Senna’s niece Bianca Senna said that her uncle would have been only too happy, if he had still been alive today, to have presented the helmet himself to Hamilton. [telegraph.co.uk]

The family of Ayrton Senna has moved to clear up confusion about the helmet presentation made to Lewis Hamilton for his 65th Formula 1 pole at the Canadian Grand Prix. [autosport.com]

Despite admitting he doesn't have much space for trophies and prizes, the Brit admits his new present will certainly not be stored away in a dusty cupboard. [dailymail.co.uk]

The present study presents a new experimental model of mitochondrial myopathy that may be useful for the best knowledge of this group of diseases and for experimental trials of drugs that could reverse the mitochondrial impairment in the mitochondrial [ncbi.nlm.nih.gov]

• Weakness

  The muscles had similar features of human mitochondrial myopathy as ragged-red fibers, cytochrome-oxidase negative fibers, and weak activity of the oxidative enzymes. Fibers with lipid storage were also present. [ncbi.nlm.nih.gov]

  Long-term use can cause changes in blood electrolytes that can cause heart function disorders, muscle weakness, liver damage, and other harmful effects. See "What Are Side Effects Associated with Using Senna?" [rxlist.com]

  Certain electrolyte imbalances can cause muscle weakness, heart problems, liver damage, and other harmful effects. Call your healthcare provider if your constipation does not improve after 1 week of use, or if your constipation gets worse. [drugs.com]

  Martin Brundle, 1993 [21] I tried to find weaknesses in Senna, but I couldn't. He is 100 per cent in everything. I learned a lot from him, so for me it was a good three years. And I still like Senna. We had good fun, a good relationship. [en.wikiquote.org]

  The more serious effects of hypokalemia, or low potassium levels, include muscle weakness, paralysis and heart arrythymias. [livestrong.com]

• Collapse

  Unbeknownst to anyone, the 18-year-old freshman had a congenital heart defect that caused him to collapse on the field. His parents were both in attendance. [wexnermedical.osu.edu]

  All the work it does with schools needs to be approved by state and city governments, but public finances are collapsing in Brazil thanks to the recession. [bbc.com]

  It was also reported by Toleman that Senna's suspension was on the point of collapse after an earlier incident and his consistent running over the curbs at the Chicane du Port, with the team believing that the damage was sufficient to cause his retirement [en.wikipedia.org]

• Unconsciousness

  The first was in Spa in 1992, when Senna leapt out of his car in the middle of a practice session to help fellow driver Erik Comas, who had been knocked unconscious in an accident. [topgear.com]

  But in Friday practice, his protégé and Jordan driver Barrichello was involved in a terrifying 230kph accident at the Variante Bassa chicane and was knocked unconscious. [irishexaminer.com]

• Fever

  Ayrton Senna, his design process and the aim of ‘disruptive technology’ Published: 12 Jan 2018 Published: 12 Jan 2018 Inside the mind of Adrian Newey: the F1 design guru opens up November 2015 Lewis Hamilton will race in F1’s Brazilian Grand Prix despite fever [theguardian.com]

  Native Americans also recognised Senna’s laxative power, but instead used it to treat fevers. Traditional use Senna has been used as a traditional medicine by ancient cultures all over the world for millennia. [indigo-herbs.co.uk]

• Nausea

  Both regimens were well tolerated, and did not significantly differ in the occurrence of nausea, bloating or headache. [ncbi.nlm.nih.gov]

  Symptoms of overdose may include: nausea/vomiting/diarrhea that doesn't stop, severe stomach/abdominal pain or cramping. Keep all medical and lab appointments. [webmd.com]

  Alternative Significant - Monitor Closely All Interactions Sort By: Adverse Effects Frequency Not Defined Abdominal pain Diarrhea Electrolyte abnormalities, including hypokalemia Excessive bowel activity Finger clubbing (long-term use) Melanosis coli Nausea [reference.medscape.com]

• Flatulence

  Most common adverse effects in both treatments were an increased in urgency and flatulence[ 13 ]. [doi.org]

