Overall 70% of patients with sclerosing cholangitis had jaundice vs. 25% without sclerosing cholangitis (p CONCLUSIONS: Our results indicate that drugs can lead to bile duct injury visualized on imaging. [ncbi.nlm.nih.gov]

Cholestatic jaundice as a paraneoplastic feature of secondary sclerosing cholangitis is rare in Hodgkin’s lymphoma. [jamc.ayubmed.edu.pk]

Later presentation includes abdominal pain, jaundice, pruritus, fever and bacterial cholangitis from ascending infection. [orpha.net]

Hepatomegaly (may also have splenomegaly at presentation). Later stages: signs of cirrhosis, portal hypertension or hepatic failure. [patient.info]

ERCP) Hepatomegaly / splenomegaly – approx 50% of patients Investigations P-ANCA – a serum antibody is found in 60% of cases LFT’s: ALP, bilirubin MRCP / ERCP – are able to visualise bile ductal abnormalities. [almostadoctor.co.uk]

Additional symptoms include a general feeling of ill health (malaise); abdominal pain, especially the upper right portion of the abdomen; nausea; dark urine; light-colored stools; unintended weight loss, and/or abnormal enlargement of the liver (hepatomegaly [rarediseases.org]

In an early multivariable analysis, hepatomegaly and a serum bilirubin level 1.5 mg/dL were found to be independently associated with a poor prognosis in PSC. [clinicalgate.com]

Hepatomegaly and splenomegaly are the most frequent findings at clinical examination at the time of diagnosis in PSC. Osteopenic bone disease is a complication of advanced PSC, although less frequent than that reported in PBC. [easl.eu]

A 55-year-old morbidly obese male presented electively with a 2-week history of low back pain and scleral icterus for 2 days. He also described severe epigastric pain that worsened postprandially and a 13 kg weight loss over the previous month. [karger.com]

Case Report A 55-year-old morbidly obese male, with an underlying history of hypertension and dyslipidemia, presented electively, on an outpatient basis, with a 2-week history of low back pain. [karger.com]

Skin findings are common and include cutaneous hyperpigmentation, excoriations resulting from pruritus, and xanthomata. [clinicalgate.com]

In conclusion, the severe sequel of SSC due to CDF should not be neglected in such immunocompromised patients, as recipients of renal transplantations. LT can be used to treat these patients with advanced SSC. References 1 R. Abdalian, E.J. [scipedia.com]

Discussion Compared with PSC, the natural history and prognosis of SSC maybe more favorable if recognition is prompt and appropriate therapy timely. 1 ; 2 Conservative treatment often fails in patients with advanced SSC, generally because of ischemic [scipedia.com]