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Sindbis Virus Infection


Presentation

  • Altogether, 86 patients with serologically verified SINV infection were recruited to the present study during the 2002 outbreak.[ncbi.nlm.nih.gov]
  • In this proposal we will identify i) the optimal strategy for expression of structural proteins of RVFV by recombinant Sindbis virus, ii) a system for delivery of recombinant genomes into antigen-presenting cells, and iii) the manufacturing procedure[grantome.com]
  • Apoptosis Genes presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications.[books.google.com]
  • Plaque assay titers in the presence of thapsigargin for 6h are presented as log pfu/ml. C ) HEK293 cells were mock or CHIKV/SINV infected (MOI-1) for 1h.[virologyj.biomedcentral.com]
Fishing
  • Blots were blocked overnight with blocking solution [2% Fish gelatin (sigma) in 1X PBS] and were probed using primary antibodies against various proteins: GFP (Abcam), BIP (Abcam), ATF-6 (Abcam), HSP-90 (cell signaling), p58IPK (cell signaling), CHOP[virologyj.biomedcentral.com]
Osteoporosis
  • Given the increased interest in the role of apoptosis genes in disease processes, this work will be useful to researchers investigating cancer, autoimmune disease, viral infection, cardiovascular disease, neurodegenerative disorders, AIDS, osteoporosis[books.google.com]
Skin Lesion
  • SINV RNA detection or virus isolation from blood and/or skin lesions was successful in 8 patients.[ncbi.nlm.nih.gov]
Suggestibility
  • These results suggest that SIN may employ a novel cell attachment/entry mechanism during infection, allowing selective targeting of colorectal cancer cells.[ncbi.nlm.nih.gov]
  • This study suggests that the response to virus is significantly different when an infection is initiated in the presence of mosquito salivary factors, and we identify a possible mechanism for potentiation of viral infections initiated by the natural mosquito[utmb.influuent.utsystem.edu]
Ataxia
  • AJ, JR. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia. ‏ الصفحة 275 - Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo.[books.google.com]
Confusion
  • Clearing up Culex Confusion: A Basis for Virus Vector Discrimination in Europe Open this publication in new window or tab 2014 (English) Doctoral thesis, comprehensive summary (Other academic) Abstract [en] Mosquito species of the Culex genus are the[diva-portal.org]

Treatment

  • A similar mode of PK-I regulatory mechanism was operative in the early stages of IFN treatment, although after a prolonged treatment a net synthesis of the PK-I protein did take place.[ncbi.nlm.nih.gov]
  • L of live oak (Quercus virginiana) leaf infusion and the adults were fed on SINV-infected (treatments) or non-infected (controls) bovine blood.[experts.illinois.edu]
  • There is no treatment for humans or vaccine for the livestock that are such important amplifiers of the virus. An experimental vaccine exists for humans, but the number of doses is limited, and there are no prospects for future manufacture.[grantome.com]
  • By plaque assay, salubrinal treatment had no effect on the production of either CHIKV or SINV infectious virus particles.[virologyj.biomedcentral.com]
  • For instance, viral infection or polyI:C treatment induces pADP-ribosylation and inhibition of RISC-associated proteins 43.[nature.com]

Etiology

  • Several viruses cause acute and chronic joint inflammation in humans, and among them, the alphaviruses are of special interest due to the increasing number of outbreaks in which they are the etiological factor.[ncbi.nlm.nih.gov]

Epidemiology

  • Complete coding sequence and molecular epidemiological analysis of Sindbis virus isolates from mosquitoes and humans, Finland . Journal of General Virology, Vol. 93, Issue. Pt_9, p. 1984. CrossRef Google Scholar Sane, J. Kurkela, S. Desdouits, M.[cambridge.org]
  • In this article we will summarize the current knowledge on epidemiology, clinical disease and pathogenesis of SINV infection in man. Copyright 2016 John Wiley & Sons, Ltd.[ncbi.nlm.nih.gov]
  • Haemaphysalis longicornis , Ixodes nipponensis , Amblyomma testudinarium [5] and Rhipicephalus microplus . [6] In addition to tick bite, SFTSV can be transmitted from person to person through contact with blood or mucus of an infected person. [7] [8] Epidemiology[en.wikipedia.org]
  • The arbovirus: epidemiology and ecology & Monath T.P. 1988 pp. 87–126. Eds. Boca Raton, FL : CRC Press. Google Scholar Hardy J.L, Houk E.J, Kramer L.D& Reeves W.C. 1983 Intrinsic factors affecting vector competence of mosquitoes for arboviruses.[rspb.royalsocietypublishing.org]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiological mechanisms of musculoskeletal and rheumatic disease caused by SINV are inadequately understood.[ncbi.nlm.nih.gov]
  • The pathophysiological roles of H19 and its mature product miR-675 to carcinogenesis have, however, not been defined. By quantitative reverse transcriptionâ “polymerase chain reaction, both H19 and...[connection.ebscohost.com]

Prevention

  • CONCLUSIONS: Educating the public in endemic areas to avoid mosquito exposure and use protective measures remain important prevention measures for SINV infection.[ncbi.nlm.nih.gov]
  • الصفحة 83 - Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. ‏[books.google.com]
  • It has also been proposed that interaction of Dicer-2 with R2D2 prevents its binding to miRNA precursors in vitro 19.[nature.com]
  • This is in contrast to SINV infection in mosquito cells where SINV is a substrate for RNAi [13], [38] and svRNAs prevented viral spread between cells in Drosophila [46].[journals.plos.org]
  • One host response mechanism that has the potential to limit virus replication is the endoplasmic reticulum (ER) stress response, also known as unfolded protein response (UPR) which, maintains cellular protein homeostasis and prevents the over-accumulation[virologyj.biomedcentral.com]

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