Presentation
Our study indicates that undiagnosed contributors are present in 26.1% of women and 27.8% of men after age 50 yr presenting with a clinical fracture. [academic.oup.com]
However, not all patients with secondary osteoporosis will present with the classic signs of the underlying condition. [ncbi.nlm.nih.gov]
Entire Body System
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Epilepsy
Pathological fractures in epilepsy. Epilepsy Behav. 2006; 9 :601–605. [ PubMed ] [ Google Scholar ] 224. Ensrud KE, Walczak TS, Blackwell T, Ensrud ER, Bowman PJ, Stone KL. [ncbi.nlm.nih.gov]
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Inflammation
Inflammation is the main determinant of low bone mineral density in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2007; 13 :416–423. [ PubMed ] [ Google Scholar ] 124. Kumar S, Votta BJ, Rieman DJ, Badger AM, Gowen M, Lee JC. [ncbi.nlm.nih.gov]
Cardiovascular
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Heart Failure
Heart failure is a risk factor for orthopedic fracture: a population-based analysis of 16,294:patients. Circulation. 2008; 118 :1946–1952. [ PubMed ] [ Google Scholar ] 255. Rejnmark L, Vestergaard P, Heickendorff L, Andreasen F, Mosekilde L. [ncbi.nlm.nih.gov]
Treatment
The diagnosis and treatment of osteoporosis have advanced greatly in the past 20 years. [annals.org]
Author Information Authors Secondary osteoporosis occurs as a consequence of various lifestyle factors (eg, eating disorders, smoking, alcoholism), disease processes (eg, endocrinopathies, gastrointestinal tract disease, hepatobiliary disease), and treatment [journals.lww.com]
American College of Rheumatology 2010;recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. [ncbi.nlm.nih.gov]
If SECOB contributors are not recognized, treatment to prevent fractures may be suboptimal ( 6 ). [academic.oup.com]
Epidemiology
The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int. 2002; 13 :777–787. [ PubMed ] [ Google Scholar ] 10. van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C. [ncbi.nlm.nih.gov]
Pathophysiology
However, our knowledge of the pathophysiology of osteoporosis has not developed at the same rate. [annals.org]
IOF Committee of Scientific Advisors Working Group on Osteoporosis Pathophysiology. Osteoporosis in young adults: pathophysiology, diagnosis, and management. [ncbi.nlm.nih.gov]
The pathophysiological alterations responsible for the renal osteodystrophy, such as increased PTH, low vitamin D status, and disorders of mineral metabolism, are evident at stage 3 of CKD. [academic.oup.com]
Prevention
Early recognition and intervention are essential to prevent further loss of bone mass and to prevent fragility fractures. Dr. Templeton is Associate Professor, Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City, KS. [journals.lww.com]
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World Health Organisation 2003 Prevention and management of osteoporosis. [academic.oup.com]