We present two cases of SPCC of the true vocal fold that presented as a benign appearing subepithelial mass. We discuss the patient presentation, voice assessment, surgical treatment, and a review of the literature. [experts.umich.edu]

Abstract The clinicopathological features of 14 laryngeal neoplasms consisting of spindle-shaped cells are presented. [ncbi.nlm.nih.gov]

• Pathologist

  The book provides a handy summary and quick reference guide for pathology residents and will serve as a Ïportable refresher courseÓ or MOC review tool for the more experienced pathologist Features : Presents the key entities and diagnoses that pathologists [books.google.com]

  However, this type of tumor poses a significant diagnostic challenge to the pathologist due to the remarkable morphological and immunohistochemical overlap with other benign and malignant spindle cell tumors ( 2, 12 ). [spandidos-publications.com]

  Most pathologists utilize a three tiered system of grading dysplasia. In general, dyskeratotic cells may be an important clue to the diagnosis. [thedoctorsdoctor.com]

  The lone presence of spindle cells might mislead the pathologist toward the diagnosis of other spindle cell lesions. [1], [2], [6] An abnormal cell can take on a number of bizarre morphologies once there is loss of cellular control in them. [jomfp.in]

• Hoarseness

  Case Report A 70-year-old male presented to our department with a 1-year history of progressive hoarseness and stridor since last 1 week. [ccij-online.org]

  Nearly all patients experienced hoarseness (n 165 [88%] patients) for a mean duration of 11.0 months. Patients admitted to smoking (n 162 [87%] patients) and/or alcohol use (n 90 [48%] patients). [journals.lww.com]

  About 1.5% of the overall population suffers from hoarseness; among the most common causes of hoarseness are vocal fold nodules and polyps. [lesterthompsonmd.com]

  In our study, the main presenting symptoms were hoarseness of voice in 69.8% of patients; Licitra et al. [22] reported that hoarseness is the main attending symptom. [ejo.eg.net]

  These include: Hoarseness Voice strain or weakness Sensation of a lump in the throat Constant coughing Difficulty swallowing Scratchy throat Ear pain Anyone with these symptoms for an extended period of time should seek medical attention to rule out laryngeal [drseanbaileystlent.com]

• Poor Oral Hygiene

  The mean age of appearance for SpCC is the sixth decade of life, and it has a male predominance. [3] The predisposing factors are the same as SCC, including tobacco use, alcohol abuse, smoking, poor oral hygiene, and previous irradiation to the site. [ccij-online.org]

  There was no history of tobacco chewing, smoking, alcohol use, previous irradiation, or poor oral hygiene. There was no history of hematuria, breathing difficulty, or palpable purpura. [idoj.in]

• Confusion

  As confusion with supporting tissue neoplasms may occur in the light microscope, the use of the electron microscope in differential diagnostics is recommended. [ncbi.nlm.nih.gov]

  Due to confusion and disparity over the diagnosis, immunohistochemistry (IHC) was done with markers pancytokeratin (Dako, AE1/AE3 clone), epithelial membrane antigen (EMA, Dako, E29 clone), CD 10, vimentin, smooth muscle actin (SMA), S-100, HMB-45, CD [jomfp.in]

• Focal Neurological Deficit

  There was no history of tuberculosis, trauma, or any focal neurological deficit. He was a chronic smoker since last 40 years. On examination, the patient had no palpable neck nodes. Laryngeal crepitus was present. [ccij-online.org]

• Paresthesia

  The patient stated there was no tenderness or paresthesia, however, the mass had been punctured and pus had been extracted at the Jiangshan Beilin Hospital (Jiangshan, China). [spandidos-publications.com]

Thus, immediate workup should be performed when any pain or swelling occurs in an irradiated field—the clinical diagnosis of RIS can be difficult due to fibrosis and induration within the irradiated field. [oapublishinglondon.com]

Histology, histogenesis, biology and treatment of the rare spindle cell carcinoma of the larynx are presented. [ncbi.nlm.nih.gov]

We discuss the patient presentation, voice assessment, surgical treatment, and a review of the literature. [experts.umich.edu]

Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. [books.google.com]

However, there was a recurrent carcinoma (rT2N0) 6 months after the treatment. Therefore, a total laryngectomy was performed. Most laryngeal spindle cell carcinomas in Japan are found at an early stage. [jstage.jst.go.jp]

