Occasional dying keratinocytes may be present as a result of direct cytotoxicity in some cases. As a result of severe toxicity, extensive epidermal necrosis may be present [ 47, 48 ]. [plasticsurgerykey.com]

Vase-shaped collections were present in five of 49 consecutive biopsy specimens of spongiotic dermatitis, but in none of 50 specimens of mycosis fungoides. [insights.ovid.com]

Clinically, it is presented by erythematous 1–2 mm flat-topped papules on extremities. [e-ijd.org]

Reactive or psoriatic arthritis would have been considered had joint involvement been present. [casereports.bmj.com]

Those cells are present around the venules of the superficial plexus and between bundles of collagen in the upper part of the dermis. [derm101.com]

• Inflammation

  Dermatitis means inflammation of the skin and 'spongiotic' means that small blisters under the skin are part of the inflammatory picture. [answers.zocdoc.com]

  Applying topical calcineurin inhibitors, such as tacrolimus ointments and pimecrolimus creams, to control inflammation during flare-ups. These medications block a chemical that triggers inflammation in the skin and causes redness and itching. [medicalnewstoday.com]

  If your skin is still itchy and uncomfortable, try holding a cold compress, like an ice pack or a bag of frozen vegetables wrapped in a towel, to your skin to relieve inflammation. [wikihow.com]

  […] dermofibrosis, and focal epidermal necrosis (from excoriation) Subacute spongiotic dermatitis with erythrocyte extravasation and transepidermal elimination of erythrocytes Spongiotic pigmented purpuric eruption (PPE) Spongiosis with purely lymphoid perivascular inflammation [brainscape.com]

  Such aeroallergens result in allergic inflammation and a strong itching sensation. Scratching further disrupts the skin and causes more inflammation and more itching. [verywellhealth.com]

• Fever

  These factors include: preexisting conditions, like Parkinson’s disease, HIV, and heart conditions allergies, especially allergic conditions that run in the family, such as hay fever asthma insect bites frequent contact with certain metals or chemicals [healthline.com]

  Atopic dermatitis tends to run in families and can occur alongside other conditions, such as asthma and hay fever. [medicalnewstoday.com]

  […] defect in epidermal barrier function, which results in increased transepidermal water loss. 1 The criteria for AD include a pruritic skin condition plus 3 or more of the following: history of involvement of the skin creases, history of asthma or hay fever [mdedge.com]

  In a recent etiological study of 103 patients with erythroderma, the most common clinical symptoms included some degree of scaling, pruritus, diffuse erythema and fever. [cureus.com]

  In addition, a history of any extracutaneous symptoms (eg fevers, arthralgia) or family history (eg psoriasis) may be useful. As an example, a clinical history of ‘skin rash on the back’ does little to refine the diagnostic possibilities. [racgp.org.au]

• Pain

  He also developed persistent low back pain in the last 2 months. [karger.com]

  Allergy tests will be done that will determine exactly what substance is causing this painful skin rash. [medigoo.com]

  He had difficulty ambulating but denied joint pain or stiffness. [casereports.bmj.com]

  No systemic symptoms are associated with Grover disease, but oral lesions can develop that resemble aphthae and may be slightly painful Physical The process usually begins as an eruption of the skin on the anterior part of the chest, the upper part of [epathologies.com]

  Both conditions cause itching, but contact dermatitis also causes pain and burning. Age The age of a person experiencing atopic dermatitis is an important distinction between these two conditions. [verywellhealth.com]

• Swelling

  Endothelial swelling. What cutaneous lesions are associated with plasma cells? Kaposi's sarcoma Syphilis Leishmaniasis Rhinoscleroma Melanoma Squamous cell carcinoma Nutritional-deficiency dermatitis Pallor and ballooning of upper epidermis. [brainscape.com]

  This causes swelling between the cells in your skin. Spongiotic dermatitis is typically seen as red, itchy areas. It can occur anywhere on the body, in one spot or widespread. [healthline.com]

  It usually involves some swelling caused by excess fluid under the skin. Spongiotic dermatitis is closely associated with atopic dermatitis or eczema. It is a widespread condition involving inflammation of the skin and is caused by allergies. [medicalnewstoday.com]

