Presentation
Present study suggested that there is no association between GST M1 null polymorphism and Handigodu syndrome risk. [yumpu.com]
The writing and presentation is concisely formatted, brilliantly accessible, and the book more than achieves its goals. [wonderclub.com]
ORPHA:99642 Synonym(s): - Prevalence: Unknown Inheritance: - Age of onset: Childhood, Adolescent, Adult ICD-10: Q77.7 OMIM: 613343 UMLS: - MeSH: - GARD: - MedDRA: - The documents contained in this web site are presented for information purposes only. [orpha.net]
Discussion: Only 2 patients presented in first 4 days of symptoms rest all presented late due to parentral neglect or failure of diagnosis or prolong medical treatment. [posi.in]
Flocculated dappled metaphyses, which definedStrudwick type as a distinct entity, are only present in the course of the disease afterthe age of 4 years. [documents.tips]
Entire Body System
- Disability
All the patients had significant disability and very low functional hip scores. [ncbi.nlm.nih.gov]
Fifty-four adult patients were examined and administered a questionnaire to evaluate the extent of disability attributable to the hips.ResultsThree patterns of changes in the hips were noted: 35% had acetabular protrusio, 33% had subluxation of the hip [scipers.com]
[…] with isolated growth hormone deficiency X-linked intellectual disability-hypogonadism-ichthyosis-obesity-short stature syndrome X-linked spondyloepimetaphyseal dysplasia [se-atlas.de]
- Pain
Spondyloepimetaphyseal dysplasia, Handigodu type Disease definition Spondyloepimetaphyseal dysplasia, Handigodu type is a rare, genetic, primary bone dysplasia disorder characterized by three distinct phenotypes, namely: 1) patients of average height with painful [orpha.net]
Pain may be felt in the arch of the foot, at the end of the first. In shoe-wearing cultures, Mortons toe can be problematic, for instance, wearing shoes with a profile that does not accommodate a longer second toe may cause foot pain. [wikivisually.com]
Medial ligament injury, Meniscal cartilage replacement therapy, Meniscal cyst, Meniscus injury, Osgood-Schlatter's disease, Osteoarthritis, Osteochondritis dissecans, Osteochondroma, Osteochondrosis, Osteosarcoma, Patellar tendinitis, Patello-femoral pain [wikidoc.org]
Keywords: Handigodu syndrome, ROS, Oxidative stress, GST M1 INTRODUCTION Handigodu syndrome is a rare, painful, endemic osteoarthritis affecting predominantly two endogamous populations Channangi and Chaluvadi residing in malnad region of Western Ghats [yumpu.com]
Clinical history regarding onset, duration and progress of pain was recorded for all patients. Vital parameters, range of motion of hip joint and severity of pain were also documented. [posi.in]
- Surgical Procedure
Another disorder is known as rachitis fetalis micromelica in which there is a deficiency in the growth of the bones, there is a surgical procedure called distraction osteogenesis which is used to lengthen long bones. [wikivisually.com]
These can be treated later or prior to graft procedure by limb lengthening procedures 7. Conclusion: Ilizarov and free fibular graft techniques are giving good results compared to other surgical procedures. [posi.in]
- Falling
Wikipedia Jog Falls, Gerosoppa Falls or Joga Falls is the second highest plunge waterfall in India located near Sagara taluk, Shimoga district in the state of Ka >>Get price Elemental Composition of Leaves of Memecylon talbotianum an endemic plant [esd-static.eu]
Mechanism of injury was falling on outstretched hand in 84; two road traffic accidents. 80 patients postermedial displacement and 6 with poster lateral displacement. 32 right and 54 left sided fractures. [posi.in]
- Swelling
He presented with a symptomatic swelling of the medial aspect of the left foot as a single swelling in the medial aspect of the foot, arising from the bone, which is hard. Skin over swelling is normal, non-tender. [posi.in]
This alleviates stressors on the foot and can decrease inflammation, icing will help reduce swelling and inflammation. [wikivisually.com]
