The patients presented with testicular enlargement, which was present for 6 months and 8 years, respectively. There was no gynecomastia. The tumors metastasized to the inguinal and para‐aortic lymph nodes. [onlinelibrary.wiley.com]

A, a mass with calcification present in right testis and calcification in left testis before surgery; B-C, calcification present in left testis 8 months (B) and 17 months (C) after right orchiectomy. [aclr.com.es]

May present in both pediatric and adult males, depending on the histologic subtype. Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia. [radiopaedia.org]

The most striking mode of presentation of SLCTs is virilization. [ccij-online.org]

[…] by Kao and colleagues. 8 This patient presented with metastatic disease to the bone and died of his disease 27 months after presentation. [read.nxtbook.com]

• Hirsutism

  Case report A 21-year-old nulliparous female presented with complaints of pelvic pain, acne, hirsutism, hoarseness of voice and oligomenorrhea for the last 6 months. [sjmms.net]

  Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high. [humpath.com]

  Signs of virilization such as hirsutism, voice hoarseness, clitoral hypertrophy, defeminization of the silhouette and changes in psycho-sexual behavior can be found in 30 to 50% of cases. [omicsonline.org]

  On clinical examination, hirsutism (on face, lip, breast, abdomen), deepening of the voice, laryngeal protuberance, and clitoromegaly were noted. She was not sexually active. Abdominal examination revealed a swelling in the pelvic region. [ccij-online.org]

  A 28-year-old female presented in the gynecology department in AIIMS, Jodhpur, with complaints of oligomenorrhea, hypomenorrhea, hirsutism, acne, and pain in abdomen. The patient is a gutka chewer for 6–7 years. [ijabmr.org]

• Clitoromegaly

  Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high. [humpath.com]

  Vaginal examination revealed clitoromegaly and a firm and mobile solid mass in the left adnexa. [sjmms.net]

  On clinical examination, hirsutism (on face, lip, breast, abdomen), deepening of the voice, laryngeal protuberance, and clitoromegaly were noted. She was not sexually active. Abdominal examination revealed a swelling in the pelvic region. [ccij-online.org]

  Case report An 11-year-old premenarchal female patient visited the Paediatrics Department with clinical characteristics of virilisation (deep voice, hirsutism of the lower limbs and moderate clitoromegaly) for the last 7 months, associated with a palpable [elsevier.es]

Laboratory tests showed elevated serum testosterone 27.6 ng/mL (normal range: 0.2-1.2 ng/mL) and dehydroepiandrosterone of 16.3 ng/mL (normal range: 0.8-3.2 ng/mL), and normal CA-125 of 22 U/mL (normal range The patient was referred to imaging workup [sjmms.net]

Palliative treatment Management of recurrent or metastatic disease- overt metastatic disease is treated with chemotherapy. As with granulosa cell tumors, the optimal regimen for treatment of advanced Sertoli-Leydig cell tumors is unknown. [omicsonline.org]

WT1 immunostaining ( 17721194 ) Localization ovarian Sertoli cell tumor testicular Sertoli cell tumor Treatment and management The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. [humpath.com]

As with most testicular tumours, the standard treatment of unilateral sex chord scrotal tumours is radical inguinal orchidectomy. It permits a definitive pathologic diagnosis and provides local tumour treatment. [bjuinternational.com]

Several new treatment algorithms are featured as well as an extensive summary of recommendations. Download the PDF from Annals of Oncology [esmo.org]

Newer agents in treatment and validated treatment protocols for such fatal metastatic tumors need larger studies. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. [ijpmonline.org]

Prognosis The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant. For malignant tumours with undifferentiated histology, prognosis is poor. [humpath.com]

The prognosis of a benign Sertoli cell tumor is good, but the prognosis of malignant Sertoli cell tumors has not been established. [synapse.koreamed.org]

The presence of heterologous elements also portends poor prognosis. Recurrence is usually within 2 years [3], [4] and occurs in the peritoneal cavity. [ijabmr.org]

[…] large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C+ (Gd) : homogeneous enhancement Treatment and prognosis [radiopaedia.org]

Definition / general Rare; excellent prognosis Mean age 30 years old, range 2-76 years Tends to secrete estrogen / progesterone, but diagnose based on morphology, not hormones Similar to a well differentiated Sertoli-Leydig tumor without a Leydig component [pathologyoutlines.com]

Karger AG, Basel References Mostofi FK: Testicular tumors: Epidemiologie, etiologic, and pathologic features. Cancer 1973;32:1186–1201. Littleton R, Farah R, Cerny J, Ohorodnik J: Sertoli cell testicular tumors. Urology 1981;17:557–579. [karger.com]

The etiology of testicular cancer is unknown. [synapse.koreamed.org]

Changes to coding designations would facilitate clinically relevant epidemiologic investigations. [ascopubs.org]

Epidemiology Sertoli and Leydig cell tumors account for 25% of endocrine tumors in the ovary. They are rare with a prevalence of 0.2% of all ovarian cancers [ 2 ]. Family forms of these types of tumors have been described [ 4 ]. [omicsonline.org]

TREATMENT Section: Our understanding of the pathophysiology of these tumors continues to advance, yet, at this point, this knowledge has not yet been translated into novel therapeutic approaches. [ascopubs.org]

Colombo, on behalf of the ESMO Guidelines Committee These updated guidelines on non-epithelial ovarian cancer cover prevention, diagnosis, treatment and follow-up for early and advanced stages and recurrences of germ cell tumours, sex cord-stromal tumours [esmo.org]

However, in general, they are not favoured to prevent incomplete resections and tumour rupture. 8 For those with stage T1 with tumours of intermediate or poor differentiation, or with capsule rupture, standard staging (omentectomy, appendectomy and pelvic [elsevier.es]

In addition, limitations in national reporting prevent an epidemiologic understanding of these tumors, including the risk for subsequent malignancies. [ascopubs.org]