Presentation
Synopses of published cases of Munchausen syndrome presenting as cystic fibrosis, and cases of Munchausen syndrome with pulmonary talcosis are presented as part of the discussion. [ncbi.nlm.nih.gov]
For mococcal lobar pneumonia, with which it was almost this reason alone, a summary of the present knowledge certainly confused in the past. Although some of the conditions discussed in this is both essential and timely. [books.google.com]
Six were symptomatic at birth with 10 of the 11 presenting at or before 3 months of age. The most common presenting sign was tachypnoea associated with rib indrawing, occurring in nine cases. [adc.bmj.com]
[…] decreased diffusing capacity UIP is relentlessly progressive Median survival 2.5-3.5 years High resolution computed tomography (HRCT) Changes predominantly basal and peripheral Reticular, linear patterns, retraction bronchiectasis Honeycombing usually present [surgpathcriteria.stanford.edu]
Duration of symptoms – Symptoms that present within days to weeks are seen more so in AIP or COP. Subacute presentations are seen with RBILD and DIP, with the remaining IIPs being chronic in nature. 3. [cancertherapyadvisor.com]
Respiratoric
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Cough
Two pulmonary diseases associated with GERD are asthma and chronic cough. [acpinternist.org]
The main symptoms are exertional dyspnea and a dry cough. Bibasilar inspiratory crackles or rales are usually heard on auscultation. Treatment is based on the underlying cause. [amboss.com]
[…] alveolitis) by unidentified agent - abnormal epithelial repair / wound healing with fibroblastic /myofibroblastic proliferation - deposition of collagen and extracellular matrix - widespread fibrosis with loss of function - variable onset of dyspnea, cough [quizlet.com]
When to get medical advice See your GP if you've struggled with your breathing for a while or have had a cough for more than three weeks. These symptoms aren't normal and shouldn't be ignored. [nhs.uk]
Signs and Symptoms Include Shortness of breath Chronic cough Fatigue and weakness Chest discomfort Loss of appetite and rapid weight loss How You Can Treat It Medication that suppresses the body’s immune system (Pirfenidone, prednisone) Oxygen Therapy [lunginstitute.com]
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Dyspnea
The main symptoms are exertional dyspnea and a dry cough. Bibasilar inspiratory crackles or rales are usually heard on auscultation. Treatment is based on the underlying cause. [amboss.com]
Dyspnea levels were measured with the use of the University of California, San Diego, Shortness of Breath Questionnaire and the Borg Dyspnea Index. [nejm.org]
[…] injury (alveolitis) by unidentified agent - abnormal epithelial repair / wound healing with fibroblastic /myofibroblastic proliferation - deposition of collagen and extracellular matrix - widespread fibrosis with loss of function - variable onset of dyspnea [quizlet.com]
It usually presents with progressive dyspnea, reduced lung volumes, bilateral lower lobe reticular opacities, and a usual interstial pneumonia UIP patter on histology. [thoracicmedicine.org]
IPF manifests with the insidious onset of exertional dyspnea and a non-productive cough that can acutely worsen to include hypoxemia. [pathwaymedicine.org]
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Dry Cough
Its main symptoms are difficulty breathing and dry cough. The process that leads to interstitial lung disease begins when the tissue of the lungs is damaged and the walls of the alveoli become inflamed. [allaboutmalignantmesothelioma.com]
Tell your doctor if you have shortness of breath or dry cough right away. Updated May 2015 [arthritis.org]
The main symptoms are exertional dyspnea and a dry cough. Bibasilar inspiratory crackles or rales are usually heard on auscultation. Treatment is based on the underlying cause. [amboss.com]
Symptoms can include: shortness of breath a persistent dry cough tiredness loss of appetite and weight loss rounded and swollen fingertips ( clubbed fingers ) Many people ignore their breathlessness at first and blame it on getting old or being out of [nhs.uk]
Results: There were 11 (31.4%) males and 24( 68.6%) females, the mean age was 46 14 years, dyspnea was the common presenting symptoms in patients 24(68.6%), dry cough was the presenting symptoms in10 (28.6%)patients, bilateral diffuse crepitations were [iqjmc.uobaghdad.edu.iq]
