This feature was in contrast to the previously described two cases, where mucinous adenocarcinoma as heterologous element was present as microscopic foci. [ncbi.nlm.nih.gov]

Figure 2B : Nests of Leydig cells present in an edematous background (H & E stain, 100x magnification ). [ispub.com]

Our case represented a diagnostic challenge, giving the unusual clinical presentation (lack of hormonal symptoms) and the late age of presentation. The gross appearance and unilaterality favored the diagnose of SLCT. [path.upmc.edu]

We here present a case report ofSertoli-Leydig Cell Tumor having the rarity of bilateral presentation and male karyotype in a 23-year-old phenotypically female patient. [medresearch.in]

• Precocious Puberty

  Twenty weeks following surgical removal, the patient presented again with central precocious puberty; inhibin B levels were raised on this occasion, a luteinizing releasing hormone stimulation test confirmed central precocious puberty. [ncbi.nlm.nih.gov]

  Primary testicular abnormalities causing precocious puberty Leydig cell tumor, Leydig cell hyperplasia, and adrenal rest tumor. Ann Clin Lab Sci 1983 ;13: 315 - 320 23. Holland FJ. Gonadotropin-independent precocious puberty. [nejm.org]

  Página 84 - Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. ‎ Página 368 - HJ. [books.google.es]

  Leydig and Sertoli cells are functionally active and patients with these tumors will have an excess of either testosterone or estrogen, which can result in precocious puberty. [lecturio.com]

  Complications of Ovarian Sertoli-Leydig Cell Tumor may include: Precocious puberty (unusually early onset of puberty) will result in short stature (height) and early menarche (onset of menstruation) Deep-seated tumors may create problems for adjoining [dovemed.com]

• Surgical Procedure

  A complete cytoreduction was achieved with surgical procedure. Histopathological examination revealed moderately differentiated SLCT with retiform areas and owergrowth of heterologous component in form of embrional rhabdomyosarcoma (RMS). [ncbi.nlm.nih.gov]

  Unilateral orchiectomy was performed in Patients 1 and 3, and a testis-sparing surgical procedure was performed in Patient 2. [nejm.org]

• Fatigue

  They had no voice and weight changes, fatigue or galactorrhea. Their modified Ferriman–Gallwey score were 19 and 36. Laboratory studies revealed normal complete blood counts, liver and kidney tests. [endocrine-abstracts.org]

  […] increased facial hair (hirsutism), which may be progressive in nature Irregularities of menstrual cycles or complete cessation of cycle Acne Enlarged clitoris Abdominal mass or pain Increased muscle tone Hairline recession Loss of appetite with weight loss Fatigue [dovemed.com]

• Inflammation

  […] lymphatic vessels carcinoid - a small tumor (benign or malignant) arising from the mucosa of the gastrointestinal tract; usually associated with excessive secretion of serotonin granuloma - a tumor composed of granulation tissue resulting from injury or inflammation [thefreedictionary.com]

• Abdominal Mass

  She returned 7 months after the surgery with a large abdominal mass, ascites, right- sided hydronephrosis and massive pulmonary embolism. Due to the widespread disease and her poor general condition, she received only palliative care. [ncbi.nlm.nih.gov]

  Hormonally inactive tumors often have a nonspecific presentation such as an abdominal mass and/or pain. The majority of patients present with stage I disease. Most tumors are unilateral (>90% of cases) and confined to the ovaries. [radiopaedia.org]

  Case report A 13-year-old female presented to the Shandong Provincial Hospital affiliated to Shandong University (Jinan, Shandong, China) with a 7-day history of abdominal distension, a 3-day history of abdominal pain and a pelvic mass. [spandidos-publications.com]

• Hypertension

  She had hypertension, obesity, and type 2 diabetes mellitus. [ncbi.nlm.nih.gov]

  […] usually slow growing and sometimes malignant neuroma - any tumor derived from cells of the nervous system phaeochromocytoma, pheochromocytoma - a vascular tumor of the adrenal gland; hypersecretion of epinephrine results in intermittent or sustained hypertension [thefreedictionary.com]

• Fracture

  539（11） side by side 2013年7月号 (Vol.29, No.7) 非血管系IVRを極める 826（A） SIF：subchondral insufficiency fracture 2016年8月号 (Vol.32, No.8) 読影でおさえておきたい最近の疾患概念の変遷 889（4） signal void 2014年5月号 (Vol.30, No.5) 血管腫・血管奇形2014 診断からIVR・治療まで 496（4） 497（6，7） signal void 2014年 [medicalview.co.jp]

  らを実験台にして死亡 Celsus ケルスス Celsus kerion ケルスス禿瘡 Cerenkov チェレンコフ Cerenkov radiation チェレンコフ放射 Chaddock チャドック Chaddock reflex チャドック反射 Chagas シャーガス Chagas' disease シャーガス病 CarlosJustiniano Ribeiro Chagas （1879 - 1934） a Brazilian physician Chance チャンス Chance fracture [jams.med.or.jp]

