Presentation in the oral cavity is rare with only two previously reported cases. We report a case of spindle cell hemangioma that presented as an asymptomatic mass of the buccal mucosa in a 44-year-old man. [ncbi.nlm.nih.gov]

Clinical presentation: These lesions usually present as a single or multiple, often painful, small circumscribed reddish blue nodules. [histopathology-india.net]

Here, we present a young adult who presented to us with multiple spindle cell hemangioendotheliomas. The case is reported due to its rarity. [e-ijd.org]

• Fever

  No history of fever or systemic symptom was associated. No history of aggravation following trauma. No history of gastrointestinal bleeding or pathological fracture was present. [e-ijd.org]

  • In up to 1/3 of the patients, a clinical syndrome occur with fever, growth failure, malaise, weight loss, anemia, and elevated erythrocyte sedimentation rate. • When the mass is exised, the syndrome disappears, and it reapperance may be sign of recurrence [pedorthpath.com]

• Short Stature

  The patient may exhibit short stature in adulthood. Enchondromas affect only one side of the body in approximately 40 percent of patients. [rarediseases.org]

• Vascular Disease

  You are more likely to have vascular disease as you get older. [icdlist.com]

  disease; Dysplasia epiphysealis hemimelica; Apophyseal avulsion fracture; Dysplasia epiphysealis hemimelica. [oxidepuzupolyyoceti.xpg.uol.com.br]

• Ulcer

  […] arch syndrome (Medical Encyclopedia) Arterial embolism (Medical Encyclopedia) Arteriogram (Medical Encyclopedia) Cerebral angiography (Medical Encyclopedia) Duplex ultrasound (Medical Encyclopedia) Venous insufficiency (Medical Encyclopedia) Venous ulcers [icdlist.com]

  Superficial region of ulceration and acute inflammation – neutrophils abound superficial lobulesLacks steroid hormone receptors Gross= Solitary, red, rapidly growing papule or nodule, with a subtle collarette of scaleM/E=Polypoid mass of angiomatous tissue [slideshare.net]

  Am J Surg Pathol 25:1061−1066 PubMed Google Scholar Forschner A, Harms D, Metzler G, Sönnichsen K, Ulmer A, Rassner G, Fierlbeck G (2003) Ulcerated epithelioid hemangioendothelioma of the foot in childhood. [link.springer.com]

  Ulceration may occur and may be complicated by infection. Senile hemangiomas are usually multiple and are most often located on the upper portions of the trunk. [ispub.com]

• Aggressive Behavior

  Despite locally aggressive behavior, however, metastasis virtually never occurs; long-term follow-up from multiple studies does not support the original concept that these lesions are a form of low-grade angiosarcoma. [clinicaladvisor.com]

  Parotid gland solitary fibrous tumor with mandibular bone destruction and aggressive behavior. J Clin Exp Dent 2014;6:e299-302. 36. Srivathsa SH. Oral solitary fibrous tumor: Short review. Sch J Dent Sci 2014;1:28-30. 37. Rao S, Dinesh BS. [cancerjournal.net]

• Confusion

  In the current study the authors describe six cases of a distinct benign epithelioid and spindle cell vascular tumor of bone that, because of their unusual morphology, were confused with aggressive vascular neoplasms. [ncbi.nlm.nih.gov]

  They are commonly confused with carcinomas because of morphological and immunophenotypic similarities. 21, 22 The vast majority of angiosarcomas of soft tissue are high-grade neoplasms with brisk mitotic activity, coagulative necrosis and significant [nature.com]

  A benign progressive angioma, not to be confused with Kaposi’s sarcoma or low-grade angiosarcoma. J Am Acad Dermatol 20:214–225 CrossRef Google Scholar Yang H, Ahmed I, Vergese M, Schroeter AL (2006) Diffuse dermal angiomatosis of the breast. [link.springer.com]

  In the past, sometimes confusing classifications were developed characterized by a colorful, inconsistent terminology. As a consequence, a clear understanding of the various biological characteristics of vascular tumors has been impeded. [ispub.com]

Spindle Cell Hemangiomas do not cause any symptoms in most cases, and therefore may not require any treatment. [dovemed.com]

Treatment Options Treatment options are summarized in Table I. Table I. [clinicaladvisor.com]

Reports of additional cases will be required to determine the most appropriate treatment for this tumor. [ncbi.nlm.nih.gov]

