A lack of uniform diagnostic criteria for small fiber neuropathy and Sjogren’s syndrome presents several challenges for treatment. [practicalneurology.com]

Vasculitis-associated neuropathy usually presents as multiple mononeuropathies or sensorimotor polyneuropathies that affect large nerve fibers; painful small fiber sensory neuropathy has not previously been described in association with vasculitis. [ncbi.nlm.nih.gov]

To help achieve this goal, the present review article discusses the clinical presentation of neuropathic pain and paresthesia and/or autonomic dysfunction due to involvement of nerves supplying exocrine glands and smooth muscle; normal findings from standard [em-consulte.com]

• Burning Pain

  Small-fiber neuropathy manifests in a variety of different diseases and often results in symptoms of burning pain, shooting pain, allodynia, and hyperesthesia. [ncbi.nlm.nih.gov]

  People with small fiber neuropathy usually experience severe sharp or burning pain, with some sensory symptoms and no significant weakness in their body. Routine tests, like nerve conduction studies, do not help detect small fiber neuropathy. [stanfordhealthcare.org]

• Aspiration

  In initial primary treatment, the patient was rewarmed of all extremities in water bath at 40 C with added chlorhexadine for 1 hour and clear blisters were aspirated. Topical aloe vera gel was applied to thawed tissue before dressings are applied. [austinpublishinggroup.com]

• Eczema

  Medical history was unremarkable other than eczema; except for eczema ointment, no other drugs were used. Family history revealed similar symptoms in the patient’s mother and older sister, although was less severe. [pediatrics.aappublications.org]

• Lacrimation

  […] autonomic subtype has a broader range of manifestations, that can be easily mimicked by several other medical conditions, such as dizziness (due to orthostatic intolerance or orthostatic hypotension), syncopal spells, anhidrosis or hyperhidrosis, decreased lacrimation [scielo.br]

• Decreased Lacrimation

  lacrimation, decreased salivation, important trophic skin changes, changes in bowel habits (constipation or diarrhea) or urinary complaints (polyuria, urinary retention or incontinence), among others ( for a more extensive review of autonomic manifestations [scielo.br]

• Foot Pain

  For instance, some people might experience foot pain when wearing socks or touching bedsheets. Symptoms can be mild or severe, though early symptoms are often mild. Small fiber neuropathy tends to affect the feet first and progress upward. [healthline.com]

• Numbness of the Feet

  CIDP often causes limb weakness but may just cause problems with balance from numbness in the feet and legs. This is one of the few types of polyneuropathy where the underlying cause be treated. [honorhealth.com]

• Denial

  Neurologic Disability. 12 One study compared the clinical response to IVIG therapy in six patients who experienced a mean decrease in the Visual Analog Scale score from 8.2 to 4.0 compared to four patients who only received symptomatic therapy due to denial [practicalneurology.com]

• Impulsivity

  On the other hand, since unmyelinated fibers are not insulated from each other, impulses conducting in one axon may spread to neighboring axons 3. [scielo.br]

• Polyuria

  […] orthostatic intolerance or orthostatic hypotension), syncopal spells, anhidrosis or hyperhidrosis, decreased lacrimation, decreased salivation, important trophic skin changes, changes in bowel habits (constipation or diarrhea) or urinary complaints (polyuria [scielo.br]

• Paresthesia

  There is a handful of case reports of dysautonomia, painful paresthesias or acute polyradiculopathies related to Hodgkin Lypmhoma. [n.neurology.org]

  Although strength remains preserved throughout the course of the disease, the pain and paresthesias are often disabling. [semanticscholar.org]

  The most common symptoms of SSFN recorded were numbness, pain and paresthesias (an abnormal sensation, such as numbness, tingling, or burning), mainly in the face, trunk, and proximal limbs. [sarcoidosisnews.com]

  The main features were burning, painful paresthesias and dysesthesias in the feet, lancinating pains, moderate to severe distal small fiber sensory loss, absent ankle reflexes, and minimal or no distal foot weakness. [ncbi.nlm.nih.gov]

• Dysesthesia

  Dysesthesia, allodynia, pain, burning, and coldness sensations frequently present in a length-dependent pattern. Additional autonomic features in gastrointestinal, urinary, or cardiovascular systems are frequent but poorly objectified. [ncbi.nlm.nih.gov]

  A semi-structured interview was conducted to assess the features of pain or dysesthesia (International Association for the Study of Pain-IASP, ). [hepatitiscnewdrugs.blogspot.com]

• Hypesthesia

  靴下状感覚消失 stocking hypesthesia靴下状感覚脱失 stocking hypesthesia靴下状知覚消失 stocking hypesthesia靴下状知覚脱失 streptozocinストレプトゾシン streptozotocinストレプトゾトシン streptozotocin-induced diabetesストレプトゾトシン惹起性糖尿病 streptozotocin-induced diabetesストレプトゾトシン糖尿病 stress hyperglycemiaストレス [jds.or.jp]

