Twenty weeks following surgical removal, the patient presented again with central precocious puberty; inhibin B levels were raised on this occasion, a luteinizing releasing hormone stimulation test confirmed central precocious puberty. [ncbi.nlm.nih.gov]

Leydig and Sertoli cells are functionally active and patients with these tumors will have an excess of either testosterone or estrogen, which can result in precocious puberty. [lecturio.com]

Complications of Ovarian Sertoli-Leydig Cell Tumor may include: Precocious puberty (unusually early onset of puberty) will result in short stature (height) and early menarche (onset of menstruation) Deep-seated tumors may create problems for adjoining [dovemed.com]

Excessive estrogen production may result in precocious puberty, abnormal vaginal bleeding, menstrual irregularities, generalized edema, weight gain, endometrial hyperplasia, endometrial polyps and endometrial carcinoma. 2, 5 Features of masculinization [pagepress.org]

Primary testicular abnormalities causing precocious puberty Leydig cell tumor, Leydig cell hyperplasia, and adrenal rest tumor. Ann Clin Lab Sci 1983 ;13: 315 - 320 23. Holland FJ. Gonadotropin-independent precocious puberty. [nejm.org]

They had no voice and weight changes, fatigue or galactorrhea. Their modified Ferriman–Gallwey score were 19 and 36. Laboratory studies revealed normal complete blood counts, liver and kidney tests. [endocrine-abstracts.org]

[…] increased facial hair (hirsutism), which may be progressive in nature Irregularities of menstrual cycles or complete cessation of cycle Acne Enlarged clitoris Abdominal mass or pain Increased muscle tone Hairline recession Loss of appetite with weight loss Fatigue [dovemed.com]

Following surgery, the patient's unique nail abnormalities also resolved gradually. The IHC evaluation also confirmed the presence of AR in nail bed tissues of females. [ncbi.nlm.nih.gov]

A 15-year-old girl presented to a primary care clinic with secondary amenorrhea, masculinization, and rapidly increasing abdominal girth. [ncbi.nlm.nih.gov]

CTR Vice President of Cancer Registry 78 y/o female admitted for vague abdominal pain and increasing abdominal girth. Initial imaging work-up revealed bilateral adnexal masses, right larger than left. No significant pelvic adenopathy. [mrahis.com]

Physical examination revealed hirsutismand normal stature. Cytogenetic study revealed 46 XY karyotype (male genome).Transvaginal scan showed rudimentary uterus and left ovarian cyst with mural nodules. [medresearch.in]

The patient was alive and well with improved hirsutism 4 years after the operation. The duration of symptoms and T level in our patient were among the highest values ever recorded in the literature. [ncbi.nlm.nih.gov]

The complete androgen insensitivity (testicular feminization) syndrome was described in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or sparse pubic or axillary hair. [ncbi.nlm.nih.gov]

The complete androgen insensitivity (testicular feminization) syndrome was described in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or sparse pubic or axillary hair. [ncbi.nlm.nih.gov]

Case Report A 23-year-old unmarried woman presented to the Gynecology OPD with primary amenorrhea and a history of intermittent pain over left lower abdomen for 8 months. Physical examination revealed hirsutismand normal stature. [medresearch.in]

A 13-year-old girl presented with acute urinary retention, excessive hair growth and deepening of the voice. A mass the size of a 28-week gravid uterus was arising from the pelvis. Serum testosterone level was raised to 145.2 ng/dl. [ncbi.nlm.nih.gov]

Rh blood group B negative Indirect Coomb’s test Negative Urine routine microscopy Normal Urine culture and sensitivity Sterile HIV, HBsAG, VDRL Not reactive Hemoglobin electrophoresis Normal Chest X-Ray and electrocardiogram Normal . [pagepress.org]

Frozen section examination identified the right ovarian mass as a poorly differentiated Sertoli-Leydig cell tumor. [ncbi.nlm.nih.gov]