Presentation
The natural history of endometriosis is uncertain, its etiology unknown, the clinical presentation inconsistent, diagnosis difficult and the treatment poorly standardized. [ncbi.nlm.nih.gov]
Appropriate treatment kills the bacteria present in the gastrointestinal tract and shortens the course of the illness. [textbookofbacteriology.net]
This kind of dysentery is not unique to shigellosis, however, making the diagnosis on clinical presentation very difficult in the absence of laboratory or epidemiologic findings. [infectionlandscapes.org]
Fever is present in about half the patients and a mild headache may be present. Diarrhoea persists as the prominent symptom for 3 or 4 days. Salmonellosis may be complicated by reactive arthritis and Reiter’s syndrome. [virology-online.com]
Entire Body System
-
Mucosal Edema
Gross pathology consists of mucosal edema, erythema, friability, superficial ulceration, and focal mucosal hemorrhage involving the rectosigmoid junction primarily. [emedicine.medscape.com]
Gastrointestinal
-
Abdominal Pain
[…] involves inflammation, haemorrhage, tissue destruction and fibrotic adhesions of the pelvic peritoneum resulting in abdominal pain and infertility. [ncbi.nlm.nih.gov]
Symptoms S. sonnei: Most common symptoms are diarrhoea (which is sometimes bloody), abdominal pain and cramps, and fever. Nausea and/or vomiting, loss of appetite, headache or malaise can also occur. [ecdc.europa.eu]
Abdominal pain, vomiting, diarrhea and a fever are the main symptoms similar to other forms of gastroenteritis and enteritis. [healthhype.com]
The onset is acute, with fever, fatigue, abdominal pain and watery diarrhoea. As the disease increases in intensity, bloody diarrhoea with mucous, faecal urgency and severe cramping abdominal pain occur. [healthengine.com.au]
-
Nausea
If you have diarrhea and cannot drink fluids by mouth because of severe nausea, you may need medical care and intravenous (IV) fluids. This is more common in small children who have shigellosis. [medlineplus.gov]
—A 23-year-old laboratory technician was admitted to the hospital on Aug. 10 with a history of fever, chills, headache, abdominal cramping, nausea, and diarrhea for four hours [jamanetwork.com]
If you have extreme nausea and vomiting, you may need intravenous fluids and medication. Most people have no lasting ill effects from shigellosis. [healthline.com]
-
Rectal Pain
Signs and Symptoms A Shigella infection can cause mild watery or loose stools with no other symptoms, or it can be more serious, with fever, abdominal cramps or tenderness, crampy rectal pain (tenesmus), and mucous-filled and sometimes bloody stools. [healthychildren.org]
Symptoms include: Acute (sudden) abdominal pain or cramping Acute fever Blood, mucus, or pus in the stool Crampy rectal pain Nausea and vomiting Watery diarrhea If you have symptoms of shigellosis, your health care provider will check for: Dehydration [medlineplus.gov]
The most serious form of the disease is called dysentery, which is characterized by severe watery (and often blood- and mucous-streaked) diarrhea, abdominal cramping, rectal pain, and fever. [medical-dictionary.thefreedictionary.com]
Apart from diarrhoea, symptoms of Shigella infection include fever, abdominal cramps, and rectal pain. Most patients recover without complications within seven days. [phagetherapycenter.com]
-
Acute Diarrhea
Diarrhoea Though the global under-five mortality from acute diarrhea has decreased from 4.5 million to 1.8 million annually, acute diarrhea continues to take a huge toll on children's health in developing countries. [phagetherapycenter.com]
Diagnosis Shigellosis is one of the many causes of acute diarrhea. Culture (growing the bacteria in the laboratory) of freshly obtained diarrhea fluid is the only way to be certain of the diagnosis. [medical-dictionary.thefreedictionary.com]
The disease is characterized by acute diarrhea (with or without blood or mucus), high fever and general toxicity ( 31 ). MICROBIOLOGY Shigellae are small nonmotile Gram-negative rods which belong to the family Enterobacteriaceae ( 11 ). [antimicrobe.org]
-
Blood in Stool
When the disease becomes established, both blood and stool may be positive, as is urine in 25% of cases. [virology-online.com]
Blood in stool and fever above 37.5 C is double weighted in the de Wit scale, while in the MVS scale, blood in stool is not a factor and fever is double weighted only when temperature is above 38.4 C. [bmcinfectdis.biomedcentral.com]
Musculoskeletal
-
Enthesopathy
RESULTS: Of the patients, 14/211 (7%) had ReA, and a further 4/211 (2%) other reactive musculoskeletal symptoms (tendonitis, enthesopathy, or bursitis). [ncbi.nlm.nih.gov]
In addition to ReA, four patients had reactive tendonitis or enthesopathy or bursitis (ReTEB). [ard.bmj.com]
Skin
-
Flushing
Such spread may occur directly by close personal contact, or indirectly by touching contaminated surfaces such as taps, toilet flush buttons, toys and nappies. Shigellosis can also be spread through oral-anal sex. [healthywa.wa.gov.au]
Stool that contaminates clothing and bedclothes of infected people should be flushed away in running water, and the soiled clothing and bedclothes should be washed in a washing machine using the hot water cycle. [merckmanuals.com]
