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Skin Cancer

Malignant Neoplasm of Skin


Presentation

  • PubMed (1966 to present), Embase (1974 to present), and Web of Science (1898 to present). All articles that reported an original effect statistic for indoor tanning and non-melanoma skin cancer were included.[ncbi.nlm.nih.gov]
  • The authors present a succinct summary of the incidence and costs of nonmelanoma skin cancers.[ncbi.nlm.nih.gov]
  • In addition to advanced stage at presentation, malignant skin lesions in skin of color often present in an atypical fashion.[ncbi.nlm.nih.gov]
  • Presented is a case of a 57-year-old Jewish man with Crohn's Disease who was diagnosed with a total of 84 NMSCs. We hope to elucidate the risk of immunosuppressants, particularly the thiopurines, on the development of NMSC.[ncbi.nlm.nih.gov]
  • In this overview article, we would like to present several representative cases and discuss our experience.[ncbi.nlm.nih.gov]
Cheilitis
  • […] s DermNet: "Solar cheilitis." NHS: "Moles." Skin Cancer Foundation: "Basal Cell Carcinoma."[webmd.com]
  • Alex Dancyger, Victoria Heard, Baikai Huang, Cameron Suley, Dorothy Tang and Anura Ariyawardana, Malignant transformation of actinic cheilitis: A systematic review of observational studies, Journal of Investigative and Clinical Dentistry, 9, 4, (2018)[doi.org]
  • References Picascia DD, Robinson JK: Actinic cheilitis: a review of the etiology, differential diagnosis, and treatment. J Am Acad Dermatol 17 (2 Pt 1): 255-64, 1987.[web.archive.org]
Skin Lesion
  • We will make every effort to provide the earliest appointments to those patients calling about concerning skin lesions. Please see What We Do page for other skin conditions we treat. We are accepting new patients and we treat people of all ages.[skincancercolumbus.com]
  • Any changing skin lesion should be examined by a dermatologist. Visit an ASDS dermatologist.[asds.net]
  • The second type of skin lesion that is not cancer is seborrheic keratosis. These lesions start to appear when people enter their 50’s, and gradually increase in number.[healthinaging.org]
  • Abstract We describe two case reports to assess the efficacy of a new method suitable to close small-sized pressure ulcers and cancer-related skin lesions.[ncbi.nlm.nih.gov]
  • Clinical photographs of the skin lesions at baseline and after Eryfotona AK-NMSC treatment were taken in all cases using a high-definition digital camera.[ncbi.nlm.nih.gov]
Fair Complexion
  • People with fair complexions are at higher risk than are people with darker skin. Having a large number of moles is also a risk factor. If you have a family history of skin cancer, you are at higher risk.[calverthealthmedicine.org]
  • Some of the risk factors for skin cancers include:- Light or fair complexion, especially blonde, red or light-brown hair and blue, green or gray eyed individuals. Dark skinned individuals may develop melanoma.[news-medical.net]
  • Middle-aged and elderly people, especially those with fair complexions and frequent sun exposure, are most likely to be affected. It often appears as a bump, or as a red, scaly patch on the rim of the ear, the face, the lips, and the mouth.[reliantmedicalgroup.org]
  • CAUSES SCC, basal cell carcinoma, and melanoma are all associated with chronic sun exposure, a light or fair complexion, and immune suppression.[assh.org]
  • Risk factors for non-melanoma skin cancers include: Sunlight (ultraviolet radiation or UV) exposure Tanning Severe, blistering sunburns Personal history of a previous skin cancer Receiving an organ transplant Family history of skin cancer Fair complexion[roswellpark.org]
