Although first-line therapies exist, it is often the case that a patient will present with an underlying disorder that prohibits the use of most currently accepted treatment modalities. [ncbi.nlm.nih.gov]

Severe acne: Severe acne is constantly present and often contains cyst and pustules. [clearclinic.com]

• Fever

  Its symptoms include: Fever Joint pain and inflammation, most often in the knees and hips Severe acne with bleeding ulcers, usually on the upper body Weight loss and a decrease in appetite Swelling of the spleen and liver Acne fulminans is a more severe [everydayhealth.com]

  Other non-dermatological features include fever, joint pains and systemic indications of inflammation evident in a raised ESR (erythrocyte sedimentation rate). It may follow through from acne conglobata especially if treatment is unsuccessful. [healthhype.com]

  […] enclosing a mixture of keratin and sebum in varying proportions. acne ful minans a rare form of severe cystic acne seen in teenage boys, characterized by highly inflammatory nodules and plaques that undergo suppurative degeneration leaving ulcerations, fever [medical-dictionary.thefreedictionary.com]

  If systemic symptoms like fever or arthritic symptoms develop in patients with acne conglobata, the disease is termed acne fulminans. Timely treatment by a dermatologist is essential. [onhealth.com]

  Acne fulminans is even more severe than acne conglobata, with systemic symptoms such as fever, joint pain, and general malaise. [emedicine.medscape.com]

• Tachycardia

  Our findings indicate that from the point of polymorphic ventricular tachycardia risk, 0.8 mg/kg/day of isotretinoin therapy is a safe choice in acne treatment. [ncbi.nlm.nih.gov]

• Skin Pustule

  Papular acne is common in people with course/oily skin. Pustules (Pimples) Pustules are another kind of inflamed pimple. They resemble a whitehead with a red ring around the bump. The bump is typically filled with white or yellow pus. [onhealth.com]

See Workup for more detail. Management Treatment of acne vulgaris should be directed toward the known pathogenic factors, including follicular hyperproliferation, excess sebum, C acnes (formerly P acnes ), and inflammation. [emedicine.medscape.com]

• Dyslipidemia

  CONCLUSIONS: We suggest using lipid ratios as a screening test in females with acne vulgaris to diagnose dyslipidemia at an early stage but further studies are required to see the effect of treating hyperlipidemia in females with severe acne vulgaris. [ncbi.nlm.nih.gov]

• Prolonged QT Interval

  CONCLUSIONS: In patients with severe acne, six months of 0.8 mg/kg/day of isotretinoin therapy neither prolongs QT interval, nor increases QT dispersion. This effect is not related to blood lipids, homocysteine or lipoprotein (a) levels. [ncbi.nlm.nih.gov]

Fractional laser resurfacing is a promising treatment for scar treatment because of its unique ability to stimulate the wound healing response and its depth of penetration. [ncbi.nlm.nih.gov]

What Is the Prognosis for Cystic Acne? With aggressive treatment, the prognosis of cystic acne is excellent. But treatment must be instituted prior to the development of significant scarring, which is irreversible and permanent. [emedicinehealth.com]

Intra-articular corticosteroid therapy, methotrexate, colchicine cystic acne Mutilating acne Dermatology A form of acne vulgaris which may affect teenagers, 2º to bacterial infection of clogged sebaceous ducts deep in the skin Management Antibiotics, isotretinoin Prognosis [medical-dictionary.thefreedictionary.com]

By age 45 years, 5% of both men and women still have acne. [22] Prognosis Acne may cause long-lasting and detrimental psychosocial and physical effects. [emedicine.medscape.com]

Abstract The etiology of dactinomycin-associated acne has not previously been studied. An 81/2 year old girl with embryonal rhabdomyosarcoma of the left petrous bone was prepubertal at the time of presentation. [ncbi.nlm.nih.gov]

Comedone formation: etiology, clinical presentation, and treatment. Clin Dermatol. 2004 Sep-Oct. 22(5):367-74. [Medline]. Gollnick H, Cunliffe W, Berson D, Dreno B, Finlay A, Leyden JJ, et al. [emedicine.medscape.com]

BACKGROUND: Little is known about the epidemiology of severe acne in the U.S. OBJECTIVES: We sought to study the U.S. prevalence, determinants and comorbidities of severe acne in adolescence. [ncbi.nlm.nih.gov]

Bhate K, Williams HC ; Epidemiology of acne vulgaris. Br J Dermatol. 2013 Mar168(3):474-85. doi: 10.1111/bjd.12149. [patient.info]

With rosacea, women ages 20 to 60 are the predominant epidemiological group. [draxe.com]

Pathophysiology The pathogenesis of acne vulgaris is multifactorial. [emedicine.medscape.com]

In addition to reducing inflammatory and non-inflammatory lesions, adapalene/BPO helps prevent lesion and microcomedone formation. [ncbi.nlm.nih.gov]

If early acne develops, teaming up with the right skincare and supplements can help keep acne from becoming severe as well as prevent physical and emotional scars. Preventing severe acne can make a difference that lasts a lifetime. [orique.com]

Medical treatment focuses on: • Healing existing spots and lessening the risk of scarring from these; Preventing future acne spots and scarring. [acneaction.ca]