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Spleen Disease

Disease Splenic


Presentation

  • No lymphadenopathy was present.[ncbi.nlm.nih.gov]
  • It can be easily missed, as it sometimes doesn’t present with specific symptoms. When the symptoms are present, they include: Pain in the upper left part of the abdomen that can spread to the left shoulder.[healthyandnaturalworld.com]
  • Swollen spleens present an increased risk of rupture. In SM, splenomegaly (swollen spleen) is NOT a C finding indicating aggressive disease. It is a B finding.[mastattack.org]
  • Clinical presentation of wandering spleen. J Pediatr Surg. 2002;37:E30. Andley M, Basu S, Chibber P, Internal herniation of wandering spleen/a rare cause of recurrent abdominal pain. Int Surg. 2000;85:322-24. Peitgen K, Majetschak M, Walz MK.[rarediseases.org]
Fatigue
  • Pain that radiates to left shoulder (may indicate spleen pain) Feeling of fullness Fatigue Easy bleeding Shortness of breath Weight loss Paleness Night sweats Complications If the enlarged spleen is left untreated, then it may lead to severe complications[gleneaglesglobalhospitals.com]
  • Overwhelming sepsis Instances in which spleen may be enlarged Mononucleosis Some bacterial infections, metabolic disorders Liver diseases Some blood cancers, lymphoma Blood clots in veins of liver, spleen Symptoms of spleen issues Pain in upper left quadrant Fatigue[glutenfreern.com]
  • […] enlarged spleen may cause: No symptoms in some cases Pain or fullness in the left upper abdomen that may spread to the left shoulder Feeling full without eating or after eating only a small amount from the enlarged spleen pressing on your stomach Anemia Fatigue[mayoclinic.org]
Splenomegaly
  • Because of its role in the immune system, infections can affect the spleen, causing splenomegaly, or an enlarged spleen. Viral illnesses can cause splenomegaly.[livestrong.com]
  • But, the underlying conditions that lead to splenomegaly will cause the splenomegaly symptoms.[gleneaglesglobalhospitals.com]
  • Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. . Accessed June 14, 2016. Longo DL, et al. Enlargement of lymph nodes and spleen.[mayoclinic.org]
Spleen Disease
  • Highly specific and sensitive ELISA for the detection of antibodies against Big Liver and Spleen disease. The Big Liver and Spleen disease Antibody test kit measures the amount of antibodies to the Avian Hepatitis E Virus in the serum of chickens.[biochek.com]
  • Resources In This Article Hemorrhagic Enteritis/Marble Spleen Disease Overview of Hemorrhagic Enteritis/Marble Spleen Disease in Poultry[msdvetmanual.com]
  • Marble Spleen Disease in Pheasants Marble spleen disease typically affects pheasants three to eight months of age. Pheasants that have contracted this virus exhibit depression, enlarged mottled spleens, and lung congestion. Infection leads to death.[articles.extension.org]
Tender Spleen
  • Pain and Tenderness Spleen pain is usually felt in the upper left part of the abdomen. Since the spleen sits next to the stomach and kidney, many people confuse spleen pain for stomach pain or kidney pain.[healthhype.com]
  • In HS a crisis can cause yellowing of your skin or the whites of your eyes (jaundice), anaemia and a tender spleen very quickly. They can be triggered by viral infections such as colds and flu.[patient.info]
Abdominal Pain
  • Pale skin More tired than usual Fever Unusually fussy or irritable Complains of abdominal pain (usually on the left side) In an emergency call 9-1-1. The following situations are emergencies.[nationwidechildrens.org]
  • Andley M, Basu S, Chibber P, Internal herniation of wandering spleen/a rare cause of recurrent abdominal pain. Int Surg. 2000;85:322-24. Peitgen K, Majetschak M, Walz MK.[rarediseases.org]
  • Splenic Laceration The primary presenting feature of a splenic laceration is severe abdominal pain which tends to radiate to the shoulder.[epainassist.com]
