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Splenic Artery Aneurysm

The splenic artery is the most common site of an aneurysm in the splanchnic circulation, occurring at the arterial bifurcation as it enters the hilus in most cases. Pathogenesis includes factors that increase vascular stress, such as multiple pregnancies and portal hypertension. This aneurysm is often discovered incidentally, but severe and life-threatening bleeding with resultant shock may develop. Diagnosis is made by imaging studies and treatment includes various surgical techniques.


Presentation

The majority of patients are asymptomatic and the diagnosis of SAA is often made incidentally. When symptoms are present, initial complaints include abdominal pain, specifically in the left upper quadrant or in the epigastric region, together with nausea and vomiting [13]. Development of rapidly progressive hypotension and hypovolemic shock can be frequently observed in the event of the aneurysmal rupture, which can often be life-threatening and can manifest with pallor, progressive weakness and poor general condition of the patient, which necessitates rapid treatment.

Splenectomy
  • Laparoscopic distal pancreatectomy with splenectomy is an appropriate minimally invasive option for the treatment of splenic artery aneurysms.[ncbi.nlm.nih.gov]
Pathologist
  • The case demonstrates how PMCT can strongly suggest the region of bleeding in the abdomen, may provide a provisional diagnosis, and guide the forensic pathologist before the formal autopsy examination, given the particular circumstances of a case, indicates[ncbi.nlm.nih.gov]
Anemia
  • Anemia is evident a few hours after the onset of symptoms [ 12 ]. Plain abdominal x-ray may show a calcified ring with central lucency [ 22 ]. CT scan or ultrasonography often confirms the diagnosis by demonstrating both SAA and hemoperitoneum.[esciencecentral.org]
Splenomegaly
  • Initially, splenomegaly and thrombocytopenia were noted; SSRS was observed later with a tortuous dilated splenic artery, and a SAA was then progressively formed and found.[ncbi.nlm.nih.gov]
  • Amany of these patients have associated portal hypertension as the causative factor, splenomegaly and splenic hilar varices may also be seen.[sonoworld.com]
  • Hypertension and splenomegaly are both risk factors identified in the present case. The SAA is an uncommon typically asymptomatic clinical entity in 80% of the cases [2].[edoriumjournals.com]
  • […] causes of SAA, [3] whereas others claim that atherosclerosis is a secondary event in SAA. [4] Preliminary weakness of the arterial wall with concomitant increase in blood pressure is considered to promote aneurysm formation. [7] Liver diseases with splenomegaly[jpgmonline.com]
Abdominal Pain
  • Left-sided abdominal pain then developed several times after strenuous physical labor, and the patient was referred to a nearby hospital.[ncbi.nlm.nih.gov]
Abdominal Pain
  • Left-sided abdominal pain then developed several times after strenuous physical labor, and the patient was referred to a nearby hospital.[ncbi.nlm.nih.gov]
Acute Abdomen
  • Spontaneous rupture of splenic artery aneurysm is a rare cause of acute abdomen with hemorrhagic shock that is a life-threatening surgical emergency.[ncbi.nlm.nih.gov]
  • Gray scale and color Doppler sonography play a key role in the diagnosis of splenic artery aneurysm, since many of these aneurysms are either detected as incidental findings or they present with rupture and as acute abdomen. Ultrasound features: 1.[sonoworld.com]
Hematemesis
  • A 77-year-old man presented with a history of intermittent episodes of hematemesis and abdominal pain. Upper gastrointestinal endoscopy showed no obvious bleeding point, but clots were seen in the stomach and duodenum.[ncbi.nlm.nih.gov]
  • Patients may also present with melena, hemosuccus pancreaticus or hematemesis [1] [2] [4].[edoriumjournals.com]
Upper Abdominal Pain
  • At admission, the patient had developed upper abdominal pain. Fetal demise and hemoperitoneum were diagnosed. An abdominal computed tomography (CT) scan revealed SAA rupture.[ncbi.nlm.nih.gov]
  • Case 2 A 27-year-old nonalcoholic male with sudden onset upper abdominal pain for two days had a sudden unexplained cardiovascular collapse.[jpgmonline.com]
  • A diagnosis of ruptured SAA should be considered in any pregnant patient who complains of sudden epigastric or upper abdominal pain, with or without shock. This is a report of two cases where the mothers were saved but the foetuses were lost.[omjournal.org]
Vascular Disease
  • Splenic artery aneurysms are an uncommon form of vascular disease, which have a significant potential for rupture, most commonly associated with pregnancy, typically presents as sudden, unexpected death.[ncbi.nlm.nih.gov]
  • Vascular diseases, such as hypertension, and polyarteritis nodosa have been mentioned as potential factors as well.[symptoma.com]
  • disease have rapidly gained interest, due to a less invasive approach, shorter hospital stays, and less patient morbidity.[vasculardiseasemanagement.com]
  • diseases I73.0 Raynaud's syndrome I73.00 …… without gangrene I73.1 Thromboangiitis obliterans [Buerger's disease] I73.8 Other specified peripheral vascular diseases I73.89 Other specified peripheral vascular diseases I73.9 Peripheral vascular disease[icd10data.com]
Fracture
  • Radiography revealed no fracture, and the patient went home. He stopped working for 7 months. Left-sided abdominal pain then developed several times after strenuous physical labor, and the patient was referred to a nearby hospital.[ncbi.nlm.nih.gov]
Wide Neck
  • We describe the endovascular treatment of a wide-neck splenic artery aneurysm (SAA) using a stent-assisted coil embolization technique.[ncbi.nlm.nih.gov]
  • Saudi J Gastroenterol 2 Stent-Assisted Coil Embolization of a Complex Wide-Neck Splenic Artery Aneurysm Nazzareno Stella,Giovanni Palombo,Christiana Taddeo,Luigi Rizzo,Maurizio Taurino Annals of Vascular Surgery. 2013; 27(8): 1187.e5 3 Intragastric rupture[saudijgastro.com]
  • Coil embolization of a wide-neck splenic artery aneurysm using a remodeling technique. Am J Roentgenol 2002:179: 1327-29.[hcplive.com]
  • The aneurysm was noted to have a wide neck with the guidewire preferentially selecting the aneurysm itself.[esciencecentral.org]
Cesarean Section
  • After being diagnosed with intra-pancreatic SAA rupture, she was delivered of a live fetus by cesarean section. This is a rare case with both fetal and maternal survival.[ncbi.nlm.nih.gov]
Flank Pain
  • A 35-year-old, morbidly obese, African American woman presented with constant left flank pain for 4 weeks. Angiography confirmed a 2.5-cm splenic artery aneurysm near the splenic hilum.[ncbi.nlm.nih.gov]
  • We report a patient who presented with acute left flank pain caused by multiple splenic hematomas without intraperitoneal bleeding and who developed hemoperitoneum with hemodynamic instability 72 hours after symptom onset.[ceemjournal.org]
Confusion
  • However, in the eventuality of death a comprehensive forensic autopsy is the only investigation to recognise such calamity and clear clinical confusion.[ncbi.nlm.nih.gov]

