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Secondary Myopathy


Presentation

  • Individual case presentations provide a valuable tool for differential diagnosis.[books.google.com]
  • Here we present a case of severe muscle weakness due to vitamin D deficiency, which rendered the patient wheel chair bound.[chanrejournals.com]
  • Prepared by internationally recognized members of The Cervical Spine Research Society Editorial Committee, the Fifth Edition presents new information, new technologies, and advances in clinical decision making.[books.google.com]
  • A 70-year-old female with extensive medical comorbidities including adult onset hypothyroidism, hypertension, hyperlipidemia, and normal baseline renal function presented with shortness of breath, myalgias, edema, and facial swelling.[journalmc.org]
  • We present a family with a distal myopathy secondary to a mutation in myotilin.[eprints.soton.ac.uk]
Pathologist
  • Keeping the pathologist in the loop paid huge dividends. We learned several things from this: A lot of patience and a huge level of clinical suspicion are needed to elicit subtle evidence of capillaritis.[hopkinsarthritis.org]
  • At present, in the UK, there is inadequate training of pathologists in the field of myology. In addition, except in specialist centres, the small throughput of samples adds little to their already limited experience.[jnnp.bmj.com]
Bulimia
  • BINGE—PURGE eating behavior is characteristic of two major eating disorders: anorexia nervosa and the more recently described syndrome of bulimia nervosa.[nejm.org]
Hydrops Fetalis
  • The first is characterized by severe perinatal disorder presenting as fetal akinesia deformation sequence (FADS) with by multiple congenital contractures (arthrogryposis multiplex congenita), hydrops fetalis, and perinatal death.[sites.google.com]
Myopathy
  • The myopathy is inhibited by prior sciatic nerve section and is accentuated by cholinesterase inhibition.[neurology.org]
  • Metabolic myopathies may be often accompanied by secondary hypovitaminosis D. Muscle biopsies can help in differentiating HDM from other myopathies.[chanrejournals.com]
  • Abstract Distal myopathies are inherited primary muscle and may be caused by defects in structural components of the sarcomere. We present a family with a distal myopathy secondary to a mutation in myotilin.[eprints.soton.ac.uk]
  • Key words: secondary myopathy, juvenile rheumatoid arthritis. Dudnyk V. M., Bereznyckyi O. V., Vyzhga Yu. V. Monitoring of the treatment effect of the secondary myopathy syndrome in patients with juvenile rheumatoid arthritis.[zenodo.org]
  • Muscle manifestations in these categories include pathogen-caused myositis, muscle infarction, rhabdomyolysis, myasthenia, immune-mediated myositis, necrotising myopathy, or vasculitis-associated myopathy.[ncbi.nlm.nih.gov]
Muscle Weakness
  • In infants, myopathy is evident from muscle weakness and hypotonia. 2 Adults may present with predominant proximal muscle weakness with difficulty in getting up from squatting position or climbing stairs.[chanrejournals.com]
  • Affected infants have profound muscle weakness and severe hypotonia.[rarediseases.org]
  • […] distal leg muscle weakness Hearing loss Retinal telangiectasias Mitochondrial myopathies 1 per 8000 population Exercise intolerance Proximal girdle muscle weakness Extraocular muscle weakness Peripheral neuropathy Migraine headaches Seizures Stroke Diabetes[clevelandclinicmeded.com]
  • The online-only version of this article offers more detailed information on additional selected causes of muscle weakness. Muscle weakness is a common complaint among patients presenting to family physicians.[aafp.org]
  • Polymyositis causes muscle weakness, usually in the muscles closest to the trunk of your body. Dermatomyositis causes muscle weakness, plus a skin rash.[icdlist.com]
Neck Muscle Weakness
  • The patient, who was wheel chair bound since two months, complained of backache, neck muscle weakness, and severe fatigue.[chanrejournals.com]
  • In utero, reduced fetal movements, polyhdramnios Hypotonia and weakness at birth, or in early childhood Ptosis, EOM weakness, hypotonia, facial, pharyngeal, laryngeal, and neck muscle weakness. Proximal and distal weakness; hyporeflexia.[sites.google.com]
Musculoskeletal Pain
  • Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin. Proc. 2003 Dec;78(12):1463-70.[chanrejournals.com]
Bone Pain
  • Other clinical characteristics of the disease include uniform generalized muscle wasting with preservation of sensation and deep tendon reflexes, and waddling gait. 3 Symptoms of bone pain may also be present.[chanrejournals.com]
  • pain, deformity and enlargement of the long-bones; and premature frontotemporal dementia (see this term), manifesting first with dysnomia, dyscalculia and comprehension deficits followed by progressive aphasia, alexia, and agraphia.[orpha.net]
Facial Swelling
  • A 70-year-old female with extensive medical comorbidities including adult onset hypothyroidism, hypertension, hyperlipidemia, and normal baseline renal function presented with shortness of breath, myalgias, edema, and facial swelling.[journalmc.org]
  • Bloody and purulent nasal discharge is associated with orbital pain and the development of facial swelling and proptosis with ophthalmoparesis on one or both sides. Visual loss from optic nerve damage may also occur.[neuroophthalmology.ca]
  • The predominant manifestations at onset are increased dyspnoea, cervical or facial swelling, subcutaneous emphysema, cervical pain and cough [ 3, 140 ]. Pneumothorax coexists in 40% of cases [ 3 ].[err.ersjournals.com]
Myopathic Facies
  • Drooling, tearing, sleep with eyes open, myopathic facies, inability to whistle, blow balloons Difficulty chewing, jaw weakness Tongue weakness - dysarthria, dysphagia, swallowing problems, pocketing food, difficulty dislodging food between cheek and[sites.google.com]
Dysesthesia
  • The symptoms of CTS include decreased sensation in the radial digits (sparing the palm) along with potential dysesthesias provoked by wrist position (including at night).[dartmouth.edu]

