We present two cases of SPCC of the true vocal fold that presented as a benign appearing subepithelial mass. [experts.umich.edu]

Abstract The clinicopathological features of 14 laryngeal neoplasms consisting of spindle-shaped cells are presented. [ncbi.nlm.nih.gov]

In the present report, three cases of SpCC of the larynx or hypopharynx were investigated. The histological and immunohistochemistry findings are presented to provide further data on this rare type of tumor. [spandidos-publications.com]

Presents full-color images throughout to match the images that you see in practice. Extensive use of "combination" imaging presents a complete picture of how to more precisely locate and target the radiotherapy field. [books.google.com]

We present a case of SpCC in a 70-year-old male, who presented with progressive hoarseness since 1 year. The mass was removed under videolaryngoscopic guidance and thereafter, the patient underwent cobalt 60 radiotherapy. [ccij-online.org]

• Pathologist

  The book provides a handy summary and quick reference guide for pathology residents and will serve as a Ïportable refresher courseÓ or MOC review tool for the more experienced pathologist Features : Presents the key entities and diagnoses that pathologists [books.google.com]

  However, this type of tumor poses a significant diagnostic challenge to the pathologist due to the remarkable morphological and immunohistochemical overlap with other benign and malignant spindle cell tumors ( 2, 12 ). [spandidos-publications.com]

  Most pathologists utilize a three tiered system of grading dysplasia. In general, dyskeratotic cells may be an important clue to the diagnosis. [thedoctorsdoctor.com]

• Swelling

  On clinical examination, a single sessile erythematous swelling with a fungating whitish mass in the center was seen [Figure 1]. [contempclindent.org]

  Types of Non-Cancerous Growths Vocal nodules Vocal polyps Granulomas caused by intubation Reinke’s Edema (swelling of the vocal cords) Cysts (fluid filled sacs) Laryngeal papillomatosis (caused by the human papillomavirus (HPV) Glandular Tumor (an abnormally [drseanbaileystlent.com]

  We report the case of a 23-year-old female who presented with ulceroproliferative growth on the hard palate, gum hyperplasia, blackening of teeth, facial swelling, and pain. [idoj.in]

  Sarcomatoid carcinoma of maxillary sinus presents as a swelling of the affected maxilla along with associated facial pain, numbness or feeling of fullness of the sinus but in the present case patient had asymptomatic swelling in maxillary labial region [journalgateway.com]

  A 40-year male patient reported to SCB Dental College, Cuttack, with a complaint of swelling in the anterior part of mouth. History revealed a rapidly growing mass in the anterior palatal gingiva with duration of 3 months. [jomfp.in]

• Inflammation

  Keratinization & intercellular bridges through-out most of the malignant lesion Undifferentiated type: Non-distinct borders/syncytial pattern Nucleoli Non keratinizing type: Well-defined cell borders Eosinophilia Extra large nuclei /bizarre nuclei Inflammation [wikidoc.org]

  Inflammation (lymphocytes, plasma cells). Long rete ridges. Numerous beeds/blobs of epithelial cells that seem unlikely to be rete ridges. Pitfalls: Tangential cuts. [librepathology.org]

  SpCC develops due to a variety of reasons, including genetic predisposition, however, it may also be caused by a combination of other factors, including injury and inflammation in patients that are thought to be predisposed to this type of tumor. [spandidos-publications.com]

  This disorder is most common in elderly men, and it is occasionally associated with chronic inflammation or with trauma. Tracheopathia osteoplastica can manifest clinically as nonspecific signs and symptoms, although stridor and dyspnea are common. [lesterthompsonmd.com]

• Soft Tissue Mass

  Sagittal image (b): Arrow showing soft tissue mass in hard palate Click here to view Squamous cell carcinoma has many morphological and histopathological variants, which include verrucous, spindle-cell (sarcomatoid), basaloid exophytic or papillary, clear [idoj.in]

  The right thyroid cartilaginous tissue is replaced by destructive, expansile tumor (Figure 1). The mass is extending into the inferior aspect of the epiglottis, soft tissue of the larynx and into right endolaryngeal space (Figure 2). [appliedradiology.com]

  Computed tomographic (CT) examinations demonstrated a soft tissue mass in the left pyriform sinus and a 4.4×4.1-cm lesion, which was not well defined from the surrounding healthy soft tissue on the left side of the neck ( Fig. 2 ). [spandidos-publications.com]

  B: Preoperative coronal CT revealing a soft tissue mass in the left external ear as well as the attic of the tympanic cavity. It was unclear whether the tumor extended into the tympanic cavity. [omicsonline.org]

