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Silicotuberculosis

Silicotuberculoses


Presentation

  • The first subject presented a multicavitary lesion in the apex of the right lung, which subsequently evolved with fibrosis.[ncbi.nlm.nih.gov]
  • On auscultation; fine crackles in bilateral upper and mid zones at the end of inspiration were present. Routine examination of blood and urine samples were normal except for raised erythrocyte sedimentation rate (40 mm/h).[annalsafrmed.org]
  • Without a licence, no further use can be made, such as: focus group presentations external presentations final materials distributed inside your organisation any materials distributed outside your organisation any materials distributed to the public ([gettyimages.co.uk]
Chest Discomfort
  • Ann Afr Med 2013;12:255-6 Sir, A 46-year-old man, working in a stone-cutting factory for last 14 years presented with a history of breathlessness, chest discomfort, dry cough, sweating, malaise, and loss of weight since September 2006.[annalsafrmed.org]
Amyloidosis
  • DD FOR BILATERAL HILAR CALCIFICATIONS Sarcoidosis Silicosis Post irradiation of hodgkins lymphoma Blastomycosis Sleroderma Histoplasmosis Amyloidosis 12.[slideshare.net]
Falling
  • India ranges widely – from 3.5% among 1977 workers in an ordnance factory to 54.6% in 593 workers in the slate-pencil industry. 5 , 6 The main challenge of eliminating silicosis in India is in the informal, unregulated sectors of industry which do not fall[who.int]
Sputum
  • Silicotuberculosis diagnosed based on professional and TB history, radiological and endoscopic picture, sputum for mycobacteria, tuberculin tests.[medicalformat.com]
  • The results of surgical treatment for unilateral major lesions and their effect on the contralateral minor lesions were clinically assessed by alterations in the chest x-ray findings and tubercle bacilli in sputum.[ncbi.nlm.nih.gov]
  • Three sputum specimens were negative for acid-fast bacilli by staining and culture.[doi.org]
  • Mycobacterium tuberculosis bacilli may not be recovered from the sputum of silicotuberculosis patients because silicotic fibrosis prevents the discharge of tubercle bacilli into the sputum. 8 Acid-fast bacilli, if cultured, are mainly non-tuberculous[who.int]
Dyspnea
  • As the disease progresses, airflow limitation occurs, manifested by dyspnea and cough. Eventually, cor pulmonale and respiratory failure develop.[emedicine.com]
  • Among symptomatic patients, dyspnea is common but is usually severe only if there is progressive massive fibrosis.[ilo.org]
  • Silicoproteinosis Chronic (Simple) Silicosis Minimal to no changes in pulmonary function (2) Acute Silicosis/Silicoproteinosis Chronic (Simple) Silicosis Simple nodules coalesce, creating larger ones ( 1 cm) that can be seen on CXR Cough Progressive dyspnea[quizlet.com]
Chronic Cough
  • Workers with Silicosis may have following symptoms: Shortness of breath following physical exertion, severe and chronic cough, fatigue, loss of appetite, chest pains and fevers.[silicosis-injury-attorneys.com]
  • Case report Section: A 76-year-old woman was initially admitted to the hospital on 9 November 2007 with a 2-week history of acute exacerbation of a chronic cough and dysphagia involving both solids and liquids.[doi.org]
  • Chronic cough and exertional dyspnea (shortness of breath) are common findings. Radiographically, chronic simple silicosis reveals a profusion of small ( 10 mm in diameter) opacities, typically rounded, and predominating in the upper lung zones.[en.wikipedia.org]
  • The details of the method of recruitment of the patients in the clinic have been explained elsewhere. [6] Inclusion criteria Patients above 15 years of age of both genders living in Shakarpur, having symptoms of chronic cough for more than 3 months and[lungindia.com]
Hemoptysis
  • Accession or the activation of tuberculosis infection is accompanied by worsening of silicosis: a rise in temperature, increase of intoxication, increased shortness of breath, cough with sputum appearance of purulent character, hemoptysis, progressive[medicalformat.com]
  • A 64-year-old man with recurrent hemoptysis, a bronchoesophageal fistula, and broncholithiasis . N Engl J Med 1991 ; 325: 1429 – 1436 . Google Scholar Crossref Medline[doi.org]
Sputum Production
  • In June 2009 (16 months later), the patient was admitted to the hospital for the third time because of a 10-day history of coughing, sputum production, dyspnoea, fever, and night sweats.[doi.org]
Cyanosis
  • In the acute form, patients develop shortness of breath, fever, and cyanosis. In the chronic form patients, develop progressive shortness of breath. 502 Pneumoconiosis due to other silica or silicates convert 502 to ICD-10-CM[icd9data.com]
  • He was dyspneic without cyanosis, clubbing, or lymphadenopathy. On auscultation; fine crackles in bilateral upper and mid zones at the end of inspiration were present.[annalsafrmed.org]
  • It is a type of pneumoconiosis.Silicosis (particularly the acute form) is characterized by shortness of breath, cough, fever, and cyanosis (bluish skin).[en.wikipedia.org]
  • Silicosis, which can take up to 15 years to develop and includes symptoms like shortness of breath, cough, fever, cyanosis (bluish skin) and frequent chest infections which lead to lung transplants and even death, can be caused by long-term exposure to[news.com.au]