If detected early, it has a very good prognosis. We present a case of SpCC in a 70-year-old male, who presented with progressive hoarseness since 1 year. [ccij-online.org]

Worst prognosis. Undifferentiated type (UT). Intermediate prognosis. EBV association. Nonkeratinizing type (NT). Good prognosis. EBV association. [librepathology.org]

In those particular cases, the prognosis was poor and chemotherapy and radiation were the only methods for controlling the cancer. [spandidos-publications.com]

The prognosis appears to be related to site, reflecting the feasibility of surgical resectability. RIS of the extremities has the best prognosis, whereas that involving the vertebral column, pelvis, shoulder girdle and neck has the worst prognosis. [oapublishinglondon.com]

The prognosis for spindle cell breast cancer is basically similar to the prognosis for other more common breast carcinomas, though at times it can be a highly aggressive neoplasm. [breast-cancer.ca]

الصفحة 53 - A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion - Henderson FW, Collier AM, Sanyal MA et al. ‏ [books.google.com]

Radiation, sun exposure, tobacco use, trauma, and alcohol consumption have been implicated as etiological factors in many cases. [4] Histological appearance may vary from case to case and even in the same patient in different areas. [idoj.in]

"The etiology and pathogenesis of laryngeal carcinoma". Otolaryngol. Clin. North Am. 30 (1): 1–19. PMID 8995133. de Miguel-Luken MJ, Chaves-Conde M, Carnero A (May 2016). "A genetic view of laryngeal cancer heterogeneity". [wikidoc.org]

A number of etiologies may be present synchronously, such that an infection may develop in association with radiation therapy, for example. Therefore, multiple etiologies may need to be addressed. [lesterthompsonmd.com]

Etiology The exact cause of laryngeal cancer is still unknown. However, several interrelated co-factors (mainly tobacco smoking and alcohol consumption), are clearly associated with an increased incidence in laryngeal cancer. [atlasgeneticsoncology.org]

Definitions, differential diagnosis, and epidemiology. Am J Surg Pathol 1996; 20(1):103-111. ‏ الصفحة 91 - Everett LA, Glaser B, Beck JC, Idol JR. Buchs A, Heyman M, Adawi F, Hazani E, Nassir E. [books.google.com]

It can be used for molecular epidemiology, diagnostics and targeting. [atlasgeneticsoncology.org]

The most recent data from the Surveillance, Epidemiology, and End Results (SEER) program (2003–2007) 1 estimated an overall incidence of 3.4 cases per 100,000 people per year, a slight decrease of 0.4 cases per 100,000 compared with the previous 5 years [clinicalgate.com]

Molecular epidemiology and retinoid chemoprevention of head and neck cancer. J Natl Cancer Inst 89 (3): 199-211, 1997. [cancerinfo.tri-kobe.org]

On microscopic histopathological analysis, spindle cells, basaloid cells, and nuclear atypia are characteristic findings of laryngeal cancer Pathophysiology Laryngeal cancer arises from squamous cells, which are cells that are normally involved in protection [wikidoc.org]

Klein-Hitpass L, Kube D, Dürig J, Dührsen U, Stanelle J, Küppers R p53 potein expression in chronic lymphocytic leukaemia Leuk Lymphoma, 2012;53:1282-8 Seifert M, Sellmann L, Bloehdorn J, Wein F, Stilgenbauer S, Dürig, J, Küppers R Cellular origin and pathophysiology [onko-mg.de]

Teflon granuloma of the larynx: etiology, pathophysiology, and management. Annu Otol Rhinol Laryngol 1995; 104 : 511–515. 38 Kuwabara H, Saito K, Shibanushi T, Kawahara T. Malignant fibrous histiocytoma of the larynx. [nature.com]

Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25:2097–116. Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. [journals.sfu.ca]

The current thinking is that these agents may delay or prevent subclinical cancer from manifesting as clinical disease but are less likely to prevent cellular transformation. [clinicalgate.com]

Early detection is the main hope for survival in RIS cases because there are no preventive measures to safeguard patients with cancer against RIS apart from limiting radiotherapy or using surgery as the primary treatment modality. [oapublishinglondon.com]

Post operative radiation therapy is used in most cases in the hopes of preventing local recurrence or metastasis. [breast-cancer.ca]

Goodman et al. [25] reported that resection of the arytenoids may interrupt physiologic airway protection in the early postoperative period; thus, a carful postoperative follow-up is needed to prevent the risk of pneumonia. [ejo.eg.net]