Blunt or penetrating trauma, most frequently seen in motor vehicle accidents, sports activities, and intentional injuries are the predominant causes of soft-tissue injury, which includes many forms and subtypes. Localized pain may be a shared feature of all soft tissue injuries, but signs and symptoms somewhat depend on the tissue involved [1]:

• Skin and subcutaneous tissue - In the setting of injury that does not penetrate the skin, main forms of injury are contusions, abrasions, and lacerations, which are more frequently encountered in milder forms of trauma. On the other hand, skin trauma extending into deeper layers of the skin and subcutaneous tissue (cuts, slashes, gunshot wounds, etc) are considered as penetrating [1]. Burns are also an important form of skin injury, while signs such as erythema and ecchymoses may also develop from trauma, especially in child abuse [2].
• Muscles, tendons, ligaments, bursae - Ligamental (sprains) or muscle strains are very common among athletes and their severity can range from mild to complete, resulting in joint instability and immense pain [1] [3]. Virtually any joint can be affected, but the knees, shoulders, ankles and wrists are most common. Overuse injuries, seen in runners, cyclists, and other athletes that put a significant amount of exertion on the musculoskeletal system [4], are particularly common and can lead to bursitis, tendinitis, sprains, tears, etc.
• Blood and lymphatic vessels - Similarly to skin and subcutaneous injuries, blunt trauma can lead to intimal injuries, the formation of arteriovenous fistulas and spasms, all predisposing to potentially severe ischemia.
• Peripheral nerves - Loss of either sensory and/or motor function are typical for peripheral nerve injury.

• Knee Pain

  Complaints of knee pain generally start in energetic children aged 9-15 years, a time of rapid growth. Discomfort tends to be localized, and palpation reveals swelling and tenderness over the tibial tubercle. [emedicine.medscape.com]

  Here are some to look out for: headaches/migraines hand/leg pain/numbness shoulder/knee pain herniated/ruptured disc neck stiffness joint/muscle tenderness whiplash muscle aches These injuries may not be immediately noticeable. [pepperodom.com]

  Joint-specific tips See the following for ways to ease a specific joint problem: Ankle or heel pain Elbow pain Hip pain Knee pain Shoulder pain Wrist pain References Citations Hurt G, Baker CL (2003). Calcific tendinitis of the shoulder. [northshore.org]

• Ankylosis

  Soft tissue injuries of the TMJ can potentially lead to internal derangement, osteoarthrosis, and possibly fibrous ankylosis, which should be considered during follow-up. [ncbi.nlm.nih.gov]

• Myalgia

  Specific names include: carpal tunnel syndrome (nerves going through wrist); degenerative disk disease (backbone); epicondylitis (tennis or golfer's elbow); myofascial pain/myalgia (tissue covering muscles); rotator cuff syndrome (shoulder tendons); sciatica [cwhn.ca]

• Neglect

  Concerns are raised regarding lengthy duration from injury to diagnosis, claimants' high healthcare use, and neglect of mention of previous health status. [ncbi.nlm.nih.gov]

The clinical presentation of soft tissue injuries is diverse, making patient history and the physical examination the most important parts in the diagnostic workup. Events that have led to injury, as well as its type, may provide sufficient clues to make an initial diagnosis and perform further procedures that can determine its severity. A detailed clinical examination of the affected joint or part of the body must be employed through adequate examinations (inspection, palpation, and various probes that estimate the range of joint motion, severity of pain, etc.), primarily to define the exact type of injury and decide which procedures can solidify clinical suspicion. Arteriography and doppler ultrasonography can be helpful in evaluating vascular injuries [5], while standard ultrasound and arthroscopy are the valuable methods for assessment of joint tissue [6]. More advanced imaging studies - computed tomography (CT) and magnetic resonance imaging (MRI) are useful for assessment of ligaments, joints, tendons and muscle injuries. Finally, electromyography (EMG) and nerve conduction studies can be employed in the case of peripheral nerve injury.

Treatment recommendation was classified as nonoperative, operative, or equivocal. [ncbi.nlm.nih.gov]

To make a full diagnosis, a professional may use nerve conduction studies to localize nerve dysfunction (e.g. carpal tunnel syndrome), assess severity, and help with prognosis. [en.wikipedia.org]

Hohl, Soft Tissue Injuries of the Neck in Automobile Accidents: Factors Influencing Prognosis, J. [adlergiersch.com]

Six patients with soft tissue injury secondary to different etiologic factors are presented. The degree and extent of tissue necrosis was precisely identified by scintigraphy. [ncbi.nlm.nih.gov]

Osteochondritis dissecans, an intra-articular disorder of unclear etiology, is most common in boys during late childhood or in male adolescents. [emedicine.medscape.com]

ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies were included if they reported: male rugby union players, a clear definition of a rugby union injury, the amount of training volume undertaken by participants, and epidemiological data for soft-tissue [ncbi.nlm.nih.gov]

Since one of the current AO principles emphasises respect for soft tissue when performing open reduction and internal fixation, this article further discusses the pathophysiology of soft-tissue injury and the specific concerns in treating compartment [ncbi.nlm.nih.gov]

Pathophysiological mechanisms involved in genesis and spread of muscular tension in occupational muscle pain and in chronic musculoskeletal pain syndromes: a hypothesis, Med. ‎ Página 99 - Adler R. [books.google.es]

NSAIDs delay, but do not prevent the inflammatory response in injured tissue and may expose athletes to an increased risk of re-injury by delaying healing. Significant adverse effects do occur in previously healthy patients who receive NSAIDs. [ncbi.nlm.nih.gov]

Compression: Bandaging the injury will compress it, and prevent any further bleeding or swelling from occurring. Elevation: Elevating the injury above the heart while resting will aid in the reduction of swelling. [en.wikipedia.org]

1. Porter RS, Kaplan JL. Merck Manual of Diagnosis and Therapy. 19th Edition. Merck Sharp & Dohme Corp. Whitehouse Station, N.J; 2011.
2. McMahon P, Grossman W, Gaffney M, Stanitski C. Soft-tissue injury as an indication of child abuse. J Bone Joint Surg Am. 1995;77(8):1179-1183.
3. Aster JC, Abbas AK, Robbins SL, Kumar V. Robbins basic pathology. Ninth edition. Philadelphia, PA: Elsevier Saunders; 2013.
4. Gabbett TJ, Ullah S. Relationship between running loads and soft-tissue injury in elite team sport athletes. J Strength Cond Res. 2012;26(4):953-960.
5. Park JJ, Campbell KA, Mercuri JJ, Tejwani NC. Updates in the management of orthopedic soft-tissue injuries associated with lower extremity trauma. Am J Orthop (Belle Mead NJ). 2012;41(2):E27-35.
6. Campbell RSD, Dunn AJ. Radiological interventions for soft tissue injuries in sport. Br J Radiol. 2012;85(1016):1186-1193.