The challenge is to identify a minority of life threatening presentations. We describe young female presenting with diffuse abdominal pain, fever and vomiting. [adc.bmj.com]

No lymphadenopathy was present. [ncbi.nlm.nih.gov]

Small fatty lesion (black arrow) is also present in liver and small exophytic renal angiomyolipoma (white arrow) is present at lower pole of right kidney. [ajronline.org]

We present a patient with intermittent dilation of the pupil with no apparent cause. Case report A 39-year-old lady presented to the casualty with a traumatic corneal abrasion to the left eye. [nature.com]

• Fatigue

  Therefore, it is important to test a similar geometry under fatigue loading for understanding the characteristics of AE signals due to fatigue cracking. [mdpi.com]

  For some people, their liver or spleen or both may remain enlarged even after their fatigue ends. Most people get better in two to four weeks; however, some people may feel fatigued for several more weeks. [cdc.gov]

  People who are anemia fatigue easily since there blood does not have enough oxygen carrying cells. [lifespan.org]

  Fatigue: Anemia causes fatigue, and it’s common for patients with Gaucher disease to experience excessive tiredness. However, not all fatigue in Gaucher disease is due to anemia. [gaucherdisease.org]

• Splenomegaly

  A length of 11 cm to 20 cm indicates splenomegaly, and a length greater than 20 cm is definitive of massive splenomegaly. [ncbi.nlm.nih.gov]

  Definition Splenomegaly is a larger-than-normal spleen. The spleen is an organ in the upper left part of the belly. [printer-friendly.adam.com]

  B) Splenectomy indicated if: Symptomatic splenomegaly ↑ rate of infections after splenectomy Risk vs. [slideshare.net]

  Because of its role in the immune system, infections can affect the spleen, causing splenomegaly, or an enlarged spleen. Viral illnesses can cause splenomegaly. [livestrong.com]

  Approach to the adult patient with splenomegaly and other splenic disorders. http://www.uptodate.com/home. Accessed June 14, 2016. Splenomegaly. [mayoclinic.org]

• Spleen Disease

  Highly specific and sensitive ELISA for the detection of antibodies against Big Liver and Spleen disease. The Big Liver and Spleen disease Antibody test kit measures the amount of antibodies to the Avian Hepatitis E Virus in the serum of chickens. [biochek.com]

  I'm sorry you are having to deal with this. http://www.thepoultrysite.com/diseaseinfo/12/big-liver-and-spleen-disease/ [backyardchickens.com]

  Marble Spleen Disease in Pheasants Marble spleen disease typically affects pheasants three to eight months of age. Pheasants that have contracted this virus exhibit depression, enlarged mottled spleens, and lung congestion. Infection leads to death. [articles.extension.org]

  Spleen disease NOS, Diseases of spleen, Splenic Diseases [Disease/Finding], disease splenic, disorders spleen, Disease;spleen, disorder spleen, disease spleen, spleen diseases, of spleen disease, diseases of the spleen, diseases of spleen, spleen disease [fpnotebook.com]

• Tender Spleen

  Fullness in Stomach In mild acute spleen conditions and chronic problems, spleen pain and tenderness are often not present. [healthhype.com]

  In HS a crisis can cause yellowing of your skin or the whites of your eyes (jaundice), anaemia and a tender spleen very quickly. They can be triggered by viral infections such as colds and flu. [patient.info]

• Nausea

  Common symptoms of a primary brain tumor are headaches, seizures, memory problems, personality changes, and nausea and vomiting. Causes and risk factors include age, gender, family history, and exposure to chemicals. [medicinenet.com]

  In moderate to severe cases, the symptoms include the following: Chills Fever Nausea Vomiting Malaise Chest pain Left upper quadrant pain Left shoulder pain [ 7 ] Spleen Rupture Splenic rupture is an emergency condition involving the destruction of the [ihealthblogger.com]

  Radiation (sometimes): spleen pain can radiate to the left middle back or the tip of the left shoulder blade Pain is often the only symptom of a splenic disorder but–depending on the cause–it can be accompanied by localized tenderness, early satiety, nausea [ehealthstar.com]

  Abdominal pain and tenderness are common and may be accompanied by left shoulder pain, a distended abdomen and nausea. [livestrong.com]

  Nausea, pallor, extreme nervousness, or fainting, may also characterize this condition. [news-medical.net]

• Abdominal Pain

  We describe young female presenting with diffuse abdominal pain, fever and vomiting. Case presentation A previously well 4 year old female presented with sudden onset of severe central abdominal pain, vomiting and fever. [adc.bmj.com]

