To present a case of central serous chorioretinopathy (CSC) treatment with spironolactone in a challenge-rechallenge pattern. [ncbi.nlm.nih.gov]

• Asymptomatic

  All patients with hyperkalemia were asymptomatic, and there were no reported adverse clinical events. [doi.org]

  All patients with hyperkalemia were asymptomatic, and there were no reported adverse clinical events. Place holder to copy figure label and caption Figure 2. [web.archive.org]

• Turkish

  Two further unobtainable articles, one in Spanish [ 73 ] and one in Turkish [ 76 ], had abstracts containing sufficient information to identify them as duplicate publications of two included case series [ 44, 60 ]. [doi.org]

• Macula

  Funduscopy showed bilateral and unilateral myopic maculopathy, and Optical Coherence Tomography (OCT) showed a dome shaped macula with neurosensory detachment. [ncbi.nlm.nih.gov]

• Retinal Cyst

  The first patient had regions of neurosensory detachment (DNS) and the second, multiple DNS, secondary intra-retinal cysts and retinal pigment epithelium detachment. [ncbi.nlm.nih.gov]

• Retinal Pigmentation

  The first patient had regions of neurosensory detachment (DNS) and the second, multiple DNS, secondary intra-retinal cysts and retinal pigment epithelium detachment. [ncbi.nlm.nih.gov]

• Relative Impotence

  impotence in males, menstrual irregularities, amenorrhea, postmenopausal bleeding, increased BUN concentrations. 256 265 a Interactions for Spironolactone Specific Drugs, Foods, and Laboratory Tests Drug, Food, or Test Interaction Comments ACE inhibitor [web.archive.org]

  impotence in males, menstrual irregularities, amenorrhea, postmenopausal bleeding, increased BUN concentrations. 256 265 Interactions for Spironolactone Specific Drugs, Foods, and Laboratory Tests Drug, Food, or Test Interaction Comments ACE inhibitors [drugs.com]

• Headache

  If potassium levels increase, anticipated symptoms would include cardiac irregularities, leg cramps, dryness of mouth, thirst, lethargy, drowsiness, and headaches. [aocd.org]

  Spironolactone is known to ameliorate mood and tension headache or migraine in women with premenstrual syndrome or clinical signs of hyperandrogenism. [ncbi.nlm.nih.gov]

  The most commonly reported side effects when taking Spiractin includes nausea, vomiting, headache, abdominal cramps and pain, diarrhoea, headache, drowsiness, lethargy, hair loss and excessive hair growth. [inhousepharmacy.vu]

Schlosser suggested considering an endocrinology workup in adult women who exhibit hirsutism, androgenetic alopecia, signs of virilization (deep voice, increased muscularity), acanthosis nigricans, central or abdominal obesity, oligomenorrhea/amenorrhea [medpagetoday.com]

• Plasma Volume Increased

  In both patients, plasma renin activity decreased, plasma volumes increased, and a "catch-up" in linear growth ensued. [ncbi.nlm.nih.gov]

• Potassium Increased

  Blood urea nitrogen, potassium: increased levels Digoxin assays: false digoxin elevation Granulocytes: decreased count Drug-food. Potassium-containing salt substitutes, potassium-rich diet: increased risk of hyperkalemia Drug-herbs. [medical-dictionary.thefreedictionary.com]

  Serum potassium increased by mean 0.41 mmol/L (95% CI: 0.37 to 0.44 mmol/L), sodium decreased by 1.7 mmol/L (95% CI: 1.5 to 1.9 mmol/L), and creatinine increased by 13.2 μmol/L (95% CI: 12.0 to 14.4 μmol/L). [hyper.ahajournals.org]

  Salt substitutes containing potassium increase the risk of hyperkalemia. Synthesis Reference Giuseppe Bernini, "Process for preparing micronized spironolactone." U.S. Patent US4332721, issued July, 1975. [drugbank.ca]

  If serum potassium increases during Spironolactona administration but drops when Spironolactona is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered. [ndrugs.com]

• HDL Increased

  At 12 months, HDL increased by 0.10 mmol/L (SD 0.24) in the spironolactone group but decreased by 0.07 mmol/L (SD 0.21) in the CPA group (P .002). [ncbi.nlm.nih.gov]

• Staphylococcus Aureus

  Aureus (MRSA) / Migraine / Muscle Spasms / Nausea / Neuromuscular Blockade / Neutropenias / Opioid Addiction / Pain NOS / Plague / Pneumonia / Prophylaxis / Psittacosis / Pulmonary Arterial Hypertension (PAH) / Q Fever / Reflux / Relapsing Fever / Rocky [drugbank.ca]

It is concluded that the patient had a calcium-sensing receptor mutation, and that treatment with spironolactone induced an effect on renal handling of calcium in this condition. It is suggested that this treatment be tried in other similar patients. [ncbi.nlm.nih.gov]

The moderate side effects in no case forced interruption of the treatment. Hair growth diminished substantially in 23 of the patients, the effect becoming evident 3-5 months after the commencement of treatment. [doi.org]

It has been reported that mineralocorticoid receptor antagonist improves the prognosis of chronic heart failure (CHF). [ncbi.nlm.nih.gov]

McKinlay, Ph.D. for the TOPCAT Investigators * Article Figures/Media Metrics 36 References 744 Citing Articles 2 Comments Abstract Background Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left [doi.org]

Kim and Donald Tredway, Hirsutism: Implications, etiology, and management, American Journal of Obstetrics and Gynecology, 140, 7, (815), (1981). K.R. JONES, M. KATZ, C. KEYZER and W. [doi.org]

He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education. [lifeinthefastlane.com]

Sirmans SM, Pate KA (2013) Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol 6:1–13 CrossRef PubMed PubMedCentral Google Scholar 4. [doi.org]

Dieleman, senior researcher 1, Bruno Stricker, professor of pharmacoepidemiology 2, Miriam Sturkenboom, associate professor of pharmacoepidemiology 1 1 Department of Medical Informatics, Erasmus MC, PO Box 1738, 3000 Rotterdam, Netherlands 2 Department of Epidemiology [dx.doi.org]

The role of stress in the pathophysiology of the dopaminergic system. Mol Psychiatry 2000;5:14–21. PubMed Crossref Google Scholar [46] Wood PB. Stress and dopamine: implications for the pathophysiology of chronic widespread pain. [doi.org]

This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. [fpnotebook.com]

Since the isolation and purification of aldosterone from adrenal extracts 50 years ago (Experientia 9 (1953) 33), scientists have learned a great deal about how and where aldosterone acts, the factors that control its release, what is its role in the pathophysiology [ncbi.nlm.nih.gov]

Diabetes predicts cardiovascular disease (CVD); some drugs are effective for CVD prevention but increase the risk of diabetes. [ncbi.nlm.nih.gov]

In addition, production of 3 alpha-hydroxy-TM suggests a mechanism to account for the prevention of CAN-induced carcinogenicity by SP. [dmd.aspetjournals.org]