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Sertoli Cell Tumor of the Testis

Sertoli Cell Testicular Tumors


Presentation

  • A 28-year-old male presented to the urology department of our hospital complaining of a painless mass in the right testicle that had been present for the past 2 years.[ncbi.nlm.nih.gov]
  • Abstract A case of a large cell calcifying Sertoli cell tumor (LCCSCT) of the testis in a 7-year-old boy is presented.[ncbi.nlm.nih.gov]
  • Abstract A 45-year old man presented with a slow-growing, unilateral beige testicular mass, with a diameter of 4 cm.[ncbi.nlm.nih.gov]
  • In conclusion, our case of LCCSCT is a rare and distinctive entity and presents a diagnostic challenge for pathologists. We hope that the present report will help in future diagnostic and treatment decisions. References 1. Proppe KH, Scully RE.[jpatholtm.org]
  • GATA Haydarpasa Hospital, 34668, Uskudar, Istanbul, Turkey. cuneytadayener@yahoo.com Abstract We report on a 20-year-old male who underwent a radical orchidectomy when he was 12 years old which revealed a Sertoli cell tumor in his right testis, and who presented[ncbi.nlm.nih.gov]
Aspiration
  • Abstract A rare case of malignant Sertoli cell tumor of the testis occurred in which the diagnosis was initially suggested on fine needle aspiration cytology.[ncbi.nlm.nih.gov]
  • Fine needle aspiration (FNA) cytologic smears showed large polygonal tumor cells with abundant finely granular or vacuolated eosinophilic cytoplasm and eccentric nuclei with one distinct nucleolus.[ncbi.nlm.nih.gov]
  • Presents two brand-new chapters covering urinary cytology and fine needle aspiration to keep you up to date. Covers newly described entities and application of ancillary study for precise diagnosis.[books.google.de]
Hyperpigmentation
  • […] multiple neoplasia syndrome, and PJS and CNC are present in 40% of reported cases. 3 PJS is a rare autosomal-dominant syndrome, presenting at a median age of 11 years, with multiple hamartomatous polyps in the gastrointestinal tract and mucocutaneous hyperpigmentation[jpatholtm.org]
Suggestibility
  • Abstract A rare case of malignant Sertoli cell tumor of the testis occurred in which the diagnosis was initially suggested on fine needle aspiration cytology.[ncbi.nlm.nih.gov]
  • Case reports in the literature on patients with late metastases suggest a very long followup after orchidectomy may be required.[ncbi.nlm.nih.gov]
  • Case reports in the literature on patients with late metastases suggest a very long followup after orchidectomy may be required. Keywords Sertoli cell tumor Testis Late metastasis This is a preview of subscription content, log in to check access.[link.springer.com]
  • A low testosterone to estrogen ratio has been suggested to be evident in patients with sex cord-stromal tumors due to excessive estrogen production by the tumor.[lecturio.com]
  • Genomic amplification of 2p16 in tumors from CNC patients suggests that an oncogene is located at this locus. Loss of heterozygosity studies of 17q22-24 in tumors from CNC patients suggest that this locus contains a tumor suppressor gene.[path.upmc.edu]
Testicular Mass
  • This case, which appears to be the first such case diagnosed by FNA cytology, shows the efficacy of FNA cytology in the presurgical evaluation of testicular masses.[ncbi.nlm.nih.gov]
  • Abstract A 45-year old man presented with a slow-growing, unilateral beige testicular mass, with a diameter of 4 cm.[ncbi.nlm.nih.gov]
  • Macroscopically, the testicular mass measured 3.0 x 2.3 x 1.5 cm and was well circumscribed. The cut surface was white to tan-gray in color. Neoplastic cells with eosinophilic cytoplasm proliferated with solid and tubular structures.[ncbi.nlm.nih.gov]
  • Therefore, it has been recommended to perform a scrotal ultrasound scan in patients with gynecomastia of unknown cause as it can reveal a testicular mass, and orchiectomy has been associated with gynecomastia regression in 80% of the cases.[lecturio.com]
  • Testicular mass or firmness. May occasionally present with precocious pseudopuberty or gynecomastia.[radiopaedia.org]

