A main focus of present-day pretreatment research is on bioscavengers, another is on centrally active reversible AChE-inhibitors combined with drugs showing anti-cholinergic, anti-glutamatergic, neuroprotective and non-sedating GABA-ergic activity. [ncbi.nlm.nih.gov]

In the present study, long-term effects of soman poisoning on learning ability, memory and neurogenesis were investigated in rats, treated with the anticholinergic atropine and the oxime HI-6 for reactivation of soman-inhibited acetylcholinesterase. [semanticscholar.org]

If the characteristic features of nerve agent poisoning are present, however, antidotal treatment should not be delayed until the result is available. [cryptome.org]

This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled "Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack". [books.google.com]

In this chapter, a review of the various neuroprotection options that have been investigated as alternatives to diazepam in the last decade is presented. [eurekaselect.com]

• Bronchorrhea

  Nerve agents cause death via respiratory failure, which in turn is caused by increased airway resistance (bronchorrhea, bronchoconstriction), respiratory muscle paralysis, and most importantly, loss of central respiratory drive. [10] Two chemical properties [emedicine.medscape.com]

  Atropine : If bronchorrhea develops, atropine (2 mg in an adult; 20 microgram/kg in a child) should be administered intravenously every 5–10 minutes until secretions are minimal and the patient is atropinized (dry skin and sinus tachycardia). [cryptome.org]

• Abdominal Cramps

  […] absorption Tightness in chest, with prolonged wheezing expiration suggestive of bronchoconstriction or increased secretion; dyspnoea, slight pain in chest; increased bronchial secretion; cough; pulmonary oedema; cyanosis Anorexia; nausea; vomiting; abdominal [emro.who.int]

  Reported side effects of PB include increased salivation, increased tearing, urinary urgency and frequency, nausea, vomiting, muscle weakness, abdominal cramps and diarrhea.167 These effects disappear when individuals stop taking PB. [pbs.org]

Essential antidotes in experimental treatment of Soman poisoning today are the powerful reactivators of Soman-inhibited AChE (e.g. HI-6, HGG-42 and BDB-27) and atropine. [ncbi.nlm.nih.gov]

Decontamination and medical treatment are important aspects of protection from effects after intoxications with chemical agents. [books.google.com]

We also investigated whether sub-chronic treatment with the reported… CONTINUE READING [semanticscholar.org]

Additionally, it was found that brain injuries induced by soman toxicity were effectively prevented by the patch treatment according to histopathological examinations. [fasebj.org]

Pathophysiology Penetrates skin, eyes, and lungs Toxic effects manifest as Cholinergic Toxicity Organophosphate esters ( Acetylcholinesterase Inhibitor s) Most toxic of chemical agents Similar to Insect icide Organophosphate s (e.g. [fpnotebook.com]

The rapid onset of toxic signs following nerve agent intoxication and the apprehension that current therapy (atropine, oxime, diazepam) may not prevent brain damage, requires supportive pretreatment. [ncbi.nlm.nih.gov]

Additionally, it was found that brain injuries induced by soman toxicity were effectively prevented by the patch treatment according to histopathological examinations. [fasebj.org]

[…] id=523&tid=93 Centers for Disease Control and Prevention. 2003. Public Health Emergency Preparedness and Response Sheets. U.S. Department of Health and Human Services. [health.ny.gov]

Inclusion of clonidine was vital for preventing atropine induced lethal ventricular arrhythmias in hypoxic animals when treatment was given late. [eurekaselect.com]

This nanodrug rapidly penetrated the blood–brain barrier in zebrafish and mice and restored cerebral AChE activity via the released HI-6, preventing the brain damage caused by soman poisoning and increasing the survival rate in mice. [pubs.rsc.org]