Symptoma

Sertoli Cell Tumor

A, a mass with calcification present in right testis and calcification in left testis before surgery; B-C, calcification present in left testis 8 months (B) and 17 months (C) after right orchiectomy. [aclr.com.es]

The patients presented with testicular enlargement, which was present for 6 months and 8 years, respectively. There was no gynecomastia. The tumors metastasized to the inguinal and para‐aortic lymph nodes. [onlinelibrary.wiley.com]

May present in both pediatric and adult males, depending on the histologic subtype. Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia. [radiopaedia.org]

The most striking mode of presentation of SLCTs is virilization. [ccij-online.org]

[…] by Kao and colleagues. 8 This patient presented with metastatic disease to the bone and died of his disease 27 months after presentation. [read.nxtbook.com]

  • Falling

    Testicular Sertoli cell tumors (SCTs) are rare, and most fall into the category of SCT–not otherwise specified (SCT-NOS). Only a few additional types of SCT are recognized. [indiana.pure.elsevier.com]

    The cells usually had pale to occasionally densely eosinophilic cytoplasm, but 6 tumors were composed of cells with prominent foamy cytoplasm, falling in the category of "lipid-rich" Sertoli cell tumor, and one had cells with clear non-foamy cytoplasm [ncbi.nlm.nih.gov]

    Most Sertoli cell tumors fall into the "not otherwise specified", or NOS, category, but subsets are represented by 2 variants: the sclerosing Sertoli cell tumor (SSCT) and the large cell calcifying Sertoli cell tumor (LCCSCT). [synapse.koreamed.org]

  • Physician

    J Coll Physicians Surg Pak 2005;15(7):437-8.. Calcagno C. Sclerosing Sertoli cell tumor of the testis. Urologia 2007;74(1):37-9.. Eugenio B, Cristian VP, Riccardo S,Christian R, Giovanni P, Barbara C, et al. [ijp.iranpath.org]

    J Coll Physicians Surg Pak. 2005; 15 :437–438. [ PubMed ] [ Google Scholar ] 7. Esber CM, Shabsigh A, Zynger DL. Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: Case report and literature review. [ncbi.nlm.nih.gov]

    J Coll Physicians Surg Pak. 2005:15:437-438. Esber CM, Shabsigh A, Zynger DL. Sclerosing Sertoli cell tumor without expression of typical sex cord stromal tumor markers: Case report and literature review. Pathol Res Pmct. 2012:208:121-125. [read.nxtbook.com]

  • Fracture

    He had a clavicular fracture at the age of three. He was not on any medications. His growth records were available from age 5 and showed consistent height at the 50th to 75th percentiles and weight at the 25th percentile. [aclr.com.es]

  • Neglect

    In our case, the patient neglected the enlargement of the abdomen over the years, the tumor reached 22 cm in the major axis. The hormonal balance depends on the symptomatology. [omicsonline.org]

Laboratory tests showed elevated serum testosterone 27.6 ng/mL (normal range: 0.2-1.2 ng/mL) and dehydroepiandrosterone of 16.3 ng/mL (normal range: 0.8-3.2 ng/mL), and normal CA-125 of 22 U/mL (normal range The patient was referred to imaging workup [sjmms.net]

  • Polyps

    Malignant changes have been reported to occur in the gastrointestinal polyps, in 2-3% of patients [4]. [sjkdt.org]

    It is most often reported in patients with the familial lentiginoses, Carney complex (CNC) along with cardiac myxomas, pituitary, and adrenal tumors [3], or Peutz-Jeghers syndrome (PJS) in association with gastrointestinal hamartomatous polyps and other [aclr.com.es]

  • Lymphocytic Infiltrate

    Seminoma with tubular pattern: has clear cells, fibrous septa and lymphocytic infiltrates; Oct3/4 and inhibin-. advertisement advertisement [auanet.org]

    Some areas showed abundant eosinophilic stroma and lymphocyte infiltrate ( Figure 1 ). [aclr.com.es]

  • Adrenocortical Hyperplasia

    The large-cell calcifying Sertoli cell subtype has been uniquely associated with precocious puberty, pituitary adenoma, adrenocortical hyperplasia, and cardiac myxoma. 8 An association between this subtype and tuberous sclerosis and Peutz-Jeghers syndrome [read.nxtbook.com]

Palliative treatment Management of recurrent or metastatic disease- overt metastatic disease is treated with chemotherapy. As with granulosa cell tumors, the optimal regimen for treatment of advanced Sertoli-Leydig cell tumors is unknown. [omicsonline.org]

WT1 immunostaining ( 17721194 ) Localization ovarian Sertoli cell tumor testicular Sertoli cell tumor Treatment and management The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. [humpath.com]

Newer agents in treatment and validated treatment protocols for such fatal metastatic tumors need larger studies. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. [ijpmonline.org]

[…] of a syndrome large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C (Gd) : homogeneous enhancement Treatment [radiopaedia.org]

Journal of Surgical Pathology. 26(5):541-550, MAY 2002 PMID: 11979085 Issn Print: 0147-5185 Publication Date: May 2002 Checking for direct PDF access through Ovid Abstract The distinction of Sertoli cell tumors from seminoma is critical to ensure proper treatment [insights.ovid.com]

Prognosis The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant. For malignant tumours with undifferentiated histology, prognosis is poor. [humpath.com]

The prognosis of a benign Sertoli cell tumor is good, but the prognosis of malignant Sertoli cell tumors has not been established. [synapse.koreamed.org]

The presence of heterologous elements also portends poor prognosis. Recurrence is usually within 2 years [3], [4] and occurs in the peritoneal cavity. [ijabmr.org]

[…] large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C (Gd) : homogeneous enhancement Treatment and prognosis [radiopaedia.org]

Their prognosis are difficult to establish; some of the tumors are almost always benign (Sertoli cell tumors, Leydig cell tumors), whereas others are malignant but with more-or-less delayed local-regional or metastatic relapses. [banglajol.info]

The etiology of testicular cancer is unknown. [synapse.koreamed.org]

Karger AG, Basel References Mostofi FK: Testicular tumors: Epidemiologie, etiologic, and pathologic features. Cancer 1973;32:1186–1201. Littleton R, Farah R, Cerny J, Ohorodnik J: Sertoli cell testicular tumors. Urology 1981;17:557–579. [karger.com]

Epidemiology Sertoli and Leydig cell tumors account for 25% of endocrine tumors in the ovary. They are rare with a prevalence of 0.2% of all ovarian cancers [ 2 ]. Family forms of these types of tumors have been described [ 4 ]. [omicsonline.org]

Changes to coding designations would facilitate clinically relevant epidemiologic investigations. [ascopubs.org]

TREATMENT Section: Our understanding of the pathophysiology of these tumors continues to advance, yet, at this point, this knowledge has not yet been translated into novel therapeutic approaches. [ascopubs.org]

Colombo, on behalf of the ESMO Guidelines Committee These updated guidelines on non-epithelial ovarian cancer cover prevention, diagnosis, treatment and follow-up for early and advanced stages and recurrences of germ cell tumours, sex cord-stromal tumours [esmo.org]

However, in general, they are not favoured to prevent incomplete resections and tumour rupture. 8 For those with stage T1 with tumours of intermediate or poor differentiation, or with capsule rupture, standard staging (omentectomy, appendectomy and pelvic [elsevier.es]

In addition, limitations in national reporting prevent an epidemiologic understanding of these tumors, including the risk for subsequent malignancies. [ascopubs.org]