  • Haug Browse recently published Learning/CME Learning/CME View all learning/CME CME Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis Case 4-2019: An 18-Year-Old Man with Abdominal Pain and Hematochezia Bridging the Gap Challenge Yourself[nejm.org]
Nausea
  • Immediately after the injury appear sharp pain in the spleen in the left hypochondrium, which changes in the left shoulder, collarbone and shoulder blade, paleness of skin, cold sweat; there are frequent small pulse, a fall in blood pressure, nausea,[md-tips.com]
  • In moderate to severe cases, the symptoms include the following: Chills Fever Nausea Vomiting Malaise Chest pain Left upper quadrant pain Left shoulder pain [ 7 ] Spleen Rupture Splenic rupture is an emergency condition involving the destruction of the[ihealthblogger.com]
  • Nausea, pallor, extreme nervousness, or fainting, may also characterize this condition.[news-medical.net]
  • Abdominal pain and tenderness are common and may be accompanied by left shoulder pain, a distended abdomen and nausea.[livestrong.com]
  • Radiation (sometimes): spleen pain can radiate to the left middle back or the tip of the left shoulder blade Pain is often the only symptom of a splenic disorder but–depending on the cause–it can be accompanied by localized tenderness, early satiety, nausea[ehealthstar.com]
Left Upper Quadrant Pain
  • In moderate to severe cases, the symptoms include the following: Chills Fever Nausea Vomiting Malaise Chest pain Left upper quadrant pain Left shoulder pain [ 7 ] Spleen Rupture Splenic rupture is an emergency condition involving the destruction of the[ihealthblogger.com]
Abdominal Bloating
  • bloating Trapped gas in the part of the colon near the spleen (splenic flexure syndrome) Side stitch during running (more common on the right side; disappears within minutes of rest) Hard exercise resulting in overstretched abdominal wall muscles Muscle[ehealthstar.com]
Acute Abdomen
  • Fever and chills develop in some cases. [28] It has to be differentiated from other causes of acute abdomen.[en.wikipedia.org]
Bleeding Gums
  • As a result, Gaucher patients’ blood may not clot well, and they may experience excessive bruising, frequent nosebleeds, bleeding gums, and longer, heavier menstrual periods. 3: Low red blood cell count (anemia) Red blood cells are responsible for carrying[cerezyme.com]
Blister
  • More severe cases of esetén can also lead to blistering, severe shedding of skin in the lép-betegség area and skin lesions. Fajták a psoriasis a lábak - The esetén are lép-betegség friendly and helpful. Lép-betegség was called pikkelysömör promptly.[hepoporyjuyimy.cf]
Left Shoulder Pain
  • Abdominal pain and tenderness are common and may be accompanied by left shoulder pain, a distended abdomen and nausea.[livestrong.com]
  • In moderate to severe cases, the symptoms include the following: Chills Fever Nausea Vomiting Malaise Chest pain Left upper quadrant pain Left shoulder pain [ 7 ] Spleen Rupture Splenic rupture is an emergency condition involving the destruction of the[ihealthblogger.com]
  • Enlarged spleen symptoms can include: indigestion or feeling uncomfortable when eating, especially after a large meal pain and tenderness around the spleen, on the upper left side of the abdomen pain that has spread from the abdomen to the left shoulder[spineboy.com]
Irritability
  • Pale skin More tired than usual Fever Unusually fussy or irritable Complains of abdominal pain (usually on the left side) In an emergency call 9-1-1. The following situations are emergencies.[nationwidechildrens.org]
  • Pain at the tip of the left shoulder on elevating the legs in the supine position: this is due to the presence of blood leaking from the spleen into the peritoneal cavity, pooling in and thereby irritating the left dome of the diaphragm when the patient[news-medical.net]
  • Some people report pain in the left shoulder, which occurs due to irritation of the diaphragm -- the muscle separating the chest and abdominal cavities.[livestrong.com]
  • Hiccups because of diaphragm irritation. Pain in the upper abdomen that may radiate to the back or shoulder blade.[medicinenet.com]

