Symptoma

Spinal Demyelination

Demyelinating Disease of the Spinal Cord

The prospective cohort comprised patients presenting to the neuroimmunology clinic for MS or other DD of 5-year-duration or less. [mdsabstracts.org]

Cord expansion may or may not be present; it was found in 47% in published series. [radiologykey.com]

This case highlights the diagnostic challenges of the spinal peripheral primitive neuroectodermal tumor that could have an initial chronic inflammatory demyelinating polyneuropathy-like presentation. [journals.sagepub.com]

Each section has been re-ordered to better present information and the Second Edition brings in many new authors and topics, more diagrams, illustrations, and tables to solidify concepts, and contains 18 entirely new chapters. [books.google.de]

Although remyelinated axons were present from 14 to 450 days post injury, remyelination was incomplete, as indicated by the presence of demyelinated axons at every time point examined. [onlinelibrary.wiley.com]

  • Severe Clinical Course

    Compared with patients who had MS, patients who had DNMO had a poor prognosis, higher age at onset, and a more sever clinical course. DNMO was most like to affect female patients. Corticosteroids are not helpful in DNMO, and the prognosis is poor. [radiologykey.com]

  • Neglect

    This is an essential but neglected issue in modeling clinical trauma, where lesions are typically extensive. [grantome.com]

    Neglect-associated fatal Marchiafava-Bignami disease in a non-alcoholic woman. Int J Legal Med 2001;115:90-93. Maki N, Hokoishi K, Komori K, Tanabe H. [A case of Marchiafava-Bignami disease caused by anorexia nervosa.] No To Shinkei 2001;53:669-671. [journal.biolpsychiatry.or.kr]

    As dementia progresses, language ability may begin to deteriorate and the individual may neglect to care for himself appropriately. [britannica.com]

  • Clonus

    The most common SMDs were tonic spasms (28), new-onset RLS (23), paroxysmal focal dystonia (9), spinal myoclonus (9), subjective fasciculations (9), spontaneous clonus (8), pseudoathetosis (7), spinal tremor (6), and hyperkeplexia (3). [mdsabstracts.org]

    This pattern is almost pathognomonic of cord compression because of cervical spondylosis at the C5-C6 interspace. 12 Ankle clonus and Babinski's sign (pathologic extension of the great toe elicited by stroking the foot) in the feet may also be revealed [aafp.org]

  • Myoclonic Jerking

    Subacute necrotizing encephalopathy, also called Leigh disease, is a lethal disorder of infancy marked by psychomotor delay, myoclonic jerks, paralyses of eye movements, and respiratory disorders. [britannica.com]

Diagnostic workup: History and physical examination MRI brain and spinal cord MRI of the optic nerves Visual and Auditory evoked potentials Somatosensory evoked potentials Lumbar puncture for CSF analysis Treatment: Disease modifying therapy: These therapy [pnpspecialists.com]

"Better explanations" in multiple sclerosis diagnostic workup: A 3-year longitudinal study. Neurology. 2019 May 1. Full article Nerve cells (neurons) Nerve cells, or neurons, make up your nervous system. [mstrust.org.uk]

Therefore, a broad workup including infectious, immunologic, and metabolic tests, as well as a systematic follow-up Magnetic Resonance Imaging (MRI) is needed to establish an accurate diagnosis[5]. [sickkids.ca]

This approach results in increased operator time but should be recommended in the initial workup of patients who are presenting for the first time with neurologic syndromes that suggest a demyelinating disease when sensitivity in detection of brain lesions [ajnr.org]

  • Hypercapnia

    Tidal volume and mean inspiratory flow (VT/TI) tended to be reduced in EtBr rats during hypercapnia/hypoxia (p 0.06 and 0.07, respectively). [fasebj.org]

  • Herpes Simplex Virus Type 2

    Register Spinal Cord and Optic Nerve Demyelination in Experimental Herpes Simplex Virus Type 2 Infection - 24 Hours access EUR 36.00 GBP 28.00 USD 45.00 Rental This article is also available for rental through DeepDyve. [academic.oup.com]

  • Gliosis

    The spinal cord lesions showed obvious loss of myelinated nerve fibers and fibrillary gliosis with minimal inflammatory cell infiltration. [springerlink.com]

    With time, gliosis develops, and plaques reach a burned-out stage consisting of demyelinated axons traversing glial scar tissue (inactive plaque). Remaining oligodendrocytes attempt to make new myelin. [neuropathology-web.org]

    Its imaging manifestations are worse than its clinical ones, possibly because early gliosis does not damage normal tissue. Hormone treatment has a poor effect on gliomas. [nrronline.org]

This book will be of interest to students, medical professionals, and others interested in understanding the pathology and treatment of spinal degenerative disease. [books.google.com]

The last MRI, performed after the plasmapheresis treatment, documented progression of the spinal demyelination process. However, the patient became febrile. Immunosuppressive treatment was interrupted for a while. [nature.com]

Treatment was then discontinued and the patient remains under follow-up. [dovepress.com]