  A skin biopsy of both atopic and contact dermatitis will show similar features—namely spongiotic changes of the epidermis, a swelling of the epidermal skin cells that appear like a sponge under a microscope. [verywellhealth.com]

  A superficial dermal perivascular lymphohistiocytic inflammatory infiltrate, swelling of endothelial cells, and papillary dermal oedema are present (figure 2). [dermnetnz.org]

• Fatigue

  Table 3 International Staging System for Multiple Myeloma [ 5 ] Eczema as a Marker of MM The common presenting symptoms of MM are nonspecific, i.e. bone pain, asthenia, fatigue, weight loss, and dyspnea. [karger.com]

• Dyspnea

  Table 3 International Staging System for Multiple Myeloma [ 5 ] Eczema as a Marker of MM The common presenting symptoms of MM are nonspecific, i.e. bone pain, asthenia, fatigue, weight loss, and dyspnea. [karger.com]

• Diarrhea

  These infants will usually have other signs of systemic illness such as failure to thrive, chronic diarrhea and/or recurrent infections. [dermatologyadvisor.com]

  A preceding prodrome may be present and includes malaise, fever, diarrhea, and concomitant lymphadenopathy [ 79 ]. Skin lesions resolve spontaneously within weeks to months without secondary dyschromia or scarring. [plasticsurgerykey.com]

• Dermatitis

  Allergic contact dermatitis (eczema) Dyshidrotic dermatitis Nummular dermatitis Stasis dermatitis Pityriasis rosea Tinea Chronic dermatitis (lichen simplex chronicus) Compact stratum corneum with irregular acanthosis, papillary dermofibrosis, and focal [brainscape.com]

  Irritant contact dermatitis is the most common subtype of contact dermatitis [ 44 ]. [plasticsurgerykey.com]

  Spongiotic dermatitis may be a feature of eczema, atopic dermatitis, seborrheic dermatitis, and other allergic skin reactions. [healthline.com]

  Spongiotic dermatitis is the histopathologic diagnosis commonly issued by dermatopathologists that encompasses atopic dermatitis, contact dermatitis, and other forms of eczematous dermatitis. [clinicaltrials.gov]

  […] seen in spongiotic dermatitis. ( 2267999 ) LeBoit PE...Epstein BA 1990 13 Erythroderma with spongiotic dermatitis. [malacards.org]

• Eczema

  The varieties of eczema; clinico pathologic correlation. Clin Dermatol 2003 Mar-Apr;21(2):95-100. Hanifin J, Reed M. A population-based survey of eczema prevalence in the United States. Dermatitis 2007;18(2):82-91. Beasley R. [jmscr.igmpublication.org]

  Three stages of eczema Clinically, eczema is grouped according to aetiology. Histologically, it is more useful to classify eczema based on chronicity. Histologically, there are three stages of eczema: acute, subacute, and chronic. [dermnetnz.org]

  Fig. 1.5 Acral skin demonstrating spongiotic dermatitis with microvesiculation is present in dyshidrotic eczema Fig. 1.6 Dyshidrotic eczema reveals a spongiotic dermatitis on acral skin 1.2.3 Pathogenesis The pathogenesis of dyshidrotic eczema is not [plasticsurgerykey.com]

  Another word for spongiotic dermatitis is 'eczema' although some doctors use spongiotic dermatitis specifically to refer only to more severe cases of eczema. [answers.zocdoc.com]

  Spongiotic dermatitis may be a feature of eczema, atopic dermatitis, seborrheic dermatitis, and other allergic skin reactions. [healthline.com]

• Eruptions

  Psoriasiform mycosis fungoides Pigmented purpuric eruption Acute spongiform dermatitis Subacute spongiotic dermatitis [brainscape.com]

  It is also important to understand that this classic histologic profile of PR can be seen in the setting of alternative eczematous eruptions, including drug reactions. [ijdvl.com]

  The eruption exclusively occurred on the surgical incision sites and adjoining area. The time lag to develop eczematous eruptions after surgical procedures ranged between 6 months and 3 years. [cdriadvlkn.org]