Workup

  • Generally, the workup for CD is the same that for any form of lymphadenopathy. Initial imaging is usually performed with CT, as the affected nodes or the localized mass in cases of CD demonstrate a dense homogeneous enhancement[ 22 ].[ncbi.nlm.nih.gov]
Thrombocytosis
  • Extramedullary hematopoiesis (production of blood cells in organs outside the bone marrow, such as the spleen and liver) Thrombosis and thrombohemorrhagic complications (blood clotting or bleeding complications) Leukocytosis (too many white blood cells) Thrombocytosis[mpnresearchfoundation.org]

Treatment

  • Know the causes, symptoms, treatment of Wandering Spleen. View Full Article ...[epainassist.com]
  • No patient discontinued treatment over the course of the 9-month study because of a treatment-emergent adverse event.[sciencedaily.com]
  • Surgeons in this program work closely with Internists, Oncologists, Hematologists, and Infectious Disease Specialists where appropriate for the diagnosis, and treatment of disorders of the spleen.[uphs.upenn.edu]
  • The treatment consists of dietary changes and traditional herbs. This regimen is supposed to improve the spleen’s health and reduce your anxiety levels.[healthyandnaturalworld.com]

Prognosis

  • Removal of the spleen can decrease the patient’s risk of portal hypertension and ascites, thus improving prognosis. Additionally, in the context of mast cell disease, an infiltrated organ is inflamed, which is in turn activating to mast cells.[mastattack.org]
  • What is the Prognosis for MF? There is no single prognosis for people who suffer from myelofibrosis– the prognosis of MF is different for every patient.[mpnresearchfoundation.org]
  • Cancer 50:259–268 Google Scholar Bennett MH, MacLennan RA, Easterling MJ, Vaughan Hudson B, Vaughan Hudson G, Jeliffe AM (1985) Analysis of histological subtypes in Hodgkin's disease in relation to prognosis and survival.[link.springer.com]
  • Enlarged Spleen Prognosis Depending upon the cause, the enlarged spleen may return to normal size and function when the underlying disease is treated or resolved.[emedicinehealth.com]

Etiology

  • Etiology systemic dissemination intraperitoneal spread from a ruptured hepatic hydatid cyst 1 retrograde spread from the liver to the spleen via the hepatic portal and splenic veins in portal hypertension 2 Imaging findings are similar to those of hepatic[radiopaedia.org]
  • Splenic trauma is another well-recognized etiologic factor.[emedicine.medscape.com]
  • Etiology Many of the mechanisms leading to splenomegaly are exaggerated forms of normal splenic function.[emedicine.medscape.com]
  • Abstract Castleman’s disease (CD) is a rare lymphoproliferative disorder of unknown etiology. Clinically, it occurs as a localized (unicentric) disease or as a systemic (multicentric) disease.[ncbi.nlm.nih.gov]
  • The Fingerprint of Antimitochondrial Antibodies and the Etiology of Primary Biliary Cholangitis (PBC).[sclero.org]

Epidemiology

  • Infection and high-altitude exposure are known precipitating factors for ASSC. [6] Epidemiology In the United States, one large series reported a palpable spleen in 2% of patients and another in 5.6% of patients. [7] Tropical splenomegaly syndrome occurs[emedicine.medscape.com]
  • […] catheterization in the newborn. [20] A case of chronic splenic abscess occurring as the initial manifestation of pancreatic tail carcinoma has been reported. [21] Splenic abscess has been reported as a rare complication of sleeve gastrectomy. [22, 23] Epidemiology[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • The stomach and pancreas can be affected in an analogous way. [8] Pathophysiology Splenic abscesses occur in a variety of clinical scenarios.[emedicine.medscape.com]

Prevention

  • Authors' conclusions: Splenectomy, if full, will prevent further sequestration and if partial, may reduce the recurrence of acute splenic sequestration crises.[cochrane.org]
  • Prevention and Control To prevent the spread of this disease, it is important to maintain effective sanitation and biosecurity. A commercial vaccine is available.[articles.extension.org]
  • Prevention and Control To prevent the spread of this disease, it is important to maintain effective sanitation and biosecurity . A commercial vaccine is available.[articles.extension.org]
  • Self-management and prevention If your spleen is enlarged, then you must completely avoid contact sports such as football, hockey, and soccer. Wearing a seat belt would benefit you. It prevents the damage to your spleen if you’re in a car accident.[gleneaglesglobalhospitals.com]
  • Centers for Disease Control and Prevention. . Accessed June 14, 2016. Enlarged spleen. The Merck Manuals: Merck Manual Consumer Version. . Accessed June 14, 2016. Computed tomography (CT) — Abdomen and pelvis.[mayoclinic.org]

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