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Spirochete Infection
Spirochetal Infections

Presentation

SpaceNext50 Britannica presents SpaceNext50, From the race to the Moon to space stewardship, we explore a wide range of subjects that feed our curiosity about space! [britannica.com]

Evasion from the immune system leads to infections that present as Leptospirosis, Syphilis, Lyme Disease and Relapsing Fever and may lead to putative persistence ... [frontiersin.org]

The time course to presentation of the rash can vary. It can occur a few days after the tick bite, or it may not present itself for a few weeks. Again, this characteristic skin rash isn’t always present. [dummies.com]

In some cases, tuberculous meningitis has a fulminant presentation, similar to bacterial meningitis. In other cases, it presents insidiously and progresses slowly over weeks or months, causing headache, confusion and cranial nerve deficits. [neuropathology-web.org]

Entire Body System

  • Fatigue

    Fatigue is noted by many patients with Lyme disease. However, fatigue in the absence of objectively measurable abnormalities is unlikely to be related to B burgdorferi infection, regardless of the serological status of the patient. [ncbi.nlm.nih.gov]

    Steere also said that after an attack of Lyme disease, patients might develop pain or fatigue syndromes that resemble fibromyalgia or chronic fatigue syndrome. [nytimes.com]

    Normally, during the worst of adrenal fatigue, I would have experienced symptoms which were activated almost immediately upon exercising—symptoms which are a hallmark of adrenal fatigue. [publichealthalert.org]

    Symptoms Babesiosis infection in humans will gradually develop fatigue, followed by a fever. The further result of infection is Hemolytic anemia, where red blood cells are destroyed and removed. [longislandlymedisease.com]

    Patients with Lyme disease are frequently misdiagnosed with chronic fatigue syndrome, fibromyalgia, multiple sclerosis, and various psychiatric illnesses, including depression. [lymedisease.org]

Gastrointestinal

  • Nausea

    The most common symptoms are as following: Tiredness Loss of appetite Drenching amounts of sweat Muscle pain Nausea/vomiting Headache Chills Blood in urine (rare) Diagnosis Babesiosis can be diagnosed via blood tests. [longislandlymedisease.com]

    […] incidentally in association with adenomatous and hyperplastic polyps, diverticular disease and inflammatory bowel disease Most cases are asymptomatic but cases in children, HIV+ patients and MSM often have diarrhea and abdominal pain and children may also have nausea [pathologyoutlines.com]

    The initial symptoms can include high fever, nausea, anorexia, and vomiting. This combination can be confusing to the clinician because you can attribute these generalized symptoms to a number of illnesses. [dummies.com]

    […] you should know A tick borne disease Rickettsia rickettsii Can cause serious damage to internal organs and even be lethal More common in the Southeastern part of the US I came in to see my physician assistant because of… Initial symptoms High Fever Nausea [physicianassistantexamreview.com]

    Besides fever, clinical signs and symptoms may include chills, headache, nausea, vomiting, myalgias, tachycardia, hyperventilation, mild hypotension, vasodilatation with flushing, and the exacerbation and new onset of skin lesions ( 104 ). [antimicrobe.org]

  • Abdominal Pain

    Clinical manifestations vary, ranging from asymptomatic infection to gastrointestinal bleeding, diarrhea, or abdominal pain. [jstage.jst.go.jp]

    pain and children may also have nausea, weight loss and failure to thrive - some improve without treatment, others with metronidazole In vulnerable patients, other pathogens should be sought Epidemiology Prevalence based on biopsy findings varies from [pathologyoutlines.com]

    He has had a mild fever and he is complaining of abdominal pain. What is the best treatment plan for this boy? Amoxicillin [physicianassistantexamreview.com]

Skin

  • Eczema

    In a 2014 study, Allen showed that eczema may be caused by biofilms — multicellular assemblages of bacteria that exude slimy, glue-like substances. Once bacteria metamorphose into a biofilm, antibiotics can no longer treat them. [newsblog.drexel.edu]

Musculoskeletal

  • Arthralgia

    In addition, over 50% of cases have fever, malaise, anorexia, weight loss, pharyngitis, laryngitis, and/or arthralgias. [antimicrobe.org]

Neurologic

  • Headache

    It is a maculopapular rash** Fever Sore throat Malaise Weight loss Hair loss Headache Physical exam findings Presence of a chancre sore Symmetrical maculopapular rash on trunk, extremities and palms and soles of feet. [physicianassistantexamreview.com]

    The most common symptoms are as following: Tiredness Loss of appetite Drenching amounts of sweat Muscle pain Nausea/vomiting Headache Chills Blood in urine (rare) Diagnosis Babesiosis can be diagnosed via blood tests. [longislandlymedisease.com]

    In that study, 80% of all patients with erythema migrans experienced malaise, fatigue and lethargy; 64% experienced headaches; and 48% experienced neck stiffness (3). [ncbi.nlm.nih.gov]

    But one child, in whom the disease was not diagnosed until four months after he was thought to have been infected, has suffered for five years with arthritis, headaches, depression and memory problems. Studies by Dr. [nytimes.com]

    Advanced symptoms include arthritis, irregular heartbeat, severe headaches, loss of sensation, carditis, meningitis, cranial neuritis, radiculoneuropathy, and migratory pain in joints, tendons, bursae, muscles or bones. [hboxygen.freeyellow.com]

