We present a series of pregnant women with VL treated with either sodium stibogluconate or liposomal amphotericin B (AmBisome), or both, in eastern Sudan over 16 months. [ncbi.nlm.nih.gov]

A significant proportion of patients with AIN present with predominant extrarenal symptoms such as fever, skin rash, arthralgias and peripheral eosinophilia. [sjkdt.org]

• Anemia

  On investigation, the patient had anemia and pancytopenia (hemoglobin was 8 g/dL, total leukocyte count was 3800/mm 3 and platelet count was 80,000/mm 3 ). Total serum bilirubin was 3 mg/dL and conjugated was 1.2 mg/dL. [sjkdt.org]

• Metallic Taste

  Minor side-effects, such as pain at the site of injection (two cases), mild diminution in appetite (12 cases), metallic taste in mouth (six cases), and joint pain (two cases), were also observed. [ncbi.nlm.nih.gov]

  Sodium stibogluconate can also cause a reduced appetite, metallic taste in mouth, nausea, vomiting, diarrhoea, headache, tiredness, joint pains, muscle aches, dizziness, and anaphylaxis. [en.wikipedia.org]

  Gastrointestinal toxicity Patients treated for some one to two weeks with parenteral antimony compounds frequently reported anorexia, nausea and vomiting with some complaints of abdominal pain, a metallic taste and diarrhoea (Davis, 1968). [inchem.org]

• Disfiguring Scar

  Skin lesions of CL heal slowly, causing disfiguring scars if remaining untreated. Current recommended treatment for CL comprises systemic administration of sodium stibogluconate (SSG) for 2-3 weeks. [ncbi.nlm.nih.gov]

• Suggestibility

  Free amastigotes in the bone marrow were forming junctions with previously undescribed cytoplasmic buddings of macrophages prior to engulfment; these buddings were suggested to be transient parasitophorous vacuoles. [ncbi.nlm.nih.gov]

  Further experiments suggested that inhibition of glycolysis and the citric acid cycle may partially explain the inability to phosphorylate ADP. [dx.doi.org]

• Lymphopenia

  Herpes zoster and lymphopenia associated with sodium stibogluconate therapy for cutaneous leishmaniasis. Clin Infect Dis. 1998;27(3):509-12. doi:10.1086/514689. [dermnetnz.org]

  Wortmann GW, Aronson NE, Byrd JC, Grever MR, Oster CN (1998) Herpes zoster and lymphopenia associated with sodium stibogluconate therapy for cutenous leishmaniasis. Clin Infect Dis 27: 509–12. View Article Google Scholar 17. [journals.plos.org]

• Cytopenia

  Reversible abdominal pain/pancreatitis, arthralgias, myalgias, headache, fatigue, mild cytopenias, and elevated transaminases were more commonly present in the SSG treated participants, whereas blistering, oozing, and erythema were more common in the [ncbi.nlm.nih.gov]

• Pancreatic Necrosis

  Med. 97, 781788.McBride, M.O., Linney, M., Davidson, R.N., Weber, J.N., 1995.Pancreatic necrosis following treatment of leishmaniasiswith sodium stibogluconate. Clin. Infect. [docslide.com.br]

  McBride MO, Linney M, Davidson RN, Weber JN (1995) Pancreatic necrosis following treatment of leishmaniasis with sodium stibogluconate. Clin Infect Dis 21: 710. View Article Google Scholar 23. [journals.plos.org]

The patient's QTc, amylase and C-reactive protein also fell following initiation of steroid treatment. The SbV treatment course was completed successfully. [ncbi.nlm.nih.gov]

Other tests that are likely candidates fordiagnosis and prognosis of VL in the future are the antigen-detecting KATEX test and a eld-adaptable version of PCR,which has to be simple, inexpensive and easily available(Sundar, 2003).Interestingly, all nine [docslide.net]

AIN is a frequent cause of AKI and accounts for 15-27% of renal biopsies performed for AKI. [16] Drug-induced AIN is currently the most common etiology; antimicrobials and non-steroidal anti-inflammatory drugs are the most frequent offending agents. [sjkdt.org]

Hywel Williams Professor of Dermato-Epidemiology, Nottingham UK. Professor Williams is coordinating editor of the Cochrane Skin Group. [books.google.com]

Ex Parasitol 69:157–163 Google Scholar Zijstra EE, Siddig Ali M, El-Hassan AM, El-Toum IA, Maria Satti, Ghalib HW (1991) Kala-azar in displaced people from Southern Sudan: epidemiological, clinical and therapeutic findings. [link.springer.com]

Epidemiological aspects. In control of the leishmaniasis, WHO Tech Rep Ser.793. World Health Organization: Geneva; 1990. p. 41-6. 2. Herwaldt BL, Stokes SL, Juranek DD. American cutaneous leishmaniasis in US travelers. [ijdvl.com]

EEC No: NIF (CHIP2, 1994) INTRODUCTION AND EPIDEMIOLOGY Sodium stibogluconate is a pentavalent antimony compound. It is used in the treatment of visceral, cutaneous and mucocutaneous leishmaniasis. [inchem.org]

Authors’ Affiliations (1) Drugs for Neglected Diseases initiative (DNDi) Africa, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya (2) MRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London [trialsjournal.biomedcentral.com]

Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology. Respiratory Research 3, 26 – 53. Haddad, J. J., Saade, N. E. and Safieh-Garabedian, B. ( 2002 ). [cambridge.org]

Application(s): antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania [ebi.ac.uk]

For patients at risk for progression to mucocutaneous leishmaniasis, first-line treatment in the United States entails the use of sodium stibogluconate (SSG), which is obtained from the Centers for Disease Control and Prevention (CDC) under an investigational [ncbi.nlm.nih.gov]

It is available in the United States on a named-patient basis from the Centers for Disease Control and Prevention (CDC). The dose of sodium stibogluconate is by slow intravenous infusion (at least five minutes with cardiac monitoring). [oncologydrugs.co.in]