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Secondary Syphilis of the Skin


  • The secondary stage of syphilis epitomizes the capacity of the infection to present in myriad ways. The skin, lymph glands and mucosal membranes are the most commonly affected tissues.[unboundmedicine.com]
  • Atypical presentations of primary genital syphilis in HIV-negative homosexually active men: a case series. Serb J Dermatol Venereol 2012;4:113-8. 17. Czelusta A, Yen-Moore A, Van der Straten M, Carrasco D, Tyring SK.[degruyter.com]
  • The amount of scale present is variable. Smaller lesions tend to have little visible scale, whereas larger lesions may be quite scaly.[streetdirectory.com]
  • Small, open sores may be present on mucous membranes . The sores may contain pus, or moist sores that look like warts may be present (condyloma lata). In dark-skinned people the sores may be a lighter color than the surrounding skin.[northshore.org]
  • Fan Li, from Sichuan University in Chengdu, China, and colleagues reported the case of a 51-year-old man who presented with a 2-month history of multiple nodules on his scalp.[infectiousdiseaseadvisor.com]
Congestive Heart Failure
  • See separate leaflets called Congestive Heart Failure and Anatomy of the heart for more details. Gummatous disease. Gummas are soft growths (tumours) caused by inflammation.[patient.info]
Mediastinal Lymphadenopathy
  • A contrast-enhanced CT scan showed presence of multiple axillary, hilar, and mediastinal lymphadenopathy ( Fig. 1 B), and bilateral and diffusely distributed pulmonary nodules with ground-glass density ( Fig. 1 C).[bjid.org.br]
  • Physical examination revealed tachypnea with normal breath sounds and a non-confluent maculo-papular rash in the trunk and extremities. No adenopathies, mucosal or palmo-plantar lesions were evident.[bjid.org.br]
Leg Pain
  • Full Text Case A 50-year-old healthy male was seen for a 6-week history of right leg pain, occasional dyspnea and extensive non-pruritic skin rash in trunk and extremities ( Fig. 1 A).[bjid.org.br]
  • Blastomycosis (Medical Encyclopedia) Boils (Medical Encyclopedia) Candida infection of the skin (Medical Encyclopedia) Carbuncle (Medical Encyclopedia) Donovanosis (granuloma inguinale) (Medical Encyclopedia) Ecthyma (Medical Encyclopedia) Erysipelas[icdlist.com]
Papular Rash
  • Physical examination revealed tachypnea with normal breath sounds and a non-confluent maculo-papular rash in the trunk and extremities. No adenopathies, mucosal or palmo-plantar lesions were evident.[bjid.org.br]
  • The clinical options for early neurosyphilis are as follows: latent meningitis; clinically acute meningitis; basal meningitis; hydrocephalus (chronic and acute); meningomyelitis; meningovascular syphilis; lesion of individual cranial nerves.[en.medicine-worlds.com]
  • […] syphilis A51.1 Primary anal syphilis A51.2 Primary syphilis of other sites A51.3 Secondary syphilis of skin and mucous membranes A51.32 Syphilitic alopecia A51.39 Other secondary syphilis of skin A51.4 Other secondary syphilis A51.41 Secondary syphilitic meningitis[icd10data.com]
  • A few meningeal infections heal spontaneously, but most remain asymptomatic (latent) for years before some are reactivated during tertiary meningeal syphilis.[histopathology-india.net]
  • Meningitis - inflammation of the coverings of the brain (the meninges) - can also occur as a more sudden-onset (acute) complication. Total loss of vision (severe sight impairment) and deafness can also occur. General paresis.[patient.info]
  • Complications of syphilis may include: Cardiovascular problems (aortitis and aneurysms) Destructive sores of skin and bones (gummas) Neurosyphilis Syphilitic myelopathy - a complication that involves muscle weakness and abnormal sensations Syphilitic meningitis[medlineplus.gov]