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Pulmonary Disorder
What to look for Currently, there is no evidence that patients with GERD need to be actively screened for asthma or other pulmonary disorders, according to Dr. Gerson. [acpinternist.org]
It is important to remember that there can be significant overlap and that none of the radiographic patterns seen are pathognomonic for any one interstitial pulmonary disorder. III. Management while the Diagnostic Process is Proceeding. A. [cancertherapyadvisor.com]
Since ILD is not a single disease but a group of more than 200 different pulmonary disorders, it can be confusing to understand exactly what you are dealing with, how a diagnosis is made and who needs to be involved. [my.clevelandclinic.org]
Steroid-responsive pulmonary disorders associated with myelodysplastic syndromes with der(1q;7p) chromosomal abnormality Am J Hematol 1995 ; 50 : 110-115 [cross-ref] [42] Sweet R.D. [em-consulte.com]
There are notable differences between these two pulmonary disorders, although they do share some similarities. [journals.plos.org]
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Sputum
Symptoms can be variable, including shortness of breath, cough (usually a dry cough with no sputum), or no symptoms at all. Symptoms usually progress slowly, but respiratory distress can also occur quickly. [myositis.org]
It's a clinical diagnosis - criteria: [1] Cough with sputum for thee months in at least two consecutive years. No other cause identified. Clinical: [1] Blue bloater (carbon dioxide retainers) Develop cor pulmonale. [librepathology.org]
We are particularly interested in how the mucin Muc5B (that gives sputum it’s ‘stringy’ quality might influence these interactions. [breathingmatters.co.uk]
[…] uncommon - due to underlying cause - hematopoietic disorders, malignancies, immunodeficiencies, lysinuric protein intolerance, acute silicosis Pulmonary Alveolar Proteinosis Clinical and Histology - non-specific respiratory complaints - cough, abundant sputum [quizlet.com]
The characteristic symptoms of COPD are chronic cough with daily variable sputum production and progressive dyspnea. Chronic cough and sputum production usually precede airflow limitation by many years ( 40 ). [jtd.amegroups.com]
Cardiovascular
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Cyanosis
[…] fibrosis, but you might also feel one or more of the following symptoms: loss of stamina loss of appetite fatigue weight loss diffuse chest pain Later on, symptoms can include: shortness of breath without exercise - eating, talking, or just resting cyanosis [medbroadcast.com]
Other signs on examination may include tachypnoea, cyanosis and also signs of cor pulmonale and right heart failure in the later stages. [patient.info]
[…] lung damage: Chest pain Cough; coughing up blood or hemoptysis Low-grade fever Shortness of breath on exertion or dyspnea Loss of activity due to muscle aches and fatigue Very low levels of oxygen in blood, also known as hypoxemia Blue-tinged skin or cyanosis [dovemed.com]
Respiratory symptoms increased respiratory rate apnoea grunting cyanosis. Cardiovascular system symptoms tachycardia bradycardic episodes poor perfusion hypotension. Cutaneous symptoms petechiae bruising bleeding from puncture sites. [bettersafercare.vic.gov.au]
[…] meninges (meningitis), adrenals (Addison's disease), bone, fallopian tubes, vertebrae (Pott disease), cervical lymphadenitis (scrofula) Diffuse Interstitial Lung Disease General Symptoms Pathogenesis Symptoms - dyspnea, tachypnea, end-inspiratory crackles, cyanosis [quizlet.com]
Skin
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Skin Lesion
The disease is characterized by skin lesions with red or purple papules, usually on the upper limbs, head and neck. These lesions correspond to neutrophilic infiltration of the superficial dermis and respond rapidly to corticosteroid therapy. [em-consulte.com]
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Night Sweats
sweats Secondary TB Findings: produces more damage tuberculous lesion located at apex of lungs (less than 3 cm) tuberculous lesions less commonly involve regional lymph nodes fibrocalcific scar (coalescent granuloma with surrounding fibroblasts, /- necrosis [quizlet.com]
Workup
Additional workup revealed a diffuse hypogammaglobulinemia, negative ANA, and elevated urine protein with sharp gamma spike (kappa light chain). [ucdenver.edu]
