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Skin Atrophy

Atrophic Skin


Presentation

  • AHO can be associated with pseudohypoparathyroidism type IA (PHP-IA) with upregulation of parathyroid hormone, whereas in pseudo-pseudohypoparathyroidism (PPHP), an endocrinopathy is not present.[ncbi.nlm.nih.gov]
  • A patient presented with significant vulvar skin atrophy following prolonged steroid application to treat vulvar dermatitis.[ncbi.nlm.nih.gov]
  • Scarring alopecia, congenital absence of three toenails, and a scarlike lesion of the tongue were also present.[ncbi.nlm.nih.gov]
  • In the present clinical trial, we validated a new score (Dermaphot( ) score) to assess the atrophogenic potential of glucocorticosteroids. 36 healthy adult volunteers were included in an investigator-initiated, blinded, randomized, intra-individual comparison[ncbi.nlm.nih.gov]
  • Abstract The present study concerns the effect of topical treatment with a cream formulation of triiodothyroacetic acid (TRIAC) in comparison with a placebo preparation in producing a reversal of skin atrophy induced by long-term employment of topical[ncbi.nlm.nih.gov]
Short Stature
  • Patients with AHO have short stature, obesity, brachydactyly and subcutaneous calcifications.[ncbi.nlm.nih.gov]
  • Skin atrophy with pigmentary changes, telangiectasia, short stature, premature aging, and skeletal abnormalities are characteristic. There is an increased risk of malignancy, particularly osteosarcomas and skin cancer.[disorders.eyes.arizona.edu]
Heat Intolerance
  • Hypohidrosis in the affected areas, heat intolerance, and febrile convulsions were noted in infancy and childhood. No new skin lesions developed, and the existing ones, the sweating disturbance, and the heat intolerance gradually improved with time.[ncbi.nlm.nih.gov]
Venous Insufficiency
  • Associated conditions Atrophie blanche is nearly always associated with chronic venous insufficiency and varicose veins.[medicinetoday.com.au]
Brachydactyly
  • Patients with AHO have short stature, obesity, brachydactyly and subcutaneous calcifications.[ncbi.nlm.nih.gov]
Skeletal Dysplasia
  • This is likely the same disorder as the previously described ‘mesodermal dysgenesis of the iris and skeletal dysplasia’ and formerly listed as 270240 in OMIM. Systemic Features: This is a clinically heterogeneous disorder.[disorders.eyes.arizona.edu]
Foot Disease
  • Blisters can quickly deteriorate and become ulcers and cause long-term foot disease. Treatment of blisters The main treatments are to minimise pain, keep the blister clean and if possible keep the blister intact.[pivotalmotionpodiatry.com.au]
Suggestibility
  • The results suggest that, compared with other fluorinated topical steroids, fluocortin butylester 0.75% is unlikely to produce significant dermal atrophy when used in the short and medium term.[ncbi.nlm.nih.gov]
  • This suggests that in vivo, glucocorticoids modulate variably the genes involved in collagen synthesis and degradation.[ncbi.nlm.nih.gov]
  • These results suggest that the risk of skin atrophy with 24-week use of TC cream for the treatment of melasma is very low.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Our observations provide a novel CD44-dependent mechanism for HA oligosaccharide-induced keratinocyte proliferation and suggest that topical HAFi application may provide an attractive therapeutic option in human skin atrophy.[ncbi.nlm.nih.gov]
  • I called the nurse at my dr's office and she suggested that I use the triamcinolone cream on my face to clear up the reaction.[medhelp.org]
Decreased Libido
  • These symptoms include burning sensations, itchiness, vaginal bleeding, bleeding after intercourse, painful intercourse, recurrent urinary infection, urgency, problems reaching orgasm, decreased libido and vaginal dryness.[fbwgynplus.com]
Febrile Convulsions
  • Hypohidrosis in the affected areas, heat intolerance, and febrile convulsions were noted in infancy and childhood. No new skin lesions developed, and the existing ones, the sweating disturbance, and the heat intolerance gradually improved with time.[ncbi.nlm.nih.gov]

Treatment

  • The reduced expression of CD44 and HAS3 in patients was specifically restored in dermatoporotic patients after treatment. No difference in skin thickness was observed in controls after treatment.[ncbi.nlm.nih.gov]
  • This study indicates that topical treatment with TRIAC appears to reverse glucocorticoid-induced skin atrophy under the narrow conditions tested.[ncbi.nlm.nih.gov]
  • Only four of these studies with three on body psoriasis evaluated the effect of long-term treatment defined as 6-month treatment duration or longer and did not identify HPA axis suppression by cortisol level measurement.[ncbi.nlm.nih.gov]
  • Abstract The calcipotriol/betamethasone dipropionate fixed-combination gel is widely used for topical treatment of psoriasis vulgaris.[ncbi.nlm.nih.gov]
  • This may also be important for the treatment of children, and sensitive areas of skin, such as the face and skin-folds.[ncbi.nlm.nih.gov]

Etiology

  • Pruritis Ani: Etiology and Management. Surg Clin N Am 2010; 90: 125-135.[fascrs.org]

Pathophysiology

  • Risk factors for reduced skin thickness and bone density: possible clues regarding pathophysiology, prevention, and treatment. J Am Acad Dermatol 1998;38(2 Pt 1):248-255. Havill S, Rademaker M.[medsafe.govt.nz]

Prevention

  • Moreover, calcipotriol is able to restore betamethasone-impaired HA synthesis in keratinocytes and prevent betamethasone-induced epidermal thinning in minipigs upon treatment with the calcipotriol/betamethasone gel.[ncbi.nlm.nih.gov]
  • Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates[icdlist.com]
  • Below we provide some information in the prevention and management of these conditions.[pivotalmotionpodiatry.com.au]
  • (ii) Since the present invention lay in the realisation of the practical application of the discovery that retinoids prevent skin atrophy, namely use of retinoids in the preparation of a medicament for use in the said prevention, there was no basis to[epo.org]
  • BACKGROUND: Dermatoporosis is an emerging clinical condition caused by chronological skin aging, long-term sun exposure and chronic use of corticosteroids; however, genomic expression in dermatoporosis and the efficacy of different therapeutic approaches to prevent[ncbi.nlm.nih.gov]

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