Lamellar ichthyosis (fish scale disease) is an inherited disease that also is characterized by darkened, scaly, dry patches of skin. [medical-dictionary.thefreedictionary.com]

In vertebrates, pigmentation varies widely from black and white stripes of zebra to muted browns in sparrows to bright colors of tropical fish. [ncbi.nlm.nih.gov]

[…] syndrome: sustained remission after treatment with corticosteroids and mesalazine. ( 30813906 ) Schulte S...Steffen HM 2019 4 Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis [malacards.org]

This may represent the first physiological demand for protection, but it is equally true that the skin provides a protective barrier against invading microbial pathogens, while also serving as a habitat for a plethora of commensal bacteria. [ncbi.nlm.nih.gov]

Diarrhea. ( 28725309 ) Iqbal U...Merrell N 2017 20 Cronkhite-Canada syndrome associated with colon cancer metastatic to liver: A case report. ( 28930817 ) Wang J...Cao B 2017 21 Cronkhite Canada syndrome complicated by pulmonary embolism-A case report [malacards.org]

Li J 2018 17 Alopecia in Cronkhite-Canada syndrome. ( 28833020 ) Stefanaki C...Stratigos A 2017 18 Alopecia areata incognita in Cronkhite-Canada syndrome. ( 28029683 ) Ong S...Stefanato CM 2017 19 Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhea [malacards.org]

In darkly pigmented skin, melanosomes are more abundant, larger, at stage IV and are singly transferred to the neighbouring cells. [ncbi.nlm.nih.gov]

Likewise, the hyperpigmentation sometimes observed in both basal cell carcinoma (BCC) and seborrhoeic keratosis (SK) has been linked to an accentuated expression of the keratinocyte-derived ET-1 67, 68 ( Fig. 2 ). [ncbi.nlm.nih.gov]

( 31056741 ) 2019 2 Major duodenal papilla prolapse in Cronkhite-Canada syndrome. ( 30731485 ) Marinoni B...Vecchi M 2019 3 Case report of patient with a Cronkhite-Canada syndrome: sustained remission after treatment with corticosteroids and mesalazine [malacards.org]

Since they lack melanin in their eyes, many people with albinism also have visual impairment. With little skin pigmentation, they also sunburn easily and are more prone to skin cancer. [medical-dictionary.thefreedictionary.com]

Polyps! And More Polyps! [malacards.org]

Matsumura T 2015 45 A case of recurrent Cronkhite-Canada syndrome containing colon cancer. ( 25785317 ) Zhu X...Tian Y 2015 46 Cronkhite-Canada Syndrome (CCS)-A Rare Case Report. ( 25954656 ) Chakrabarti S 2015 47 A Case of Cronkhite-Canada Syndrome with a Colitis-mimicking [malacards.org]