• Cranial Neuropathy

  neuropathy, and inflammatory myopathy. 1 Although peripheral neuropathy in pSS has not have been unequivocally identified or classified across studies, up to 40 percent of all patients with the disease have described “burning,” “tearing,” or “raking” [practicalneurology.com]

• Neglect

  The requests for cryoglobulin tests are far less frequent than would be expected, which suggests that cryoglobulinemia in SFN could be an important but neglected clinical condition[ 18 ]. [journals.plos.org]

CONCLUSIONS: Skin biopsy changed management or diagnosis in 52% of patients evaluated for a possible SFN and appears to play a valuable role in the workup of these patients. Copyright 2013 Wiley Periodicals, Inc. [ncbi.nlm.nih.gov]

Once the diagnosis has been established, there is an uncertainty how SFN may progress, whether larger fibers will become involved over time, whether quality of life may be compromised, or whether repeated diagnostic workup in patients with unknown underlying [karger.com]

• Hypocapnia

  The heart rate response to deep breathing is affected by several factors (hypocapnia, sympathetic activity, position of the individual, medication, obesity and depth of breathing) but age and rate of breathing are the two most important modulating factors [scielo.br]

• Lymphocytic Infiltrate

  As lymphocytic infiltration with T-cells in the DRG is a proposed pathogenic mechanism of non-length-dependent neuropathic pain in pSS patients, one would expect that immunologic therapeutic modalities may provide effective treatment. 1,12 Currently, [practicalneurology.com]

Management of small-fiber neuropathy depends on the underlying etiology with concurrent treatment of associated neuropathic pain. [ncbi.nlm.nih.gov]

Treatment is based on multidisciplinary management, combining symptomatic treatment, psychological management and treatment of an associated etiology. 3 It should be clear that these three sample studies of many published reports outline that there are [caringmedical.com]

[…] is difficult for many patients to accept, especially when they learn that treatment often involves only diet and exercise, which they find difficult to sustain, and symptomatic pain management, which is often only modestly effective. 6 An uncertain prognosis [jamanetwork.com]

It also contributes to the poor prognosis of diabetic neuropathy because it plays a key role in the pathogenesis of foot ulceration and autonomic neuropathy. [ncbi.nlm.nih.gov]

The long-term prognosis is quite good in our participants. [journals.plos.org]

Each can have its own symptoms and prognosis. These are common types of peripheral neuropathy: Small fiber peripheral neuropathy is a polyneuropathy that occurs from damage to small peripheral nerve fibers present in the skin. [honorhealth.com]

Etiological and clinical heterogeneity of small fiber neuropathy (SFN) precludes a unifying approach and necessitates reliance on recognizable clinical syndromes. [ncbi.nlm.nih.gov]

The etiology of DSPSFN is associated with various disorders. [journals.plos.org]

This review focuses on SFN involving nociception and temperature, examining epidemiology, etiology, clinical presentation, diagnosis, pathophysiology, and management. [ncbi.nlm.nih.gov]

In adults, recent calculations show that SFN has a minimum prevalence of 53 cases in 100 000, which indicates it is not a rare disorder. 4 The impact on quality of life is severe, both physically and mentally. 5 In children, little is known about the epidemiology [pediatrics.aappublications.org]

Veves A, Backonja M, Malik RA (2008) Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options. Pain Med 9:660–674 PubMed CrossRef Google Scholar 4. [link.springer.com]

Aetiology, epidemiology and pathogenesis The exact incidence and prevalence of SFN is unknown. 1, 11, 12 There have been no satisfactory studies to assess the epidemiology of SFN, because until recently, there was no generally accepted definition for [pn.bmj.com]

This review focuses on SFN involving nociception and temperature, examining epidemiology, etiology, clinical presentation, diagnosis, pathophysiology, and management. [ncbi.nlm.nih.gov]

The conclusions of the authors was: Elevated local proinflammatory cytokines may be involved in the pathophysiology of pain in length-dependent small fiber neuropathy. [neuropathie.nu]

“We are developing a drug involving the clotting mechanism that prevents neuropathy in mice. We produced diabetes in the rodents, and this drug prevented damage to their small fibers; we used a control group to compare the effects. [jpost.com]

Future studies are needed to clarify whether affected patients benefit from GLA enzyme replacement therapy for end-organ damage prevention. [ncbi.nlm.nih.gov]

Thus, topical treatment with XIB4035 is as effective at preventing progressive SFN in line-D mice as GDNF skin overexpression. Table 1. [pnas.org]