A, a mass with calcification present in right testis and calcification in left testis before surgery; B-C, calcification present in left testis 8 months (B) and 17 months (C) after right orchiectomy. [aclr.com.es]

The patients presented with testicular enlargement, which was present for 6 months and 8 years, respectively. There was no gynecomastia. The tumors metastasized to the inguinal and para‐aortic lymph nodes. [onlinelibrary.wiley.com]

May present in both pediatric and adult males, depending on the histologic subtype. Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia. [radiopaedia.org]

The most striking mode of presentation of SLCTs is virilization. [ccij-online.org]

[…] by Kao and colleagues. 8 This patient presented with metastatic disease to the bone and died of his disease 27 months after presentation. [read.nxtbook.com]

• Falling

  Testicular Sertoli cell tumors (SCTs) are rare, and most fall into the category of SCT–not otherwise specified (SCT-NOS). Only a few additional types of SCT are recognized. [indiana.pure.elsevier.com]

  The cells usually had pale to occasionally densely eosinophilic cytoplasm, but 6 tumors were composed of cells with prominent foamy cytoplasm, falling in the category of "lipid-rich" Sertoli cell tumor, and one had cells with clear non-foamy cytoplasm [ncbi.nlm.nih.gov]

  Most Sertoli cell tumors fall into the "not otherwise specified", or NOS, category, but subsets are represented by 2 variants: the sclerosing Sertoli cell tumor (SSCT) and the large cell calcifying Sertoli cell tumor (LCCSCT). [synapse.koreamed.org]

• Familial Adenomatous Polyposis

  Bilateral Sertoli cell tumor Sertoli cell tumor with familial adenomatous polyposis (FAP) bilateral Sertoli cell tumor The tumors have a conventional Sertoli cell tumor morphology, but with different morphology in the left and right sites. [humpath.com]

• Lacrimation

  Primary ductal adenocarcdinoma of the lacrimal sac: The first reported case. Int J Clin Exp Pathol. 2013; 6 :1929–34. [ PMC free article ] [ PubMed ] [ Google Scholar ] 12. Oliva E, Garcia-Miralles N, Vu Q, Young RH. [ncbi.nlm.nih.gov]

• Skin Lesion

  His mother has a past medical history significant for numerous cardiac myxomas, follicular thyroid carcinoma, pituitary adenoma, atypical mesenchymal neoplasm with unknown malignant potential of the uterus, adrenal hyperplasia, and multiple skin lesions [path.upmc.edu]

• Fracture

  He had a clavicular fracture at the age of three. He was not on any medications. His growth records were available from age 5 and showed consistent height at the 50th to 75th percentiles and weight at the 25th percentile. [aclr.com.es]

• Advanced Bone Age

  Both boys had gynecomastia, rapid growth and advanced bone age [15]. [sjkdt.org]

• Increased Libido

  No history of anorexia, weight loss, increased libido, or breast recession was noted. Her medical and family history was unremarkable. Vaginal examination revealed clitoromegaly and a firm and mobile solid mass in the left adnexa. [sjmms.net]

• Loss of Libido

  No history of anorexia, weight loss, increased libido, or breast recession was noted. Her medical and family history was unremarkable. Vaginal examination revealed clitoromegaly and a firm and mobile solid mass in the left adnexa. [sjmms.net]

• Neglect

  In our case, the patient neglected the enlargement of the abdomen over the years, the tumor reached 22 cm in the major axis. The hormonal balance depends on the symptomatology. [omicsonline.org]

Laboratory tests showed elevated serum testosterone 27.6 ng/mL (normal range: 0.2-1.2 ng/mL) and dehydroepiandrosterone of 16.3 ng/mL (normal range: 0.8-3.2 ng/mL), and normal CA-125 of 22 U/mL (normal range The patient was referred to imaging workup [sjmms.net]

• Nephrolithiasis

  His only notable medical history was nephrolithiasis. There was no personal or family history of testicular cancer or cryptorchidism. On physical examination, he was a well-nourished, well-masculinized young man without gynecomastia. [read.nxtbook.com]

Palliative treatment Management of recurrent or metastatic disease- overt metastatic disease is treated with chemotherapy. As with granulosa cell tumors, the optimal regimen for treatment of advanced Sertoli-Leydig cell tumors is unknown. [omicsonline.org]

WT1 immunostaining ( 17721194 ) Localization ovarian Sertoli cell tumor testicular Sertoli cell tumor Treatment and management The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. [humpath.com]

Newer agents in treatment and validated treatment protocols for such fatal metastatic tumors need larger studies. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. [ijpmonline.org]

[…] of a syndrome large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C+ (Gd) : homogeneous enhancement Treatment [radiopaedia.org]

Journal of Surgical Pathology. 26(5):541-550, MAY 2002 PMID: 11979085 Issn Print: 0147-5185 Publication Date: May 2002 Checking for direct PDF access through Ovid Abstract The distinction of Sertoli cell tumors from seminoma is critical to ensure proper treatment [insights.ovid.com]

Prognosis The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant. For malignant tumours with undifferentiated histology, prognosis is poor. [humpath.com]

The prognosis of a benign Sertoli cell tumor is good, but the prognosis of malignant Sertoli cell tumors has not been established. [synapse.koreamed.org]

The presence of heterologous elements also portends poor prognosis. Recurrence is usually within 2 years [3], [4] and occurs in the peritoneal cavity. [ijabmr.org]

Definition / general Rare; excellent prognosis Mean age 30 years old, range 2-76 years Tends to secrete estrogen / progesterone, but diagnose based on morphology, not hormones Similar to a well differentiated Sertoli-Leydig tumor without a Leydig component [pathologyoutlines.com]

[…] large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C+ (Gd) : homogeneous enhancement Treatment and prognosis [radiopaedia.org]

The etiology of testicular cancer is unknown. [synapse.koreamed.org]

Karger AG, Basel References Mostofi FK: Testicular tumors: Epidemiologie, etiologic, and pathologic features. Cancer 1973;32:1186–1201. Littleton R, Farah R, Cerny J, Ohorodnik J: Sertoli cell testicular tumors. Urology 1981;17:557–579. [karger.com]

Changes to coding designations would facilitate clinically relevant epidemiologic investigations. [ascopubs.org]

Epidemiology Sertoli and Leydig cell tumors account for 25% of endocrine tumors in the ovary. They are rare with a prevalence of 0.2% of all ovarian cancers [ 2 ]. Family forms of these types of tumors have been described [ 4 ]. [omicsonline.org]

TREATMENT Section: Our understanding of the pathophysiology of these tumors continues to advance, yet, at this point, this knowledge has not yet been translated into novel therapeutic approaches. [ascopubs.org]

However, in general, they are not favoured to prevent incomplete resections and tumour rupture. 8 For those with stage T1 with tumours of intermediate or poor differentiation, or with capsule rupture, standard staging (omentectomy, appendectomy and pelvic [elsevier.es]

In addition, limitations in national reporting prevent an epidemiologic understanding of these tumors, including the risk for subsequent malignancies. [ascopubs.org]