Symptoma

Sodium Stibogluconate

After 15 d treatment parasite clearance with 20 mg/kg for 30 d and 20 mg/kg for 15 d was more profound than with 10 mg/kg for 30 d (P 0.05), but the difference was no longer present at the end of treatment. [ncbi.nlm.nih.gov]

  • Rigor

    These data show that every batch of generic SSG should be subject to rigorous quality control prior to use. [ncbi.nlm.nih.gov]

    Limitations This case series is a retrospective review and so may be less rigorous than a prospective study, although the use of the ‘Integrated Care Pathway’ protocol in the patients' management and its recording tool has enhanced the quality of our [journals.plos.org]

  • Anemia

    On investigation, the patient had anemia and pancytopenia (hemoglobin was 8 g/dL, total leukocyte count was 3800/mm 3 and platelet count was 80,000/mm 3 ). Total serum bilirubin was 3 mg/dL and conjugated was 1.2 mg/dL. [sjkdt.org]

  • Metallic Taste

    Minor side-effects, such as pain at the site of injection (two cases), mild diminution in appetite (12 cases), metallic taste in mouth (six cases), and joint pain (two cases), were also observed. [ncbi.nlm.nih.gov]

    Sodium stibogluconate can also cause a reduced appetite, metallic taste in mouth, nausea, vomiting, diarrhoea, headache, tiredness, joint pains, muscle aches, dizziness, and anaphylaxis. [en.wikipedia.org]

    Gastrointestinal toxicity Patients treated for some one to two weeks with parenteral antimony compounds frequently reported anorexia, nausea and vomiting with some complaints of abdominal pain, a metallic taste and diarrhoea (Davis, 1968). [inchem.org]

  • Disfiguring Scar

    Skin lesions of CL heal slowly, causing disfiguring scars if remaining untreated. Current recommended treatment for CL comprises systemic administration of sodium stibogluconate (SSG) for 2-3 weeks. [ncbi.nlm.nih.gov]

  • Suggestibility

    Free amastigotes in the bone marrow were forming junctions with previously undescribed cytoplasmic buddings of macrophages prior to engulfment; these buddings were suggested to be transient parasitophorous vacuoles. [ncbi.nlm.nih.gov]

    Further experiments suggested that inhibition of glycolysis and the citric acid cycle may partially explain the inability to phosphorylate ADP. [aac.asm.org]

  • Meningism

    We report the first known case of an immunocompetent adult who developed VZV aseptic meningitis and dermatomal herpes zoster during treatment with sodium stibogluconate. [ncbi.nlm.nih.gov]

    Hatzell JD, Aronson NE, Nagaraja S, Whitman T, Hawkes CA, et al. (2006) Varicella zoster virus meningitis complicating sodium stibogluconate treatment for cutaneous leishmaniasis. Am J Trop Med Hyg 74: 591–2. View Article Google Scholar 19. [journals.plos.org]

  • Cytopenia

    Reversible abdominal pain/pancreatitis, arthralgias, myalgias, headache, fatigue, mild cytopenias, and elevated transaminases were more commonly present in the SSG treated participants, whereas blistering, oozing, and erythema were more common in the [ncbi.nlm.nih.gov]

  • Prolonged QT Interval

    Numerous antimicrobials including pentavalent antimonials are implicated in causing prolong QT-interval and ventricular tachycardia. Torsades de pointes is rarely documented with use of sodium stibogluconate. [ncbi.nlm.nih.gov]

    People with an abnormal heart rhythm seen on the heart monitoring trace ( ECG ) as a 'prolonged QT interval', people with a family history of this, and people taking other medicines that can could increase the risk of this problem (see end of page for [netdoctor.co.uk]

The patient's QTc, amylase and C-reactive protein also fell following initiation of steroid treatment. The SbV treatment course was completed successfully. [ncbi.nlm.nih.gov]

Other tests that are likely candidates fordiagnosis and prognosis of VL in the future are the antigen-detecting KATEX test and a eld-adaptable version of PCR,which has to be simple, inexpensive and easily available(Sundar, 2003).Interestingly, all nine [docslide.net]

AIN is a frequent cause of AKI and accounts for 15-27% of renal biopsies performed for AKI. [16] Drug-induced AIN is currently the most common etiology; antimicrobials and non-steroidal anti-inflammatory drugs are the most frequent offending agents. [sjkdt.org]

Hywel Williams Professor of Dermato-Epidemiology, Nottingham UK. Professor Williams is coordinating editor of the Cochrane Skin Group. [books.google.com]

EEC No: NIF (CHIP2, 1994) INTRODUCTION AND EPIDEMIOLOGY Sodium stibogluconate is a pentavalent antimony compound. It is used in the treatment of visceral, cutaneous and mucocutaneous leishmaniasis. [inchem.org]

Authors’ Affiliations (1) Drugs for Neglected Diseases initiative (DNDi) Africa, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya (2) MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London [trialsjournal.biomedcentral.com]

Leishmania/HIV co-infections: epidemiology in Europe. Annals of Tropical Medicine & Parasitology 97 ( suppl. 1 ), 3 – 15. Di Masi, F., Ursini, T., Iannece, M. [cambridge.org]

Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology. Respiratory Research 3, 26 – 53. Haddad, J. J., Saade, N. E. and Safieh-Garabedian, B. ( 2002 ). [cambridge.org]

We conclude that sodium stibogluconate-sensitive VL is emerging in this region and that urgent and effective vector control measures may be warranted to prevent the disease from becoming a major health problem and to ensure that resistance to sodium stibogluconate [ncbi.nlm.nih.gov]

It is available in the United States on a named-patient basis from the Centers for Disease Control and Prevention (CDC). [en.wikipedia.org]

[…] by protozoan parasites that belong to the genus Leishmania. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan [ebi.ac.uk]

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