Edit concept Question Editor Create issue ticket

Secondary Pulmonary Hypertension


Presentation

  • Primary PHT tended to present after a shorter duration of lupus than secondary PHT (8.8 vs 43.2 months, P 0.118). At presentation, Raynaud's phenomenon was present in 34.8% of subjects with primary or secondary PHT.[ncbi.nlm.nih.gov]
Fatigue
  • Symptoms of pulmonary hypertension include: Shortness of breath Fatigue Chest pain Dizziness or fainting Severe pulmonary hypertension can lead to heart failure.[uwhealth.org]
  • Dyspnea and/or fatigue may be present at rest, and discomfort is increased by any physical activity.[aafp.org]
Localized Pain
  • Local pain at the infusion site is a potential issue with this therapy 21. Oral beraprost Beraprost sodium is absorbed rapidly after oral administration and reaches a peak concentration after 30 min. It has an elimination half-life of 35–40 min.[ejca.eg.net]
Medication Noncompliance
  • Medication noncompliance was the main reason for removal from the transplant list. LVADs were implanted in 15 (45.5%) of patients as bridge therapy to transplantation; only 1 patient had emergency LVAD placement.[ajhp.org]
Noncompliance
  • Medication noncompliance was the main reason for removal from the transplant list. LVADs were implanted in 15 (45.5%) of patients as bridge therapy to transplantation; only 1 patient had emergency LVAD placement.[ajhp.org]
Pulmonary Disorder
  • Suspect pulmonary hypertension if patients have dyspnea unexplained by another clinically evident cardiac or pulmonary disorder. Begin diagnostic testing with chest x-ray, spirometry, ECG, and transthoracic Doppler echocardiography.[merckmanuals.com]
  • Interstitial Lung Disease Interstitial lung diseases are a heterogeneous group of pulmonary disorders characterized by parenchyma destruction and dysfunction, usually in the setting of abnormal immune function and inflammation ( Table 2 ).[phaonlineuniv.org]
Chest Pain
  • Chest pain is another symptom, as are the most common signs of heart trouble such as dizziness and exhaustion. This disease can be suffered in different intensities either the mild or the severe forms.[healthy-blood-pressure-tips.com]
  • Symptoms of PH include Shortness of breath during routine activity, such as climbing two flights of stairs Tiredness Chest pain A racing heartbeat Pain on the upper right side of the abdomen Decreased appetite As PH worsens, you may find it hard to do[icdlist.com]
  • Symptoms of pulmonary hypertension include: Shortness of breath Fatigue Chest pain Dizziness or fainting Severe pulmonary hypertension can lead to heart failure.[uwhealth.org]
Malar Rash
  • The lupus manifestations had been polyserositis, malar rash, and elevation of antinuclear antibodies.[ncbi.nlm.nih.gov]

Workup

  • An immunologic workup had shown antinuclear antibody at 1:640 dilutions and a homogenous pattern. Skin-sensitizing antibody (SSA-RO), anti-DNA antibodies, and DNA-binding antibodies were strongly positive.[ncbi.nlm.nih.gov]
  • The normal value for the TPG is The differential diagnosis includes an endless list of cardiopulmonary conditions; however, a transthoracic echocardiography must be part of the workup of patients with symptoms such as the ones described above.[clinicaladvisor.com]
  • […] arteries – Pulmonary embolism (thrombus, tumour, and/or parasites) – In situ thrombosis Miscellaneous, e.g. sarcoidosis DIAGNOSTIC EVALUATION As the most successful strategy in the treatment of pulmonary hypertension is to treat the underlying cause, the workup[adc.bmj.com]
Pulmonary Arterial Pressure Increased
  • arterial pressure, increase cardiac output, and thus decrease pulmonary vascular resistance without symptomatic systemic hypotension.[thorax.bmj.com]
Incomplete Right Bundle Branch Block
  • Right axis deviation (short arrow), increased P-wave amplitude in lead II (black arrowhead), and incomplete right bundle branch block (white arrowhead) are highly specific but lack sensitivity for the detection of right ventricular hypertrophy. 12 View[aafp.org]

Treatment

  • Their cardio-pulmonary haemodynamics were measured with right heart catheterization prior to treatment, post-treatment at 2, 6 and 12 months and subsequently depending upon clinical need. Six-minute walk distance was also measured.[ncbi.nlm.nih.gov]

Prognosis

  • INTRODUCTION: Secondary pulmonary hypertension (PH) and right ventricular dysfunction are common and associated with poor prognosis in HF patients with left ventricular assist devices (LVADs).[ncbi.nlm.nih.gov]
  • This study is designed to determine the prevalence and prognosis of secondary pulmonary hypertension in adult patients with sickle cell anemia, and to determine whether genetic polymorphisms in candidate genes contribute to its development or response[clinicaltrials.gov]
  • However, the involvement of distal microvessels, particularly when the thromboses have occurred in subsegmental arteries, often indicates a worse prognosis.[ahajournals.org]

Etiology

  • While there are a myriad of etiologies for PAH, many times a cardiac etiology may be present. This is particularly important from both diagnostic and therapeutic standpoints, as many lesions are readily repairable with corrective surgery.[ncbi.nlm.nih.gov]
  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]

Epidemiology

  • "Obesity Hypoventilation Syndrome Epidemiology and Diagnosis". Sleep Medicine Clinics. 9 (3): 341–347. doi : 10.1016/j.jsmc.2014.05.007. PMC 4210766. PMID 25360072. Reynolds, PN (February 2011).[en.wikipedia.org]
  • Epidemiology The possible association between PH and CMPDs has been suggested by several case reports and small case series.[err.ersjournals.com]
  • Epidemiology There are few reliable figures for prevalence of cor pulmonale in the population at large, as the condition is difficult to diagnose reliably on the basis of clinical symptoms and signs alone.[patient.info]
  • Pulmonary arterial hypertension: epidemiology and registries. J Am Coll Cardiol . 2013 Dec 24. 62 (25 Suppl):D51-9. [Medline] . Sitbon O, Lascoux-Combe C, Delfraissy JF, et al.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • We will review the pathophysiology, diagnostic tools, and treatment strategies in SPHtn with an emphasis on cor pulmonale associated with chronic obstructive pulmonary disease (COPD), pulmonary vasculopathies, and pulmonary embolus.[ncbi.nlm.nih.gov]
  • The Role of the Endothelium in Pathophysiology and Management Originally published 22 Mar 2018 Circulation. 2018;102:1718-1723 Abstract Abstract —Pulmonary vascular resistance is frequently elevated in patients with chronic left ventricular failure as[ahajournals.org]

Prevention

  • The combination of both drugs prevented PAP increase and fibrosis progression.[academic.oup.com]
  • Prevention Can pulmonary hypertension be prevented or avoided? Not all pulmonary hypertension can be prevented. But you can make an effort to prevent other conditions that can cause the disease.[familydoctor.org]
  • Continuously Infused Epoprostenol — This drug dilates and reverses thickening of the blood vessels of the lungs, and helps prevent platelets from clotting the blood.[ucsfhealth.org]
  • Pulmonary Hypertension Prevention Prevention of pulmonary hypertension may focus on reducing risk factors that may lead to the underlying cause. This is not always possible, especially in situations where the risk factors are not controllable.[emedicinehealth.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!