• Surgical Procedure

  In the present study, CT was required to perform the surgical procedures on the patients. Surgical removal is the preferred method, with radiation providing an effective adjunctive therapy. [spandidos-publications.com]

  Newer, more technically sophisticated voice-conserving surgical procedures have been developed. [clinicalgate.com]

  Before radiotherapy the patients were evaluated to determine the surgical procedure of choice. Either 66-68.4 Gy (33-38 fractions) or 63-65 Gy (28-29 fractions) of radiation therapy (RT) were administered. [thedoctorsdoctor.com]

• Hoarseness

  Case Report A 70-year-old male presented to our department with a 1-year history of progressive hoarseness and stridor since last 1 week. [ccij-online.org]

  About 1.5% of the overall population suffers from hoarseness; among the most common causes of hoarseness are vocal fold nodules and polyps. [lesterthompsonmd.com]

  Nearly all patients experienced hoarseness (n = 165 [88%] patients) for a mean duration of 11.0 months. Patients admitted to smoking (n = 162 [87%] patients) and/or alcohol use (n = 90 [48%] patients). [journals.lww.com]

  In our study, the main presenting symptoms were hoarseness of voice in 69.8% of patients; Licitra et al. [22] reported that hoarseness is the main attending symptom. [ejo.eg.net]

  These include: Hoarseness Voice strain or weakness Sensation of a lump in the throat Constant coughing Difficulty swallowing Scratchy throat Ear pain Anyone with these symptoms for an extended period of time should seek medical attention to rule out laryngeal [drseanbaileystlent.com]

• Pharyngitis

  Throat Cancer Also called: Hypopharyngeal cancer, Laryngeal cancer, Laryngopharyngeal cancer, Nasopharyngeal cancer, Oropharyngeal cancer, Pharyngeal cancer Throat cancer is a type of head and neck cancer. [icdlist.com]

  Review of pretreatment CT and/or MRI to determine presence of retropharyngeal LNs Outcome: Highest incidence in NPC (74%) and pharyngeal wall (19%). [en.wikibooks.org]

  The posterior pharyngeal wall, vocal cords, subglottic region and the base of the tongue appeared to be healthy. [spandidos-publications.com]

  Late development of laryngeal and pharyngeal carcinoma in previously irradiated areas. Laryngoscope 1953 ; 63 : 105 – 112. 20 van Iterson CJA. A case of carcinoma of the larynx at the age of 13. [onlinelibrary.wiley.com]

  The posterior larynx makes its anterior border, and posteriorly it again is a continuation of the posterior pharyngeal wall. Hypopharyngeal cancers also commonly present as nodal metastases. [clinicalgate.com]

• Laryngeal Disease

  Laryngeal cancer remains predominantly a disease affecting men. [clinicalgate.com]

• Odynophagia

  There were no associated complaints of dysphagia, odynophagia, or weight loss. There was no history of tuberculosis, trauma, or any focal neurological deficit. He was a chronic smoker since last 40 years. [ccij-online.org]

  He denied any dysphagia, odynophagia, change in voice, nasal obstruction, purulent rhinorrhea, anosmia, facial pain, or weight loss. [pagepress.org]

  No acute side-effects were noted, however, mucositis and odynophagia were observed. Following discharge from hospital the patient was administered with Chinese traditional medicine, including Angelica, Astragalus, Prunella and toad skin. [spandidos-publications.com]

  According to the clinical presentation, the most common complaint was hoarseness of voice in 35 (66%) patients, followed by stridor in 21 (39.6%), dysphagia to solids in four (7.5%), odynophagia in two (3.8%), and dry cough and hemoptysis with referred [ejo.eg.net]

• Foreign Body Sensation

  Case three A 57-year-old male presented at the Department of Otolaryngology and Head and Neck Surgery, Sir Run Run Shaw Hospital (Hangzhou, China) with a one-year history of pharyngeal foreign body sensation. [spandidos-publications.com]

• Paresthesia

  The patient stated there was no tenderness or paresthesia, however, the mass had been punctured and pus had been extracted at the Jiangshan Beilin Hospital (Jiangshan, China). [spandidos-publications.com]

Thus, immediate workup should be performed when any pain or swelling occurs in an irradiated field—the clinical diagnosis of RIS can be difficult due to fibrosis and induration within the irradiated field. [oapublishinglondon.com]

Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. [books.google.com]

We discuss the patient presentation, voice assessment, surgical treatment, and a review of the literature. [experts.umich.edu]

However, there was a recurrent carcinoma (rT2N0) 6 months after the treatment. Therefore, a total laryngectomy was performed. Most laryngeal spindle cell carcinomas in Japan are found at an early stage. [jstage.jst.go.jp]

Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. [ncbi.nlm.nih.gov]