  However, PEG can cause nausea, flatulence, and diarrhea, especially in the elderly, and the dosage should be titrated upward according to response. 19 In fact, some studies also reported efficacy at a low dosage of PEG. 145–147 For lactulose, at least [jabfm.org]

• Jaundice

  A 77 year old male was referred with abdominal pain, jaundice and elevated transaminase levels. A diagnosis of extrahepatic cholestasis was first suspected, due to the observation of a duodenal diverticulum and dilated proximal choledocus. [ncbi.nlm.nih.gov]

  PubMed Citation (28 year old woman developed jaundice after drinking herbal tea containing senna leaves, with positive rechallenge [ALT ~1390 U/L, GGT ~190 U/L], with Rhein anthrone detectable in serum). [livertox.nih.gov]

  […] of your fingers and toes; low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice [drugs.com]

• Fracture

  The Rebellion Racing driver suffered a hairline fracture to his right ankle in a crash at Copse which halted the opening FIA World Endurance Championship session of the weekend for 30 minutes. [sportscar365.com]

  Confirmation reached DSC moments ago that Rebellion Racing driver Bruno Senna, involved in an accident in Free Practice 1 at the exit of Copse corner, has suffered a fracture to his right ankle, and will play no further part in the Silverstone meeting [dailysportscar.com]

  Following his accident in Free Practice 1, the Brazilian driver has a foot fracture and will not drive this weekend. All Team REBELLION wish him a good recovery! [grandprix247.com]

  The Brazilian is reported to have got out of the car unaided, but was taken to the medical centre for checks and was diagnosed with a fracture to his right ankle. [motorsport.com]

  The force of the wheel’s impact with his head caused skull fractures. On top of that, a piece of the suspension upright assembly still attached to the wheel penetrated his Bell M3 helmet just above the right eye. [irishexaminer.com]

• Withdrawn

  Tegaserod was withdrawn for the United States market due to the number of patients that reported serious side effects, mainly ischemic cardiovascular events. [doi.org]

  Zakspeed had withdrawn after five unsuccessful seasons and returned to sports car racing, while Rial had folded after just two seasons. [en.wikipedia.org]

• Grieving

  Lance Senn has had as much time to grieve the loss of his son as he had to spend with him. The grief changes, but it doesn’t diminish. He still chokes up when he recounts the origin of the phrase that became Connor Senn’s legacy. [wexnermedical.osu.edu]

  In the journalists and their writing, I found people just like me, people trying to make sense of the tragedy, people grieving. It helped me come to terms with the mortality of a man I had always seen as immortal. [willthef1journo.wordpress.com]

• Irritability

  Andrew Weil says that certain laxatives, including senna, are "irritant types." They induce bowel movements "quickly, sometimes violently, by irritating the bowel." [empowher.com]

  Senna is also used for irritable bowel syndrome (IBS), hemorrhoids, and weight loss. Senna fruit seems to be gentler than senna leaf. [rxlist.com]

  ‘Magnesium hydroxide is less likely to irritate the digestive tract than a stimulant laxative such as senna.’ 1.2 Used in names of plants of the pea family that are similar to senna, e.g. bladder senna. [en.oxforddictionaries.com]

  Other Gastrointestinal Disorders Senna is sometimes used for irritable bowel syndrome (IBS). When looking specifically at irritable bowel syndrome with constipation (IBS-C), however, there is minimal research supporting the safe use of senna. [verywellhealth.com]

  Senna works to treat constipation by irritating the lining of the intestines, which stimulates the digestive tract to move stool through it. [altmedicine.about.com]

• Confusion

  The family of Ayrton Senna has moved to clear up confusion about the helmet presentation made to Lewis Hamilton for his 65th Formula 1 pole at the Canadian Grand Prix. [autosport.com]

  Lewis Hamilton holds the replica Ayrton Senna helmet the Brazilian's family gifted him Credit: Mark Thompson/Getty Images North America T he family of Ayrton Senna has moved to clear up confusion about the helmet presentation made to Lewis Hamilton for [telegraph.co.uk]

