This feature was in contrast to the previously described two cases, where mucinous adenocarcinoma as heterologous element was present as microscopic foci. [ncbi.nlm.nih.gov]

Figure 2B : Nests of Leydig cells present in an edematous background (H & E stain, 100x magnification ). [ispub.com]

Our case represented a diagnostic challenge, giving the unusual clinical presentation (lack of hormonal symptoms) and the late age of presentation. The gross appearance and unilaterality favored the diagnose of SLCT. [path.upmc.edu]

We here present a case report ofSertoli-Leydig Cell Tumor having the rarity of bilateral presentation and male karyotype in a 23-year-old phenotypically female patient. [medresearch.in]

• Virilization

  Androblastomas occur in the TESTIS or the OVARY causing precocious masculinization in the males, and defeminization, or virilization (VIRILISM) in the females. In some cases, the Sertoli cells produce ESTROGENS. [connects.catalyst.harvard.edu]

  A 24-year-old woman was admitted to hospital because of hirsutism, virilism and amenorrhea, which had appeared 6 months earlier. [ncbi.nlm.nih.gov]

• Swelling

  A swollen part; a swelling: a plant tumor. [Middle English tumour, from Latin tumor, from tumēre, to swell; see teuə- in Indo-European roots.] tu′mor·al, tu′mor·ous adj. American Heritage® Dictionary of the English Language, Fifth Edition. [thefreedictionary.com]

  Figure 2 Sertoli-Leydig cell tumor in a 22-year-old woman with irregular menses and abdominal swelling. [ovarianresearch.biomedcentral.com]

  Other symptoms that a patient may experience are abdominal pain and swelling. Diagnosis and Staging Ovarian tumors are diagnosed by a physician during a pelvic exam or other physical examination. [knowcancer.com]

  Testicular tumor Leydig cell tumor 発行日: Jan-1998 出版者: 泌尿器科紀要刊行会 誌名: 泌尿器科紀要 巻: 44 号: 1 開始ページ: 61 終了ページ: 63 抄録: 左陰嚢内の無痛性腫瘤を訴えた63歳男で,超音波検査で精巣腫瘍が示唆されたので,左高位精巣摘除を行った.組織学的に精巣腫瘍はLeydig細胞腫であった A 63-year-old male visited our hospital with a complaint of painless swelling [repository.kulib.kyoto-u.ac.jp]

  Tumor was called androblastoma or arrhenoblastoma in the past May present with masculinization (virilization). [1] May present as abdominal swelling or pain. [librepathology.org]

• Precocious Puberty

  Twenty weeks following surgical removal, the patient presented again with central precocious puberty; inhibin B levels were raised on this occasion, a luteinizing releasing hormone stimulation test confirmed central precocious puberty. [ncbi.nlm.nih.gov]

  Primary testicular abnormalities causing precocious puberty Leydig cell tumor, Leydig cell hyperplasia, and adrenal rest tumor. Ann Clin Lab Sci 1983 ;13: 315 - 320 23. Holland FJ. Gonadotropin-independent precocious puberty. [nejm.org]

  Página 84 - Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. ‎ Página 368 - HJ. [books.google.es]

  Leydig and Sertoli cells are functionally active and patients with these tumors will have an excess of either testosterone or estrogen, which can result in precocious puberty. [lecturio.com]

  Complications of Ovarian Sertoli-Leydig Cell Tumor may include: Precocious puberty (unusually early onset of puberty) will result in short stature (height) and early menarche (onset of menstruation) Deep-seated tumors may create problems for adjoining [dovemed.com]

• Falling

  A woman with severe hyperandrogenemia and virilization was found to have a fall in serum testosterone (T) concentration while taking an oral contraceptive containing norethindrone (500 vs. 164 ng/dL). [ncbi.nlm.nih.gov]

  Serum AFP levels were measured at follow up, which showed drastic fall after treatment. Figure 4 shows the fall of AFP level during her treatment. Serum testosterone was normal. Her virilization signs have reduced in 6 months follow up. [npplweb.com]

  Am J Pathol 21: 1167–1192 Google Scholar Held E, Schreiner WE (1959) Über einen Fall von Arrhenoblastom. Gynaecologia (Basel) 147: 402–414 Google Scholar Hughesdon PE (1966) Ovarian lipoid and theca cell tumors: their origins and interrelations. [link.springer.com]

  Some tumors are composed of cells with prominent foamy cytoplasm, falling in the category of "lipid-rich" Sertoli cell tumor, and one had cells with clear non-foamy cytoplasm. [humpath.com]

  The cells usually had pale to occasionally densely eosinophilic cytoplasm, but 6 tumors were composed of cells with prominent foamy cytoplasm, falling in the category of "lipid-rich" Sertoli cell tumor, and one had cells with clear non-foamy cytoplasm [thedoctorsdoctor.com]

• Surgical Procedure

  A complete cytoreduction was achieved with surgical procedure. Histopathological examination revealed moderately differentiated SLCT with retiform areas and owergrowth of heterologous component in form of embrional rhabdomyosarcoma (RMS). [ncbi.nlm.nih.gov]

  Unilateral orchiectomy was performed in Patients 1 and 3, and a testis-sparing surgical procedure was performed in Patient 2. [nejm.org]