Disclaimer : The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. [practo.com]

Compared with patients who had MS, patients who had DNMO had a poor prognosis, higher age at onset, and a more sever clinical course. DNMO was most like to affect female patients. Corticosteroids are not helpful in DNMO, and the prognosis is poor. [radiologykey.com]

Lumbar puncture may be helpful in establishing the diagnosis, as oligoclonal bands are found in more than 80% of patients. 4 Prognosis is directly related to the MS subtype: primary progressive, progressive relapsing, relapsing remitting, and secondary [jaocr.org]

Prognosis 94% recover 20/40 or better at 5 years out in the ONTT. 20/200 or worse visual outcome occurred in 3% of patients at 5 years out in the ONTT. [eyewiki.aao.org]

Clinicopathologic findings and prognosis of chronic inflammatory demyelinating polyneuropathy. Neurology. 1999;52:498-503. Lewis RA. Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. Muscle Nerve. 1999;22:1738-39. Nevo Y. [rarediseases.org]

This disorder is of a heterogeneous pathology, with many different etiologies, including infections, inflammatory, malignant, and metabolic, but a substantial amount of cases remain idiopathic. [sickkids.ca]

However, transverse myelitis encompasses multiple diverse etiologies. Acute idiopathic transverse myelitis is a diagnosis of exclusion once viral and autoimmune causative factors are eliminated. [jaocr.org]

In patients with non-MS phenotypes who are negative for the known autoantibodies, other inflammatory (e.g systemic inflammation) or non-inflammatory (e.g inherited white matter disorders) etiologies should be considered. [frontiersin.org]

This brief guide will help the general ophthalmologist to understand: Optic neuritis is a clinical diagnosis, thus MRI of the orbit with gadolinium looking for optic nerve enhancement, blood testing for inflammatory or infectious etiologies, and lumbar [eyewiki.aao.org]

[…] sensory level and bilateral signs and symptoms; (3) proof of inflammation within the spinal cord by MR imaging or CSF examination; (4) symptoms from onset to reach maximal deficit between few hours and 21 days; and (5) exclusion of extra-axial compressive etiology [radiologykey.com]

26) Gastroenterology and Hepatology (25) Cardiology, Angiology (25) Dentistry (24) Obstetrics, Gynaecology (22) Genetics (17) Ophthalmology and Optometry (17) Medical Chemistry and Biochemistry (16) Otorhinolaryngology (16) Histology, Embryology (15) Epidemiology [portal.mefanet.cz]

Pathogenesis and epidemiology of multiple sclerosis. . Accessed June 9, 2017. See more Expert Answers . [mayoclinic.org]

In this Research Topic, we welcome original research, review papers, case reports and viewpoint pieces concerning the epidemiology of atypical demyelinating diseases. [frontiersin.org]

Context Epidemiological and experimental evidence suggests that high levels of vitamin D, a potent immunomodulator, may decrease the risk of multiple sclerosis. There are no prospective studies addressing this hypothesis. [tilltrip.phagy.com]

(Epidemiology)", "What Causes MS" PubMed Health: "Myelin Sheath" UpToDate: "Clinical Course and Classification of Multiple Sclerosis. [onhealth.com]

The study will also continue to provide basic information on the biophysical organization of myelinated axon, and on the more general phenomenon of demyelination pathophysiology in the mammalian nervous system. [grantome.com]

Some likely mechanisms for the pathophysiological damage are as follows. [dovepress.com]

In conclusion, metrics variation in MS patients, especially ihMTratio, suggest important demyelination in normal-appearing WM, consistent with MS pathophysiology. [onlinelibrary.ectrims-congress.eu]

Neurology (136) Pathology and Forensic Medicine (118) Paediatrics, Neonatology (66) Internal Medicine (64) Surgery, Traumatology and Orthopaedics (62) Infectology (52) Oncology, Radiation Therapy (45) Neurosurgery (44) Anatomy (43) Physiology and Pathophysiology [portal.mefanet.cz]

Research underway // Treatment can manage symptoms, but there isn’t much we can do yet to prevent demyelination from happening. [health.clevelandclinic.org]

There are a number of treatments used to prevent demyelination. Immunosuppression Preventing the inflammatory process is central to the treatment of many demyelinating conditions, such as MS, ADEM, and GBS. [verywellhealth.com]

Gastroenterology and Hepatology (25) Cardiology, Angiology (25) Dentistry (24) Obstetrics, Gynaecology (22) Genetics (17) Ophthalmology and Optometry (17) Medical Chemistry and Biochemistry (16) Otorhinolaryngology (16) Histology, Embryology (15) Epidemiology, Preventive [portal.mefanet.cz]

James Sejvar of the US Centers for Disease Control and Prevention who was not involved in the study told The Washington Post. [the-scientist.com]

Caregivers may help move your limbs when you can’t to prevent clots. Later, you’ll get physical therapy to help you use your limbs again. HTLV-I Associated Myelopathy (HAM) This condition results from a virus called HTLV-1. [webmd.com]