Workup

Although various imaging studies may determine the presence of SAA, the general condition of the patient may significantly reduce the number of viable imaging studies and the diagnosis of may be difficult to attain during early stages. Ultrasonography is usually the initial method of choice, while an emergency CT scan can be used to determine the presence of an aneurysm through the use of contrast [14]. If the patient is stable, regular CT or MRI of the abdomen may be performed. However, the gold standard in diagnosing SAA is angiography [15], which can detect the exact location and size of the aneurysm. More importantly, information obtained by this diagnostic method including size, location, and degree of rupture are vital in determining optimal treatment strategies.

Coxiella Burnetii
  • We report the first known case of a 6 cm mycotic splenic artery aneurysm proximal to the splenic hilum, secondary to bacterial endocarditis from Coxiella burnetii. Resection of the aneurysm, splenectomy, and distal pancreatectomy were performed.[ncbi.nlm.nih.gov]

Treatment

Surgery is the mainstay of treating patients with SAA and indications for surgical treatment include symptomatic aneurysms and those that are > 2 cm in diameter [14]. Women in their childbearing age and liver transplant candidates are individuals in whom asymptomatic SAA is indicated for surgical management [14]. Various modalities exist [1]:

  • Open laparotomy - This method was once considered to be preferable in managing SAA, which includes ligation of the aneurysm, but in some cases, splenectomy was necessary because of the location of the aneurysm. However, recent advances in surgical techniques have replaced this method, presumably in the attempt to preserve the spleen and reduce the number of complications this procedure can cause in comparison to newer techniques.
  • Percutaneous embolization and stent grafting - These minimally invasive methods are often used and are considered to be the preferable methods of treatment [16], because of their low complication rates, the need for only local anesthesia and reduced hospital stay. However, SAA occurring at the splenic hilum cannot be managed by this method and requires other forms of surgery [1].
  • Laparoscopic ligation - Since the introduction of laparoscopy, surgical management of many conditions has been revolutionized. This method provides much lower complication rates compared to open surgery and has the ability to perform almost exact procedures. In the case of SAA, laparoscopy with ligation of splenic artery and dissection of the aneurysm can be performed together with the ability to preserve splenic blood flow. This procedure carries complications as well, including pancreatic injury during dissection of the aneurysm.

