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Sporadic Goitrous Cretinism


  • Weiner, Bernard Gonik, Caroline Crowther, and Stephen Robson present an evidence-based approach to the available management options, equipping you with the most appropriate strategy for each patient.[books.google.com]
  • We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.[medicine.academic.ru]
  • Elsevier Science, 22.10.2013 - 356 Seiten Modern Trends in Physiological Sciences, Volume 36: Thyroiditis and Thyroid Function: Clinical, Morphological, and Physiopathological Studies presents a detailed understanding of the incipient stages of hypothyroidism[books.google.de]
  • Other chapters consider the various types of thyroid diseases, including simple goiter, acute inflammations, Grave's disease, and granulomatous diseases of the thyroid.[books.google.com]
  • The disorder occurs usually in areas where the diet is deficient in iodine and where goiter is common. Early treatment with thyroid hormone generally promotes normal physical growth but may not prevent mental retardation.[medical-dictionary.thefreedictionary.com]
  • The differentiation is easily made if a goiter is discernible, but if it is not, radioiodine uptake should be measured, for in this condition the uptake is normal or greater.[ncbi.nlm.nih.gov]
  • Thyroid nodule Uninodular goiter (nontoxic) 241.1 Nontoxic multinodular goiter Multinodular goiter (nontoxic) 241.9 Unspecified nontoxic nodular goiter Adenomatous goiter Nodular goiter (nontoxic) NOS Struma nodosa (simplex) 242 Thyrotoxicosis with or[icd9cm.blogspot.com]
  • Diagnostic Considerations Conditions to consider in the differential diagnosis of iodine deficiency include the following: Euthyroid sick syndrome Hurthle cell carcinoma Hypothermia Hypothyroidism Goiter - Nontoxic, toxic nodular, lithium-induced Thyroiditis[emedicine.medscape.com]
  • Clinical Synopsis: Neck: Ectopic thyroid; Hypoplastic thyroid; Thyroid agenesis; Goiter HEENT: Large posterior fontanel; Noisy breathing; Nasal stuffiness; Macroglossia Neuro: Hypothermia; Lethargy; Hypotonia Cardiac: Bradycardia Growth: Poor feeding;[genome.jp]
  • Also desirable administration of sedative antihistamine drugs, adrenergic blockers, cardiac glycosides, oxygenotherapy, hypothermia, particularly on regions of major vessels, medical narcosis, extracorporal method of detoxycation.[intranet.tdmu.edu.ua]
Cat Scratch
  • Features up-to-date information on HIV/AIDS, with an emphasis on Africa; malaria; tropical gastroenterological problems; dengue and dengue hemorrhagic fever; tuberculosis; Sexually Transmitted Diseases; SARS; avian flu; bartonellosis, cat-scratch disease[books.google.ro]
  • Cerebral thrombosis claimedone, a carcinoma of the splenic flexure with hepaticsecondaries claimed another at the end of two and a halfyears, and the 3rd died of coronary thrombosis associatedwith chronic myeloid leukaemia after twenty-one months.Partial[dokumen.tips]
  • Cretinism  Fetal or infantile hypothyroidism  Endemic and sporadic  Sporadic –agenesis ,dyshormonogenesis  Hoarse cry, macroglossia, umbilical hernia  Immediate diagnosis and treatment 4.[slideshare.net]
  • Macroglossia may be due to tumor; eg, lymphangioma. The dry skin of ichthyosis may be misleading. All causes of stunted growth and skeletal development must be considered as well.[generalhealthtopics.com]
  • The physical examination may reveal failure to thrive, large anterior and post fontanelles, dry skin, jaundice (usually prolonged), mottling, umbilical hernia, macroglossia and coarsening of the facies. A goiter may be present.[omicsonline.org]
  • Clinical Synopsis: Neck: Ectopic thyroid; Hypoplastic thyroid; Thyroid agenesis; Goiter HEENT: Large posterior fontanel; Noisy breathing; Nasal stuffiness; Macroglossia Neuro: Hypothermia; Lethargy; Hypotonia Cardiac: Bradycardia Growth: Poor feeding;[genome.jp]
  • Affected children have a large head, short limbs, puffy eyes, coarse hair, a round abdomen, a thick and protruding tongue with drooling, excessively dry skin, lack of coordination, and mental retardation.[medical-dictionary.thefreedictionary.com]
  • Our one poor resultwas in a woman whose ulcer did not show on barium mealbut was discovered on gastroscopy.[dokumen.tips]
  • It can result in keratitis with corneal ulceration, which finally can lead to blindness.[intranet.tdmu.edu.ua]
Disproportionate Dwarfism
  • This offensive term should be avoided. cretinism (krē tənizəm) (congenital hypothyroidism), cretinism arrested physical and mental development with dystrophy of bones and soft tissues, resulting in disproportionate dwarfism.[medical-dictionary.thefreedictionary.com]
  • Ditto for phenylketonuria.) * The early screening will often miss iodotyrosine dehydrogenase deficiency, which will produce a goiter and hypothyroidism with the danger of neurologic damage if it is missed: NEJM 358 : 1856, 2008.[pathguy.com]


  • […] in a young individual (often diagnosed due to routine screening of newborns for congenital hypothyroidism) Radiologic evaluation includes thyroid ultrasound and scintiscan Correlation of clinical signs with laboratory and ancillary tests Laboratory workup[pathologyoutlines.com]
  • OBJECTIVES Recognize the common signs, symptoms, causes, and anatomic pathology of each of the following: acquired hypothyroidism congenital hypothyroidism hyperthyroidism goiter Do a proper lab workup for each of these.[pathguy.com]
Delayed Bone Age
  • Roentgenological examination of the wrists showed delayed bone age in 76.5 per cent, but 32.7 per cent of the normal children of the same age in the same locality showed slightly delayed bone age, considered to be the result of malnutrition.[archive.unu.edu]
  • Delayed bone age; "stippling" of epiphyses. General Considerations The causes of cretinism and juvenile hypothyroidism are as follows (after Wilkins): A.[generalhealthtopics.com]


