At least 21 patients with ALS deficiency have been described presenting 16 different homozygous or compound heterozygous inactivating mutations of the IGFALS gene. [ncbi.nlm.nih.gov]

Partial gonadal dysfunction and osteoporosis may also be present. [orpha.net]

In conclusion, the results of the present study demonstrated that cetuximab blocked EGRF while concurrently inducing activation of IGF-IR and Src. [spandidos-publications.com]

Treatment with these agents is associated with improved glucose control and weight loss ( 7 ). [doi.org]

Experience with IGF-I treatment is limited and the risks of long-term treatment are not known. [annals.org]

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]

Furthermore, the combination treatment reduced colony formation in MGC803 cells relative to that of treatment with cetuximab alone ( Fig. 5C ). [spandidos-publications.com]

Prognosis Prognosis varies depending on the underlying molecular anomaly. The documents contained in this web site are presented for information purposes only. [orpha.net]

Prognosis Prognosis varies depending on the underlying molecular anomaly. Last updated: 5/22/2008 This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. [rarediseases.info.nih.gov]

PMID: 25465274 Prognosis Dizdarević-Hudić L, Kusljugić Z, Baraković F, Hajder M, Hudić I Acta Clin Croat 2016 Sep;55(3):345-353. doi: 10.20471/acc.2016.55.03.01. [ncbi.nlm.nih.gov]

Variants in the ER gene may also explain paradoxical observations on the association between tumour ER expression and breast cancer prognosis after primary treatment. [annonc.oxfordjournals.org]

We suggest sex steroid priming prior to provocative GH testing in prepubertal boys older than 11 and in prepubertal girls older than 10 years with AH prognosis within -2 SD of the reference population mean in order to prevent unnecessary GH treatment [karger.com]

Etiology IGF-I deficiency is caused by homozygous mutations in the insulin-like growth factor 1 gene ( IGFI ; 12q22-q24.1). IGF-I is essential for foetal and postnatal growth, brain development and metabolism. [orpha.net]

Etiology Kujawska-Luczak M, Szulinska M, Skrypnik D, Musialik K, Swora-Cwynar E, Kregielska-Narozna M, Markuszewski L, Grzymislawska M, Bogdanski P J Physiol Pharmacol 2018 Oct;69(5) Epub 2019 Jan 21 doi: 10.26402/jpp.2018.5.08. [ncbi.nlm.nih.gov]

Summary Epidemiology The syndrome is extremely rare and only four cases have been reported in the literature so far. Clinical description Addition clinical features include microcephaly, adiposity, and insulin resistance. [orpha.net]

Relevant External Links for IGF1 Genetic Association Database (GAD) IGF1 Human Genome Epidemiology (HuGE) Navigator IGF1 Tumor Gene Database (TGDB): IGF1 Atlas of Genetics and Cytogenetics in Oncology and Haematology: IGF1 No data available for Genatlas [genecards.org]

Epidemiology The syndrome is extremely rare and only four cases have been reported in the literature so far. Clinical description Addition clinical features include microcephaly, adiposity, and insulin resistance. [rarediseases.info.nih.gov]

Pathophysiology/Complications Abstract OBJECTIVE Obesity is associated with an increased risk of type 2 diabetes and cardiovascular complications. The risk depends significantly on adipose tissue distribution. [doi.org]

(Ungraded good practice statement) Pathophysiological and epidemiological observations prompt concern that GH might increase risk of malignancy during or after therapy. [karger.com]

The main role of ALS is the extension of IGF-I half life by protecting it from degradation and preventing the passage of IGF-I to the extravascular compartment. [ncbi.nlm.nih.gov]

Conclusions Intervention trials in breast cancer prevention would greatly benefit from surrogate response markers which could predict long-term benefit. [annonc.oxfordjournals.org]

Another limitation is the lack of postintervention follow-up, which prevented assessment of the durability of our findings, in particular on adipose tissue distribution. [doi.org]

If these findings are confirmed by others, the plasma concentration of IGFBP-3 could be used to improve the accuracy of predictive models of dementia and as a potential new factor to assist in the development of prevention and treatment strategies. [nature.com]

The consensus panel endorses harm prevention in the treatment of children with GH. [karger.com]