  In adulthood, wandering spleen most often causes abdominal pain or present as an abdominal mass that does not cause symptoms (asymptomatic). Causes The exact cause of wandering spleen is not known. [rarediseases.org]

  pain Acute pancreatitis Stomach ulcer or cancer Rare causes of upper left abdominal pain: Adrenal gland tumor Abdominal adhesions (after surgery or in endometriosis) Broken rib An injury of the long thoracic nerve Shingles (Herpes zoster) Pneumothorax–collapsed [ehealthstar.com]

  Abdominal pain and back pain can have other causes. If you notice these symptoms see your doctor. [healthline.com]

• Left Upper Quadrant Pain

  In moderate to severe cases, the symptoms include the following: Chills Fever Nausea Vomiting Malaise Chest pain Left upper quadrant pain Left shoulder pain [ 7 ] Spleen Rupture Splenic rupture is an emergency condition involving the destruction of the [ihealthblogger.com]

  The spleen is an intraperitoneal organ in the left upper quadrant and is supported by the gastrosplenic and splenorenal ligaments. [ajronline.org]

• Abdominal Bloating

  […] left abdominal pain is caused by: Abdominal bloating Trapped gas in the part of the colon near the spleen (splenic flexure syndrome) Side stitch during running (more common on the right side; disappears within minutes of rest) Hard exercise resulting [ehealthstar.com]

  Abdominal bloating, distended abdomen, anorexia, and/or early satiety may also occur. Commonly, patients will present with symptoms due to the underlying illness causing splenomegaly. [ncbi.nlm.nih.gov]

• Abdominal Mass

  In adulthood, wandering spleen most often causes abdominal pain or present as an abdominal mass that does not cause symptoms (asymptomatic). Causes The exact cause of wandering spleen is not known. [rarediseases.org]

• Jaundice

  Jaundice can occur for many different reasons. (For example, a common reason for jaundice is because the liver isn't working properly.) In HS you become jaundiced because your red cells are broken down too quickly. [patient.info]

  Liver diseases like cirrhosis also present with jaundice and can cause hypersplenism as well thereby leading to more severe jaundice. Bleeding Disorders The spleen also holds up to 40% of the total platelet mass in the body. [healthhype.com]

  The cells eventually become damaged and results in anemia and jaundice. Children with HS are given folic acid supplements on a daily basis. The spleen is removed after a child reaches the age of five. [my.clevelandclinic.org]

  Jaundice, or yellowing of the skin, eyes, and mouth. Jaundice is a common sign and symptom of sickle disease. Sickle cells do not live as long as normal red blood cells and, therefore, they are dying faster than the liver can filter them out. [hopkinsmedicine.org]

  […] that may include: Jaundice Fatigue Weakness Itching Loss of appetite Easy bruising Ineffective white blood cell function may cause infections more often. [medicinenet.com]

• Bleeding Gums

  These can vary from bleeding gums, petechiae (bruises) that occur spontaneously and easily on the skin, prolonged menstrual periods and heavy on the female, to bleeding, even cerebral. [bendomd.com]

  As a result, Gaucher patients’ blood may not clot well, and they may experience excessive bruising, frequent nosebleeds, bleeding gums, and longer, heavier menstrual periods. 3: Low red blood cell count (anemia) Red blood cells are responsible for carrying [cerezyme.com]

• Fracture

  […] susceptible to fractures. 8: Pathological fracture Pathological fractures are broken bones caused by disease rather than by trauma (such as impact from a fall or accident). [cerezyme.com]

  Spontaneous fractures: Osteopenia (bone loss) and osteoporosis weaken the bones, making them more likely to break. Bone fractures in patients with Gaucher disease can occur even without trauma. [gaucherdisease.org]

  Head injuries due to bleeding are generally classified by the location of the blood within the skull, these include: epidural hematoma, subdural hematoma, subarachnoid bleed, intracranial bleed, sheer injury, edema, and skull fracture. [medicinenet.com]

  In spite of this, it may occur with a very forceful blow to the abdominal area, as may happen during a fight, a motor accident, during a contact sport, or because of a rib fracture, with the broken end of the rib penetrating the spleen. [news-medical.net]

• Left Shoulder Pain

  Abdominal pain and tenderness are common and may be accompanied by left shoulder pain, a distended abdomen and nausea. [livestrong.com]

  […] body, such as the shoulders, left side of the chest, back, and umbilicus. [ihealthblogger.com]