Papule
  • Learn More Close Merkel Cell Carcinoma Kaposi Sarcoma Kaposi sarcoma KS lesions may be flat (patches or macules), raised (plaques or papules), or bumpy (nodules). They are usually red, purple, or brown.[skincancer.net]
  • Characteristic features of BCCs may include: A few millimetres to several centimetres in diameter Waxy small raised lesions (papules) with a depressed centre Pearl-like and translucent in appearance Ulcer-like in appearance Tendency to bleed Red and scaly[southerncross.co.nz]
  • Although the classic clinical presentation as a rapidly growing papule in a sun-exposed site of an elderly patient is not specific, certain histopathologic and ancillary pathologic features allow for its discrimination in most cases.[doi.org]
  • Centrally located erythematous papule represents invasive melanoma with surrounding macular lentigo maligna (melanoma in situ). It grows slowly over 5-20 years.[web.archive.org]
  • […] and symptoms Approximately 85% of BCCs occur on the face, head (scalp included), and neck; others appear on the trunk or extremities; rarely, they may occur on the hands. [4, 5] Other characteristic features of BCC tumors include the following: Waxy papules[emedicine.medscape.com]
Blonde Hair
  • Race: People with fair skin, freckling or red or blond hair have a higher risk. The risk of skin cancer is much higher for whites than for dark-skinned African Americans.[idph.state.il.us]
  • Risk factors include having several large or many small moles; exposure to natural or artificial sunlight over long periods; a fair complexion with light eyes and red or blond hair; and a family history of unusual moles or melanoma.[livescience.com]
  • Whites with fair skin, freckles, or red or blond hair have a higher risk of melanoma. Red-haired people have the highest risk.[skincancerprevention.org]
  • Some of these include: Sun exposure (especially extensive and/or unprotected) Pale skin Red or blonde hair Light eyes (green or blue eyes) Skin that rarely tans and burns easily Family and/or personal history of skin cancer Having one of several genetic[verywellhealth.com]
  • Red or blond hair. Being exposed to natural sunlight or artificial sunlight (such as from tanning beds) over long periods of time. Being exposed to certain factors in the environment (in the air, your home or workplace, and your food and water).[web.archive.org]
Skin Ulcer
  • SCC can also begin within scars or skin ulcers on other places on the body. As with basal cell carcinoma, the available treatments are very effective if the tumor is detected while it is small and thin.[verywellhealth.com]
  • ulcers, xeroderma pigmentosum and human papillomavirus infection all increase risk.[aafp.org]
  • People with chronic cutaneous inflammation, as seen in long-standing skin ulcers, are predisposed to the development of SCC. Immune suppression.[cancer.gov]
  • People with chronic sun damage, sites of prior burns, arsenic exposure, chronic cutaneous inflammation as seen in longstanding skin ulcers, and sites of previous x-ray therapy are predisposed to the development of SCC.[ 4 ] SCCs are composed of keratinizing[web.archive.org]
Facial Scar
  • The ablative fractional laser device of the present report safely minimizes and improves facial scars demonstrating not only textural alterations but also some pigmentary and vascular changes after reconstruction of skin cancer defects.[ncbi.nlm.nih.gov]

