A term newborn presented with widespread cutaneous erythematous to bluish lesions since birth. He had extensive lesions in the gastrointestinal tract, brain, retina, heart, and bones. [ncbi.nlm.nih.gov]

• Aspiration

  Pulmonary infections were ruled out by specific stainings and cultures of BAL, bronchial aspirates, and blood cultures. After the elimination of all possible causes, sirolimus-induced pneumonitis was considered probable. [ncbi.nlm.nih.gov]

• Shagreen Patch

  RESULTS: Long-term mTORI use resulted in skin lesion regression (angiofibromas, "confetti" skin lesions, shagreen patch) and disease stabilization in brain, abdominal, and chest magnetic resonance imaging/computed tomography scans. [ncbi.nlm.nih.gov]

• Angiokeratoma

  These anomalies consisted of three extratruncular micro- and macrocystic lymphatic malformations and one each verrucous venous malformation, truncular lymphatic malformation with angiokeratomas, and infantile hemangioma. [ncbi.nlm.nih.gov]

A workup of infectious causes was undertaken and was negative. All the patients had resolution of visceral effusions after sirolimus discontinuation. [scielo.mec.pt]

An extensive workup was negative for an infectious etiology, including JC polyomavirus or demyelination. Sirolimus was discontinued and the headaches resolved within a few days. [bloodjournal.org]

Effect of treatment discontinuation. Summary of observations in 6 patients who discontinued rapamycin treatment. (A) Status of rapamycin treatment is indicated by [−]/[+]. [haematologica.org]

BACKGROUND: Systemic treatment with sirolimus, as used for immunosuppression in transplant patients, results in markedly low rates of in-stent restenosis. [ncbi.nlm.nih.gov]

Its development worsens patient prognosis, with a significant decrease in survival. Currently, there are no unified guidelines regarding its management, and different combinations of immunosuppressants have been used with variable success. [ncbi.nlm.nih.gov]

In this report, we will characterize the temsirolimus-related pneumonitis and not the interferon-related pneumonitis that occurred in patients with poor-prognosis ARCC. [dx.doi.org]

The rapamycin- regulated gene expression signature determines prognosis for breast cancer Molecular Cancer 8(75), (2009). 3. Zhang, H.H., Huang, J., Düvel, K., et al. [caymanchem.com]

BACKGROUND: Gorham-Stout disease (GSD) is a rare disease of unknown etiology characterized by vascular proliferation that produces destruction of bone matrix. [ncbi.nlm.nih.gov]

Currently, we leverage a variety of techniques to study the etiology and pathogenesis of iMCD. [med.upenn.edu]

Based on the absence of a previous infectious condition and any signs of rejection in the endocardial biopsy that could be triggers, and given the recent introduction of sirolimus, the latter was considered the etiological factor, with blood levels within [revespcardiol.org]

Epidemiologic literature is saturated with general discussions of the limitations of retrospective studies. Posttransplantation diabetes is a relatively frequent and unfortunate complication in patients carrying renal allografts. [jasn.asnjournals.org]

Clinical features, epidemiology, and therapy of lymphangioleiomyomatosis. Clin Epidemiol. 2015;7:249-57. Lee L, Sudentas P, Donohue B, et al. Efficacy of a Rapamycin Analog (CCI-779) and INF-gamma in Tuberous Sclerosis Mouse Models. [specialtypharmacytimes.com]

An epidemiological study of renal pathology in tuberous sclerosis complex. BJU Int. 2004;94:853–7. 25. Marti HP, Frey FJ. Nephrotoxicity of rapamycin: an emerging problem in clinical medicine. Nephrol Dial Transplant. 2005;20:13–5. 26. [ojrd.biomedcentral.com]

Aarhus University Hospital, Aarhus, Denmark (5) Department of Epidemiology, Boston University, Boston, MA, USA References Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O’Shaughnessy C, et al: Sirolimus-eluting stents versus standard stents [bmccardiovascdisord.biomedcentral.com]

CLINICAL EPIDEMIOLOGY JASN July 2008, 19 (7) 1411-1418; DOI: https://doi.org/10.1681/ASN.2007111202 This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. [doi.org]

This case highlights the need for early recognition of adverse drug effects and further research into their pathophysiology and management. [ncbi.nlm.nih.gov]

[…] concentration during therapy, particularly in individuals coadministered CYP3A4 substrates, inhibitors, or inducers Adjusting dose to optimize immunosuppression while minimizing toxicity Evaluating patient compliance Clinical Information Discusses physiology, pathophysiology [mayomedicallaboratories.com]

Oxygen and BagValveMask Ventilation 217 Assessment and Management of the Pediatric Airway 223 Vascular Access 253 Shock An Overview 274 Acute Respiratory Failure 299 Pediatric Transport Medicine 308 Withdrawal of Life Support 320 Brain Death 324 The Pathophysiology [books.google.ro]

The exact pathophysiology is unknown. [revespcardiol.org]

CONCLUSION: Our findings show that systemic sirolimus treatment effectively prevents SMC and EC proliferation in vivo without directly affecting these cells. [ncbi.nlm.nih.gov]

antibacterial drug A drug used to treat or prevent bacterial infections. antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals. [ebi.ac.uk]

Sirolimus may also have a role in prevention of organ rejection in heart or lung transplantation, and prevention of graft-versus-host disease in patients undergoing bone marrow transplantation. [encyclopedia.com]

It is recommended that Rapamune is used with ciclosporin and corticosteroids (other medicines to prevent organ rejection) for two to three months. [ema.europa.eu]