Cardiovascular
- Heart Disease
Like many developing countries in Asia, it is passing through both demographic and epidemiological transitions whereby, at least in some parts, the diseases of severe poverty are being replaced by those of Westemisation; obesity, diabetes, and heart disease [books.google.com]
disease-characteristic facies syndrome Short stature-webbed neck-heart disease syndrome Short stature-wormian bones-dextrocardia syndrome Short-limb skeletal dysplasia with severe combined immunodeficiency Silver-Russell syndrome Silver-Russell syndrome [se-atlas.de]
While performing the physical examination, one should take care to search for nonosseous abnormalities such as cataracts, cleft palate, and congenital heart disease that would be useful in establishing the diagnosis and be helpful in formulating a treatment [musculoskeletalkey.com]
Liver, Gall & Pancreas
- Jaundice
Rajakumar, M B Shivanna Isolation, Identification and Asses >>Get price District, Haryana, India | Journal of Ethnobiology and The total population of the District was 880072, (684975 in Rural and villagers of Dharapuram Taluk, Tamil Nadu for treatment of jaundice [esd-static.eu]
Musculoskeletal
- Arthritis
Endemic familial arthritis of Malnad. Ind J Med Res. 1977;66:777–86. Google Scholar 2. Krishnamachari KVAR, Bhat RV. Endemic familial arthritis of Malnad. An outbreak in southern India. Trop Geog Med. 1977;30:33–7. Google Scholar 3. [link.springer.com]
All the patients had developed degenerative arthritis of the hips by the fourth decade of life irrespective of the pattern of hip involvement. [scipers.com]
Endemic familial arthritis of Malnad. Ind J Med Res. 1977;66:777–86. 2. Krishnamachari KVAR, Bhat RV. Endemic familial arthritis of Malnad. An outbreak in southern India. Trop Geog Med. 1977;30:33–7. 3. [springermedizin.de]
Juvenile chronic arthritis, Juvenile idiopathic arthritis, Juvenile Rheumatoid Arthritis, Still's disease, Erythema nodosum, Osteochondrosis, Psoriasis, Reactive arthritis, Reiter’s syndrome, Rheumatoid arthritis, Seronegative spondyloarthropathy, Synovitis [wikidoc.org]
- Platyspondyly
and 3) patients with dwarfism, various associated skeletal abnormalities (particularly of the knees and hands) and severe epiphyseal dysplasia (of hips, knees, hands, wrists) associated with significant platyspondyly. [orpha.net]
[…] sclerosis of articular margins, presence of osteophytes, protrusio acetabuli, flattening of femoral head, flattening and fragmentation of epiphyses, coxa vara, subchondral sclerosis, small pelvis, wedge-shaped vertebrae, irregularity of end plates, and platyspondyly [yumpu.com]
Here we describe a novel type of SEMD in two unrelated Turkish patients who presented with severe platyspondyly, kyphoscoliosis, pelvic distortion, constriction of the proximal femora and brachydactyly. [pubfacts.com]
The shortening of the spine in Morquio syndrome is primarily a result of platyspondyly. Another classification system is based on the age at which the first manifestation of the skeletal dysplasia appears. [musculoskeletalkey.com]
- Coxa Vara
vara, subchondral sclerosis, small pelvis, wedge-shaped vertebrae, irregularity of end plates, and platyspondyly [1,3]. [yumpu.com]
Orthopaedic complications include coxa vara,hip dislocation, kyphoscoliosis, cervical spine instability, genu valgum and prematureosteoarthritis. Regular ophtalmological survey is needed to evaluate myopia and pre-vent retinal detachment. [documents.tips]
vara pericarditis (CACP) AR Christian Brachydactyly AD 18. [gamuts.isradiology.org]
Spondylometaphyseal dysplasia (SMD) corner fracture type (also known as SMD "Sutcliffe" type, MIM 184255) is a rare skeletal dysplasia that presents with mild to moderate short stature, developmental coxa vara, mild platyspondyly, corner fracture-like [pubfacts.com]
