In conclusion, our case of LCCSCT is a rare and distinctive entity and presents a diagnostic challenge for pathologists. We hope that the present report will help in future diagnostic and treatment decisions. References 1. Proppe KH, Scully RE. [jpatholtm.org]

A 28-year-old male presented to the urology department of our hospital complaining of a painless mass in the right testicle that had been present for the past 2 years. [ncbi.nlm.nih.gov]

However, up to 20 % of the patients with sex cord-stromal tumors present with distant metastasis at the time of presentation. Like germ cell tumors, sex cord-stromal tumors are usually seen in young adults. [lecturio.com]

May present in both pediatric and adult males, depending on the histologic subtype. Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia. [radiopaedia.org]

• Testicular Mass

  Macroscopically, the testicular mass measured 3.0 x 2.3 x 1.5 cm and was well circumscribed. The cut surface was white to tan-gray in color. Neoplastic cells with eosinophilic cytoplasm proliferated with solid and tubular structures. [ncbi.nlm.nih.gov]

  Diagnostic Work-up for Sex Cord-Stromal Tumors of the Testis Ultrasonography is the main investigation to be performed in any patient presenting with a testicular mass. It has a very high sensitivity for testicular tumors that can reach 100%. [lecturio.com]

  Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia. [radiopaedia.org]

Review Topic QID: 106375 5 No further workup, instruct patient to return if symptomatic M1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only ARTICLES (4) VIDEOS (1) Topic COMMENTS (12 [medbullets.com]

Testicular Cancer Workup. Available online at http://emedicine.medscape.com/article/279007-overview. Accessed July 2014. Motzer RJ, Agarwal N, Beard C, et al. Testicular Cancer. [labtestsonline.it]

It would be helpful to have an algorithm for the management of testis tumors, outlining how to make the diagnosis of malignancy and which treatment and follow-up to pursue. [ncbi.nlm.nih.gov]

Treatment depends on the specific type of cancer. [cancer.org]

Treatment & Prognosis Radical orchiectomy is the initial treatment for Leydig cell tumors. [health.am]

Orchidectomy is treatment of choice; usually sufficient because most tumors are benign Benefit of chemotherapy or radiotherapy is not well documented Gross description Spherical, lobulated, well circumscribed tumors Mean 3.5 cm ( Am J Surg Pathol 1998 [pathologyoutlines.com]

Testicular Cancer (PDQ®): Treatment Patient Version. National Cancer Institute [On-line information]. Available online at http://www.cancer.gov/cancerinfo/pdq/treatment/testicular/patient/. (2006 July 24, Modified). [labtestsonline.it]

Seminoma late metastasis and excellent prognosis Embryonal worse prognosis than seminoma Choriocarcinoma worst prognosis in contrast to good prognosis in females metastasizes to lungs Please rate topic. [medbullets.com]

Germ cell tumors (germinoma, 90643; germ cell tumor, nonseminomatous, 90653) Seminoma (90613, 90623, 90663; most common 40-50%; slow to spread; more likely to occur in older patients; highly radiosensitive; good prognosis) Non-Seminoma (teratoma and embryonal [training.seer.cancer.gov]

[…] large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C+ (Gd) : homogeneous enhancement Treatment and prognosis [radiopaedia.org]

Prognosis : good if tumor removed before metastasizes; better prognosis for scrotal testicle. Pathogenesis Pathophysiology About 25% estrogenic, especially if retained. (About 10-15% have blood dyscrasia). [vetstream.com]

Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work. [lecturio.com]

Discussion The etiology of LCTs is unknown and it seems to be heterogeneous. Furthermore, the molecular basis of LCTs is poorly understood. Some studies showed a possible role of genetic factors in the etiology of this tumor. [bmcresnotes.biomedcentral.com]

Leydig Cell Tumors Epidemiology & Pathology Leydig cell tumors are the most common non-germ cell tumors of the testis and account for 1-3% of all testicular tumors. [health.am]

Definition / general Sex cord stromal tumor of testis composed of cells expressing, to a varying degree, features of fetal, prepubertal or adult Sertoli cells Terminology Also called androblastoma Epidemiology < 1% of testicular tumors Occurs in normally [pathologyoutlines.com]

Epidemiology Leydig cell tumours constitute 1-3% of all testicular tumours. Clinical features In children, they may present with isosexual pseudoprecocity. In adults, they present with a mass and/or gynaecomastia. [e-immunohistochemistry.info]

Introduction Testicular tumors can be of germ cell or non-germ cell origin germ cell origin are the majority (95%) and are more commonly malignant non-germ cell origin usually benign Epidemiology incidence most common cancer in men between 15-35 years [medbullets.com]

Epidemiology of Sex Cord-Stromal Tumors of the Testis Sex cord-stromal tumors of the testis can be considered as the rarest form of testicular tumors. The most common form of testicular cancer is germ cell tumors. [lecturio.com]

Pathogenesis Pathophysiology About 25% estrogenic, especially if retained. (About 10-15% have blood dyscrasia). Incidence greatest in right testicle (cf cryptorchidism). 10% malignancy - metastasis to iliac, sublumbar, inguinal nodes. [vetstream.com]

Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work. [lecturio.com]

Diagnosis This article is available in full to registered subscribers Sign up now to purchase a 30 day trial, or Login Treatment This article is available in full to registered subscribers Sign up now to purchase a 30 day trial, or Login Prevention This [vetstream.com]

It is necessary to establish preventive diagnostic strategies from an early age in these patients. Acknowledgments The authors thank Dr. M. Nistal, Department of Pathology, La Paz University Hospital, for providing histopathological assistance. [ibimapublishing.com]

Available online at https://www.cancer.org/cancer/testicular-cancer/causes-risks-prevention/risk-factors.html. Accessed on 2/13/18. (February 12, 2016) Testicular Cancer Survival Rates. American Cancer Society. [labtestsonline.it]