  • Apraxia

    A patient, who had shown quite a similar picture in many respects (profound mental impairment, sensory aphasia, agnosia and apraxia), and who, just like case F; had no abnormality of complement in either blood or cerebral spinal fluid on repeated examinations [frontiersin.org]

Workup

Other Pathologies

  • Neurofibrillary Tangle

    He first described neurofibrillary tangles, which, were called for a long time “Alzheimer’s fibrillary degeneration”. [frontiersin.org]

Treatment

Early antibiotic treatment of the infection is highly effective. [ncbi.nlm.nih.gov]

But there is very little useful information for people who actually have a case of Lyme Disease that is not responding to conventional antibiotic treatment. Lyme Disease sufferers need to know how to get better, not how to identify a tick. [books.google.com]

Treatment In mild-to-moderate Babesiosis, the treatment of choice is a combination of A tovaquone and A zithromycin. This regimen is preferred to other treatment options because of having less side effects. [longislandlymedisease.com]

Tips for Success When Treating Parasites Treatment Timing Like most of the other treatments covered in this book, parasite treatments only work when the treatment being used matches the susceptible organisms located on the top layer of the infective onion [publichealthalert.org]

Perhaps this is why there is so much confusion and difficulty in getting proper treatment for Lyme disease. [holtorfmed.com]

Prognosis

Lyme Disease Treatment and Prognosis Centers for Disease Control and Prevention [On-line information]. Available online at http://www.cdc.gov/ncidod/dvbid/lyme/ld_humandisease_treatment.htm. Accessed March 2009. Mayo Clinic Staff (2008 May 2). [labtestsonline.it]

Prognosis The Lyme Lymphozytom and the Erythema migrans mostly heal with an antibiotic therapy, without consequences. With the advanced Acrodermatitis chronica atrophicans, a therapy does not always arrive at a complete restitution. [morgellons-research.org]

Etiology

Further analysis of probable spirochetal etiology of Flegel disease will show whether this was just an isolated case, or Borrelia can trigger the immune reaction that will result in HLP manifestations. [atlasofscience.org]

“The lack of progress in Alzheimer’s research suggests that the etiological hypotheses followed by the mainstream scientific community are either wrong or incomplete,” Ehrlich says. [newsblog.drexel.edu]

“Possible viral etiology of neurofibrillary changes and neuritic plaques,” in Aging Alzheimer’s Disease: Senile Dementia and Related Disorders, eds R. Katzman, R. D. Terry and K. L. Bick (New York: Raven Press), 7, 555–558. [frontiersin.org]

Etiology The chronic arthritis clinically resembles rheumatoid arthritis. Live agent is almost never cultivated from the joint (in common with other forms of reactive arthritis such as Reiter's syndrome and rheumatic fever). [microbiologybook.org]

Epidemiology

Stefanie Russell, a periodontist and Assistant Professor of Epidemiology & Health Promotion; and Dr. Robert Norman, Research Associate Professor of Epidemiology & Health Promotion, all of the NYU College of Dentistry; Dr. [martinimplants.com]

The conference will include presentations on ecology, evolution, epidemiology, genomics, pathogenic mechanisms/virulence attributes, and the role of the host immune response in clearance and in pathogenesis. [grc.org]

[…] children, HIV+ patients and MSM often have diarrhea and abdominal pain and children may also have nausea, weight loss and failure to thrive - some improve without treatment, others with metronidazole In vulnerable patients, other pathogens should be sought Epidemiology [pathologyoutlines.com]

Epidemiology Bejel is found in the Middle-East, Africa, Australia and central Asia. It is also known as sahel disease in West Africa. Pinta Treponema carateum Pinta is another non-venereal, treponematous disease which is caused by T. carateum. [microbiologybook.org]

JAMA. 2002 Mar 13; 287(10): 1259-60 Piacentino,-J-D; Schwartz,-B-S Occupational risk of Lyme disease: an epidemiological review. [malattierare.regione.veneto.it]

Pathophysiology

[…] intestine and the appendix may be involved Generally considered to be more common in the distal colon and rectum; however in a recent single institution study from Japan, disease was more common in the right colon ( Annals Diagn Pathol 2015;19:414 ) Pathophysiology [pathologyoutlines.com]

Prevention

Centers for Disease Control and Prevention. Frequently Asked Questions – Lyme Disease. Available online at http://www.cdc.gov/lyme/faq/index.html#accurate. Accessed July 2012. Centers for Disease Control and Prevention. Transmission – Lyme Disease. [labtestsonline.it]

Prevention The major concern to have is to avoid exposure to ticks, as they are the primary reason and source of the disease. One should avoid walking through the woods, tall grasses. [longislandlymedisease.com]

Health-News. 2001 May; 7(5): 6 Meyerhoff,-John Single-dose doxycycline prevented Lyme disease after an Ixodes scapularis tick bite. [malattierare.regione.veneto.it]

The issue of undiagnosed diabetes is especially critical because early treatment and secondary prevention efforts may help to prevent or delay the long-term complications of diabetes that are responsible for reduced quality of life and increased levels [martinimplants.com]

Although this can be microbiologically cured, the threat of permanent resultant neurologic damage, often severe in neurosyphilis and usually less so in neuroborreliosis, leads to considerable concern and emphasizes the need for prevention or early and [ncbi.nlm.nih.gov]

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