vara pericarditis Christian brachydactyly Craniofacial conodysplasia Geleophysic dysplasia Myhre dysplasia Pseudohypoparathyroidism (Albright hereditary osteodystrophy) Saldino-Mainzer dysplasia Trichorhinophalangeal dysplasia type II (Langer-Giedion [musculoskeletalkey.com]
- Hip Dislocation
[…] knee, Dislocated patella, Fallen arches, Femoral condyle fracture, Fractured patella, Fractured tibial plateau, Gait problems, Gout, Gram's syndrome, Hip dislocation, Hip injury, Hip Replacement, Intermittent hydrarthrosis, Johansson-Sinding-Larsen syndrome [wikidoc.org]
11 There is progressive joint laxity with hip dislocation, andgenu valgum and mild scoliosis during childhood. [documents.tips]
Old infantile septic arthritis of hip 5 2. Tuberculosis of Hip 5 3. Unreduced old traumatic hip dislocation 2 4. Old unreduced DDH 4 5. Idiopathic chondrolysis 2 6. [posi.in]
- Osteophyte
Pressure allows enzymes to penetrate into subchondral bone bone neoformation spondylosis subchondral sclerosis enthesopathies periosteal calcifications osteophytes endo- or paraarticular calcifications deposits in seronegative spondyloarthropathies (interapophysary [ufrgs.br]
Radiographic investigations of affected individuals shows narrowing of the joint space, irregularity and sclerosis of articular margins, presence of osteophytes, protrusio acetabuli, flattening of femoral head, flattening and fragmentation of epiphyses [yumpu.com]
By the third decade of life 50% of the patients had osteophytes, 70% had demonstrable reduction of the joint space, 80% had incongruency of the articular surfaces and 100% had subchondral sclerosis. [posi.in]
Psychiatrical
- Suggestibility
Although so far there are limited data about genetic diseases in India, enough is known already to suggest that this will be an extremely fruitful area of research. [books.google.com]
Present study suggested that there is no association between GST M1 null polymorphism and Handigodu syndrome risk. [yumpu.com]
However Mubarak and Linton et al have shown that bowing of 1 mm of the dorsal border is suggestive of old ulnar deformity. Historically it has been suggested that Monteggia lesions are asymptomatic and should be left alone in childhood. [posi.in]
The existence of discrete inheritable units was first suggested by Gregor Mendel, from 1857 to 1864, in Brno, he studied inheritance patterns in 8000 common edible pea plants, tracking distinct traits from parent to offspring. [wikivisually.com]
Neurologic
- Excitement
In the current excitement generated by the human genome project and the molecular and genetic approach to the study of human disease, there is little doubt that this field will develop and flourish in India in the future. [books.google.com]
- Irritability
Conclusion: No obvious benefit of aspiration in clinically benign irritable hips. Aspiration increases analgesic requirements and probably increases in-patient stay. [posi.in]
Onset
- Onset in Adolescence
ORPHA:99642 Synonym(s): - Prevalence: Unknown Inheritance: - Age of onset: Childhood, Adolescent, Adult ICD-10: Q77.7 OMIM: 613343 UMLS: - MeSH: - GARD: - MedDRA: - The documents contained in this web site are presented for information purposes only. [orpha.net]
Treatment
The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment. [orpha.net]
Treatment is via a number of differing surgical procedures, congenital causes include, Aarskog syndrome, Albrights hereditary osteodystrophy, and Apert syndrome. Can be caused by a trauma, although the mechanism is not known. [wikivisually.com]
Research and treatment of various anomalies. [posi.in]
India N Rajakumar, M B Shivanna Isolation, Identification and Asses >>Get price District, Haryana, India | Journal of Ethnobiology and The total population of the District was 880072, (684975 in Rural and villagers of Dharapuram Taluk, Tamil Nadu for treatment [esd-static.eu]
Pediatric Orthopedic Deformities: Pathobiology and Treatment of Dysplasias, Physeal Fractures, Length Discrepancies, and Epiphyseal and Joint Disorders. New York: Springer; 2016. Vol 1: 338. Yang SS, Chen H, Williams P, et al. [emedicine.medscape.com]