  Enlarged spleen symptoms can include: indigestion or feeling uncomfortable when eating, especially after a large meal pain and tenderness around the spleen, on the upper left side of the abdomen pain that has spread from the abdomen to the left shoulder [spineboy.com]

• Blister

  More severe cases of esetén can also lead to blistering, severe shedding of skin in the lép-betegség area and skin lesions. Fajták a psoriasis a lábak - The esetén are lép-betegség friendly and helpful. Lép-betegség was called pikkelysömör promptly. [hepoporyjuyimy.cf]

• Dizziness

  Pain of the the spleen may be with pain in left shoulder (radiation), and other symptoms such as dizziness or fainting. [bendomd.com]

  Lightheadedness or Dizziness The spleen holds and filters large amounts of blood. A rupture in the spleen can affect the hemodynamics in the body. [healthhype.com]

  When substantial bleeding occurs, signs and symptoms of shock often develop, including: Low blood pressure Rapid heart rate and breathing Cold, clammy skin Dizziness or fainting Blurry vision Anxiousness or restlessness A splenic infarction refers to [livestrong.com]

  Cardiovascular instability such as dizziness and tachycardia because of intraperitoneal haemorrhage. [news-medical.net]

  C arose from sleep to urinate when, just before micturition, she felt dizzy and subsequently had to sit down on the bathroom floor. She was shaky and sweaty, but after a few moments the symptoms passed and she went back to bed. [clinicaladvisor.com]

• Irritability

  Stage 1: irritation of the ipsilateral parasympathetic fibers overlying the oculomotor nerve → constriction of the ipsilateral pupil Stage 2: Compression of the ipsilateral parasympathetic fibers overlying the oculomotor nerve → dilation of the ipsilateral [amboss.com]

  Pale skin More tired than usual Fever Unusually fussy or irritable Complains of abdominal pain (usually on the left side) In an emergency call 9-1-1. The Following Situations Are Emergencies. [nationwidechildrens.org]

  Hiccups because of diaphragm irritation. Pain in the upper abdomen that may radiate to the back or shoulder blade. [medicinenet.com]

  Some people report pain in the left shoulder, which occurs due to irritation of the diaphragm -- the muscle separating the chest and abdominal cavities. [livestrong.com]

• Vertigo

  If the cholesteatoma passes posteriorly through the aditus ad antrum into the mastoid itself, erosion of the tegmen mastoideum, with exposure of the dura and erosion of the lateral semicircular canal with deafness and vertigo, may result. [radiologyassistant.nl]

  Vertigo. Huimaus, heidytys, pyöry, wiemistyö, V-gine afficior. Huimaun, huimerrun. Vesania Heikkomielisyys, houste. Vesica urinaria. Kusitin, kusirakko Vibex. Palko, wannet, mustelma, V. rufa. Werinaarma, werijuoni, sinelmä, sini marja. [doctrinepublishing.com]

Jaundice Itching Rashes Eczematous rash Icterus Cherry red retinal spots Cloudy corneas Dyspnea Fatigue New murmur Abdominal tenderness Enlarged liver Joint pain Poor bone growth Bone pain Poor vision Uveitis Iritis Loss of developmental milestones Workup [emedicine.medscape.com]

Generally, the workup for CD is the same that for any form of lymphadenopathy. Initial imaging is usually performed with CT, as the affected nodes or the localized mass in cases of CD demonstrate a dense homogeneous enhancement[ 22 ]. [ncbi.nlm.nih.gov]

• Thrombocytosis

  […] hereditary spherocytosis pyruvate kinase deficiency thrombotic thrombocytopenic purpura (TTP) neoplastic/proliferative/redistribution of hematopoiesis myeloproliferative neoplasms* chronic myeloid leukemia primary myelofibrosis polycythemia vera essential thrombocytosis [radiopaedia.org]

  Extramedullary hematopoiesis (production of blood cells in organs outside the bone marrow, such as the spleen and liver) Thrombosis and thrombohemorrhagic complications (blood clotting or bleeding complications) Leukocytosis (too many white blood cells) Thrombocytosis [mpnresearchfoundation.org]

Know the causes, symptoms, treatment of Wandering Spleen. View Full Article ... [epainassist.com]

No patient discontinued treatment over the course of the 9-month study because of a treatment-emergent adverse event. [sciencedaily.com]

Treatment for spleen disorders Treatment depends on the disorder and its specific cause. [betterhealth.vic.gov.au]