  Participants will receive a UF/IFAS Extension Money Management Calendar 01/02/2018 How to: Demystify Florida’s Food Safety Regulating Agencies Interested in starting a new food related business in Lee County but confused as to what regulatory agency regulates [lee.ifas.ufl.edu]

  McLaren and supercar fans might be confused by the engine -- a twin-turbocharged 4.0-liter V8. Similar to the M840T under the rear clamshell of the 720S, it’s got an extra letter (an R) and more power. [autoweek.com]

  The deadly crash of the three-time Formula 1 world champion was surrounded by secrecy and controversy for many years to follow due to the confusing nature of the mechanical failures that caused Senna to lose control. [thedrive.com]

• Dizziness

  These adverse reactions, which can range from minor nausea, stomachache and diarrhea, can lead to more severe effects that might include severe cramping, dizziness and bloody stools, to name a few. [livestrong.com]

  However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. [webmd.com]

  Notify your doctor promptly if you experience: rectal bleeding, rapid heart rate, weakness, dizziness, fainting, sweating, skin rash, unrelieved constipation. This medication may cause the urine to turn pink, red or brownish in color. [medicinenet.com]

• Aura

  "His sister is such a warm, loving person, and she has a certain aura around here, like I hear Ayrton had. It is great to have that love and support from someone close to him. [telegraph.co.uk]

• Agitation

  He took an active role in agitating for better safety standards in the sport, which earned him the ire of its higher-ups and took on a particular poignance after his death in a preventable crash during a race. [nonfics.com]

In the United States, constipation accounts for 7 million physician visits per year 24 and is among the top 5 outpatient gastrointestinal diagnoses. 25 Annually, diagnostic workup for constipation averages US$3000 per patient, 26 and it takes another [doi.org]

Of 22,843 cases with CA, 506 (2.2%) had mothers with senna treatment, while of 38,151 control newborn infants without CA, 937 (2.5%) were born to mothers with senna treatment (adjusted OR with 95% CI: 1.0, 0.9-1.1), and of 834 malformed controls with [ncbi.nlm.nih.gov]

The clinician should also weigh the cost-benefits of investigations and only order those that help diagnose the etiology of chronic constipation and affect the treatment and prognosis in such patients. [doi.org]

Mechanism of Injury The liver injury due to senna has been attributed to the anthraquinone derivatives present in the herbal extract, but the clinical characteristics of the published cases suggest an idiosyncratic rather than direct hepatotoxic etiology [livertox.nih.gov]

Conclusions: Chronic constipation should be managed according to its etiology and guided by the best evidence-based treatment. [doi.org]

Abstract Previously, the possible teratogenic effect of frequently used laxative drug, senna has not been checked in case-control epidemiological study. [ncbi.nlm.nih.gov]

She’s pursuing a concentration in epidemiology and is most interested in infectious disease. And just to make things more interesting, she’s using her Covid year of eligibility to swim for GW. [davidson.edu]

Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol 2004 ; 99 : 750 –9. ↵ Bouras EP, Tangalos EG. Chronic constipation in the elderly. [doi.org]

Abstract Retarded colonic transit and disturbed defecation are the most prominent pathophysiological mechanisms in constipation. Both may be influenced by bulking agents and by laxatives such as senna. [ncbi.nlm.nih.gov]

Pathophysiology of chronic constipation of the slow transit type from the aspect of the type of rectal movements. Hepatogastroenterology 2008 ; 55 : 1298 –303. ↵ Bassotti G, de Roberto G, Castellani D, Sediari L, Morelli A. [doi.org]

Abstract Natural products can be a source of biomolecules with antioxidant activity which are able to prevent oxidative stress-induced diseases and show antitumor activity, making them important sources of new anticancer drug prototypes. [ncbi.nlm.nih.gov]

There are many things you can do to prevent constipation. [nlm.nih.gov]

OTHER Prevention Magazine. http://www.prevention.com. Greg Annussek Teresa G. Odle [encyclopedia.com]

This information is not intended to diagnose, treat, cure, or prevent any disease. [mountainroseherbs.com]