  […] acrodermatitis + Agammaglobulinemia, Microcephaly, and Severe Dermatitis atopic dermatitis + Autoimmune Progesterone Dermatitis Bahemuka Brown syndrome bullous skin disease + contact dermatitis + Dandruff dermatitis herpetiformis + dermatosis papulosa nigra Drug Eruptions [rgd.mcw.edu]

  Acrally located eruptions in younger individuals should raise the possibility of Gianotti Crosti syndrome. [dermnetnz.org]

• Pruritus

  Allergic contact dermatitis typically manifests as pruritus and vesicular or eczematous lesions associated with direct exposure to environmental haptenic allergens. [clinicaltrials.gov]

  Case Presentation A 47-year-old Caucasian male presented to the emergency department (ED) for diffuse erythema and pruritus of three weeks’ duration. [cureus.com]

  History One of the hallmarks of Grover disease is pruritus, and all individuals who are affected experience variable degrees of itching, sometimes severe in nature. [epathologies.com]

  Pruritus is prominent feature of AD. Infants may rub themselves against objects such as carpet or bedding, causing excoriation. Intense pruritus often leads to sleep disturbance and/or secondary infection. [dermatologyadvisor.com]

  Berger, “Pruritus and Cutaneous Inflammatory Conditions in HIV Disease,” Clinics in Dermatology, Vol. 18, No. 4, 2000, pp. 479-484. doi:10.1016/S0738-081X(99)00143-1 [10] D. Rigopoulos, V. Paparizos and A. [m.scirp.org]

• Skin Disease

  The treatment varies depending on the type and severity; it is normally treated with topical corticosteroid cream. [6] See also [ edit ] Skin lesion Skin disease List of skin diseases References [ edit ] ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo [en.wikipedia.org]

  CONGENITAL CATARACT, AND PSORIASIFORM DERMATITIS Neonatal Inflammatory Skin and Bowel Disease + neurodermatitis neurotic excoriation Perioral Dermatitis photosensitivity disease + pustulosis of palm and sole pyoderma + Radiodermatitis Seborrhea-Like [rgd.mcw.edu]

  Skin biopsy: Biopsy issues in specific diseases. J Am Acad Dermatol 2016;74(1):1–16; quiz 7–8. Sladden C, Kirchhof MG, Crawford RI. [racgp.org.au]

  A new model for an ancient T-cell-mediated skin disease. Viewpoint. J Cutan Pathol 2001;28:57-64. 2. Elias AN, Barr RJ, Nanda VS. p16 expression in psoriatic lesions following therapy with propylthiouracil, an antithyroid thioureylene. [idoj.in]

  2016/61/3/348/182471 Sir, In 1990, Grosshan and Marot first described blaschkitis (BL), an acquired linear inflammatory dermatosis following Blaschko lines in an adult patient. [1] BL is a rare skin disease with many similarities to lichen striatus (LS [e-ijd.org]

A thorough history and physical examination can provide the necessary clues for further workup. [mdedge.com]

Increased recognition of NE as a possible diagnosis for rash on the reconstructed breast can prevent excessive diagnostic workup, aggressive management, and worse quality of life outcomes in breast cancer patients. [tandfonline.com]

[…] superinfection Allergy and radioallergosorbent testing is of little value Biopsy shows an acute, subacute, or chronic spongiotic dermatitis pattern that is nonspecific but can be helpful to rule out other conditions (eg, cutaneous T-cell lymphoma) See Workup [emedicine.medscape.com]

A large part of initial spongiotic dermatitis treatment involves avoidance. [dermatitisinformation.com]

Treatment: The major part of the treatment involves avoiding chemicals present in soaps, washing powders, foods, etc that may trigger the rash. [medigoo.com]

A treatment plan including medication, skincare, and lifestyle changes can do a lot to relieve the symptoms and to reduce the risk of future flare-ups. [medicalnewstoday.com]

A, After 19 months of treatment with efalizumab monotherapy, he noted regrowth of eyebrows and eyelashes. B, Most of the scalp hair also regrew after 19 months of treatment. [jamanetwork.com]

Treatment Options Treatment options are listed in Table I. Table I. [dermatologyadvisor.com]

The prognosis is good with resolution of dermatitis if the offending agent is avoided. [plasticsurgerykey.com]

