To present a case of central serous chorioretinopathy (CSC) treatment with spironolactone in a challenge-rechallenge pattern. [ncbi.nlm.nih.gov]

• Headache

  If potassium levels increase, anticipated symptoms would include cardiac irregularities, leg cramps, dryness of mouth, thirst, lethargy, drowsiness, and headaches. [aocd.org]

  The most commonly reported side effects when taking Spiractin includes nausea, vomiting, headache, abdominal cramps and pain, diarrhoea, headache, drowsiness, lethargy, hair loss and excessive hair growth. [inhousepharmacy.vu]

  Spironolactone is known to ameliorate mood and tension headache or migraine in women with premenstrual syndrome or clinical signs of hyperandrogenism. [ncbi.nlm.nih.gov]

Schlosser suggested considering an endocrinology workup in adult women who exhibit hirsutism, androgenetic alopecia, signs of virilization (deep voice, increased muscularity), acanthosis nigricans, central or abdominal obesity, oligomenorrhea/amenorrhea [medpagetoday.com]

• Potassium Increased

  Blood urea nitrogen, potassium: increased levels Digoxin assays: false digoxin elevation Granulocytes: decreased count Drug-food. Potassium-containing salt substitutes, potassium-rich diet: increased risk of hyperkalemia Drug-herbs. [medical-dictionary.thefreedictionary.com]

  If serum potassium increases during Spironolactona administration but drops when Spironolactona is discontinued, a presumptive diagnosis of primary hyperaldosteronism should be considered. [ndrugs.com]

  Serum potassium increased by mean 0.41 mmol/L (95% CI: 0.37 to 0.44 mmol/L), sodium decreased by 1.7 mmol/L (95% CI: 1.5 to 1.9 mmol/L), and creatinine increased by 13.2 μmol/L (95% CI: 12.0 to 14.4 μmol/L). [hyper.ahajournals.org]

It is concluded that the patient had a calcium-sensing receptor mutation, and that treatment with spironolactone induced an effect on renal handling of calcium in this condition. It is suggested that this treatment be tried in other similar patients. [ncbi.nlm.nih.gov]

The moderate side effects in no case forced interruption of the treatment. Hair growth diminished substantially in 23 of the patients, the effect becoming evident 3-5 months after the commencement of treatment. [doi.org]

It has been reported that mineralocorticoid receptor antagonist improves the prognosis of chronic heart failure (CHF). [ncbi.nlm.nih.gov]

Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012;125(13):1635–42 CrossRef 6. Rosa J, Widimský P, Waldauf P. [springermedizin.de]

McKinlay, Ph.D. for the TOPCAT Investigators * Article Figures/Media Metrics 36 References 744 Citing Articles 2 Comments Abstract Background Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left [doi.org]

Kim and Donald Tredway, Hirsutism: Implications, etiology, and management, American Journal of Obstetrics and Gynecology, 140, 7, (815), (1981). K.R. JONES, M. KATZ, C. KEYZER and W. [doi.org]

He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education. [lifeinthefastlane.com]

Sivamani, Epidemiology and Management of Acne in Adult Women, Current Dermatology Reports, 3, 1, (29), (2014) ., Take specific considerations into account when treating acne in patients with skin of colour, Drugs & Therapy Perspectives, 30, 7, (252), [doi.org]

Dieleman, senior researcher 1, Bruno Stricker, professor of pharmacoepidemiology 2, Miriam Sturkenboom, associate professor of pharmacoepidemiology 1 1 Department of Medical Informatics, Erasmus MC, PO Box 1738, 3000 Rotterdam, Netherlands 2 Department of Epidemiology [dx.doi.org]

Abstract: Mineralocorticoid receptor (MR) antagonism has proven to effectively attenuate the pathophysiological effects of aldosterone in clinical and experimental settings of hypertension and heart failure. [doi.org]

Since the isolation and purification of aldosterone from adrenal extracts 50 years ago (Experientia 9 (1953) 33), scientists have learned a great deal about how and where aldosterone acts, the factors that control its release, what is its role in the pathophysiology [ncbi.nlm.nih.gov]

It prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. This medicine is also used to treat or prevent hypokalemia (low potassium levels in the blood). [mayoclinic.org]

Long-term treatment with spironolactone controlled the hypertension and prevented hypokalemic alkalosis in this patient, without any deleterious effects on steroid biosynthesis. [ncbi.nlm.nih.gov]