Workup

  • Review Topic QID: 106375 5 No further workup, instruct patient to return if symptomatic M1 Select Answer to see Preferred Response PREFERRED RESPONSE 2 Sorry, this question is for PEAK Premium Subscribers only ARTICLES (4) VIDEOS (1) Topic COMMENTS (12[medbullets.com]
  • Testicular Cancer Workup. Available online at . Accessed July 2014. Motzer RJ, Agarwal N, Beard C, et al. Testicular Cancer. Journal of the National Comprehensive Cancer Care Network . 2009;7:672-693. Available online at . Accessed July 2014.[labtestsonline.it]

Treatment

  • It would be helpful to have an algorithm for the management of testis tumors, outlining how to make the diagnosis of malignancy and which treatment and follow-up to pursue.[ncbi.nlm.nih.gov]
  • […] of a syndrome large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C (Gd) : homogeneous enhancement Treatment[radiopaedia.org]
  • Abstract The distinction of Sertoli cell tumors from seminoma is critical to ensure proper treatment.[ncbi.nlm.nih.gov]
  • Treatment of Sex Cord-Stromal Tumors of the Testis Once the diagnosis of a sex cord-stromal tumor is confirmed, radical inguinal orchiectomy is the treatment of choice to achieve the lowest recurrence rate.[lecturio.com]
  • S. et al. (2005). “ Sertoli Cell Tumor Causing Prepubertal Gynecomastia in a Boy with Peutz-Jeghers Syndrome: The Outcome of 1-Year Treatment with the Aromatase Inhibitor Testolactone ,” Hormone Research in Paediatrics. 63(5):252-6.[ibimapublishing.com]

Prognosis

  • […] large cell subtype may present with multiple and bilateral mass with large areas of calcification MRI limited characterization in the literature, nonspecific appearance T2: homogeneously hypointense T1 C (Gd) : homogeneous enhancement Treatment and prognosis[radiopaedia.org]
  • Seminoma late metastasis and excellent prognosis Embryonal worse prognosis than seminoma Choriocarcinoma worst prognosis in contrast to good prognosis in females metastasizes to lungs Please rate topic.[medbullets.com]
  • It highlights a rare type of primary tumor of the testis that features a good prognosis.[ncbi.nlm.nih.gov]
  • Germ cell tumors (germinoma, 90643; germ cell tumor, nonseminomatous, 90653) Seminoma (90613, 90623, 90663; most common 40-50%; slow to spread; more likely to occur in older patients; highly radiosensitive; good prognosis) Non-Seminoma (teratoma and embryonal[training.seer.cancer.gov]

Etiology

  • Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work.[lecturio.com]

Epidemiology

  • Epidemiology of Sex Cord-Stromal Tumors of the Testis Sex cord-stromal tumors of the testis can be considered as the rarest form of testicular tumors. The most common form of testicular cancer is germ cell tumors.[lecturio.com]
  • Leydig Cell Tumors Epidemiology & Pathology Leydig cell tumors are the most common non-germ cell tumors of the testis and account for 1-3% of all testicular tumors.[health.am]
  • Introduction Testicular tumors can be of germ cell or non-germ cell origin germ cell origin are the majority (95%) and are more commonly malignant non-germ cell origin usually benign Epidemiology incidence most common cancer in men between 15-35 years[medbullets.com]
  • Definition / general Sex cord stromal tumor of testis composed of cells expressing, to a varying degree, features of fetal, prepubertal or adult Sertoli cells Terminology Also called androblastoma Epidemiology 1% of testicular tumors Occurs in normally[pathologyoutlines.com]
  • Epidemiology Leydig cell tumours constitute 1-3% of all testicular tumours. Clinical features In children, they may present with isosexual pseudoprecocity. In adults, they present with a mass and/or gynaecomastia.[e-immunohistochemistry.info]
Sex distribution
Age distribution

Pathophysiology

  • Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work.[lecturio.com]
  • Pathogenesis Pathophysiology About 25% estrogenic, especially if retained. (About 10-15% have blood dyscrasia). Incidence greatest in right testicle (cf cryptorchidism). 10% malignancy - metastasis to iliac, sublumbar, inguinal nodes.[vetstream.com]

Prevention

  • It is necessary to establish preventive diagnostic strategies from an early age in these patients. Acknowledgments The authors thank Dr. M. Nistal, Department of Pathology, La Paz University Hospital, for providing histopathological assistance.[ibimapublishing.com]
  • Diagnosis This article is available in full to registered subscribers Sign up now to purchase a 30 day trial, or Login Treatment This article is available in full to registered subscribers Sign up now to purchase a 30 day trial, or Login Prevention This[vetstream.com]

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