Presentation
It is often assumed that LC3 is recruited around bacteria present in the cytoplasm through the formation of canonical double-membrane autophagosomes. [ncbi.nlm.nih.gov]
Gastrointestinal
- Diarrhea
Pathology In humans and other primates, Shigella flexneri causes an acute bloody diarrhea known as shigellosis or bacillary dysentery (Jin et al.). Aside from bloody diarrhea, other symptoms include fever and stomach cramps. [microbewiki.kenyon.edu]
Shigella flexneri 2a was isolated from a patient with Reiter's syndrome (RS) following a family outbreak of traveler's diarrhea. Among 3 members at risk, only the patient was positive for HLA-B27. [ncbi.nlm.nih.gov]
It is the leading cause of endemic diarrhea in high income countries. [about-shigella.com]
- Abdominal Pain
In March 2017, a 45-year-old Italian man who has sex with men was admitted to the Infectious Diseases Department of Trieste Hospital (northeast Italy), because of fever, abdominal pain and dysentery. [ncbi.nlm.nih.gov]
This causes shigellosis with (mucous and bloody) diarrhea, fever and abdominal pain. [abcam.com]
- Nausea
—A 23-year-old laboratory technician was admitted to the hospital on Aug. 10 with a history of fever, chills, headache, abdominal cramping, nausea, and diarrhea for four hours [jamanetwork.com]
Symptoms include an acute onset of diarrhea, fever, nausea, vomiting, and abdominal cramps. The infectious dose is very low (as few as 10 organisms) and the bacteria are spread by the fecal-oral route. [meridianbioscience.com]
If you have extreme nausea and vomiting, you may need intravenous fluids and medication. Most people have no lasting ill effects from shigellosis. [healthline.com]
The shigella bacteria are very similar to the campylobacter, E coli and salmonella bacteria in that they all cause a form of food poisoning which is characterised by nausea, vomiting and diarrhoea. [medic8.com]
Workup
Colonoscopy
- Colitis
The 19-year-old male patient who presented with fulminating haemorrhagic colitis died nine days after the onset of symptoms. [ncbi.nlm.nih.gov]
This is in opposition to the diarrheal symptoms seen in patients suffering from extensive Shigella colitis, and the pathologic basis for this is unknown. [textbookofbacteriology.net]
Advertisement Colon non tumor Infectious colitis (specific microorganisms) Shigella of colon Topic Completed: 01 January 2016 Revised: 10 January 2017, last major update January 2016 Copyright: (c) 2003-2017, PathologyOutlines.com, Inc. [pathologyoutlines.com]
Infections with Shiga toxin-producing bacteria are known to cause bloody diarrhea (hemorrhagic colitis). [certest.es]
The aim of the present study is to report a case of severe course of colitis with severe complications caused by Shi-gella fexneri in 10-year old girl. [medicalproblems.eu]
Treatment
The aims of this investigation were to; (i) study the effect of X-ray treatments in reducing Escherichia coli O157:H7, Listeria monocytogenes, Salmonella enterica and Shigella flexneri on whole mangoes, and (ii) study the effect of X-ray treatments on [ncbi.nlm.nih.gov]
No MSM with ciprofloxacin resistance received ciprofloxacin; the remaining 26/33 (78%) did not receive antimicrobial treatment and their diarrhoea resolved. [sti.bmj.com]
The revived sample A was divided into two parts Gr.I (control) and Gr.II (revived; treatment); likewise, ATCC B was labeled as Gr.III (lyophilized; treatment). Biofield treatment strategy The Gr. I remained as untreated. The treatment Gr. [trivedieffect.com]
Prognosis
Although prognosis after local treatment is good, shigellosis is a systemic infection, possibly leading to dehydration. [ncbi.nlm.nih.gov]
Pyroptosis correlates with tumor immunity and prognosis Xiaoying Lou, Kexin Li … Wei Cui Communications Biology Open Access 06 September 2022 Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis Lili Zhuang, Xiaoqing Luo [nature.com]
The prognosis for shigellosis is generally good and most people recover even without medications within five to seven days. What is shigellosis? Shigellosis is a diarrheal disease caused by a group of bacteria called Shigella. [medicinenet.com]
Etiology
A bacterium which is one of the etiologic agents of bacillary dysentery (DYSENTERY, BACILLARY) and sometimes of infantile gastroenteritis. [connects.catalyst.harvard.edu]
These bacteria express multiple copies of a syringe-like protein complex, the Type Three Secretion apparatus (T3SA), which is instrumental in the etiology of the disease. [ncbi.nlm.nih.gov]
Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. [uniprot.org]
Epidemiology
Together, our findings reveal insights into the genomic evolution of the understudied Shigella flexneri serotype 6, providing a new piece in the puzzle of Shigella epidemiology and evolution. [microbiologyresearch.org]
Descriptive Epidemiology 587 Mechanisms and Routes of Transmission 7 Pathogenesis and Immunity 590 Patterns of Host Response 591 Control and Prevention 592 References 593 Suggested Reading 595 Rocky Mountain Spotted Fever Theodore E Woodward and J Stephen [books.google.de]
This review attempts to provide the recent findings of S. flexneri related to epidemiology and the emergence of multidrug resistance. [pubmed.ncbi.nlm.nih.gov]
Epidemiological surveys of Shigella spp. infections reported to DSP Montréal-Centre in 2001 were analysed. [canada.ca]
It was not possible to identify epidemiological links associated with these small clusters using only the limited epidemiological data available from laboratory report forms. [journal.frontiersin.org]
Pathophysiology
Sites Disease occurs primarily in the left colon and involvement of the terminal ileum is common Disease may occur in other parts of the large bowel Very rarely, fulminant disease occurs because of massive small intestinal invasion (Ikari syndrome) Pathophysiology [pathologyoutlines.com]
[2] Together with Shigella flexneri, it is responsible for 90% of shigellosis cases. [3] Shigella sonnei is named for the Danish bacteriologist Carl Olaf Sonne. [4] [5] It is a Gram-negative, rod-shaped, nonmotile, non-spore-forming bacterium. [6] Pathophysiology [en.wikipedia.org]
References Pathophysiology of gastrointestinal infections: the role of bismuth subsalicylate. Scottsdale, Arizona, 11-14 February 1988. Proceedings. Rev Infect Dis. 1990;12 Suppl 1:S1-119. Steffen R. [cdc.gov]
Prevention
Prevention, Shenzhen, Guangdong, China. 4 State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. [ncbi.nlm.nih.gov]