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Severe Asthma

Presentation

Presentation A 15-year-old girl with severe persistent asthma presents to the emergency department with acute respiratory distress. Her common triggers are environmental allergens, predominantly dogs and cats. [pedsinreview.aappublications.org]

Discussion Berlinski: Thank you for your presentation. [rc.rcjournal.com]

Methods The definition, diagnosis, and treatment of severe asthma are presented on the basis of a selective literature review and the authors’ clinical experience. [ncbi.nlm.nih.gov]

The last may be defined as a persistent and refractory type that is unyielding to presently available therapeutic measures. [jamanetwork.com]

Demographic data, initial presentation data, MICU course, and outcome were collected. Results were compared to our previous study during the 5‐year period 19951999 at this institution. 5 Data are presented as means standard deviations. [journalofhospitalmedicine.com]

Treatment

[…] or by oral corticosteroid treatment (for at least six months per year), or is lost when the treatment is reduced. [ncbi.nlm.nih.gov]

Treatment With any asthma attack, you must start treatment right away, at the first sign of symptoms, either at home or in your doctor's office. [webmd.com]

# ↓ MONITORING : Repeat measurement of PEF 15–30 minutes after starting treatment. [handbook.ggcmedicines.org.uk]

Once you have an eosinophilic asthma diagnosis, together, you and your doctor will decide if adding a different kind of asthma treatment could help. [nucala.com]

Five Treatments In a pediatric patient with a severe asthma exacerbation, treatment should be initiated immediately on EMS arrival. This treatment consists of five potentially life-saving interventions. [jems.com]

Prognosis

Chapter 14 Status Asthmaticus and Pending Pulmonary Failure First published: 06 March 2015 Summary This chapter discusses background, prevention, diagnosis, treatment, and prognosis for status asthmaticus and pending pulmonary failure. [onlinelibrary.wiley.com]

Prognosis Unless you have a complicating illness like congestive heart failure or chronic obstructive pulmonary disease, you should do well as long as you get treatment on time. Pagination [webmd.com]

Etiology

Notwithstanding, allergen immunotherapy (AIT) is considered the only etiological treatment able to prevent asthma development ( 97 ), to improve asthma symptoms in AR affected children ( 98 ), and to prevent new sensitizations in already sensitized patients [frontiersin.org]

Epidemiology

The epidemiology of severe childhood asthma. En: Forno E, Sagliani S, eds. Severe asthma in children and adolescents. mechanisms and management. Cham, CH: Springer, 2020:3-18. [ Links ] 9. [scielo.edu.uy]

According to a new randomized control trial ketamine and aminophylline are also effective in children with acute asthma who responds poorly to standard therapy. [4] Epidemiology [ edit ] Status asthmaticus is slightly more common in males and is more [en.wikipedia.org]

Epidemiology Status asthmaticus is slightly more common in males and is more common among African Americans and Hispanics. [dictionnaire.sensagent.leparisien.fr]

Asthma in France: a review of descriptive epidemiological data. Rev Mal Respir. 2010;27:151–9. 2. Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis. 2014;18:1269–78. 3. Werner HA. [annalsofintensivecare.springeropen.com]

Relationships of active and passive smoking to total IgE in adults of the Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA). [frontiersin.org]

Pathophysiology

Pathophysiological phenotyping in those with true severe therapy-resistant asthma (STRA) and the current array of add-on therapies will be discussed. [journals.lww.com]

Irregularities in the heart beat and abnormal lowering of the blood pressure may be observed. [2] Pathophysiology [ edit ] Inflammation in asthma is characterized by an influx of eosinophils during the early-phase reaction and a mixed cellular infiltrate [en.wikipedia.org]

The gene locus glutathione dependent S-nitrosoglutathione (GSNOR) has been suggested as one possible correlation to development of status asthmaticus. [ 1 ] Pathophysiology Inflammation in asthma is characterized by an influx of eosinophils during the [dictionnaire.sensagent.leparisien.fr]

Chest 1976 ;70: 740 - 746 Google Scholar | Crossref | Medline | ISI Hopewell PC, Miller RT Pathophysiology and management of severe asthma. [journals.sagepub.com]

Schematic demonstrating asthma pathophysiology. Note the change in the cross-sectional airway from a normal airway (A) to an asthma bronchiole (B), with smooth muscle bronchoconstriction, mucosal edema, and mucus clinging to airway walls. [rc.rcjournal.com]

Prevention

Based on these premises, it is reasonable that prevention strategies and proper treatments of atopic diseases could prevent occurrence of severe asthma and viceversa. [frontiersin.org]

Chapter 14 Status Asthmaticus and Pending Pulmonary Failure First published: 06 March 2015 Summary This chapter discusses background, prevention, diagnosis, treatment, and prognosis for status asthmaticus and pending pulmonary failure. [onlinelibrary.wiley.com]

Global strategy for asthma management and prevention, 2019. Fontana, WI: GINA, 2019. Disponible en: https://ginasthma.org/wp-content/uploads/2019/06/GINA-2019-main-report-June-2019-wms.pdf Consulta: 15 mayo 2020. [ Links ] 3. Busch A, Fleming L. [scielo.edu.uy]

Prevention You may not be able to prevent all severe asthma attacks. But you can take steps to make them less likely: Take your asthma medication as often as your doctor recommends. Use a peak flow meter several times a day. [webmd.com]

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