Worst prognosis. Undifferentiated type (UT). Intermediate prognosis. EBV association. Nonkeratinizing type (NT). Good prognosis. EBV association. [librepathology.org]

If detected early, it has a very good prognosis. We present a case of SpCC in a 70-year-old male, who presented with progressive hoarseness since 1 year. [ccij-online.org]

The prognosis appears to be related to site, reflecting the feasibility of surgical resectability. RIS of the extremities has the best prognosis, whereas that involving the vertebral column, pelvis, shoulder girdle and neck has the worst prognosis. [oapublishinglondon.com]

The prognosis for spindle cell breast cancer is basically similar to the prognosis for other more common breast carcinomas, though at times it can be a highly aggressive neoplasm. [breast-cancer.ca]

SMALL CELL (NEUROENDOCRINE) VERRUCOUS CARCINOMA Large exophytic tumors with only mild cytologic atypia but may be localy aggressive PROGNOSIS AND TREATMENT CHARACTERIZATION PROGNOSIS GENERAL Prognostic factors in squamous cell carcinoma of the larynx. [thedoctorsdoctor.com]

الصفحة 53 - A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion - Henderson FW, Collier AM, Sanyal MA et al. ‏ [books.google.com]

Radiation, sun exposure, tobacco use, trauma, and alcohol consumption have been implicated as etiological factors in many cases. [4] Histological appearance may vary from case to case and even in the same patient in different areas. [idoj.in]

"The etiology and pathogenesis of laryngeal carcinoma". Otolaryngol. Clin. North Am. 30 (1): 1–19. PMID 8995133. ↑ de Miguel-Luken MJ, Chaves-Conde M, Carnero A (May 2016). "A genetic view of laryngeal cancer heterogeneity". [wikidoc.org]

A number of etiologies may be present synchronously, such that an infection may develop in association with radiation therapy, for example. Therefore, multiple etiologies may need to be addressed. [lesterthompsonmd.com]

Etiology The exact cause of laryngeal cancer is still unknown. However, several interrelated co-factors (mainly tobacco smoking and alcohol consumption), are clearly associated with an increased incidence in laryngeal cancer. [atlasgeneticsoncology.org]

Definitions, differential diagnosis, and epidemiology. Am J Surg Pathol 1996; 20(1):103-111. ‏ الصفحة 91 - Everett LA, Glaser B, Beck JC, Idol JR. Buchs A, Heyman M, Adawi F, Hazani E, Nassir E. [books.google.com]

It can be used for molecular epidemiology, diagnostics and targeting. [atlasgeneticsoncology.org]

The most recent data from the Surveillance, Epidemiology, and End Results (SEER) program (2003–2007) 1 estimated an overall incidence of 3.4 cases per 100,000 people per year, a slight decrease of 0.4 cases per 100,000 compared with the previous 5 years [clinicalgate.com]

Molecular epidemiology and retinoid chemoprevention of head and neck cancer. J Natl Cancer Inst 89 (3): 199-211, 1997. [cancerinfo.tri-kobe.org]

On microscopic histopathological analysis, spindle cells, basaloid cells, and nuclear atypia are characteristic findings of laryngeal cancer Pathophysiology Laryngeal cancer arises from squamous cells, which are cells that are normally involved in protection [wikidoc.org]

Klein-Hitpass L, Kube D, Dürig J, Dührsen U, Stanelle J, Küppers R p53 potein expression in chronic lymphocytic leukaemia Leuk Lymphoma, 2012;53:1282-8 Seifert M, Sellmann L, Bloehdorn J, Wein F, Stilgenbauer S, Dürig, J, Küppers R Cellular origin and pathophysiology [onko-mg.de]

Teflon granuloma of the larynx: etiology, pathophysiology, and management. Annu Otol Rhinol Laryngol 1995; 104 : 511–515. 38 Kuwabara H, Saito K, Shibanushi T, Kawahara T. Malignant fibrous histiocytoma of the larynx. [nature.com]

Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25:2097–116. Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. [journals.sfu.ca]

The current thinking is that these agents may delay or prevent subclinical cancer from manifesting as clinical disease but are less likely to prevent cellular transformation. [clinicalgate.com]

Early detection is the main hope for survival in RIS cases because there are no preventive measures to safeguard patients with cancer against RIS apart from limiting radiotherapy or using surgery as the primary treatment modality. [oapublishinglondon.com]

Post operative radiation therapy is used in most cases in the hopes of preventing local recurrence or metastasis. [breast-cancer.ca]

Goodman et al. [25] reported that resection of the arytenoids may interrupt physiologic airway protection in the early postoperative period; thus, a carful postoperative follow-up is needed to prevent the risk of pneumonia. [ejo.eg.net]