Presentation A 15-year-old girl with severe persistent asthma presents to the emergency department with acute respiratory distress. Her common triggers are environmental allergens, predominantly dogs and cats.[pedsinreview.aappublications.org]
Methods The definition, diagnosis, and treatment of severe asthma are presented on the basis of a selective literature review and the authors’ clinical experience.[ncbi.nlm.nih.gov]
Even though asthma is not always present in AERD, asthma symptoms develop 1–3 years after the development of rhinitis or later.[frontiersin.org]
. # IF LIFE-THREATENING FEATURES ARE PRESENT: Discuss with senior clinician and ICU team. Consider IV magnesium sulphate 1.2–2g infusion over 20 minutes (unless already given).[handbook.ggcmedicines.org.uk]
You may have increased levels of eosinophils, which can worsen inflammation in your lungs. Inflammation can cause severe asthma attacks.[nucala.com]
In addition, ongoing airway inflammation is thought to cause the airway hyperreactivity characteristic of asthma.[en.wikipedia.org]
If we are to progress toward individualized therapy for STRA, pragmatic clinical trials of biologics in accurately phenotyped children are needed. a Department of Respiratory Paediatrics, Royal Brompton Hospital b Department of Inflammation Repair and[journals.lww.com]
., dendritic cells) to drive type 2 immune responses and stimulate several cell types (including basophils, eosinophils, mast cells, and ILCs) to start and maintain allergic inflammation also in regional draining lymph nodes (e.g., B-cell IgE skewing)[frontiersin.org]
Treatment of the bronchial tree from beginning to end: Targeting small airway inflammation in asthma. Allergy. 2013; 68 :16–26. [ PubMed ] [ Google Scholar ] 22. Dias-Junior SA, Reis M, de Carvalho-Pinto RM, Stelmach R, Halpern A, Cukier A.[ncbi.nlm.nih.gov]
Extrinsic compression [ edit ] Airways can be compressed from vascular structures, such as vascular rings, lymphadenopathy, or tumors. Congestive heart failure [ edit ] Airway edema may cause wheezing in CHF.[en.wikipedia.org]
Acute severe asthma is an acute exacerbation of asthma that does not respond to standard treatments of bronchodilators (inhalers) and corticosteroids. [1] Symptoms include chest tightness, rapidly progressive dyspnea (shortness of breath), drycough,[en.wikipedia.org]
. # Transfer to ICU accompanied by doctor prepared to intubate if: Deteriorating PEF, worsening or persisting hypoxia, or hypercapnia. Exhaustion, altered consciousness Poor respiratory effort or respiratory arrest.[handbook.ggcmedicines.org.uk]
Once you have an eosinophilic asthma diagnosis, together, you and your doctor will decide if adding a different kind of asthma treatment could help.[nucala.com]
Although robust safety and efficacy data, with reduced exacerbations, are available for omalizumab, biomarkers predicting response to treatment are lacking.[journals.lww.com]
Acute severe asthma is an acute exacerbation of asthma that does not respond to standard treatments of bronchodilators (inhalers) and corticosteroids. [1] Symptoms include chest tightness, rapidly progressive dyspnea (shortness of breath), dry cough,[en.wikipedia.org]
According to a new randomized control trial ketamine and aminophylline are also effective in children with acute asthma who responds poorly to standard therapy. [4] Epidemiology [ edit ] Status asthmaticus is slightly more common in males and is more[en.wikipedia.org]
Relationships of active and passive smoking to total IgE in adults of the Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA).[frontiersin.org]
Pathophysiological phenotyping in those with true severe therapy-resistant asthma (STRA) and the current array of add-on therapies will be discussed.[journals.lww.com]
Irregularities in the heart beat and abnormal lowering of the blood pressure may be observed. [2] Pathophysiology [ edit ] Inflammation in asthma is characterized by an influx of eosinophils during the early-phase reaction and a mixed cellular infiltrate[en.wikipedia.org]
Therefore, as AD and the subsequent atopic march mostly present in early infancy, primary, and secondary prevention should be attempted as early as possible to prevent asthma symptoms onset ( 35 ).[frontiersin.org]
Azithromycin for prevention of exacerbations in severe asthma (AZISAST): A multicentre randomised double-blind placebo-controlled trial. Thorax. 2013; 68 :322–329. [ PubMed ] [ Google Scholar ] 34. Bousquet J, Aubier M, Sastre J, et al.[ncbi.nlm.nih.gov]