Presentation
[…] outlet obstruction 5 years after roux-en-y gastric bypass. ( 29202677 ) Gys B...Hubens G 2017 28 Steroid Responsive Mononeuritis Multiplex in the Cronkhite-Canada Syndrome. ( 27899913 ) Lo YL...Mesenas S 2016 29 Cronkhite-Canada syndrome: A rare disease presenting [malacards.org]
Several skin conditions are more common in children who have dark skin, and common disorders such as atopic dermatitis and pityriasis rosea may have different presentations. [pedsinreview.aappublications.org]
Mentions of whitening of the skin were also present circa 1400 BCE in sacred Indian texts such as Atharvaveda as well as Shinto prayers in East Asia circa 1200 BCE. [en.wikipedia.org]
Alterations in the melanogenic cytokine networks is present also in melasma, an hyperpigmented dysfunction primarily localized on sun-exposed sites, generally the face. [ncbi.nlm.nih.gov]
Entire Body System
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Fishing
Lamellar ichthyosis (fish scale disease) is an inherited disease that also is characterized by darkened, scaly, dry patches of skin. [medical-dictionary.thefreedictionary.com]
In vertebrates, pigmentation varies widely from black and white stripes of zebra to muted browns in sparrows to bright colors of tropical fish. [ncbi.nlm.nih.gov]
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Sepsis
[…] syndrome: sustained remission after treatment with corticosteroids and mesalazine. ( 30813906 ) Schulte S...Steffen HM 2019 4 Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis [malacards.org]
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Plethora
This may represent the first physiological demand for protection, but it is equally true that the skin provides a protective barrier against invading microbial pathogens, while also serving as a habitat for a plethora of commensal bacteria. [ncbi.nlm.nih.gov]
Gastrointestinal
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Chronic Diarrhea
Diarrhea. ( 28725309 ) Iqbal U...Merrell N 2017 20 Cronkhite-Canada syndrome associated with colon cancer metastatic to liver: A case report. ( 28930817 ) Wang J...Cao B 2017 21 Cronkhite Canada syndrome complicated by pulmonary embolism-A case report [malacards.org]
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Diarrhea
Li J 2018 17 Alopecia in Cronkhite-Canada syndrome. ( 28833020 ) Stefanaki C...Stratigos A 2017 18 Alopecia areata incognita in Cronkhite-Canada syndrome. ( 28029683 ) Ong S...Stefanato CM 2017 19 Cronkhite-Canada Syndrome: A Rare Cause of Chronic Diarrhea [malacards.org]
Skin
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Darkly Pigmented Skin
In darkly pigmented skin, melanosomes are more abundant, larger, at stage IV and are singly transferred to the neighbouring cells. [ncbi.nlm.nih.gov]
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Keratosis
Likewise, the hyperpigmentation sometimes observed in both basal cell carcinoma (BCC) and seborrhoeic keratosis (SK) has been linked to an accentuated expression of the keratinocyte-derived ET-1 67, 68 ( Fig. 2 ). [ncbi.nlm.nih.gov]
Eyes
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Visual Impairment
Since they lack melanin in their eyes, many people with albinism also have visual impairment. With little skin pigmentation, they also sunburn easily and are more prone to skin cancer. [medical-dictionary.thefreedictionary.com]
Workup
Colonoscopy
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Polyps
Polyps! And More Polyps! [malacards.org]
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Colitis
Matsumura T 2015 45 A case of recurrent Cronkhite-Canada syndrome containing colon cancer. ( 25785317 ) Zhu X...Tian Y 2015 46 Cronkhite-Canada Syndrome (CCS)-A Rare Case Report. ( 25954656 ) Chakrabarti S 2015 47 A Case of Cronkhite-Canada Syndrome with a Colitis-mimicking [malacards.org]
Treatment
( 31056741 ) 2019 2 Major duodenal papilla prolapse in Cronkhite-Canada syndrome. ( 30731485 ) Marinoni B...Vecchi M 2019 3 Case report of patient with a Cronkhite-Canada syndrome: sustained remission after treatment with corticosteroids and mesalazine [malacards.org]
Its treatment is different from that of NSV. [en.wikipedia.org]
Treatment may include covering smaller patches with long-lasting dyes, light-sensitive drugs, ultraviolet A light therapy, corticosteroid creams, and depigmentation of the remaining skin. [childrensnational.org]
Treatment For albinism, healthcare providers advise people to cover up, use sunscreen and avoid excess sunlight to prevent skin cancer. People with albinism also must wear protective sunglasses and, in some cases, prescription corrective lenses. [medical-dictionary.thefreedictionary.com]
See your personal physician or dermatologist to confirm the cause, diagnosis and treatment of your skin disorder. Treatment The first step is to confirm a diagnosis of a skin disorder is by seeing a physician or dermatologist. [sutterhealth.org]
Prognosis
Syndrome. ( 27899913 ) Lo YL...Mesenas S 2016 29 Cronkhite-Canada syndrome: A rare disease presenting with dermatological and gastrointestinal manifestations. ( 26094686 ) Kronborg C...Howard A 2016 30 Endoscopic and clinical evaluation of treatment and prognosis [malacards.org]
Prognosis Most skin pigmentation disorders do not affect a person's health, only the outward appearance. Prevention In most cases, doctors will recommend using sunscreen and avoiding too much sun exposure. Resources Periodicals Wilson, Tracy. [medical-dictionary.thefreedictionary.com]
Prevention
Melanin also creates eye color, and serves as a filter that prevents too much light from entering the eye. Since they lack melanin in their eyes, many people with albinism also have visual impairment. [medical-dictionary.thefreedictionary.com]
Transplantation Substance Use and Addiction Surgery Surgical Innovation Surgical Pearls Teachable Moment Technology and Finance The Rational Clinical Examination Tobacco and e-Cigarettes Toxicology Trauma and Injury Treatment Adherence United States Preventive [jamanetwork.com]
One basic function of the skin is the prevention of water loss from the body. [ncbi.nlm.nih.gov]