• Abdominal Mass

  She returned 7 months after the surgery with a large abdominal mass, ascites, right- sided hydronephrosis and massive pulmonary embolism. Due to the widespread disease and her poor general condition, she received only palliative care. [ncbi.nlm.nih.gov]

  Hormonally inactive tumors often have a nonspecific presentation such as an abdominal mass and/or pain. The majority of patients present with stage I disease. Most tumors are unilateral (>90% of cases) and confined to the ovaries. [radiopaedia.org]

  Case report A 13-year-old female presented to the Shandong Provincial Hospital affiliated to Shandong University (Jinan, Shandong, China) with a 7-day history of abdominal distension, a 3-day history of abdominal pain and a pelvic mass. [spandidos-publications.com]

• Hirsutism

  Prepregnancy findings included hirsutism, clitoromegaly, secondary amenorrhea, and elevated peripheral plasma testosterone (T; 5.7 ng/ml). [ncbi.nlm.nih.gov]

  Treatment Rapid onset Hirsutism, virilization, adnexal mass Elevated testosterone Surgery Use of spironolactone disorders with excess androgen? Will help with? (But?) [brainscape.com]

• Cesarean Section

  They are usually incidental findings at the time of Cesarean section or tubal ligation, but in one quarter of the cases, they produce enough androgenic hormone to virilize the mother and also any female offspring. [glowm.com]

  section; 卵巣成熟嚢胞性奇形腫のMRI画像と病理組織学的所見の対比 : 加齢による変化の検討(卵巣腫瘍VIII, 第57回日本産科婦人科学会学術講演会) 日本産科婦人科學會雜誌,57(2):- 2005 Author:山田 智子; 伊東 和子; 花岡 由里子; 岡 賢二; 堀内 晶子; 加藤 清; 増澤 秀幸; 塩沢 丹里; 小西 郁生; 母体血清中 sflt-1値と妊娠中毒症発症及び重症化との関連についてA close link between the serum sflt-1 levels [soar-rd.shinshu-u.ac.jp]

Our goals are to review the workup of androgen-secreting tumors and discuss the clinical importance of the DICER1 mutation in the context of SLCT. [ncbi.nlm.nih.gov]

Laboratory tests showed elevated serum testosterone 27.6 ng/mL (normal range: 0.2-1.2 ng/mL) and dehydroepiandrosterone of 16.3 ng/mL (normal range: 0.8-3.2 ng/mL), and normal CA-125 of 22 U/mL (normal range The patient was referred to imaging workup [sjmms.net]

The utility of serum alpha-fetoprotein in disease response to treatment and for surveillance of recurrence is also shown. [ncbi.nlm.nih.gov]

[…] to advances in diagnosis and treatment. [rarediseases.info.nih.gov]

Treatment Rapid onset Hirsutism, virilization, adnexal mass Elevated testosterone Surgery Use of spironolactone disorders with excess androgen? Will help with? (But?) [brainscape.com]

The prognosis of SLCTs is good, although poorly differentiated tumors may recur. [path.upmc.edu]

It seems that when rhabdomyosarcoma is a significant or predominant component of SLT, as occurred in this case, the prognosis is poor and is that of rhabdomyosarcoma in general. [ncbi.nlm.nih.gov]

Some authors opine that although overall SertoliLeydig cell tumors have a relatively good prognosis, intermediate tumors with retiform pattern and those containing heterologous elements have poorer prognosis. [ispub.com]

When such multiple conditions involving one system occur in an individual, the possibility of single etiology arises, but beside some hypothesis, no definite link could be established in any of the cases reported. [ncbi.nlm.nih.gov]

Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work. [lecturio.com]

(Etiology) The exact cause of Ovarian Sertoli-Leydig Cell Tumor is not known Research studies seem to indicate that certain genetic mutations (in the DICER1 gene) may play a role in many cases What are the Signs and Symptoms of Ovarian Sertoli-Leydig [dovemed.com]

Etiology There appear to be several established clinical syndromes associated with several subtypes of sex cord-stromal tumours. 30% of patients with sex cord tumours with annular tubules have Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder [atlasgeneticsoncology.org]

Epidemiology of Sex Cord-Stromal Tumors of the Testis Sex cord-stromal tumors of the testis can be considered as the rarest form of testicular tumors. The most common form of testicular cancer is germ cell tumors. [lecturio.com]

Epidemiology The tumors typically occur in young females, sometimes children who typically present with sexual precocity, and occasional patients have Peutz-Jeghers syndrome. [humpath.com]

Epidemiology The frequency of sex cord-stromal tumours is similar throughout the world. There does not appear to a racial predisposition, in contrast to epithelial ovarian cancers. [atlasgeneticsoncology.org]

Corresponding Author Departments of Pathophysiological and Experimental Pathology and Katsuaki Sato, MD, Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University, 1‐1 Daigaku, Uchinada, Kahoku‐gun, Ishikawa 920‐0293, Japan [onlinelibrary.wiley.com]

Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]

Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work. [lecturio.com]

There is at present no good evidence that postoperative adjuvant therapy is effective in preventing recurrence. [ncbi.nlm.nih.gov]

Currently, there are no effective measures to prevent the occurrence of Sertoli-Leydig Cell Tumor of Ovary. [dovemed.com]

Getting connected with these people is critical to getting preventative care for other risks. My younger daughter has not had cancer, but she tested positive for dicer 1 and is being monitored by the NIH. [cancercompass.com]