Workup

  • Because these symptoms may be nonspecific and lack any clear temporal or anatomic pattern, their workup may entail costly and uninformative tests.[the-rheumatologist.org]
  • A neurologic examination that shows deficits in a single nerve or radicular distribution indicates a possible mononeuritis, entrapment neuropathy, or radiculopathy, and calls for a different workup than that required for a limb paresis in a patient with[aafp.org]
  • Secondary: Postradiation neck extensor myopathy, Anterior scar contracture, Postbotulinum toxin injection, Cushing syndrome, Carnitine deficiency, Hypothyroidism, Hypokalemia, Hyperparathyroidism Other : Malignancy, Postsurgical Diagnostic Workup of Dropped[sites.google.com]

Treatment

  • Features coverage of the latest treatment innovations including antibiotic residue testing, care of individual metabolic disease, troubleshooting, and much more.[books.google.com]
  • Over the course of 2 weeks and six hemodialysis treatments, the patient’s renal status failed to improve.[journalmc.org]
  • Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders.[books.google.com]
  • We provided examination of 43 patients with JRA to monitor effect of the treatment.[zenodo.org]
  • Treatment of muscle involvement in systemic diseases is based on elimination of the underlying cause and supportive measures.[ncbi.nlm.nih.gov]

Prognosis

  • Prognosis of secondary muscle disease in systemic diseases is usually fair if the underlying condition is accessible to treatment. 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.[ncbi.nlm.nih.gov]
  • The patient finally refused any further hemodialysis or medical interventions seeing that her kidneys failed to respond to treatment, and her clinical prognosis remained poor.[journalmc.org]
  • In addition, correlations are emerging between some genotypes and the clinical phenotype or prognosis.[err.ersjournals.com]
  • […] subgroup analysis suggests that intensive insulin therapy/tight glucose control may reduce the incidence but not generally recommended simply to prevent ICU acquired weakness early mobilization Treatment no specific treatment treat underlying condition Prognosis[aic.cuhk.edu.hk]
  • Prognosis This depends on the specific diagnosis. The primary disorders are incurable conditions with varied prognosis. Secondary myopathy may be corrected by treating the underlying cause.[patient.info]