Use hot soapy water to clean taps, door handles, the toilet flush and seat at home very often. 3. Avoid: Sex, until a week after symptoms stop. Sharing towels. Use separate towels at home. Jacuzzis/hot tubs/spas. [tht.org.uk]
-
Hirsutism
Increased hirsutism prompted a change to tacrolimus therapy. During 11 months the mean tacrolimus level was 8.2 ng/mL. [ncbi.nlm.nih.gov]
Urogenital
-
Pelvic Pain
It causes significant morbidity due to pelvic pain and infertility among 15-25% of women during their reproductive age. [ncbi.nlm.nih.gov]
Neurologic
-
Dizziness
Also call the doctor if your child has diarrhea and shows signs of dehydration, such as: a dry or sticky mouth peeing less than usual no tears when crying dizziness or drowsiness Date reviewed: February 2019 [kidshealth.org]
Symptoms include lightheadedness, dizziness, lack of tears in children, sunken eyes and dry diapers. Severe dehydration can lead to shock and death. Seizures. Some children who run high fevers with a shigella infection have seizures. [mayoclinic.org]
You could be lightheaded, dizzy, lack tears, and sunken eyes. Watch for dry diapers in children. Post- infectious arthritis. This is joint pain (in ankles, knees, feet, hips). You could also get eye irritations and painful urination. [webmd.com]
-
Excitement
In these protocols, artefacts linked to a prolonged exposure and photodamage associated with the excitation of Ca 2 fluorescent probes are troubleshot by stringently controlling the acquisition parameters over defined time periods during a Shigella invasion [ncbi.nlm.nih.gov]
Workup
Blood, stool and urine specimens were collected for both bacteriological culture and parasitic workup. Concurrent infections with both Shigella sonnei and Vibrio cholerae were determined to be the cause of the infectious diarrhea. [clsjournal.ascls.org]
Shigella Infection Workup. Jun 25, 2012. Created by Jake Morgan, Michael McCoy and Kyle Trinidad, students of Tyrrell Conway at the University of Oklahoma. [microbewiki.kenyon.edu]
Serum
-
Hyponatremia
In one study, hyponatremia, defined as serum sodium levels below 120 meq/L, was noted in 29% of patients hospitalized with diarrhea due to type 1 S dysenteriae. [26] However, the hyponatremia is generally caused by the syndrome of inappropriate antidiuretic [emedicine.medscape.com]
Treatment
FINDINGS: 3649 papers were identified and 60 studies were included for analyses: 13 for mortality, 27 for diagnostic value, and 20 for treatment. [ncbi.nlm.nih.gov]
Treatment The first aim of treatment is to keep up nutrition and avoid dehydration. Ideally, a physician should be consulted before starting any treatment. Antibiotics may not be necessary, except for the more severe infections. [medical-dictionary.thefreedictionary.com]
People with mild illness usually get better on their own, with no specific treatment. [sfcdcp.org]
Prognosis
Prognosis of shigellosis The disease is self-limiting, usually resolving within 5 to 7 days without antibiotics. In severe cases, the infection may last 3 to 6 weeks. [healthengine.com.au]
What Is the Prognosis? In most cases, Shigella infections run their course in 2 to 3 days. [healthychildren.org]
Prognosis Many patients with mild infections need no specific treatment and recover completely. In those with severe infections, antibiotics will decrease the length of symptoms and the number of days bacteria appear in the feces. [medical-dictionary.thefreedictionary.com]
The prognosis for shigellosis is generally good and most people recover even without medications within five to seven days. What is shigellosis? Shigellosis is a diarrheal disease caused by a group of bacteria called Shigella. [medicinenet.com]
Etiology
Mechanical, hormonal, immunological, environmental and genetic factors have been implicated in its etiology but provide inconclusive explanations. [ncbi.nlm.nih.gov]
Cohen Abstract Author Information Authors Article Metrics Metrics Shigella spp. are important etiologic agents of diarrhea worldwide. [journals.lww.com]
Epidemiology
This review summarizes the recent findings on the epidemiology, diagnosis, virulence genes, and pathobiology of Shigella infection. [ncbi.nlm.nih.gov]
The Epidemiology and the Landscape. Both sporadic and epidemic occurrence of shigellosis is common. [infectionlandscapes.org]
Pathophysiology
The improved understanding of the pathophysiology is hoped to lead to innovative therapeutic approaches against shigellosis and new generations of vaccine candidates. [ncbi.nlm.nih.gov]
References Pathophysiology of gastrointestinal infections: the role of bismuth subsalicylate. Scottsdale, Arizona, 11-14 February 1988. Proceedings. Rev Infect Dis. 1990;12 Suppl 1:S1-119. Steffen R. [cdc.gov]
Shigellosis Pathophysiology The Shigella bacteria primarily infect the epithelial cells lining intestine. It enters the gut through the mouth when consuming contaminated food and water. [healthhype.com]
Prevention
The best approach for shigellosis is prevention and a few simple measures can effectively prevent the infection altogether. Supportive Treatment Proper hydration requires the use of oral rehydration solutions (ORS). [healthhype.com]
Centers for Disease Control and Prevention/Kenya Medical Research Institute Research Station, Kisumu, Kenya; Centre for Nutrition and Food Security, Mohakhali, Dhaka, Bangladesh [email protected] [ncbi.nlm.nih.gov]