At least 21 patients with ALS deficiency have been described presenting 16 different homozygous or compound heterozygous inactivating mutations of the IGFALS gene. [ncbi.nlm.nih.gov]

Partial gonadal dysfunction and osteoporosis may also be present. [orpha.net]

In conclusion, the results of the present study demonstrated that cetuximab blocked EGRF while concurrently inducing activation of IGF-IR and Src. [spandidos-publications.com]

• Short Finger

  Addition features include variable degrees of intellectual deficit, microcephaly and dysmorphism (broad nasal bridge and tip, smooth philtrum, thin upper and everted lower lips, short fingers, clinodactyly, wide-set nipples and pectus excavatum). [orpha.net]

• Sepsis

  Insulin-like growth factor I production is inhibited in human sepsis. Arch Surg. 1988; 123:1409-14. Maes M, Underwood LE, Ketelslegers JM. [annals.org]

• Nausea

  All patients were able to tolerate the maximum dosage of liraglutide (1.8 mg once daily), except one patient who continued with a dose of 1.2 mg/day because of persistent nausea. [doi.org]

• Myalgia

  In the last 2 to 3 weeks, however, adverse effects appeared, including arthralgia in his hips and knees, generalized myalgia, exhaustion, lower back pain, and chills for up to 30 minutes several times each day. [annals.org]

• Hip Pain

  Four of the 48 patients receiving the higher dose experienced effects consistent with GH excess, such as enlarging shoe size, ankle swelling, and hip pain. [karger.com]

• Hearing Impairment

  impairment 0008619 Congenital sensorineural hearing impairment 0008527 Failure to thrive Faltering weight Weight faltering [ more ] 0001508 Insulin resistance Body fails to respond to insulin 0000855 Intellectual disability, mild Mental retardation, [rarediseases.info.nih.gov]

• Withdrawn

  In all cases, after obtaining an informed written consent from the subjects' parents, 5 ml of venous blood was withdrawn for measurement of IGF-1 and serum ferritin. [thefreelibrary.com]

• Hyperactivity

  Showing of 45 80%-99% of people have these symptoms Abnormal facial shape Unusual facial appearance 0001999 Attention deficit hyperactivity disorder Attention deficit Attention deficit disorder Attention deficit-hyperactivity disorder Attention deficits [rarediseases.info.nih.gov]

• Renal Insufficiency

  It occurs at an overall incidence of 28 per 100,000 treatment-years, with a higher rate among patients with chronic renal insufficiency, Turner syndrome, and organic GHD, and at a lower rate in patients with ISS. [karger.com]

• Glycosuria

  Daily fasting and preprandial glucose measurements continued to range from 11.1 to 27.8 mmol/L and polyuria, glycosuria, and ketonuria persisted. [annals.org]

Treatment with these agents is associated with improved glucose control and weight loss ( 7 ). [doi.org]

Experience with IGF-I treatment is limited and the risks of long-term treatment are not known. [annals.org]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

Furthermore, the combination treatment reduced colony formation in MGC803 cells relative to that of treatment with cetuximab alone ( Fig. 5C ). [spandidos-publications.com]

Prognosis Prognosis varies depending on the underlying molecular anomaly. The documents contained in this web site are presented for information purposes only. [orpha.net]

Prognosis Prognosis varies depending on the underlying molecular anomaly. Last updated: 5/22/2008 This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. [rarediseases.info.nih.gov]

PMID: 25465274 Prognosis Dizdarević-Hudić L, Kusljugić Z, Baraković F, Hajder M, Hudić I Acta Clin Croat 2016 Sep;55(3):345-353. doi: 10.20471/acc.2016.55.03.01. [ncbi.nlm.nih.gov]

Variants in the ER gene may also explain paradoxical observations on the association between tumour ER expression and breast cancer prognosis after primary treatment. [annonc.oxfordjournals.org]

We suggest sex steroid priming prior to provocative GH testing in prepubertal boys older than 11 and in prepubertal girls older than 10 years with AH prognosis within -2 SD of the reference population mean in order to prevent unnecessary GH treatment [karger.com]

Etiology IGF-I deficiency is caused by homozygous mutations in the insulin-like growth factor 1 gene ( IGFI ; 12q22-q24.1). IGF-I is essential for foetal and postnatal growth, brain development and metabolism. [orpha.net]

Etiology Kujawska-Luczak M, Szulinska M, Skrypnik D, Musialik K, Swora-Cwynar E, Kregielska-Narozna M, Markuszewski L, Grzymislawska M, Bogdanski P J Physiol Pharmacol 2018 Oct;69(5) Epub 2019 Jan 21 doi: 10.26402/jpp.2018.5.08. [ncbi.nlm.nih.gov]

Summary Epidemiology The syndrome is extremely rare and only four cases have been reported in the literature so far. Clinical description Addition clinical features include microcephaly, adiposity, and insulin resistance. [orpha.net]

Relevant External Links for IGF1 Genetic Association Database (GAD) IGF1 Human Genome Epidemiology (HuGE) Navigator IGF1 Tumor Gene Database (TGDB): IGF1 Atlas of Genetics and Cytogenetics in Oncology and Haematology: IGF1 No data available for Genatlas [genecards.org]

Epidemiology The syndrome is extremely rare and only four cases have been reported in the literature so far. Clinical description Addition clinical features include microcephaly, adiposity, and insulin resistance. [rarediseases.info.nih.gov]

Pathophysiology/Complications Abstract OBJECTIVE Obesity is associated with an increased risk of type 2 diabetes and cardiovascular complications. The risk depends significantly on adipose tissue distribution. [doi.org]

(Ungraded good practice statement) Pathophysiological and epidemiological observations prompt concern that GH might increase risk of malignancy during or after therapy. [karger.com]

The main role of ALS is the extension of IGF-I half life by protecting it from degradation and preventing the passage of IGF-I to the extravascular compartment. [ncbi.nlm.nih.gov]

Conclusions Intervention trials in breast cancer prevention would greatly benefit from surrogate response markers which could predict long-term benefit. [annonc.oxfordjournals.org]

Another limitation is the lack of postintervention follow-up, which prevented assessment of the durability of our findings, in particular on adipose tissue distribution. [doi.org]

If these findings are confirmed by others, the plasma concentration of IGFBP-3 could be used to improve the accuracy of predictive models of dementia and as a potential new factor to assist in the development of prevention and treatment strategies. [nature.com]

The consensus panel endorses harm prevention in the treatment of children with GH. [karger.com]