• Hirsutism

  Prepregnancy findings included hirsutism, clitoromegaly, secondary amenorrhea, and elevated peripheral plasma testosterone (T; 5.7 ng/ml). [ncbi.nlm.nih.gov]

  Treatment Rapid onset Hirsutism, virilization, adnexal mass Elevated testosterone Surgery Use of spironolactone disorders with excess androgen? Will help with? (But?) [brainscape.com]

• Tremor

  Gunn （1850-1909） Scottishophthalmologist Marek マレック Marek's disease virus マレック病ウイルス Marfan マルファン Marfan's syndrome マルファン症候群 AntoineBernard-Jean Marfan （1858-1942） French pediatrician Marie マリー Marie's ataxia マリー運動失調症 Marie-Kahler マリー・カーレル Marie-Kahler tremor [jams.med.or.jp]

Our goals are to review the workup of androgen-secreting tumors and discuss the clinical importance of the DICER1 mutation in the context of SLCT. [ncbi.nlm.nih.gov]

Laboratory tests showed elevated serum testosterone 27.6 ng/mL (normal range: 0.2-1.2 ng/mL) and dehydroepiandrosterone of 16.3 ng/mL (normal range: 0.8-3.2 ng/mL), and normal CA-125 of 22 U/mL (normal range The patient was referred to imaging workup [sjmms.net]

The utility of serum alpha-fetoprotein in disease response to treatment and for surveillance of recurrence is also shown. [ncbi.nlm.nih.gov]

[…] to advances in diagnosis and treatment. [rarediseases.info.nih.gov]

Treatment Rapid onset Hirsutism, virilization, adnexal mass Elevated testosterone Surgery Use of spironolactone disorders with excess androgen? Will help with? (But?) [brainscape.com]

The prognosis of SLCTs is good, although poorly differentiated tumors may recur. [path.upmc.edu]

It seems that when rhabdomyosarcoma is a significant or predominant component of SLT, as occurred in this case, the prognosis is poor and is that of rhabdomyosarcoma in general. [ncbi.nlm.nih.gov]

Some authors opine that although overall SertoliLeydig cell tumors have a relatively good prognosis, intermediate tumors with retiform pattern and those containing heterologous elements have poorer prognosis. [ispub.com]

When such multiple conditions involving one system occur in an individual, the possibility of single etiology arises, but beside some hypothesis, no definite link could be established in any of the cases reported. [ncbi.nlm.nih.gov]

Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work. [lecturio.com]

(Etiology) The exact cause of Ovarian Sertoli-Leydig Cell Tumor is not known Research studies seem to indicate that certain genetic mutations (in the DICER1 gene) may play a role in many cases What are the Signs and Symptoms of Ovarian Sertoli-Leydig [dovemed.com]

Etiology There appear to be several established clinical syndromes associated with several subtypes of sex cord-stromal tumours. 30% of patients with sex cord tumours with annular tubules have Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder [atlasgeneticsoncology.org]

Epidemiology of Sex Cord-Stromal Tumors of the Testis Sex cord-stromal tumors of the testis can be considered as the rarest form of testicular tumors. The most common form of testicular cancer is germ cell tumors. [lecturio.com]

Epidemiology The tumors typically occur in young females, sometimes children who typically present with sexual precocity, and occasional patients have Peutz-Jeghers syndrome. [humpath.com]

Epidemiology The frequency of sex cord-stromal tumours is similar throughout the world. There does not appear to a racial predisposition, in contrast to epithelial ovarian cancers. [atlasgeneticsoncology.org]

Corresponding Author Departments of Pathophysiological and Experimental Pathology and Katsuaki Sato, MD, Department of Pathophysiological and Experimental Pathology, Kanazawa Medical University, 1‐1 Daigaku, Uchinada, Kahoku‐gun, Ishikawa 920‐0293, Japan [onlinelibrary.wiley.com]

Signs and Symptoms (Pathophysiology) Symptoms can include infrequent or no menstrual periods, the development of facial hair, a hoarse voice, increased muscle mass, acne, and clitoromegaly. [knowcancer.com]

Etiology and Pathophysiology of Sex Cord-Stromal Tumors of the Testis Image : “Adolescent with Gynecomastia.” by David Andrew Copeland, Dr. Mordcai Blau www.gynecomastia-md.com – Own work. [lecturio.com]

There is at present no good evidence that postoperative adjuvant therapy is effective in preventing recurrence. [ncbi.nlm.nih.gov]

Currently, there are no effective measures to prevent the occurrence of Sertoli-Leydig Cell Tumor of Ovary. [dovemed.com]

Getting connected with these people is critical to getting preventative care for other risks. My younger daughter has not had cancer, but she tested positive for dicer 1 and is being monitored by the NIH. [cancercompass.com]