Patient and method: A 13 year-old male patient diagnosed with selective IgA deficiency presenting with recurrent respiratory infections, allergic asthma, allergic rhinitis, gastrointestinal disturbances and epilepsy has been followed up at our hospital [bib.irb.hr]

In conclusion, the data from this study, in combination with data from similar studies in adults, present a disturbing picture of humoral immune dysregulation early in the course of HIV infection. [academic.oup.com]

• Recurrent Infection

  infections, which may develop from selective IgA deficiency. [bib.irb.hr]

  Immunoglobulins in the hyperimmunoglobulin E and recurrent infection (Job's) syndrome. Deficiency of anti-Staphylococcus aureus immunoglobulin A. Dreskin SC, Goldsmith PK, Gallin JI. Dreskin SC, et al. [pubmed.ncbi.nlm.nih.gov]

  Primary immunodeficiency – recurrent infections in children. Australian Doctor 2008;28:21–8. Yee A, De Ravin SS, Elliott E, Ziegler JB. Severe combined immunodeficiency: a national surveillance study. Paediatr Allergy Immunol 2008;19:298–302. [racgp.org.au]

• Asymptomatic

  Most affected persons are asymptomatic and do not appear to be at increased risk for infection. [ncbi.nlm.nih.gov]

  Most patients are asymptomatic, while some can have recurrent sinopulmonary infections in later childhood. [racgp.org.au]

• Epilepsy

  Patient and method: A 13 year-old male patient diagnosed with selective IgA deficiency presenting with recurrent respiratory infections, allergic asthma, allergic rhinitis, gastrointestinal disturbances and epilepsy has been followed up at our hospital [bib.irb.hr]

• Recurrent Respiratory Infections

  Patient and method: A 13 year-old male patient diagnosed with selective IgA deficiency presenting with recurrent respiratory infections, allergic asthma, allergic rhinitis, gastrointestinal disturbances and epilepsy has been followed up at our hospital [bib.irb.hr]

• Streptococcus Pneumoniae

  The impact of HIV on Streptococcus pneumoniae bacteraemia in a South African population, AIDS, 1998, vol. 12 (pg. 2177 - 84 ) 3, ,, et al. [academic.oup.com]

  Patients with antibody deficiency are particularly predisposed to recurrent sinopulmonary infections, especially with polysaccharide encapsulated organisms including Streptococcus pneumoniae and Haemophilus influenzae. [racgp.org.au]

• Staphylococcus Aureus

  Deficiency of anti-Staphylococcus aureus immunoglobulin A. Dreskin SC, Goldsmith PK, Gallin JI. Dreskin SC, et al. J Clin Invest. 1985 Jan;75(1):26-34. doi: 10.1172/JCI111683. J Clin Invest. 1985. PMID: 3871199 Free PMC article. [pubmed.ncbi.nlm.nih.gov]

• HLA-B8

  Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype. Tissue Antigens. 2000 Sep. 56(3):207-16. [Medline]. [emedicine.medscape.com]

The HAART-receiving, HIV load-positive group was a mixed population that included patients who were not treatment compliant and those who were in the early stages of treatment, before their HIV load was under control. [academic.oup.com]

Advances in the understanding and treatment of human severe combined immunodeficiency. Buckley RH. Buckley RH. Immunol Res. 2000;22(2-3):237-51. doi: 10.1385/IR:22:2-3:237. Immunol Res. 2000. PMID: 11339359 Review. [pubmed.ncbi.nlm.nih.gov]

Severe combined immunodeficiency is a medical emergency, and patients should be urgently referred to specialist centres for continuation of diagnosis and treatment as soon as it is suspected (ie. if patients have low absolute lymphocyte counts and low [racgp.org.au]

PMID: 17173844 Prognosis Aghamohammadi A, Abolhassani H, Biglari M, Abolmaali S, Moazzami K, Tabatabaeiyan M, Asgarian-Omran H, Parvaneh N, Mirahmadian M, Rezaei N Int Arch Allergy Immunol 2011;156(4):462-8. Epub 2011 Aug 10 doi: 10.1159/000323903. [ncbi.nlm.nih.gov]

The highest IgD concentration (163 mg/100 ml) was found in serum from a boy with variable immunodeficiency who had a lifelong history of severe recurrent pharyngeal infections, primarily streptococcal in etiology. [unboundmedicine.com]

[from NCI] Etiology Aghamohammadi A, Abolhassani H, Biglari M, Abolmaali S, Moazzami K, Tabatabaeiyan M, Asgarian-Omran H, Parvaneh N, Mirahmadian M, Rezaei N Int Arch Allergy Immunol 2011;156(4):462-8. Epub 2011 Aug 10 doi: 10.1159/000323903. [ncbi.nlm.nih.gov]

HLA-B8, SC01, DR3 in white subjects in an American study. [12] A 2008 report noted that depletion of circulating IgD+ memory B cells occurs in pediatric HIV infection, despite control of viral load with highly active anti-retroviral therapy (HAART). [13] Epidemiology [emedicine.medscape.com]

Pathophysiology Genetic rearrangements occur during the maturation of B lymphocytes, eventually resulting in the surface expression of both immunoglobulin M (IgM) and IgD on mature B cells. Cell signaling occurs through this surface IgD. [emedicine.medscape.com]