Prognosis
Methods of measuring in Legg-Calve-Perthes disease with special regard to the prognosis. Clin Orthop. 1980;150:103–9. PubMed Google Scholar 9. Wiberg G. [link.springer.com]
Methods of measuring in Legg-Calve-Perthes disease with special regard to the prognosis. Clin Orthop. 1980;150:103–9. PubMed 9. Wiberg G. Shelf operation in congenital dysplasia of the acetabulum and in subluxation and dislocation of the hip. [springermedizin.de]
This classification is now widely used for planning treatment and for predicting prognosis in Perthes’ disease. [posi.in]
Prognosis SED is nonlethal, and life expectancy is not reduced. However, morbidity is increased, and regular monitoring and follow-up care should be encouraged. [emedicine.medscape.com]
Background : Spondyloepimetaphyseal dysplasia, short limb-abnormal calcifications type (SEMD, SL-AC) is a rare autosomal recessive condition with a grave prognosis. [pubfacts.com]
Etiology
Background : Environmental factors contribute to the etiology of cleft palate (CP). [pubfacts.com]
Bailey suggested two groups in addition to SED congenita and SED tarda: pseudo-Morquio disease and pseudoachondroplasia SED. [9] In this article, only the most common types of SED (ie, SED congenita and SED tarda) are discussed in detail. [10] Etiology [emedicine.medscape.com]
Epidemiology
Like many developing countries in Asia, it is passing through both demographic and epidemiological transitions whereby, at least in some parts, the diseases of severe poverty are being replaced by those of Westemisation; obesity, diabetes, and heart disease [books.google.com]
"Blood Pressure" [SH] (epidemiology AND humans) [SH] SI Secondary Source ID The SI field identifies secondary source databanks and accession numbers, e.g., GenBank, GEO, PubChem, ClinicalTrials.gov, ISRCTN. [biomedsearch.com]
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA. [pubfacts.com]
Linguistic Variant - Portuguese, Brazil) 2015AB LNC-RU-RU (LOINC Linguistic Variant - Russian, Russia) 2015AB LNC-TR-TR (LOINC Linguistic Variant - Turkish, Turkey) 2015AB LNC-ZH-CN (LOINC Linguistic Variant - Chinese, China) 2015AB MCM (Glossary of Clinical Epidemiologic [doctor.am]
Epidemiology International statistics SED congenita is a rare genetic disorder. The prevalence is approximately 3.4 per million population. [7] The incidence rate is approximately 1 per 100,000 live births. [emedicine.medscape.com]
Pathophysiology
In bone tissues, ROS generation is a key modulator of bone cell function/pathophysiology of mineralized tissues and is influenced by Research Article, Biotechnol. [yumpu.com]
Spranger and Langer provided a further review of 29 patients in 1970. [2] In 1969, Fraser noted the particular association of SED with myopia, retinal detachment, and deafness. [3] In 1939, Jacobsen recognized SED tarda in a report of 20 patients. [4] Pathophysiology [emedicine.medscape.com]
Prevention
Physical therapy can help prevent the symptoms from returning. Orthotic devices can help prevent future symptoms, the orthotic device will dig into the edge of the accessory navicular and cause discomfort. [wikivisually.com]
NCI_CTEP-SDC (Cancer Therapy Evaluation Program - Simple Disease Classification) 2015AB NCI_CareLex (Content Archive Resource Exchange Lexicon) 2015AB NCI_DCP (NCI Division of Cancer Prevention Program) 2015AB NCI_DICOM (Digital Imaging Communications [doctor.am]
CDC [CN] Centers for Disease Control and Prevention" [CN] DP Publication Date The date that the article was published. 2007/1/31[DP] 2001/3:2001/10[DP] 2009[DP] DTRE Date Revised The date a change was last made to a record as a result of NLM's individual [biomedsearch.com]
Management is aimed at maintainingmobility and preventing dislocations. [documents.tips]
One lesion in an older child progressed and a humeral nail was inserted to prevent stress fracture. The tibial lesion also failed to heal and needed intramedullary fixation to prevent a fracture. The femoral lesion had healed by one year. [posi.in]