  • Prepare for clinical challenges and save time in addressing them thanks to expert advice on treatment options from international contributors.[books.google.ro]
  • Thyroid replacement is the treatment in either the athyreotic state or the metabolic deficiency.[ncbi.nlm.nih.gov]


  • Prognosis - Cretinism athyreotic Not supplied. Treatment - Cretinism athyreotic Not supplied. Resources - Cretinism athyreotic Not supplied.[checkorphan.org]
  • The prognosis for full mental and physical maturation is much better if the onset is later in life. Congenital cretins almost never attain full mental development.[generalhealthtopics.com]
  • Klein AH, Meltzer S, Kenny FM (1972) Improved prognosis in congenital hypothyroidism treated before age three months. J Pediatr 81: 912-915. Czernichow P (1998) Congenital hypoparathyroidism. Annales Nestle 56: 94-100.[omicsonline.org]
  • Mortality is about 50%, and the prognosis seems to depend solely on size of the primary and the stage of the cancer.[pathguy.com]
  • This histologic type enjoys a favorable prognosis in several published series.[intranet.tdmu.edu.ua]


  • This book discusses as well the etiological or clinico-pathological basis of the classification of simple goiter. The final chapter deals with the post-operative complications of thyroidectomy and their treatment.[books.google.com]
  • For many years the etiology and pathogenesis of goiter in the Himalayas had remained obscure. Studies of the problem indicate that the endemic in Southeast Asia is primarily the result of environmental iodine deficiency.[annals.org]
  • […] cretinism of the untreated congenitally hypothyroid child, the use of the same word has inadvertently lead to the widely-held, and quite erroneous, opinion that the clinical presentation and neurological damage would be the same and, having the same etiology[karger.com]
  • So far as the etiology is concerned, it seems certain that the conditions are due to a defect of the thyroid substance—diminution or loss of the thyroid hormones.[gluedideas.com]


  • In 1848, King Carlo Alberto of Sardinia commissioned the first epidemiological study of congenital iodine deficiency syndrome, in northern Savoy where it was frequent.[en.wikipedia.org]
  • […] of colloid, frequent internodular bizarre cells and bridging fibrosis Terminology Dyshormonogenetic goiter thyroid dyshormonogenesis Also known as inherited congenital / familial goiter and congenital / sporadic goitrous cretinism (more vague terms) Epidemiology[pathologyoutlines.com]
  • Toublanc JE (1992) Comparison of epidemiological data on congenital hypothyroidism in Europe with those of other parts in the world. Horm Res 38: 230-235.[omicsonline.org]
  • A major epidemiologic study failed to find any identifiable risk factor for this (J. Clin. Endo.[pathguy.com]
  • MALIGNANT TUMORS OF THE BREAST Epidemiology The likelihood of developing breast cancer is highly dependent on both age and the interval over which an individual is at risk.[intranet.tdmu.edu.ua]
Sex distribution
Age distribution


  • […] enlarged upon until the introduction of I 131 to clinical studies of human thyroid metabolism by Hamilton and Soley in 1939. 2 While sporadic goitrous hypothyroidism has subsequently undergone rather extensive investigation, attempts to clarify its pathophysiology[jamanetwork.com]
  • Pathophysiology [ edit ] Congenital hypothyroidism can be endemic, genetic, or sporadic. If untreated, it results in mild to severe impairment of both physical and mental growth and development.[en.wikipedia.org]
  • 15%) after thyroid dysgenesis F M (2:1) Mean age at surgery is 16 years (range varies from neonates to sixth decade), with 80% cases occur before 25 years No racial or ethnic predilection ( Thyroid 2011;21:13 ) Sites Diffuse involvement of both lobes Pathophysiology[pathologyoutlines.com]
  • .: Discordance of monozygotic twins for thyroid dysgenesis: implications for screening and for molecular pathophysiology. J. Clin. Endocr. Metab. 87: 4072-4077, 2002. 33. Rosenberg, T.; Gilboa, Y.: Familial thyroid ectopy and hemiagenesis. Arch.[genome.jp]
  • Recognize patients who may have each of the following, and describe the anatomic pathology and what we know of the etiology and pathophysiology of each: DeQuervain's subacute thyroiditis Graves's disease Hashimoto's disease "Idiopathic" goiter Jod-Basedow[pathguy.com]


  • Early treatment with thyroid hormone generally promotes normal physical growth but may not prevent mental retardation. The use of iodized salt dramatically reduces the incidence of cretinism in a population.[medical-dictionary.thefreedictionary.com]
  • Prompt thyroid hormone therapy is essential in order to prevent progressive neurological and motor deterioration.[checkorphan.org]
  • The misnamed ‘sporadic' cretins, on the other hand, identified by neonatal screening programs, require prompt postnatal treatment with thyroid hormones to prevent their mental retardation.[karger.com]
  • Kinderklinik Datteln, Universität Witten-Herdecke Further Information Publication History Publication Date: 13 March 2008 (online) Abstract The aim of neonatal screening programs for congenital hypothyroidism is to ensure early treatment in order to prevent[thieme-connect.com]
  • Newborn screening and prompt treatment prevents mental retardation in children it also has been shown to save in treatment and home and institutionalized care in those with CH.[omicsonline.org]

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