  • Viral: Shingles, warts, and herpes simplex Fungal: Athlete's foot and yeast infections Parasitic: Body lice, head lice, and scabies Treatment of skin infections depends on the cause.[icdlist.com]
  • Treatment: Lesions fade without treatment, but treatment is still necessary to prevent the stigmata of late syphilis. See: Syphilis for treatment details. Back to Dermatology Glossary - S Index Back to Dermatology Glossary Index[skincareguide.ca]
  • This would provide confirmation of adequate treatment.[medicalnewstoday.com]
  • […] an accurate baseline for monitoring treatment.[sti.guidelines.org.au]


  • What Is The Prognosis? The treatment of syphilis with penicillin can resolve the infection. Patients should have blood tests to confirm that the infectious bacteria have been eliminated.[healthychildren.org]
  • Course and Prognosis The ulcer of primary syphilis (chancre) appears 2 to 3 weeks after exposure to an infected person.[streetdirectory.com]
  • Prognosis : The invention of penicillin has reduced the spread of Syphilis which can now be cured without causing permanent damage.[diseaseslab.com]
  • Prognosis With proper antibiotic treatment, early syphilis infection can be cured without causing permanent damage. Although later stages of syphilis also respond to antibiotics, treatment will not repair any organ damage caused by the disease.[drugs.com]
  • Syphilis Prognosis Primary, secondary, and early latent syphilis can be treated successfully with antibiotics. Late latency (more than 1 year after the secondary stage) is difficult to treat.[healthcommunities.com]


  • […] treatment of sex partners principle (for syphilis) syphilis is a reportable disease 70% of syphilis cases are in this population syphilus etiological agent "corkscrew shaped, motile microaerophilic bacterium can't be cultured in vitro cannot be viewed[quizlet.com]
  • (Etiology) Syphilis is a contagious bacterial infection that is transmitted through sex with an affected individual.[dovemed.com]
  • Acute syphilitic meningitis does not have any typical symptoms, the clinic is similar to meningitis of a different etiology. A person feels a headache of diffuse and arching nature, fever and vomiting without nausea and not bringing relief.[en.medicine-worlds.com]
  • Fifth, even the physicians did distinguish co-existing cardiac disease or CNS disease that had a different etiology from cardiac or CNS disease at the diagnosis stage, these data were not collected.[nature.com]


  • Recent trends in the epidemiology of STI in the European Union. Sex Transm Infect 2004;80:255-63. 8. Lacey HB, Higgins SP, Graham D. An outbreak of early syphilis: cases from North Manchester General Hospital. Sex Transm Infect 2001;77:311-3. 9.[degruyter.com]
  • Syphilis in China from 2000 to 2013: epidemiological trends and characteristics. Chin J Dermatol 5, 6 (2014). 4. Chung, G., Kantor, G. R. & Whipple, S. Tertiary syphilis of the face.[nature.com]
Sex distribution
Age distribution


  • Encyclopedia) RPR test (Medical Encyclopedia) Syphilis (Centers for Disease Control and Prevention) Syphilis - primary (Medical Encyclopedia) Syphilis and MSM (Men Who Have Sex with Men) (Centers for Disease Control and Prevention) VDRL test (Medical[icdlist.com]
  • Center for Disease Control and Prevention: report of infectious diseases in Belgrade in 2014. Belgrade: City Institute of Public Health of Belgrade; 2015. p. 31-5. 6. 6. Bjekić M, Šipetić S.[degruyter.com]
  • External resources CDC National Prevention Information Network (NPIN) National Center for HIV, STD and TB Prevention P.O.[drugs.com]
  • The Centers for Disease Control and Prevention advise against the excessive use of alcohol and drugs.[wikihow.com]
  • Prevention Preventive measures to decrease the risk of syphilis, include: abstaining from sex long-term mutual monogamy with an uninfected partner condom use, although these protect only against genital sores and not those on the body.[medicalnewstoday.com]

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