Edit concept Question Editor Create issue ticket

Senna

Senna Extract


Presentation

  • The present study presents a new experimental model of mitochondrial myopathy that may be useful for the best knowledge of this group of diseases and for experimental trials of drugs that could reverse the mitochondrial impairment in the mitochondrial[ncbi.nlm.nih.gov]
  • Despite admitting he doesn't have much space for trophies and prizes, the Brit admits his new present will certainly not be stored away in a dusty cupboard.[dailymail.co.uk]
  • They made a 40-minute presentation about what they would do in the documentary, which convinced them to authorize and support the project. The presentation was called "The Life and Death of Ayrton Senna".[imdb.com]
El Salvador
  • Virgin Islands (British) [Tortola] CENTRAL AMERICA: Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama NORTHERN SOUTH AMERICA: French Guiana, Guyana, Suriname, Venezuela BRAZIL: Brazil [Rio Grande do Sul, Santa Catarina, Paraná] WESTERN[npgsweb.ars-grin.gov]
  • ., Central African Repu, Central American Pac, Chad, Chile Central, Chile North, Colombia, Costa Rica, Cuba, Djibouti, Dominican Republic, East Himalaya, Ecuador, Egypt, El Salvador, Eritrea, Ethiopia, Fiji, Florida, Free State, French Guiana, Galápagos[plantsoftheworldonline.org]
Down Syndrome
  • syndrome, 26 (3.1%) had mothers with the use of senna (OR with 95% CI: 0.7, 0.5-1.1).[ncbi.nlm.nih.gov]
Dermatitis
  • Senna induced dermatitis is rare, but may occur when patients need a higher dose. All of the cases described had a long period of exposure of the skin to stool.[ncbi.nlm.nih.gov]

Workup

  • In the United States, constipation accounts for 7 million physician visits per year 24 and is among the top 5 outpatient gastrointestinal diagnoses. 25 Annually, diagnostic workup for constipation averages US 3000 per patient, 26 and it takes another[doi.org]
Pseudomonas
  • The extract also had free radical scavenging activity as well as reasonable antibacterial activity against Pseudomonas aeruginosa, Enterococcus faecalis, Escherichia coli and Staphylococcus aureus with MICs ranging from 0,08 to 0.16 mg/ml in the same[ncbi.nlm.nih.gov]
Hepatocellular Carcinoma
  • KEYWORDS: ( )-Cassine; ( )-Spectaline; Cell cycle arrest; Hepatocellular carcinoma; Piperidine alkaloids; Senna spectabilis[ncbi.nlm.nih.gov]

Treatment

  • Of 22,843 cases with CA, 506 (2.2%) had mothers with senna treatment, while of 38,151 control newborn infants without CA, 937 (2.5%) were born to mothers with senna treatment (adjusted OR with 95% CI: 1.0, 0.9-1.1), and of 834 malformed controls with[ncbi.nlm.nih.gov]

Prognosis

  • The clinician should also weigh the cost-benefits of investigations and only order those that help diagnose the etiology of chronic constipation and affect the treatment and prognosis in such patients.[doi.org]

Etiology

  • Mechanism of Injury The liver injury due to senna has been attributed to the anthraquinone derivatives present in the herbal extract, but the clinical characteristics of the published cases suggest an idiosyncratic rather than direct hepatotoxic etiology[livertox.nih.gov]
  • Conclusions: Chronic constipation should be managed according to its etiology and guided by the best evidence-based treatment.[jabfm.org]

Epidemiology

  • Abstract Previously, the possible teratogenic effect of frequently used laxative drug, senna has not been checked in case-control epidemiological study.[ncbi.nlm.nih.gov]
  • Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004 ; 99 : 750 –9. Bouras EP, Tangalos EG. Chronic constipation in the elderly. Gastroenterol Clin North Am 2009 ; 38 : 463 –80.[jabfm.org]
Sex distribution
Age distribution

Pathophysiology

  • Abstract Retarded colonic transit and disturbed defecation are the most prominent pathophysiological mechanisms in constipation. Both may be influenced by bulking agents and by laxatives such as senna.[ncbi.nlm.nih.gov]
  • Pathophysiology of chronic constipation of the slow transit type from the aspect of the type of rectal movements. Hepatogastroenterology 2008 ; 55 : 1298 –303. Bassotti G, de Roberto G, Castellani D, Sediari L, Morelli A.[jabfm.org]

Prevention

  • Abstract Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes.[ncbi.nlm.nih.gov]
  • Provide feedback for this name Providers NZFLORA Sender Email Feedback Please complete the following test to help prevent spamming on this site plus equals[nzor.org.nz]
  • This information is not intended to diagnose, treat, cure, or prevent any disease.[mountainroseherbs.com]
  • OTHER Prevention Magazine. . Greg Annussek Teresa G. Odle[encyclopedia.com]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!