history of epilepsy (10.5-fold when considering patients of Mexican ancestry only). [ncbi.nlm.nih.gov]

Notably, we find that the presence of repeat interruptions within the SCA10 expansion confers a 6.80-fold increase in the risk of an SCA10 patient developing epilepsy and a 12.92-fold increase in having a positive family history of epilepsy. [ashg.org]

The mean scores of excessive daytime sleepiness were worse in the SCA10 group. Scores of fatigue were higher in the SCA10 sample compared to healthy individuals, but better than in the MJD. [ncbi.nlm.nih.gov]

Conclusions: This study confirms previous findings in ataxia hyposmia when compared with Parkinson’s disease. However association of the olfactory deficit with disease duration or repeat expansion was not found. [mdsabstracts.org]

In addition to ataxia, an abnormal eye movement known as nystagmus may appear on the neurological examination. SCA7 SCA7 only comprises 2 to 5 percent of autosomal dominant spinocerebellar ataxias. [verywell.com]

Egan RA, Camicioli R, Popovich BW: A small 55-repeat MJD1 CAG allele in a patient with Machado-Joseph disease and abnormal eye movements. Eur Neurol 2000; 44: 189-190. [scabase.eu]

On examination, she had horizontal and vertical nystagmus, fragmented ocular pursuit, ocular dysmetria, scanning speech, mild limb and gait ataxia with a widened base, slow speed, and inability to perform tandem walking. [ng.neurology.org]

On examination, both siblings displayed ocular dysmetria, dysdiadokinesia, impaired finger-to-nose exam, gait ataxia and hyperreflexia. [annalsofian.org]

There is a broad-based gait, scanning dysarthria, explosive speech, intention tremor, dysdiadochokinesia, dysmetria and abnormalities of eye movements. There may be movement disorders. [patient.info]

Coordination was intact to the finger-nose-finger test, but the heel-to-shin test was slightly impaired with mild dysmetria. There was no dysdiadochokinesia. [journals.plos.org]

Babinski sign 0003487 Cerebellar atrophy Degeneration of cerebellum 0001272 Distal sensory impairment Decreased sensation in extremities 0002936 Hyporeflexia Decreased reflex response Decreased reflexes [ more ] 0001265 Impaired smooth pursuit 0007772 Limb dysmetria [rarediseases.info.nih.gov]

The clinical manifestations in our cases were cerebellar ataxia accompanied by epilepsy, hyperreflexia and cognitive impairment. [ncbi.nlm.nih.gov]

In addition to cerebellar signs, hyperreflexia and decreased vibration sense are frequently observed. [orpha.net]

Additional features may include hand tremor, dysarthria, hyperreflexia, and saccadic eye movements (summary by {1:Guo et al., 2014}). [diseaseinfosearch.org]

On examination, both siblings displayed ocular dysmetria, dysdiadokinesia, impaired finger-to-nose exam, gait ataxia and hyperreflexia. [annalsofian.org]

This 45-year-old woman first noted gait imbalance at 40 years of age with accompanying dysgraphia, dysarthria, diplopia, short-term memory loss, anxiety, irritability, occasional bouts of insomnia, and recurrent headaches. [ng.neurology.org]

She later developed dizziness, insomnia, rapid memory loss, and frequent (up to once weekly) and often prolonged (up to 24 hours) apparent complex partial seizures consisting of altered mental status and automatism. [ng.neurology.org]

Although the primary pathology in SCA10 in humans is reportedly the loss of Purkinje cells, brain MRI revealed frontal lobe atrophy with white matter lesions. [ncbi.nlm.nih.gov]

MRI of the brain showed mild generalized cerebral atrophy, white matter ischemic changes and an old left parietal small infarct. No disproportional cerebellar atrophy was noted. Electroencephalogram was normal. [journals.plos.org]