Infection related tests (septic workup) Non-specific markers C-reactive protein (CRP): CRP rises approximately 12 hours after onset of sepsis and returns to normal within two to seven days of successful treatment. [bettersafercare.vic.gov.au]
“Lack of efficacy of the urine culture as part of the initial workup of suspected neonatal sepsis”. Pediatr Infect Dis J. vol. 11. 1992. pp. 764-6. Visser, VE, Hall, RT. “Urine culture in the evaluation of suspected neonatal sepsis”. [cancertherapyadvisor.com]
[…] often needed to make a diagnosis, with pertinent information and expertise contributed by the pulmonologist, radiologist and pathologist. 4 High-resolution CT should be obtained in virtually all patients with a suspected ILD. 4 Additional diagnostic workup [appliedradiology.com]
A comprehensive diagnostic workup including HRCT, ventilation/perfusion scan, complete lung function testing, CPET, sleep study and RHC (with or without and pulmonary angiogram) may be considered if therapeutic consequences are to be expected. [err.ersjournals.com]
X-Ray
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Pulmonary Infiltrate
Página 54 - Ward HN: Pulmonary infiltrates associated with leukoagglutinin transfusion reactions. Ann Intern Med 73:689-694. 1970. 234. Thompson JSA. [books.google.es]
These publications indicate the importance of looking for an underlying blood disease when hypereosinophilia is associated with pulmonary infiltrates. [em-consulte.com]
infiltrates - good response to steroid or immunosuppressive therapy - lungs are consolidated and heavy - histologically similar to Goodpasture's syndrome (no renal involvement) - no anti-basement membrane antibodies Autoimmune disease involving upper [quizlet.com]
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Kerley A Lines
B line prominence Lymphangitic carcinomatosis, CHF HRCT Nodules Sarcoidosis HP, CBD, pneumoconiosis, RA, malignancy Septal thickening Edema, malignancy, infection, drug toxicity, PVOD Cyst formation LAM, LCH, LIP, DIP, SS Reticular lines IPF, asbestosis [transrespmed.springeropen.com]
Pulmonary Function Test
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Restrictive Pulmonary Function
Restrictive pulmonary function was seen in all patients. There was no improvement in percent predicted lung function in the three year period between first and latest testing. [adc.bmj.com]
Treatment
Conditions that improve with immune suppressive treatment probably are not idiopathic pulmonary fibrosis. The toxicity and side effects of treatments can be serious. [medicinenet.com]
Several treatments can help reduce the rate at which IPF gets worse, but there's currently no treatment that can stop or reverse the scarring of the lungs. [nhs.uk]
In some units, 48-hourly LPs are performed in cases of Gram-negative meningitis, with treatment continuing for 14 days after the first negative culture - in practice this usually equates with a 21-day treatment course. [bettersafercare.vic.gov.au]
Treatment will depend on your baby’s symptoms, age, and general health. It will also depend on how severe the condition is. Early diagnosis and treatment is the best way to stop sepsis. [urmc.rochester.edu]
Prognosis
The prognosis in infancy is thought to be poor 2-4 ; a recent case series 2 recorded nine deaths out of ten patients. The authors suggested that a delay in diagnosis might have contributed to the poor prognosis. [adc.bmj.com]
Treatment and prognosis The clinical course is that of gradual deterioration and the condition carries a rather poor prognosis with median survival ranging from 2.5 to 3.5 years from the time of diagnosis (at the time of initial writing) 2. [radiopaedia.org]
(Outcomes/Resolutions) Prognosis of Radiation-Induced Pulmonary Fibrosis depends upon the extent of scarring in the lungs and resulting symptoms. [dovemed.com]
The prognosis of MDS is variable considering the heterogeneous nature of these entities, with life expectancy varying from a few weeks to a few years. [em-consulte.com]
Prevalence and prognosis of unclassifiable interstitial lung disease. Eur Respir J 2013;42:750–57. Troy L, Glaspole I, Goh N, et al. Prevalence and prognosis of unclassifiable interstitial lung disease. Eur Respir J 2014;43:1529–30. [racgp.org.au]
Etiology
Immune modulators and corticosteroids are used in cases of unknown etiology. In advanced stages of disease ILD can result in pulmonary insufficiency and respiratory heart failure with right ventricular insufficiency. [amboss.com]
