The prospective cohort comprised patients presenting to the neuroimmunology clinic for MS or other DD of 5-year-duration or less. [mdsabstracts.org]

Cord expansion may or may not be present; it was found in 47% in published series. [radiologykey.com]

Usually, only a single lesion is present. Contrast may be present, although this is not the dominant feature. Signal alteration usually and initially involves the anterior gray matter (anterior spinal artery distribution). [emedicine.medscape.com]

Case Presentation A 26-year-old previously healthy man presented to the emergency department with rapidly progressing upper and lower extremity weakness that developed following episodes of pain and tingling. [jaocr.org]

The criteria proposed by Paty et al (10) define imaging findings as definitely abnormal when four or more lesions are present or when at least three lesions, one of which is in a periventricular location, are present. [ajnr.org]

• Severe Clinical Course

  Clinical findings that favor DNMO are higher age at onset and severe course. [radiologykey.com]

• Chancre

  Primary syphilis produces a chancre, or sore, at the site of infection. Weeks later, secondary syphilis develops and causes a skin rash and signs of meningitis. [britannica.com]

Diagnostic workup: History and physical examination MRI brain and spinal cord MRI of the optic nerves Visual and Auditory evoked potentials Somatosensory evoked potentials Lumbar puncture for CSF analysis Treatment: Disease modifying therapy: These therapy [pnpspecialists.com]

"Better explanations" in multiple sclerosis diagnostic workup: A 3-year longitudinal study. Neurology. 2019 May 1. Full article Nerve cells (neurons) Nerve cells, or neurons, make up your nervous system. [mstrust.org.uk]

Therefore, a broad workup including infectious, immunologic, and metabolic tests, as well as a systematic follow-up Magnetic Resonance Imaging (MRI) is needed to establish an accurate diagnosis[5]. [sickkids.ca]

This approach results in increased operator time but should be recommended in the initial workup of patients who are presenting for the first time with neurologic syndromes that suggest a demyelinating disease when sensitivity in detection of brain lesions [ajnr.org]

This book will be of interest to students, medical professionals, and others interested in understanding the pathology and treatment of spinal degenerative disease. [books.google.com]

The last MRI, performed after the plasmapheresis treatment, documented progression of the spinal demyelination process. However, the patient became febrile. Immunosuppressive treatment was interrupted for a while. [nature.com]

Lumbar puncture may be helpful in establishing the diagnosis, as oligoclonal bands are found in more than 80% of patients. 4 Prognosis is directly related to the MS subtype: primary progressive, progressive relapsing, relapsing remitting, and secondary [jaocr.org]

Compared with patients who had MS, patients who had DNMO had a poor prognosis, higher age at onset, and a more sever clinical course. DNMO was most like to affect female patients. Corticosteroids are not helpful in DNMO, and the prognosis is poor. [radiologykey.com]

Prognosis 94% recover 20/40 or better at 5 years out in the ONTT. 20/200 or worse visual outcome occurred in 3% of patients at 5 years out in the ONTT. [eyewiki.aao.org]

Clinicopathologic findings and prognosis of chronic inflammatory demyelinating polyneuropathy. Neurology. 1999;52:498-503. Lewis RA. Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. Muscle Nerve. 1999;22:1738-39. Nevo Y. [rarediseases.org]

This disorder is of a heterogeneous pathology, with many different etiologies, including infections, inflammatory, malignant, and metabolic, but a substantial amount of cases remain idiopathic. [sickkids.ca]

However, transverse myelitis encompasses multiple diverse etiologies. Acute idiopathic transverse myelitis is a diagnosis of exclusion once viral and autoimmune causative factors are eliminated. [jaocr.org]

In patients with non-MS phenotypes who are negative for the known autoantibodies, other inflammatory (e.g systemic inflammation) or non-inflammatory (e.g inherited white matter disorders) etiologies should be considered. [frontiersin.org]

This brief guide will help the general ophthalmologist to understand: Optic neuritis is a clinical diagnosis, thus MRI of the orbit with gadolinium looking for optic nerve enhancement, blood testing for inflammatory or infectious etiologies, and lumbar [eyewiki.aao.org]

An infectious etiology has been suggested by the following evidence: The distribution of MS is very non-uniform. Temperate climates have a higher incidence than warm climates, but the disease is uncommon in Japan. [dartmouth.edu]

26) Gastroenterology and Hepatology (25) Cardiology, Angiology (25) Dentistry (24) Obstetrics, Gynaecology (22) Genetics (17) Ophthalmology and Optometry (17) Medical Chemistry and Biochemistry (16) Otorhinolaryngology (16) Histology, Embryology (15) Epidemiology [portal.mefanet.cz]

Pathogenesis and epidemiology of multiple sclerosis. https://www.uptodate.com/home. Accessed June 9, 2017. See more Expert Answers . [mayoclinic.org]

In this Research Topic, we welcome original research, review papers, case reports and viewpoint pieces concerning the epidemiology of atypical demyelinating diseases. [frontiersin.org]

Context Epidemiological and experimental evidence suggests that high levels of vitamin D, a potent immunomodulator, may decrease the risk of multiple sclerosis. There are no prospective studies addressing this hypothesis. [tilltrip.phagy.com]

(Epidemiology)", "What Causes MS" PubMed Health: "Myelin Sheath" UpToDate: "Clinical Course and Classification of Multiple Sclerosis.", "Diagnosis of Multiple Sclerosis in Adults", "Treatment of Progressive Multiple Sclerosis in Adults." © 2005-2019 WebMD [onhealth.com]

The study will also continue to provide basic information on the biophysical organization of myelinated axon, and on the more general phenomenon of demyelination pathophysiology in the mammalian nervous system. [grantome.com]

Neurology (136) Pathology and Forensic Medicine (118) Paediatrics, Neonatology (66) Internal Medicine (64) Surgery, Traumatology and Orthopaedics (62) Infectology (52) Oncology, Radiation Therapy (45) Neurosurgery (44) Anatomy (43) Physiology and Pathophysiology [portal.mefanet.cz]

Some likely mechanisms for the pathophysiological damage are as follows. [dovepress.com]

In conclusion, metrics variation in MS patients, especially ihMTratio, suggest important demyelination in normal-appearing WM, consistent with MS pathophysiology. [onlinelibrary.ectrims-congress.eu]

Research underway // Treatment can manage symptoms, but there isn’t much we can do yet to prevent demyelination from happening. [health.clevelandclinic.org]

There are a number of treatments used to prevent demyelination. Immunosuppression Preventing the inflammatory process is central to the treatment of many demyelinating conditions, such as MS, ADEM, and GBS. [verywellhealth.com]

Gastroenterology and Hepatology (25) Cardiology, Angiology (25) Dentistry (24) Obstetrics, Gynaecology (22) Genetics (17) Ophthalmology and Optometry (17) Medical Chemistry and Biochemistry (16) Otorhinolaryngology (16) Histology, Embryology (15) Epidemiology, Preventive [portal.mefanet.cz]

James Sejvar of the US Centers for Disease Control and Prevention who was not involved in the study told The Washington Post. [the-scientist.com]

Preceding infection can also disrupt the normal process of prevention of self-immunity by removing regulatory cells that would otherwise have prevented inappropriate autoimmune responses. [clinicaladvisor.com]