The secondary stage of syphilis epitomizes the capacity of the infection to present in myriad ways. The skin, lymph glands and mucosal membranes are the most commonly affected tissues. [unboundmedicine.com]

The amount of scale present is variable. Smaller lesions tend to have little visible scale, whereas larger lesions may be quite scaly. [streetdirectory.com]

Patients may present with CNS vascular insufficiency or outright stroke. [emedicine.medscape.com]

While most patients presented with multiple skin lesions, two patients presented with single isolated lesions, which makes the diagnosis almost impossible without histologic examination and a high-degree of suspicion [ 20, 25 ]. [omicsonline.org]

Small, open sores may be present on mucous membranes. The sores may contain pus, or moist sores that look like warts may be present (condyloma lata). In dark-skinned people the sores may be a lighter color than the surrounding skin. [northshore.org]

• Mediastinal Lymphadenopathy

  A contrast-enhanced CT scan showed presence of multiple axillary, hilar, and mediastinal lymphadenopathy ( Fig. 1 B), and bilateral and diffusely distributed pulmonary nodules with ground-glass density ( Fig. 1 C). [bjid.org.br]

• Tachypnea

  Physical examination revealed tachypnea with normal breath sounds and a non-confluent maculo-papular rash in the trunk and extremities. No adenopathies, mucosal or palmo-plantar lesions were evident. [bjid.org.br]

• Bony Swelling

  Neurogenic arthropathy (Charcot joints), a painless joint degeneration with bony swelling and abnormal range of movement, is a classic manifestation of neuropathy. [msdmanuals.com]

Treatment of Syphilis FIGURE 1. Recommended approach to the treatment of syphilis. [aafp.org]

Syphilis alternative treatments for Late latent and Unknown Duration Syphilis Doxycycline 100mg PO BID x 4 weeks OR complication of PCN treatment in pregnancy Jarish Herxheimer Reaction "acute febrile reaction occuring after PCN treatment can occur at [quizlet.com]

Treatment of the Rash of Secondary Syphilis The rash of secondary syphilis does not require any specific treatment because it does not usually cause any symptoms such as itching. The rash will resolve on its own with or without treatment. [skincare.lovetoknow.com]

This would provide confirmation of adequate treatment. [medicalnewstoday.com]

What Is The Prognosis? The treatment of syphilis with penicillin can resolve the infection. Patients should have blood tests to confirm that the infectious bacteria have been eliminated. [healthychildren.org]

Course and Prognosis The ulcer of primary syphilis (chancre) appears 2 to 3 weeks after exposure to an infected person. [streetdirectory.com]

Prognosis : The invention of penicillin has reduced the spread of Syphilis which can now be cured without causing permanent damage. [diseaseslab.com]

Prognosis With proper antibiotic treatment, early syphilis infection can be cured without causing permanent damage. Although later stages of syphilis also respond to antibiotics, treatment will not repair any organ damage caused by the disease. [drugs.com]

Syphilis Prognosis Primary, secondary, and early latent syphilis can be treated successfully with antibiotics. Late latency (more than 1 year after the secondary stage) is difficult to treat. [healthcommunities.com]

[…] treatment of sex partners principle (for syphilis) syphilis is a reportable disease 70% of syphilis cases are in this population syphilus etiological agent "corkscrew shaped, motile microaerophilic bacterium can't be cultured in vitro cannot be viewed [quizlet.com]

(Etiology) Syphilis is a contagious bacterial infection that is transmitted through sex with an affected individual. [dovemed.com]

Acute syphilitic meningitis does not have any typical symptoms, the clinic is similar to meningitis of a different etiology. A person feels a headache of diffuse and arching nature, fever and vomiting without nausea and not bringing relief. [en.medicine-worlds.com]

[…] traumatic ulcer, furuncle (boil), and aphthous ulcer. 12 A selected differential diagnosis is provided in Table 1. 12, 13 View/Print Table TABLE 1 Selected Differential Diagnosis of Genital Lesions Disorder or disease Characteristics of genital lesion Etiology [aafp.org]

Etiology T. pallidum is a motile, corkscrew-shaped spirochete. Spirochetes are gram negative and have a flagellar bundle running through their periplasmic space causing the cells to move in a corkscrew fashion. Its size varies from 6 to 20um. [dermatologyadvisor.com]

Recent trends in the epidemiology of STI in the European Union. Sex Transm Infect 2004;80:255-63. 8. Lacey HB, Higgins SP, Graham D. An outbreak of early syphilis: cases from North Manchester General Hospital. Sex Transm Infect 2001;77:311-3. 9. [degruyter.com]

Epidemiologic studies in San Francisco, Seattle and New York City, however, have not found an increase in HIV coincident with the significant growth of syphilis in those urban centers. [clinicaladvisor.com]

Syphilis in China from 2000 to 2013: epidemiological trends and characteristics. Chin J Dermatol 5, 6 (2014). 4. Chung, G., Kantor, G. R. & Whipple, S. Tertiary syphilis of the face. [nature.com]

Clinical and epidemiological features of study subjects. Table 1. Clinical and epidemiological features of study subjects. Cellular elements of innate and adaptive immunity in secondary syphilis skin lesions. [academic.oup.com]

"A systematic review of epidemiologic studies assessing condom use and risk of syphilis". Sex Transm Dis. 36 (7): 401–5. doi : 10.1097/OLQ.0b013e3181a396eb. PMID 19455075. ^ a b "Syphilis - CDC Fact Sheet". [en.wikipedia.org]

Precise understanding of the pathophysiology of syphilis is compromised by the inability to grow the spirochete in culture, and therefore it has been studied in animal models and in some controversial human studies, for example, the Tuskegee study in [clinicaladvisor.com]

Encyclopedia) RPR test (Medical Encyclopedia) Syphilis (Centers for Disease Control and Prevention) Syphilis - primary (Medical Encyclopedia) Syphilis and MSM (Men Who Have Sex with Men) (Centers for Disease Control and Prevention) VDRL test (Medical [icdlist.com]

Centers for Disease Control and Prevention. Syphilis Fact Sheet. Available online at http://www.cdc.gov/std/Syphilis/STDFact-Syphilis.htm. Accessed June 2009. Centers for Disease Control and Prevention. STD surveillance, 2007. [labtestsonline.org]

External resources CDC National Prevention Information Network (NPIN) National Center for HIV, STD and TB Prevention P.O. [drugs.com]

Congenital syphilis can be prevented by treating the mother for syphilis during pregnancy. [everydayhealth.com]

Prevention First As with any other sexually transmitted infection, prevention is the key to avoid being infected with syphilis. Avoid unprotected sex with multiple partners. Insist on the use of condoms with every sexual partner. [skincare.lovetoknow.com]