Its symptoms include: Fever Joint pain and inflammation, most often in the knees and hips Severe acne with bleeding ulcers, usually on the upper body Weight loss and a decrease in appetite Swelling of the spleen and liver Acne fulminans is a more severe [everydayhealth.com]

Other non-dermatological features include fever, joint pains and systemic indications of inflammation evident in a raised ESR (erythrocyte sedimentation rate). It may follow through from acne conglobata especially if treatment is unsuccessful. [healthhype.com]

[…] enclosing a mixture of keratin and sebum in varying proportions. acne ful minans a rare form of severe cystic acne seen in teenage boys, characterized by highly inflammatory nodules and plaques that undergo suppurative degeneration leaving ulcerations, fever [medical-dictionary.thefreedictionary.com]

If systemic symptoms like fever or arthritic symptoms develop in patients with acne conglobata, the disease is termed acne fulminans. Timely treatment by a dermatologist is essential. [onhealth.com]

Acne fulminans is even more severe than acne conglobata, with systemic symptoms such as fever, joint pain, and general malaise. [emedicine.medscape.com]

Our findings indicate that from the point of polymorphic ventricular tachycardia risk, 0.8 mg/kg/day of isotretinoin therapy is a safe choice in acne treatment. [ncbi.nlm.nih.gov]

Papular acne is common in people with course/oily skin. Pustules (Pimples) Pustules are another kind of inflamed pimple. They resemble a whitehead with a red ring around the bump. The bump is typically filled with white or yellow pus. [onhealth.com]

CONCLUSIONS: We suggest using lipid ratios as a screening test in females with acne vulgaris to diagnose dyslipidemia at an early stage but further studies are required to see the effect of treating hyperlipidemia in females with severe acne vulgaris. [ncbi.nlm.nih.gov]

CONCLUSIONS: In patients with severe acne, six months of 0.8 mg/kg/day of isotretinoin therapy neither prolongs QT interval, nor increases QT dispersion. This effect is not related to blood lipids, homocysteine or lipoprotein (a) levels. [ncbi.nlm.nih.gov]