Workup

  • (See Workup .) Neglected tumors can continue to grow and lead to significant local destruction and even disfigurement.[emedicine.medscape.com]
  • Diagnosis Diagnostic workup of suspected cSCC will include computed tomography (CT) scanning to evaluate for soft tissue or bony invasion and lymph node metastasis.[emedicine.medscape.com]
  • BCC rarely metastasizes, so a metastatic workup is usually not necessary. There are several factors that correlate with poor prognosis for recurrence and metastasis.[cancer.gov]
  • Staging workup, sentinel node biopsy, and follow-up tests for melanoma: update of current concepts. Arch Dermatol. 2004 Jan. 140(1):107-13. [Medline]. Wang TS, Johnson TM, Cascade PN, Redman BG, Sondak VK, Schwartz JL.[emedicine.medscape.com]

Treatment

  • Talk with your doctor about the goals of each treatment and what you can expect while receiving the treatment. Learn more about making treatment decisions .[cancer.net]
  • The treatments available for skin cancer include topical therapies (treatment applied to the skin cancer), surgery, radiation therapy, chemotherapy and/or targeted therapy.[targetingcancer.com.au]
  • When high-dose-rate (HDR) treatments are given, treatments are usually scheduled two days per week instead of each day.[southeastradiation.com]
  • Immunotherapies in the Treatment of Advanced Melanoma Immunotherapy is treatment that uses certain parts of the immune system to fight illnesses, including cancer.[cancercare.org]
  • The model described may not be useful for nonexcision type treatments such as topical chemotherapy, electrodessication and curettage, or radiation treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Early detection greatly improves the prognosis of patients with malignant melanoma.[ncbi.nlm.nih.gov]
  • Most patients with primary SCC have an excellent prognosis.[ncbi.nlm.nih.gov]
  • Skin cancers that are found and treated early need less invasive treatment and have a better outcome (prognosis). What about spots that aren't cancer? Not all spots that appear on your skin are cancerous.[mydr.com.au]
  • In general, the prognosis is good for people with squamous cell carcinoma.[cbsnews.com]
  • Prognosis depends on how deep into the skin the tumour has invaded.[stjames.ie]

Etiology

  • This article provides a comprehensive and thorough overview of skin cancer, with an emphasis on understanding its epidemiology, incidence, etiology and related risk factors.[ncbi.nlm.nih.gov]
  • Neoplastic disorders are, among others, blamed in etiology. We describe here, for the first time, a case of TO associated with skin cancer. A 40-year-old man with a scalp cancer was admitted for further evaluation of an occasional dry cough.[ncbi.nlm.nih.gov]
  • Ultraviolet radiation (UVR) is the major etiologic agent in the development of skin cancers. UVR causes DNA damage and genetic mutations, which subsequently lead to skin cancer.[ncbi.nlm.nih.gov]
  • The etiology of CTCL remains unknown and risk factors are poorly documented.[ncbi.nlm.nih.gov]
  • Understanding the etiology and pathogenesis of skin cancer remains a goal for healthcare systems. A clearer understanding of causative factors is an essential step in the prevention of skin cancer.[doi.org]

Epidemiology

  • Epidemiology of cutaneous melanoma and nonmelanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer). Br J Dermatol 2003; 149:1200–6.[doi.org]
  • Epidemiological studies have reported significantly more non-melanoma skin cancer in men than in women. Life-style choices and difference in immunosuppression play a major role in this gender disparity.[ncbi.nlm.nih.gov]
  • To provide a general overview of malignant melanoma and non-melanoma skin cancer, with an emphasis on epidemiology, clinical presentation, and the multiple and varied risk factors associated with skin cancer.[ncbi.nlm.nih.gov]
  • J Epidemiol 1999(9):S14–S21 Google Scholar Armstrong B, Kricker A (2001) The epidemiology of UV induced skin cancer.[doi.org]
  • This article provides a comprehensive and thorough overview of skin cancer, with an emphasis on understanding its epidemiology, incidence, etiology and related risk factors.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • It also presents new coverage of pathophysiology, diagnostic reasoning, evidence-based practice, geriatrics, and pediatrics.[books.google.com]
  • Porth pathophysiology: concepts of altered health states (1st Canadian ed.). Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 660. ISBN 978-1-60547-781-7 . Robbins S, Kumar V, Abbas A, Fausto N (2007).[en.wikipedia.org]
  • Pathophysiology The sequence of events in which normal melanocytes transform into melanoma cells, referred to as melanoma genesis, is poorly understood.[web.archive.org]

Prevention

  • Similar findings were observed in a subgroup meta-analysis of 10 studies on both primary prevention trials (RR 0.98; 95% CI 0.93–1.03) and secondary prevention trials (RR 0.97; 95% CI 0.83–1.13).[doi.org]
  • Several clinical trials give evidence that long-term use of sunscreen prevents the appearance of non-melanotic skin cancer such as AK and SCC, but not of BCC.[ncbi.nlm.nih.gov]
  • Preventive Services Task Force in updating its 2003 recommendation on behavioral counseling to prevent skin cancer. Existing systematic reviews, database searches through February 2010, and outside experts.[ncbi.nlm.nih.gov]
  • Similar findings were observed in a subgroup meta-analysis of 10 studies on both primary prevention trials (RR 0.98; 95% CI 0.93-1.03) and secondary prevention trials (RR 0.97; 95% CI 0.83-1.13).[ncbi.nlm.nih.gov]
  • Prevention Prevention is a major component in the management of NMSC.[doi.org]

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