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Secondary Osteoporosis

Pathologic Osteoporosis


Presentation

  • Our study indicates that undiagnosed contributors are present in 26.1% of women and 27.8% of men after age 50 yr presenting with a clinical fracture.[academic.oup.com]
  • However, not all patients with secondary osteoporosis will present with the classic signs of the underlying condition.[ncbi.nlm.nih.gov]
Epilepsy
  • Pathological fractures in epilepsy. Epilepsy Behav. 2006; 9 :601–605. [ PubMed ] [ Google Scholar ] 224. Ensrud KE, Walczak TS, Blackwell T, Ensrud ER, Bowman PJ, Stone KL.[ncbi.nlm.nih.gov]
Inflammation
  • Inflammation is the main determinant of low bone mineral density in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2007; 13 :416–423. [ PubMed ] [ Google Scholar ] 124. Kumar S, Votta BJ, Rieman DJ, Badger AM, Gowen M, Lee JC.[ncbi.nlm.nih.gov]
Falling
  • Immediate fall of bone formation and transient increase of bone resorption in the course of high-dose, short-term glucocorticoid therapy in young patients with multiple sclerosis.[ncbi.nlm.nih.gov]
Heart Failure
  • Heart failure is a risk factor for orthopedic fracture: a population-based analysis of 16,294:patients. Circulation. 2008; 118 :1946–1952. [ PubMed ] [ Google Scholar ] 255. Rejnmark L, Vestergaard P, Heickendorff L, Andreasen F, Mosekilde L.[ncbi.nlm.nih.gov]
Osteoporosis
  • SUMMARY Secondary osteoporosis is less common than primary osteoporosis. It may be suspected in patients who present with a fragility fracture despite having no risk factors for osteoporosis.[ncbi.nlm.nih.gov]
  • In this study we summarize the causes of secondary osteoporosis we encountered in patients currently on follow-up in our osteoporosis outpatient clinic. A total of 1015 female patients are involved in the study.[semanticscholar.org]
  • The diagnosis and treatment of osteoporosis have advanced greatly in the past 20 years.[annals.org]
  • Some of the disease entities underlying secondary osteoporosis may be clinically silent and identified only during evaluation for documented osteoporosis. The pathogenesis of osteoporosis in these settings is typically multifactorial.[journals.lww.com]
  • Guidelines on osteoporosis advocate the evaluation of patients presenting with osteoporosis to exclude diseases that mimic osteoporosis and identify the cause of osteoporosis and contributory factors [National Osteoporosis Guideline Group ( 1, 2 )] before[academic.oup.com]

Treatment

  • The diagnosis and treatment of osteoporosis have advanced greatly in the past 20 years.[annals.org]
  • Author Information Authors Secondary osteoporosis occurs as a consequence of various lifestyle factors (eg, eating disorders, smoking, alcoholism), disease processes (eg, endocrinopathies, gastrointestinal tract disease, hepatobiliary disease), and treatment[journals.lww.com]
  • American College of Rheumatology 2010;recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis.[ncbi.nlm.nih.gov]
  • If SECOB contributors are not recognized, treatment to prevent fractures may be suboptimal ( 6 ).[academic.oup.com]

Epidemiology

  • The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporos Int. 2002; 13 :777–787. [ PubMed ] [ Google Scholar ] 10. van Staa TP, Leufkens HG, Abenhaim L, Zhang B, Cooper C.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • However, our knowledge of the pathophysiology of osteoporosis has not developed at the same rate.[annals.org]
  • IOF Committee of Scientific Advisors Working Group on Osteoporosis Pathophysiology. Osteoporosis in young adults: pathophysiology, diagnosis, and management.[ncbi.nlm.nih.gov]
  • The pathophysiological alterations responsible for the renal osteodystrophy, such as increased PTH, low vitamin D status, and disorders of mineral metabolism, are evident at stage 3 of CKD.[academic.oup.com]

Prevention

  • Early recognition and intervention are essential to prevent further loss of bone mass and to prevent fragility fractures. Dr. Templeton is Associate Professor, Department of Orthopaedic Surgery, University of Kansas Medical Center, Kansas City, KS.[journals.lww.com]
  • SHOWING 1-10 OF 34 REFERENCES Osteoporosis prevention, diagnosis, and therapy Bone mineral density and frequency of osteoporosis in female with rheumatoid arthritis : results from 349 patients in the Oslo County Rheumatoid Arthritis register[semanticscholar.org]
  • Nih Consensus Development Panel on Osteoporosis Prevention D Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001; 285 :785–795. [ PubMed ] [ Google Scholar ] 4.[ncbi.nlm.nih.gov]
  • World Health Organisation 2003 Prevention and management of osteoporosis.[academic.oup.com]

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