The classification also includes subcutaneous panniculitis-like T-cell lymphoma (SPTCL), for which there has been emerging evidence that the αβ variant has a better prognosis and is distinct from the γδ form. [cancernetwork.com]

Prognosis Most patients improve; this can occur at any age. While the frequency of atopic dermatitis (AD) is as high as 20% in childhood, [37] it is 0.9% in adults. One third of patients develop allergic rhinitis. [emedicine.medscape.com]

Etiology is certainly of interest with erythroderma because the differential is extensive. [cureus.com]

[…] within this locus, some of which are calcium-dependent adhesion molecules, such as cadherins, which are important in maintaining the structural integrity of epithelial tissues including the skin. 1.3 Nummular Eczema 1.3.1 Clinical Features The specific etiology [plasticsurgerykey.com]

Therefore, in the absence of an identifiable etiology, recalcitrant eczema in an adult should raise the suspicion of an internal malignancy, including MM. [karger.com]

Rosen et al. predicted the etiology to be a result of skin tension and venous stasis, although these authors described post-reconstruction dermatitis and not specifically NE [ 2 Rosen A, Goh C, Lacouture M, et al. [tandfonline.com]

[…] keratinocytes, including thymic stromal lymphopoietin (TSLP), IL-25, and IL-33. [17] Taken together, these studies highlight a new paradigm in which, in addition to classical adaptive Th2 cells, innate type 2 immune cells play critical roles in the etiology [emedicine.medscape.com]

Lichen striatus: Clinical and epidemiological review of 23 cases. Eur J Pediatr 2006;165:267-9. 3. Lipsker D, Stark J, Schneider GA. Blaschko-linear dermatitis in adulthood (Grosshans-Marot disease) with antinuclear antibodies. [e-ijd.org]

It is considered a rare disease with few published studies concerning epidemiology [5]. Etiology is certainly of interest with erythroderma because the differential is extensive. [cureus.com]

Further research in broader study populations is necessary to elucidate the pathophysiology, clinical features, and epidemiology of NE of the reconstructed breast. IRB approval This study was exempted from review by the institutional IRB. [tandfonline.com]

Epidemiology Frequency United States The prevalence rate for atopic dermatitis (AD) is 10-12% in children and 0.9% in adults. [emedicine.medscape.com]

Kaposi’s sarcoma: epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. J Am Acad Dermatol 1993; 28 :371–95. [ PubMed ] [ Google Scholar ] 21. Hartmann K, Henz BM. [ncbi.nlm.nih.gov]

Spencer Dermatology Group, Crawfordsville, Indiana Clay J Cockerell, MD, Director, Clinical Professor, Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center To view the complete reference including pathophysiology [epathologies.com]

Further research in broader study populations is necessary to elucidate the pathophysiology, clinical features, and epidemiology of NE of the reconstructed breast. IRB approval This study was exempted from review by the institutional IRB. [tandfonline.com]

The pathophysiologic mechanism of spongiosis remains unknown. [ijdvl.com]

This gradual response may be attributable to the severity of their disease or to the time required for efalizumab to correct the pathophysiologic conditions. [jamanetwork.com]

Erythrodermic psoriasis: pathophysiology and current treatment perspectives. Psoriasis. 2016, 6:93-104. 10.2147/ptt.s101232 Tan GF, Kong YL, Tan AS, Tey HL: Causes and features of erythroderma. Ann Acad Med Singapore. 2014, 43:391-394. [cureus.com]

There is no real cure, but outbreaks can be prevented. [medigoo.com]

Wearing bandages, dressings, or wet wraps on top of creams to stop the ointment from rubbing off, and to prevent scratching. Wet wraps are not recommended for babies or children as they can become too cold. [medicalnewstoday.com]

Regular application of creams or ointments helps reduce and can prevent a flare of atopic dermatitis. [verywellhealth.com]

Avoidance of known skin irritants be they chemicals in washing powders, elements in clothing or components of foods is all part of spongiotic dermatitis treatment if one subscribes to the view that prevention is better than cure. [dermatitisinformation.com]

Conclusions: Treg cells have been proved to suppress other skin-resident T-cells and prevent autoimmunity. [ijdpdd.com]