucleus prevent normal gland development before birth. [endocrineweb.com]