Prognosis

In the past few decades, the use of novel imaging techniques has led to the discovery of many SAAs incidentally, as the majority of patients are asymptomatic, and they have a good prognosis when discovered in early stages. The overall risk of rupture varies between studies and ranges between 5-25% [5]. When ruptures do occur, they can cause severe and life-threatening complications, with mortality rates reaching up to 70% [5]. Pregnant women in their third trimester or prior to labor are at most risk in the event of SAA rupture, as mortality rates have been established to be 70% for the mother and 90-95% for the fetus [3], which illustrates the risk this condition may cause.

Etiology

The exact cause of SAA remains to be discovered, but several factors are thought to be involved. Estrogen effects on vascular tissue, accelerated blood flow and disturbances in collagen synthesis have all been implied in the pathogenesis. Numerous conditions that exert such effects have been associated with SAA, including pregnancy and portal hypertension being the two most important, while medial fibrodysplasia, atherosclerosis, pancreatitis, collagen vascular disease and various other have been associated with this type of aneurysm [1]. Vascular diseases, such as hypertension, and polyarteritis nodosa have been mentioned as potential factors as well [1].

Epidemiology

SAAs are rare but are established to be the most common visceral aneurysms, comprising about 60% [7], and it is established to be the third most common aneurysm overall, with abdominal aortic and iliac being first and second, respectively [8]. The most common site is established to be at the bifurcation as the splenic artery enters the hilum, but aneurysms can occur at any point during its course and sometimes more than one aneurysm can develop. Incidence rates of SAA range from 0.02%-10.4% in the general population [8], while prevalence rates range from 0.1%-2% according to certain studies [9][10]. Gender predilection toward females is quite prominent, as SAA is almost four times more frequently seen in women, with multiple pregnancies being the most important risk factor. Increasing age is also deemed to be a risk factor for SAA, but patients of any age may develop this type of aneurysm [11].

Sex distribution
Age distribution

Pathophysiology

Initial theories of SAA development included congenital defects of arterial walls, as well as atherosclerosis, as potential causes of this vascular malformation, but recent studies indicate that atherosclerosis plays a minor role. Presumably, increased local pressures within vascular compartments due to portal hypertension or multiple pregnancies cause significant amounts of stress to the vessel wall [11]. Pathological changes in the tunica media include degeneration of collagen and elastic fibers that result in disruption of normal arterial architecture [12]. Cells of the tunica media are replaced by a mucoid material, eventually leading to the formation of aneurysms. However, the exact pathophysiologic mechanism of SAA remains to be discovered.

Prevention

Since the cause and pathogenesis of SAA have only been partially determined, current preventive strategies could be aimed at the screening of individuals who are at risk for developing this lesion, such as those with portal hypertension, pancreatitis, and pregnant women. Cause-directed prevention is currently not possible.

Summary

Splenic artery aneurysm (SAA) is one of the most frequently encountered aneurysms, as it is the most common aneurysm of the splanchnic circulation and the third most common overall, after abdominal aortic and iliac [1]. The majority of SAAs are true aneurysms and several theories have been made regarding its pathogenesis. Having in mind the fact that it is almost four times more frequently diagnosed in women and that multiple pregnancies are established to be one of the most important risk factors, the effects of estrogen on vascular tissue is assumed to play a significant role [2]. Additionally, portal hypertension, pancreatitis and various other conditions that increase splenic blood flow are thought to contribute as well [1]. Atherosclerosis, on the other hand, is thought to be only partially involved. The majority of SAAs are discovered incidentally since the majority of patients are asymptomatic, but when symptomatic, it may cause bleeding that can be life-threatening. The overall risk of rupture ranges from 5-25% in different studies. More importantly, mortality rates in case of rupture are very high in pregnant women, with maternal mortality rates reaching 70%, while fetal mortality rates are over 90% [3], implying that SAA can be fatal for patients if not diagnosed on time. Abdominal pain, vomiting and rapid development of shock are most common findings in symptomatic SAAs. The diagnosis can be made by various imaging studies, including computed tomography (CT scan), ultrasonography, and magnetic resonance imaging (MRI), but the definite method of assessing the features of an aneurysm and determine the need for therapy is angiography [4]. Indications for surgical treatment, which is the method of choice, includes symptomatic aneurysms, the diameter of > 2 cm, pregnancy and progressive growth of the aneurysm [5]. Open laparotomy, laparoscopy, open surgery and percutaneous embolization are all options. Their utilization depends on various factors [6], including the location of the aneurysm, diameter and general condition of the patient.