Surgeons in this program work closely with Internists, Oncologists, Hematologists, and Infectious Disease Specialists where appropriate for the diagnosis, and treatment of disorders of the spleen. [uphs.upenn.edu]

What is the Prognosis for MF? There is no single prognosis for people who suffer from myelofibrosis– the prognosis of MF is different for every patient. [mpnresearchfoundation.org]

6.1 INTRODUCTION 6.1.1 Maintenance and Prognosis 6.1.2 Types of Maintenance 6.1.2.1 Corrective Maintenance 6.1.2.2 Preventive Maintenance 6.1.2.3 Condition-Based Maintenance 6.2 PROGNOSIS TECHNIQUES 6.2.1 Concept of Prognostics 6.2.2 Remaining Useful [schweitzer-online.de]

Differential Diagnosis Malaria Lymphoma Portal hypertension Schistosomiasis Gaucher disease Thalassemia Niemann Pick disease Prognosis The prognosis for patients with splenomegaly depends on the condition causing the enlargement. [ncbi.nlm.nih.gov]

Removal of the spleen can decrease the patient’s risk of portal hypertension and ascites, thus improving prognosis. Additionally, in the context of mast cell disease, an infiltrated organ is inflamed, which is in turn activating to mast cells. [mastattack.org]

From What is the prognosis for an enlarged spleen? Can you live without it? Often, the prognosis for an enlarged spleen depends entirely upon the underlying illness. [medicinenet.com]

Etiology Physiological anisocoria: idiopathic; occurs in up to 20% of individuals Size difference between pupils is typically < 1 mm Degree of anisocoria does not change in response to changes in ambient light Typically intermittent and self-limiting [amboss.com]

Etiology systemic dissemination intraperitoneal spread from a ruptured hepatic hydatid cyst 1 retrograde spread from the liver to the spleen via the hepatic portal and splenic veins in portal hypertension 2 Imaging findings are similar to those of hepatic [radiopaedia.org]

Splenomegaly may be a transient condition due to acute illness or may be due to serious underlying acute or chronic pathology.[1][2][3] Etiology The most common causes of splenomegaly include: Liver disease (cirrhosis, hepatitis) Acute or chronic infection [ncbi.nlm.nih.gov]

Splenic AbscessSplenic Abscess  Uncommon, but fatal  Erode into adjacent structures  Most are secondary in etiology  Bacterial endocarditis  Intrabdominal infections (pyelo-, etc)  Infected splenic hematoma  Infected splenic infarctions (embolizations [slideshare.net]

Den vetenskapliga litteraturen kring psykotraumatologi och traumatisk stress specifikt, varierar i sina definitioner omkring trauma, dess etiologi och terminologi. [trolec.guineegames.org]

[…] probabilities are becoming increasingly relevant to our understanding of multi-parasite epidemiology [30,31,32]. [parasitesandvectors.biomedcentral.com]

The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunity. Ann Trop Med Parasitol. 1995 Aug. 89(4):359-76. [Medline]. Pitney WR. [emedicine.medscape.com]

Epidemiology Splenomegaly is a rare condition, with an estimated prevalence of approximately 2% of the total United States population. In adults, there has been no reported predominance in prevalence based on ethnicity, gender, or age. [ncbi.nlm.nih.gov]

Pathophysiology Anatomy The spleen is the largest lymphoid organ in the body. [emedicine.medscape.com]

Pathophysiology Splenomegaly can be classified based on its pathophysiologic mechanism: Congestive, by pooled blood (e.g., portal hypertension) Infiltrative, by invasion by cells foreign to the splenic environment (e.g., metastases, myeloid neoplasms, [ncbi.nlm.nih.gov]

Changes in pupil size are governed by pupillary sphincter (parasympathetic) and the pupillary dilator muscle (sympathetic) tone in response to ambient light, adrenergic and cholinergic tone, and local pharmacologic or pathophysiologic conditions. [ajnr.org]

We identified robust multi-parasite associations that were not predicted to vary much across environmental gradients, suggesting these associations represent true biological phenomena that can be used to gain deeper insights into (i) which pathophysiological [parasitesandvectors.biomedcentral.com]

Authors' conclusions: Splenectomy, if full, will prevent further sequestration and if partial, may reduce the recurrence of acute splenic sequestration crises. [cochrane.org]

Prevention and Control To prevent the spread of this disease, it is important to maintain effective sanitation and biosecurity. A commercial vaccine is available. [articles.extension.org]

Prevention Vaccines can protect against harmful infections. Washing your hands is one of the best ways to help prevent getting an infection. [cdc.gov]