Sarcoidosis might have an infectious etiology as it has been linked to mycobacterium infection, but this finding remains debatable. [lecturio.com]
In order to rule out any reversible etiology for an acute decompensation of a previously stable IPF patient diagnostic modalities include computerized tomographic angiogram (CTA) coupled with high-resolution computerized tomography (HRCT) imaging of the [thoracicmedicine.org]
While there are multiple methods by which to classify these diseases, one option is to classify by their etiologies. There are seven categories that are frequently used: 1. [cancertherapyadvisor.com]
A number of interstitial lung diseases of unknown etiology have characteristic histology, clinical features, or presentation and thus are considered unique diseases, including In up to 30% of patients who have interstitial lung diseases with no clear [merckmanuals.com]
Epidemiology
Biochemistry (66) Paediatrics, Neonatology (62) Neurology (38) Otorhinolaryngology (32) Radiology and Imaging (32) Internal Medicine (31) Nuclear Medicine (29) Ophthalmology and Optometry (28) Genetics (27) Histology, Embryology (24) Infectology (24) Epidemiology [portal.mefanet.cz]
Based on the Bernalillo County, NM, USA registry data published in 1994, the overall estimated incidence is approximately 30 cases per 100,000 persons per year. [2] Rates of interstitial lung disease are somewhat higher in men than in women, and the epidemiology [emedicine.medscape.com]
Padilla, who has extensively studied the epidemiology, biomarkers/genetics, and comorbidities of IPF and managed a large population of patients suffering with this complex illness. Learn more about our clinical trials. [icahn.mssm.edu]
Additional Information & Resources: Simple Steps to Prevent Infections During Pregnancy Reducing the Spread of Illness in Child Care Prevent Urinary Tract Infections in Children Cuts, Scrapes & Scar Management: Parent FAQs Trends in the Epidemiology of [healthychildren.org]
The Epidemiology of Interstitial Lung Diseases. Am J Respir Crit Care Med. Oct 1994;150(4):967-72. cited by Michaelson JE, Aguayo SM, Roman J. Idiopathic Pulmonary Fibrosis: A Practical Approach for Diagnosis and Management. Chest. [en.wikipedia.org]
Pathophysiology
The pathogenesis, pathophysiology and clinical implications of the pulmonary vascular and cardiac impairment in ILD are summarised in figure 1. [err.ersjournals.com]
Biophysics (644) Physiology and Pathophysiology (83) Medical Chemistry and Biochemistry (66) Paediatrics, Neonatology (62) Neurology (38) Otorhinolaryngology (32) Radiology and Imaging (32) Internal Medicine (31) Nuclear Medicine (29) Ophthalmology and [portal.mefanet.cz]
Eosinophilic pneumonia Eosinophilic pneumonia is similar to organizing pneumonia in pathophysiology, but is mediated instead by an inappropriate increase in the number of eosinophils and macrophages in alveoli. [appliedradiology.com]
Because of our unique experience in pulmonary asbestosis, sarcoidosis, and collagen-vascular diseases, the Division of Pulmonary and Critical Care has become a center for the study of interstitial lung diseases concentrating on: Pathophysiology Epidemiology [icahn.mssm.edu]
Overgrowth of these organisms in the neonatal lumen can be a component of the multifactorial pathophysiology of necrotizing enterocolitis. [emedicine.medscape.com]
Prevention
Pregnant women may need preventive antibiotics if they have: Chorioamnionitis Group B strep colonization Given birth in the past to a baby with sepsis caused by bacteria Other things that can help prevent sepsis include: Preventing and treating infections [medlineplus.gov]
Prevention The key to preventing sepsis is to prevent an infection from occurring in the first place. If an infection does set in, it must be treated as quickly and effectively as possible. [sepsis.org]
Archer, MD, Department of Family and Preventive Medicine, Rocky Mountain Center for Occupational and Environmental Health, University of Utah School of Medicine, Building 512, Salt Lake City, UT 84112. Williams & Wilkins 1998. All Rights Reserved. [journals.lww.com]
Examples of preventive measures include stopping smoking, avoiding exposure to known irritants, attending any flu jabs and oxygen therapy. [news-medical.net]
It's not always possible to prevent sepsis. But preventing infections can help lower the chances of sepsis. Here are four ways you can help protect your kids from infection: Get your kids immunized on the recommended schedule. [kidshealth.org]