Patient Information

Splenic artery aneurysm is a condition that describes the development of an aneurysm in the splenic artery. An aneurysm is a sac-like formation of the blood vessel wall. This part of the vessel wall is more prone to rupture and can result in bleeding that can be life-threatening. The exact cause, however, remains unknown, but in the case of splenic artery aneurysm, factors that are established to significantly increase the risk of its development include portal hypertension (increased pressure in the vessels of organs situated in the abdomen) and multiple pregnancies. Moreover, this disorder is almost four times more frequently diagnosed in women, which indicated that perhaps hormonal factors also play a role in the development of this vascular malformation. Although the majority of patients are asymptomatic and this aneurysm is often discovered incidentally, rupture of splenic artery aneurysm can occur and can be fatal. The overall risk of rupture is estimated to be between 5-25%. Women in their third trimester or prior to labor are at a very high risk of developing life-threatening complications, which is why screening for this condition may be favorable. Symptoms, when present, include the sudden appearance of abdominal pain, nausea, and vomiting. A rapid onset of decreased blood pressure and shock may be evident, which requires immediate treatment. The diagnosis can be made by various imaging techniques, such as ultrasound, computed tomography (CT scan) or magnetic resonance imaging (MRI), but a definite diagnosis can be made by angiography, which comprises insertion of contrast that will visualize all blood vessels and determine the site of the rupture. Treatment is indicated in all symptomatic patients and in those where the aneurysm exceeds 2 centimeters in diameter, with surgery being the universal method. Various surgical techniques can be used, including laparoscopy, laparotomy, open surgery, use of stents and catheterization and the choice depends on several factors, including the location of the aneurysm, its size but also the general condition of the patients. Overall, this condition can pose a life-threatening risk for patients and its identification during asymptomatic stages can significantly reduce the rate of complications.

References

Article

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  2. Hallett JW. Jr. Splenic artery aneurysms. Semin Vasc Surg. 1995;8(4):321–326.
  3. Cailouette JC, Merchant EB. Ruptured splenic artery aneurysm in pregnancy: twelfth reported case with maternal and fetal survival. Am J Obstet Gynecol. 1993;168(6 Pt 1):1810–1813.
  4. Jesinger RA, Thoreson AA, Lamba R. Abdominal and pelvic aneurysms and pseudoaneurysms: imaging review with clinical, radiologic, and treatment correlation. Radiographics. 2013;33:E71–96.
  5. Pasha SF, Gloviczki P, Stanson AW, Kamath PS. Splenic artery aneurysm. Mayo Clin Proc. 2007;82(4):472–479.
  6. Hashizume M, Ohta M, Ueno K, Okadome K, Sugimachi K. Laparoscopic ligation of splenic artery aneurysm. Surgery. 1993;113(3):352–354.
  7. Agrawal A, Whitehouse R, Johnson RW, Augustine T. Giant splenic artery aneurysm associated with arteriovenous malformation. J Vasc Surg. 2006;44:1345–1349.
  8. Abbas MA, Stone WM, Fowl RJ, et al. Splenic artery aneurysms: two decades experience at Mayo Clinic. Ann Vasc Surg. 2002;16(4):442–449.
  9. Stanley JC, Wakefeld TW, Graham, LM et al. Clinical importance and management of splanchnic aneurysms. J Vasc Surg. 1986;3:836-840.
  10. Carr SC, Pearce WH, Vogelzang RL, et al. Current management of visceral artery aneurysms. Surgery. 1996;120:627-633.
  11. Deshpande AA, Kulkarni VM, Rege S, Dalvi AN, Hardikar JV. Ruptured true aneurysm of the splenic artery: an unusual cause of haemoperitoneum. J Postgrad Med. 2000;46(3):191–192.
  12. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. Harrison's Principles of Internal Medicine, 18e. New York, NY: McGraw-Hill; 2012.
  13. Sarikaya S, Ekci B, Aktas C, Cetin A, Ay D, Demirag A. A rare clinic presentation of abdominal pain: rupture of splenic artery aneurysm: a case report. Cases J. 2009;2:148.
  14. Zubaidi A. Rupture of Multiple Splenic Artery Aneurysms: A Common Presentation of a Rare Disease with a Review of Literature. Saudi J Gastroenterol. 2009;15(1):55-58.
  15. Wagner WH, Allins AD, Treiman RL, et al. Ruptured visceral artery aneurysms. Ann Vasc Surg. 1997;11:342–347.
  16. Sessa C, Tinelli G, Porcu P, Aubert A, Thony F, Magne JL. Treatment of visceral artery aneurysms: description of a retrospective series of 42 aneurysms in 34 patients. Ann Vasc Surg. 2004;18:695–703.

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Last updated: 2019-07-11 20:44