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2.1
Silicone Granuloma
Siliconomas

Images

WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0
WIKIDATA, CC BY-SA 3.0

Presentation

In this case presentation, the authors report two patients who developed granulomatous reactions following silicone injections. Case 1 A 39-year-old man presented with subcutaneous nodules along both nasolabial folds (Figure 1A). [ncbi.nlm.nih.gov]

CASE REPORT The patient, a 54-year-old woman, presented to our emergency room with 4 days of erythema, induration, and pain in her bilateral buttocks (Fig. 1). [journals.lww.com]

Skin

  • Skin Ulcer

    Skin ulcer: A long-term complication after massive liquid silicone oil infiltration. Aesthetic Plast Surg 2013;37:1220-4. 9. Fumo G, Ferreli F, Murgia S, Galletti R, Pau M. [ijps.org]

  • Angioedema

    Ilva Petushi Angioedema and anaphylaxis– Dentistry CPD training session, Shkurt 2022, Msc. Ilva Petushi Oral cancer: Early detection- Dentistry CPD training session, Shkurt 2022, Msc. [ual.edu.al]

Workup

MRI of the penis by combining both conventional and functional information represents an important imaging tool in the preoperative workup of silicone-induced penile lipogranuloma. [clinicalimagingscience.org]

Other Pathologies

  • Granulomatous Tissue

    Pathology results confirmed granulomatous tissue without malignancy. There were no postoperative complications and the patient was discharged after five days in the hospital. [jcasonline.com]

Treatment

32 and laser treatments.33 Combination treatments are sometimes necessary and effective as seen in the two patients described in this report. [ncbi.nlm.nih.gov]

Pain improved tremendously; however, the induration and subcutaneous nodules remained unchanged (after 1 month of treatment with etanercept). Treatment of silicone granulomas is difficult and often unsuccessful. [jamanetwork.com]

treatments and I have heard used in silicone related illness treatments as well. [gotpummped.wordpress.com]

Prognosis

The disease has a relatively higher occurrence among young people, and its prognosis (3-year-survival of only 38%) is extremely poor compared to breast cancer. [ncbi.nlm.nih.gov]

Breast cancer diagnosis and prognosis in augmented women. Plast Reconstr Surg. 2006;118(3):587–93. discussion 594-6. 14. Peng HL, Wu CC, Choi WM, Hui MS, Lu TN, Chen LK. [wjso.biomedcentral.com]

Biana Brovina et bp Maj, 2012 FACTOR AFFECTING THE PROGNOSIS OF ALBANIAN ADULTS PATIENTS WITH GENERALIZED TETANUS. PILACA, A. Beqiri, A.NDREU. Il Giornale di chirurgia ISSN 0391-9005 UDC 61, VOL, 18, Prill 2012. [ual.edu.al]

Etiology

[…] mammoplasty and joint prostheses ( Hum Pathol 1980;11:240 ) Once released into tissue, silicone migrates to distant sites through lymphatic channels and bloodstream Once it reaches lymph nodes, it elicits a reaction and cause silicone lymphadenopathy Etiology [pathologyoutlines.com]

The extent of lymphocytic cuffing was more extensive than typically observed in sarcoidosis, but pathology alone could not rule out sarcoidosis or an infectious etiology. [avensonline.org]

(poster) THE EPIDEMIONOLOGICAL THE ETIOLOGICAL AND THE CLINICAL APECTS OF THE COMA STATE IN INFECTIOUS DISEASES. Ndreu. The 6 Euroasia Congress of Infectious Diseases 24-27 September 2014. Belgrade, Serbia. [ual.edu.al]

Epidemiology

The role of silicone gel in relation to connective tissue disease or amyloidosis has not been proved by current serologic, immunologic, or epidemiologic tests. [doi.org]

EPIDEMIOLOGICAL ASPECTS, CLINICAL AND THERAPEUTIC OF CEREBAL MALARIA CASES IMPORTED IN ALABANIA NDREU, A. Andoni, D.Hajdari, Dh.Kraja,. [ual.edu.al]

Pathophysiology

[…] enlargement of regional lymph nodes caused by the presence of silicone carried from tributary organs Either an incidental finding or causes painful / enlarged lymph node May be associated with granulomatous inflammation ( Histol Histopathol 1997;12:1003 ) Pathophysiology [pathologyoutlines.com]

Understanding their pathophysiology is essential in differential diagnosis and appropriate management. [aestheticsjournal.com]

"Amyloidosis and silicone synovitis: Updated classification, updated pathophysiology, and synovial articular abnormalities". Radiologic Clinics of North America. 34 (2): 375–94, xi. PMID 8633122. [en.wikipedia.org]

Prevention

Thick sections (10-30 micrometer thick) prevent loss of silicone droplets during tissue processing. The silicones can be detected by adding stamp pad ink to the mounting medium. [histopathology-india.net]

An interleukin 1 receptor antagonist was started to prevent the extension of amyloidosis, but to no avail as far as the kidneys are concerned. [doi.org]

Counselling the patient and adopting preventative measures such appropriate filler choice and prevention of infection should be part of every case of dermal filler injections. [aestheticsjournal.com]

When comparing with other causes of implant rupture, CSG potentially damaging effect may most likely only play a minor role in implant rupture but is surgically preventable. [pubs.sciepub.com]

It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. [gotpummped.wordpress.com]

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