Workup

Cavitary Lesion
  • Axial HRCT scan (C:-600, W: 1600) shows an irregular thick-walled cavitary lesion (arrow) in the upper lobe of right lung, suggestive of pulmonary tuberculosis.[ijri.org]
Pleural Exudate
  • Occupational history, radiology (conventional chest radiography and computed tomography) and microbiology (identification of Mycobacterium tuberculosis in sputum and pleural exudate) are helpful for the correct diagnosis, which, in turn, is important[ncbi.nlm.nih.gov]
Pleural Adhesions
  • First hospitalization chest radiography showed bilateral pleural adhesions, diffuse lung fibrosis with signs of a specific lung process.[ncbi.nlm.nih.gov]

Treatment

  • It should be emphasized that surgical treatments more aggressive than have been heretofore practiced can be employed.[ncbi.nlm.nih.gov]
  • Treatment is carried out anti silicotuberculosis of chemotherapy on the same principles as the treatment of tuberculosis.[medicalformat.com]

Prognosis

  • Occupational history, radiology (conventional chest radiography and computed tomography) and microbiology (identification of Mycobacterium tuberculosis in sputum and pleural exudate) are helpful for the correct diagnosis, which, in turn, is important for prognosis[ncbi.nlm.nih.gov]
  • Prognosis depends on the stage of silicosis, tuberculosis, associated disorders. Any complications silicotuberculosis are factors aggravating the prognosis. All patients with silicosis should receive TB chemoprophylaxis.[medicalformat.com]
  • Patients have a poor prognosis and the disease rarely ha s a chance to become one of the chronic forms. Acute silicosis, is caused by a massive outpouring of protein debris and fluid into lung sacs.[silicosis-injury-attorneys.com]
  • Treatment and prognosis Treatment is to remove the exposure, although silicosis may progress despite removal from the dust environment.[radiopaedia.org]
  • In general, the prognosis is favourable. In our case, the patient’s occupational history and radiologic features helped with the diagnosis of silicosis, but the complications of silicosis are incompletely understood.[doi.org]

Etiology

  • This pattern was present for both Alzheimer’s disease–related dementia and cerebrovascular disease etiologies, and persisted in analyses restricted to nonsmokers.[ajrccm.atsjournals.org]
  • If there is no progressive massive fibrosis and emphysema is present, then smoking plays a more significant role in the etiology of the emphysema and is often considered part of the etiology of the patient's disability.[web.archive.org]
  • Silicosis has as etiologic factor prolonged exposure to silica dust (sized between 3-5 microns), which causes progressive fibrosis.[pathologyatlas.ro]
  • Meletis and Ben Bramwell, Rheumatoid Arthritis: Etiology and Naturopathic Treatments, Alternative and Complementary Therapies, 7, 6, (347), (2001). Judy Van de Water, Hiromi Ishibashi, Ross L. Coppel and M.[doi.org]

Epidemiology

  • A comprehensive, and profusely illustrated description of the common and uncommon images which will be found in a wide range of tropical diseases, correlated with the clinical and laboratory findings, and the epidemiology and pathology.[books.google.de]
  • Business Media , 8 nov. 2000 - 789 pagini A comprehensive, and profusely illustrated description of the common and uncommon images which will be found in a wide range of tropical diseases, correlated with the clinical and laboratory findings, and the epidemiology[books.google.ro]
  • DHHS (NIOSH) Publication Number 2004-146 The Worker Health Chartbook 2004 is a descriptive epidemiologic reference on occupational morbidity and mortality in the United States.[web.archive.org]
  • The epidemiology of tuberculosis in gold miners with silicosis. Am J Respir Crit Care Med 1994;150:1460-2. [Figure 1], [Figure 2] Article Access Statistics Viewed 1764 Printed 44 Emailed 2 PDF Downloaded 19 Comments [Add][annalsafrmed.org]
Sex distribution
Age distribution

Pathophysiology

  • Grasp the nuances of the pathophysiology of today’s major respiratory conditions—including pulmonary hypertension, COPD, asthma, environmental lung disease, sleep disorders, infections of the immunocompromised, neonatal breathing disorders, and drug-resistant[books.google.de]
  • Modification of coal-induced lesions by Jaggery (gur): Part II--Pathophysiological evidence in rats. Indian J Exp Biol. 1988 Feb; 26 (2):112–117. [ PubMed ] [ Google Scholar ] Upreti RK, Sahu AP, Shukla L, Srivastava SN, Shanker R.[ncbi.nlm.nih.gov]
  • Shuko Murakami, Yasumitsu Nishimura, Megumi Maeda, Naoko Kumagai, Hiroaki Hayashi, Ying Chen, Masayasu Kusaka, Takumi Kishimoto and Takemi Otsuki, Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases[doi.org]

Prevention

  • […] to understand the interaction of silicosis and tuberculosis in this setting, the importance of maintaining continuity of care in the management of these conditions in miners and former miners, and control of silica dust exposure as a primary form of prevention[ncbi.nlm.nih.gov]
  • Existing status of silicosis and implementation of NHRC recommendations on preventive, remedial, rehabilitative and compensation aspects of silicosis in the State of Gujrat [Internet].[who.int]
  • Prevention Silicosis is prevented by avoiding inhalation of dust containing free crystalline silica.[web.archive.org]

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