Primary PHT tended to present after a shorter duration of lupus than secondary PHT (8.8 vs 43.2 months, P=0.118). At presentation, Raynaud's phenomenon was present in 34.8% of subjects with primary or secondary PHT. [ncbi.nlm.nih.gov]

Establishing an underlying cause and treatment plan for patients with pulmonary hypertension presents a significant challenge to practicing physicians. [scholars.northwestern.edu]

• Fatigue

  Symptoms are fatigue, exertional dyspnea, and, occasionally, chest discomfort and syncope. Diagnosis is made by finding elevated pulmonary artery pressure (estimated by echocardiography and confirmed by right heart catheterization). [merckmanuals.com]

  Dyspnea and/or fatigue may be present at rest, and discomfort is increased by any physical activity. [aafp.org]

  Symptoms of pulmonary hypertension include: Shortness of breath Fatigue Chest pain Dizziness or fainting Severe pulmonary hypertension can lead to heart failure. [uwhealth.org]

• Medication Noncompliance

  Medication noncompliance was the main reason for removal from the transplant list. LVADs were implanted in 15 (45.5%) of patients as bridge therapy to transplantation; only 1 patient had emergency LVAD placement. [ajhp.org]

• Pulmonary Disorder

  Classification of Pulmonary Hypertension Group Type Specific Disorders 1 Pulmonary arterial hypertension (PAH) Disorders associated with PAH: Congenital heart disorders Connective tissue disorders HIV infection Portal hypertension Schistosomiasis Drug [merckmanuals.com]

  sleep-disordered breathing, alveolar hypoventilation disorders, and chronic exposure to high altitude. [phaonlineuniv.org]

• Chest Pain

  Symptoms of PH include Shortness of breath during routine activity, such as climbing two flights of stairs Tiredness Chest pain A racing heartbeat Pain on the upper right side of the abdomen Decreased appetite As PH worsens, you may find it hard to do [icdlist.com]

  Chest pain is another symptom, as are the most common signs of heart trouble such as dizziness and exhaustion. This disease can be suffered in different intensities either the mild or the severe forms. [healthy-blood-pressure-tips.com]

  She reports mild chest pain when climbing the stairs or walking a few blocks. She has also noticed some swelling in both of her legs. Medical history is remarkable for sarcoidosis and she denies any alcohol, cigarette, or illicit drug use. [step2.medbullets.com]

  The mechanism is unclear, but anginal chest pain may be due to pulmonary artery stretching or right ventricular ischemia. [aafp.org]

• Malar Rash

  The lupus manifestations had been polyserositis, malar rash, and elevation of antinuclear antibodies. [ncbi.nlm.nih.gov]

The normal value for the TPG is The differential diagnosis includes an endless list of cardiopulmonary conditions; however, a transthoracic echocardiography must be part of the workup of patients with symptoms such as the ones described above. [clinicaladvisor.com]

[…] arteries – Pulmonary embolism (thrombus, tumour, and/or parasites) – In situ thrombosis Miscellaneous, e.g. sarcoidosis DIAGNOSTIC EVALUATION As the most successful strategy in the treatment of pulmonary hypertension is to treat the underlying cause, the workup [adc.bmj.com]

An immunologic workup had shown antinuclear antibody at 1:640 dilutions and a homogenous pattern. Skin-sensitizing antibody (SSA-RO), anti-DNA antibodies, and DNA-binding antibodies were strongly positive. [ncbi.nlm.nih.gov]

• Pulmonary Arterial Pressure Increased

  Furthermore, the addition of hypoxic pulmonary hypertension will increase pulmonary artery pressures and therefore the load on the right heart. In this patient population exercise should be restricted and guided by symptoms. [thorax.bmj.com]

• Incomplete Right Bundle Branch Block

  Right axis deviation (short arrow), increased P-wave amplitude in lead II (black arrowhead), and incomplete right bundle branch block (white arrowhead) are highly specific but lack sensitivity for the detection of right ventricular hypertrophy. 12 View [aafp.org]

Their cardio-pulmonary haemodynamics were measured with right heart catheterization prior to treatment, post-treatment at 2, 6 and 12 months and subsequently depending upon clinical need. Six-minute walk distance was also measured. [ncbi.nlm.nih.gov]

Significant advances in treatment have been made and will be discussed in detail in part 2 of this article. [scholars.northwestern.edu]

INTRODUCTION: Secondary pulmonary hypertension (PH) and right ventricular dysfunction are common and associated with poor prognosis in HF patients with left ventricular assist devices (LVADs). [ncbi.nlm.nih.gov]

Prognosis Prognosis of Pulmonary Hypertension. Early diagnosis and treatment substantially improves the prognosis for pulmonary hypertension associated with systemic sclerosis (scleroderma). ISN. [sclero.org]

This study is designed to determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia, and to determine whether genetic polymorphisms in candidate genes contribute to its development or response [clinicaltrials.gov]

Prognosis is poor overall if a treatable secondary cause is not found. [merckmanuals.com]

While there are a myriad of etiologies for PAH, many times a cardiac etiology may be present. This is particularly important from both diagnostic and therapeutic standpoints, as many lesions are readily repairable with corrective surgery. [ncbi.nlm.nih.gov]

Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]

Epidemiology The possible association between PH and CMPDs has been suggested by several case reports and small case series. [err.ersjournals.com]

Epidemiology There are few reliable figures for prevalence of cor pulmonale in the population at large, as the condition is difficult to diagnose reliably on the basis of clinical symptoms and signs alone. [patient.info]

Pulmonary arterial hypertension: epidemiology and registries. J Am Coll Cardiol. 2013 Dec 24. 62 (25 Suppl):D51-9. [Medline]. Sitbon O, Lascoux-Combe C, Delfraissy JF, et al. [emedicine.medscape.com]

Pregnancy is sometimes described as contraindicated in these women. [87] [88] [89] Epidemiology [ edit ] The epidemiology of IPAH is about 125–150 deaths per year in the U.S., and worldwide the incidence is similar to the U.S. at 4 cases per million. [en.wikipedia.org]

We will review the pathophysiology, diagnostic tools, and treatment strategies in SPHtn with an emphasis on cor pulmonale associated with chronic obstructive pulmonary disease (COPD), pulmonary vasculopathies, and pulmonary embolus. [ncbi.nlm.nih.gov]

The combination of both drugs prevented PAP increase and fibrosis progression. [academic.oup.com]

Prevention Can pulmonary hypertension be prevented or avoided? Not all pulmonary hypertension can be prevented. But you can make an effort to prevent other conditions that can cause the disease. [familydoctor.org]

Continuously Infused Epoprostenol — This drug dilates and reverses thickening of the blood vessels of the lungs, and helps prevent platelets from clotting the blood. [ucsfhealth.org]

Pulmonary Hypertension Prevention Prevention of pulmonary hypertension may focus on reducing risk factors that may lead to the underlying cause. This is not always possible, especially in situations where the risk factors are not controllable. [emedicinehealth.com]