Treatment Several treatments are used, depending on the severity of the tumor. For many benign tumors, a 'wait and see' stance will be taken or steroids will be administered. [rare-cancer.org]

Sicht wurde mir zu einer operativen Entfernung der Lipome geraten.What Are my Lipoma Treatment Options? I might have a lipoma and I am just curious about what kind of lipoma treatments exist. [oxidepuzupolyyoceti.xpg.uol.com.br]

Prognosis: • Benign with occasional recurrence. [pedorthpath.com]

The authors describe in-depth the clinical and morphologic aspects of each entity and detail their clinicopathologic correlation, differential diagnosis, prognosis, and therapy. [books.google.com]

The 5-year overall survival rate was 69.3%, and the histological assessment according to the tumor necrotic rate mainly corresponded to the prognosis of these patients in comparison with the graphical assessment. [ci.nii.ac.jp]

Weiss in 1996 as "spindle cell hemangioma", rather than hemangioendothelioma, due to the excellent prognosis observed in a group of 78 patients. [5] Retiform hemangioendothelioma (also known as a "Hobnail hemangioendothelioma" [3] ) is a low-grade angiosarcoma [en.wikipedia.org]

TERMINOLOGY Synonyms Formerly known as spindle cell hemangioendothelioma Definitions Benign vascular tumor characterized by cavernous vascular spaces and spindled cell areas ETIOLOGY/PATHOGENESIS Unknown Some cases associated with Mafucci syndrome, Klippel-Trenaunay [basicmedicalkey.com]

Etiology The etiology of spindle cell hemangioma is not clearly known at this time. The literature contains a great deal of discussion regarding the fundamental nature of these lesions. [clinicaladvisor.com]

The ultrasonography (USG) report was suggestive of a right intraparotid mass of uncertain etiology; whereas magnetic resonance imaging (MRI) report inclined toward a mass associated with chronic inflammatory pathology. [jcytol.org]

(Etiology) The exact cause for development of Spindle Cell Hemangiomas is unknown Since family history is an important risk factor, it may be caused by genetic mutations that are yet to be well-characterized Spindle Cell Hemangiomas have been known to [dovemed.com]

The etiology of kaposiform hemangioendothelioma remains unknown. It is not associated with HHV8 infection or Kaposi sarcoma. Tumors often involve soft tissue of extremities as ill-defined, violaceous lesions and may encase normal structures. [path.upmc.edu]

Epidemiology: • Rare lesion on the digits of young children. [pedorthpath.com]

Other malignancies associated with Maffucci syndrome include pancreatic and hepatic adenocarcinoma, ovarian tumors, brain gliomas, astrocytomas, and other types of sarcomas. [5] Epidemiology Frequency United States Maffucci syndrome is rare. [emedicine.medscape.com]

Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. [link.springer.com]

Pathophysiology Maffucci syndrome affects the skin and the skeletal systems. Superficial and deep vascular lesions (venous malformations) often protrude as soft nodules or tumors, usually on the distal extremities, but they can appear anywhere. [emedicine.medscape.com]

Pathophysiology This entity was originally described in 1986 by Weiss and Enzinger as a low-grade form of angiosarcoma. It seems that this classification was errant. [clinicaladvisor.com]

Am J Surg Pathol 21:1083–1089 PubMed CrossRef Google Scholar Navarro-Nunez L, Langan SA, Nash GB et al (2013) The physiological and pathophysiological roles of platelet CLEC-2. [link.springer.com]

Currently there are no specific methods or preventative techniques for the formation of Spindle Cell Hemangiomas. [dovemed.com]

Is chronic lung disease in low birth weight infants preventable? A survey of eight centers. ‎ Página 84 - Tanner JM, Whitehouse RH, Marubini E, Resele LF. The adolescent growth spurt of boys and girls of the Harpenden growth study. ‎ [books.google.es]

Low-dose interferon alpha 2b and intralesional and intra-arterial administration of recombinant interleukin 2 have been successful in treating and preventing recurrence of inaccessible or multiple SCH. [5], [6] Radiotherapy should be considered cautiously [ccij-online.org]

Although there may be multiple agents that can be used in conjunction with surgery to prevent recurrence, it is not clear, based on the current evidence, which agents will be best and how they should be utilized. [clinicaladvisor.com]