We present two cases of SPCC of the true vocal fold that presented as a benign appearing subepithelial mass. [experts.umich.edu]

Case report: A 76 year old male smoker presented with dysphonia. Vocal cord injury was found on examination but no lymphadenopathy or metastases were present. Laryngeal microsurgery was performed with complete excision of the lesion. [pubmed.ncbi.nlm.nih.gov]

In the present report, three cases of SpCC of the larynx or hypopharynx were investigated. The histological and immunohistochemistry findings are presented to provide further data on this rare type of tumor. [spandidos-publications.com]

Abstract The clinicopathological features of 14 laryngeal neoplasms consisting of spindle-shaped cells are presented. [ncbi.nlm.nih.gov]

We present a case of SpCC in a 70-year-old male, who presented with progressive hoarseness since 1 year. The mass was removed under videolaryngoscopic guidance and thereafter, the patient underwent cobalt 60 radiotherapy. [ccij-online.org]

• Hoarseness

  Case Report A 70-year-old male presented to our department with a 1-year history of progressive hoarseness and stridor since last 1 week. [ccij-online.org]

  About 1.5% of the overall population suffers from hoarseness; among the most common causes of hoarseness are vocal fold nodules and polyps. [lesterthompsonmd.com]

  Nearly all patients experienced hoarseness (n = 165 [88%] patients) for a mean duration of 11.0 months. Patients admitted to smoking (n = 162 [87%] patients) and/or alcohol use (n = 90 [48%] patients). [journals.lww.com]

  In our study, the main presenting symptoms were hoarseness of voice in 69.8% of patients; Licitra et al. [22] reported that hoarseness is the main attending symptom. [ejo.eg.net]

  These include: Hoarseness Voice strain or weakness Sensation of a lump in the throat Constant coughing Difficulty swallowing Scratchy throat Ear pain Anyone with these symptoms for an extended period of time should seek medical attention to rule out laryngeal [drseanbaileystlent.com]

• Laryngeal Disease

  Laryngeal cancer remains predominantly a disease affecting men. [clinicalgate.com]

Thus, immediate workup should be performed when any pain or swelling occurs in an irradiated field—the clinical diagnosis of RIS can be difficult due to fibrosis and induration within the irradiated field. [oapublishinglondon.com]

We discuss the patient presentation, voice assessment, surgical treatment, and a review of the literature. [experts.umich.edu]

Recommended treatment for T2-T1 stages is an excisional biopsy which can be followed by adjuvant radiotherapy; radiotherapy alone has also been successful. [pubmed.ncbi.nlm.nih.gov]

Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. [ncbi.nlm.nih.gov]

However, there was a recurrent carcinoma (rT2N0) 6 months after the treatment. Therefore, a total laryngectomy was performed. Most laryngeal spindle cell carcinomas in Japan are found at an early stage. [jstage.jst.go.jp]

In our primary treatment group of 22 patients (median follow-up, 6.4 years), 4 (18%) had local recurrence, 3 (14%) had distant metastasis, and 4 (18%) died of disease. [mayoclinic.pure.elsevier.com]

If detected early, it has a very good prognosis. We present a case of SpCC in a 70-year-old male, who presented with progressive hoarseness since 1 year. [ccij-online.org]

Worst prognosis. Undifferentiated type (UT). Intermediate prognosis. EBV association. Nonkeratinizing type (NT). Good prognosis. EBV association. [librepathology.org]

The prognosis appears to be related to site, reflecting the feasibility of surgical resectability. RIS of the extremities has the best prognosis, whereas that involving the vertebral column, pelvis, shoulder girdle and neck has the worst prognosis. [oapublishinglondon.com]

Prognosis depends on the stage and the presence or not of metastases. Both epithelial markers EMA, cytokeratin (AE1-AE3), epithelial membrane antigen, Ki 67 and mesenchymal markers such as vimentin, desmin, S-100 may be positive in these tumours. [pubmed.ncbi.nlm.nih.gov]

