Next we used the same hyaluronic acid hydrogel engineer human microvasculature for the treatment of diabetic foot ulcers (DFUs), one of the leading healthcare problems in the US. [jscholarship.library.jhu.edu]

It helps prevent wounds or foot ulcers from becoming infected and painful or resulting in gangrene. Good foot care also helps prevent amputation. [msdmanuals.com]

The ulcers may be brown or black, and they're often painful (as opposed to diabetic foot ulcers, which may be painless due to diabetes-related nerve damage). [health.com]

[…] smooth, looks "punched out" PAD or PVD: Ulcer located on tips of toes, foot, lateral malleolus PAD or PVD: Wound drainage minimal PAD or PVD: Wound tissue is black eschar or pale pink granulation PAD or PVD: Intermittent claudication or rest pain in foot [quizlet.com]

Prevent critical artery occlusion that can lead to foot ulcers, gangrene, and amputation. Prevent heart attacks and strokes. [medicinenet.com]