Etiology

  • Code First Code First Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]
  • Rhabdomyolysis may also be seen with infectious etiologies, alcohol, and toxic exposures.[clevelandclinicmeded.com]
  • The number of conditions leading to some form of myopathy is quite large, thus in a broad sense, the definition of myopathy should include “any” condition that results in functional muscle deficits regardless of the etiology.[link.springer.com]
  • The etiologies of hyperadrenalism include pituitary or ectopic overproduction of adrenocorticotropic hormone (ACTH), adrenal tumors, or exogenous corticosteroid administration.[emedicine.medscape.com]
  • Partial response to therapy in GER should prompt search for an underlying secondary etiology.[annalsofian.org]

Epidemiology

  • […] doi: 10.1097/BOR.0000000000000024 EPIDEMIOLOGY AND HEALTH-RELATED SERVICES: Edited by Allan C.[journals.lww.com]
  • Updated February 2015 by Charles Gomersall Difficult to distinguish between critical illness polyneuropathy and critical illness myopathy and it may be preferable to group the two together as ICU acquired weakness Epidemiology occurs in 25-63% of patients[aic.cuhk.edu.hk]
  • Epidemiology These are all relatively uncommon diseases: Duchenne muscular dystrophy is easily the most common childhood-onset muscular dystrophy and affects 1 in 3,300 boys. [ 6 ] The prevalence of Duchenne muscular dystrophy is 63 cases per million.[patient.info]
  • Epidemiology including risk factors and primary prevention Baseline risk factors for toxic myopathy include: Decreased ability to metabolize or excrete a drug and its metabolites Hepatic or renal failure Older adults Infants/children Concomitant use of[now.aapmr.org]
  • McGraw Hill, New York, pp 2013–2030 Google Scholar Neumann L, Buskila D (2003) Epidemiology of fibromyalgia.[link.springer.com]
Sex distribution
Age distribution

Pathophysiology

  • Overall, the underlying pathophysiological mechanisms of SAMS is still largely unknown.[epccs.eu]
  • Steroid myopathy is the most common endocrine myopathy. [1] Pathophysiology Although abnormal endocrine states usually present with muscle weakness—most often proximal weakness—the exact pathophysiology remains incompletely understood.[emedicine.medscape.com]
  • The exact pathophysiologic mechanisms are not fully known.[now.aapmr.org]
  • […] common in females associated with: sepsis, SIRS multiorgan dysfunction neuromuscular blocking agents corticosteroids (in some but not all studies) hyperglycaemia (independent factor in one trial) cytotoxics status asthmaticus with neuromuscular blockade Pathophysiology[aic.cuhk.edu.hk]
  • Many drugs can cause a myopathy. 1 – 10 The pathophysiological mechanisms are diverse and, in many instances, unclear. Medications can have either a direct or an indirect adverse effect on muscle.[neurology.mhmedical.com]

Prevention

  • Revised drug usage recommendations and legal considerations present the most current information in these critical areas to help you prevent dangerous or costly errors.[books.google.com]
  • Is It Possible to Prevent Cardiomyopathy? Cardiomyopathy is a term that describes the end result of many diseases and illnesses.[emedicinehealth.com]
  • […] subgroup analysis suggests that intensive insulin therapy/tight glucose control may reduce the incidence but not generally recommended simply to prevent ICU acquired weakness early mobilization Treatment no specific treatment treat underlying condition[aic.cuhk.edu.hk]
  • […] can prevent serious complications.[uspharmacist.com]
  • Because patients taking prednisone are at risk for osteoporosis, they should receive proper treatment to prevent it.[rheumatology.org]

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