The prognosis for spindle cell breast cancer is basically similar to the prognosis for other more common breast carcinomas, though at times it can be a highly aggressive neoplasm. [breast-cancer.ca]

الصفحة 53 - A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion - Henderson FW, Collier AM, Sanyal MA et al. ‏ [books.google.com]

Radiation, sun exposure, tobacco use, trauma, and alcohol consumption have been implicated as etiological factors in many cases. [4] Histological appearance may vary from case to case and even in the same patient in different areas. [idoj.in]

"The etiology and pathogenesis of laryngeal carcinoma". Otolaryngol. Clin. North Am. 30 (1): 1–19. PMID 8995133. ↑ de Miguel-Luken MJ, Chaves-Conde M, Carnero A (May 2016). "A genetic view of laryngeal cancer heterogeneity". [wikidoc.org]

A number of etiologies may be present synchronously, such that an infection may develop in association with radiation therapy, for example. Therefore, multiple etiologies may need to be addressed. [lesterthompsonmd.com]

Etiology The exact cause of laryngeal cancer is still unknown. However, several interrelated co-factors (mainly tobacco smoking and alcohol consumption), are clearly associated with an increased incidence in laryngeal cancer. [atlasgeneticsoncology.org]

Definitions, differential diagnosis, and epidemiology. Am J Surg Pathol 1996; 20(1):103-111. ‏ الصفحة 91 - Everett LA, Glaser B, Beck JC, Idol JR. Buchs A, Heyman M, Adawi F, Hazani E, Nassir E. [books.google.com]

It can be used for molecular epidemiology, diagnostics and targeting. [atlasgeneticsoncology.org]

The most recent data from the Surveillance, Epidemiology, and End Results (SEER) program (2003–2007) 1 estimated an overall incidence of 3.4 cases per 100,000 people per year, a slight decrease of 0.4 cases per 100,000 compared with the previous 5 years [clinicalgate.com]

Molecular epidemiology and retinoid chemoprevention of head and neck cancer. J Natl Cancer Inst 89 (3): 199-211, 1997. [cancerinfo.tri-kobe.org]

On microscopic histopathological analysis, spindle cells, basaloid cells, and nuclear atypia are characteristic findings of laryngeal cancer Pathophysiology Laryngeal cancer arises from squamous cells, which are cells that are normally involved in protection [wikidoc.org]

Klein-Hitpass L, Kube D, Dürig J, Dührsen U, Stanelle J, Küppers R p53 potein expression in chronic lymphocytic leukaemia Leuk Lymphoma, 2012;53:1282-8 Seifert M, Sellmann L, Bloehdorn J, Wein F, Stilgenbauer S, Dürig, J, Küppers R Cellular origin and pathophysiology [onko-mg.de]

Teflon granuloma of the larynx: etiology, pathophysiology, and management. Annu Otol Rhinol Laryngol 1995; 104 : 511–515. 38 Kuwabara H, Saito K, Shibanushi T, Kawahara T. Malignant fibrous histiocytoma of the larynx. [nature.com]

Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25:2097–116. Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. [journals.sfu.ca]

The current thinking is that these agents may delay or prevent subclinical cancer from manifesting as clinical disease but are less likely to prevent cellular transformation. [clinicalgate.com]

Early detection is the main hope for survival in RIS cases because there are no preventive measures to safeguard patients with cancer against RIS apart from limiting radiotherapy or using surgery as the primary treatment modality. [oapublishinglondon.com]

Post operative radiation therapy is used in most cases in the hopes of preventing local recurrence or metastasis. [breast-cancer.ca]

Goodman et al. [25] reported that resection of the arytenoids may interrupt physiologic airway protection in the early postoperative period; thus, a carful postoperative follow-up is needed to prevent the risk of pneumonia. [ejo.eg.net]