We present a unique case of a patient with SCC of the rectum presenting with lower abdominal pain and significant weight loss. Discussion SCC of the rectum is very rare and presents in a similar fashion to rectal adenocarcinoma. [tandfonline.com]

We are presenting a rare and unique case of patient with SCC of the rectum presenting with lower abdominal pain and significant weight loss. [jim.bmj.com]

In the present study a case of a metastatic pure SCC of the rectum to the liver is presented. [wjso.biomedcentral.com]

Case Presentation A 59-year-old man presented in December 2017 an indurated lesion of the anal margin causing burning sensation, measuring 1 cm (Figure 1). The biopsy revealed moderately differentiated squamous cell carcinoma. [hindawi.com]

Rectal SCC can clinically present with pelvic discomfort, rectal bleeding, constipation, rarely local or distant metastasis and paraneoplastic syndrome (such as hypercalcemia). [jgo.amegroups.com]

• Soft Tissue Mass

  Computerized tomography (CT) of abdomen and pelvis revealed a soft tissue mass at the left lateral wall of the rectum, mild perirectal nodularity on the left lateral wall, and small lymph node on right side. [omicsonline.org]

  Axial and sagittal images demonstrate intense uptake (SUVmax = 17.4) localising to a rectal soft tissue mass. [ecancer.org]

A preoperative workup showed localized disease with absence of metastatic disease. PATHOLOGY SLIDE OF FIGURE 2. A picture of the pathology of the mass at the ileostomy. click to enlarge PATHOLOGY SLIDE OF FIGURE 2 B. [abdominalsurg.org]

The image below depicts the staging and workup of rectal cancer. Diagnostics. Staging and workup of rectal cancer patients. Signs and symptoms Bleeding is the most common symptom of rectal cancer, occurring in 60% of patients. [emedicine.medscape.com]

Further workup with colonoscopy and biopsies confirmed an unusual basaloid SCC of the rectum approximately 5 cm above the anal verge with positive p16 expression, a surrogate marker for HPV status. [ecancer.org]

• Entamoeba Histolytica

  Risk factors for SCC of the rectum have not clearly been established; however, there is an association with inflammatory processes such as ulcerative colitis, entamoeba histolytica, and HPV (13–(15)). [tandfonline.com]

  While risk factors have not been clearly defined, SCC of the rectum has been associated with inflammatory processes such as ulcerative colitis, Entamoeba histolytica, schistosomiasis, and human papilloma virus, which has a strong association with squamous [karger.com]

  Interrelation with the HPV infection has not been demonstrated (9) although it has been associated with another type of infections as the colitis by Entamoeba histolytica or schistosomiasis (4). [scielo.isciii.es]

  In addition, several cases have been reported in patients with ulcerative colitis [12-15] and in patients with infections including Schistosomiasis [16] and Entamoeba histolytica [17]. [surgicalcasereports.springeropen.com]

Pathology was rereviewed, tumor immunophenotype was compared to control cases of anal squamous-cell carcinoma and rectal adenocarcinoma, treatment modalities and outcomes were analyzed. [synapse.mskcc.org]

Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. Don't hesitate to ask him or her questions about your treatment options. [cancer.org]

When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. [cancer.gov]

These treatment regimens primarily used 5-flurouracil with either mitomycin-C or cisplatin and radiotherapy following the same treatment modality used for SCC of the anus (6, 19) (20). [tandfonline.com]

Although abdominoperineal resection (APR) was proposed as a radical treatment at the institution, the patient consulted our institution about alternative treatments including CRT. [surgicalcasereports.springeropen.com]

[…] survival and prognosis. [wjso.biomedcentral.com]

These have a worse prognosis than non-mucinous carsinomas. Photomicrograph of a primary mucinous adenocarcinoma. Click to enlarge. [oncolex.org]

Prognosis of Anal Cancer (Squamous Cell Carcinoma of the Anus) Anal cancer prognosis depends upon the size of the anal tumour, where the anal tumour is and whether it has spread to the lymph nodes. [healthengine.com.au]

The prognosis of this disease seems to be worse than that of adenocarcinoma. Keywords: Colonoscopy, prognosis, squamous How to cite this article: Al-Shelfa W, Al-Sadik M, Al-Nakoury E, Hashim A, Farid A. [saudisurgj.org]

Author information 1 Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan. [email protected] Abstract Primary squamous cell carcinoma (SCC) of the colorectum is a rare malignancy of unknown etiology and pathogenesis. [ncbi.nlm.nih.gov]

Though its etiology and pathogenesis remains unclear, it has been associated with chronic inflammation and infections. [karger.com]

The etiology and pathogenesis remain unclear, although, various mechanisms have been postulated. Squamous cell rectal carcinoma is a distinct and extremely rare form of colorectal malignancy which has been primarily reported as case reports. [omicsonline.org]

The etiology of colorectal SCC is still unclear; however, chronic inflammation (infectious or autoimmune) may play a pivotal role. [jgo.amegroups.com]

It addresses epidemiology, biology, screening and chemoprevention, the role of imaging in diagnosis, staging and prognosis, radiation therapy, medical and surgical treatment, as well as new modalities of therapy, including laparoscopy, and transanal endoscopic [books.google.com]

Due to its rarity, epidemiological data, demographic risk factors, and the natural history of the pathogenicity of SCC are not well defined. Over the course of this cancer history, certain criteria have been established for the diagnosis of SCC. [tandfonline.com]

With only 300 cases in literature, additional studies are necessary to define the epidemiology and course of leiomyosarcoma of the rectum. [academic.oup.com]

The objective of this study is to compare the overall survival (OS), cancer specific survival (CSS) and prognostic factors of RSCC to those of rectal adenocarcinoma (RAC) using the Surveillance, Epidemiology, and End Results (SEER) registry. [ascopubs.org]

In conclusion, SCC of rectum is a distinct entity and it is important to shed some light on this rare condition because it has different epidemiology, etiology, pathogenies and requires a different treatment approach than other colorectal carcinomas. [jim.bmj.com]

Studies suggest four possible hypotheses with regard to the pathophysiology of the SCC. [tandfonline.com]

Also, there is an increased incidence in individuals with multiple sexual partners, practice anal-receptive intercourse, have condyloma infections, or have AIDS.[5][6] Pathophysiology The pathophysiology of the development of anal cancer is believed to [statpearls.com]

Although rectal SCC is a well-established entity, the pathophysiology and risk factors remain largely unknown. Diagnostic criteria are based on the widely-accepted Williams exclusion criteria. [jgo.amegroups.com]

Almost four different pathophysiological theories regarding the origin of squamous cell carcinoma of the colorectum have been proposed in the literature so far. [jmedicalcasereports.biomedcentral.com]

Univariate sub-group analyses showed that the treatment effect for surgery alone vs preoperative radiotherapy plus surgery was not significant in patients whose cancer (TNM stage I to IV) was located between 10.1 cm and 15 cm from the anal verge. [5] Pathophysiology [emedicine.medscape.com]

Preventive Services Task Force. Screening for Cervical Cancer: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine, March 6, 2012, 156(5). [labtestsonline.it]

"HPV vaccine may help to prevent anal cancer". International Herald Tribune. [en.wikipedia.org]

Routine cancer screening of the colon and rectum is the best way to prevent rectal cancer. [emedicinehealth.com]

[Guideline] US Preventive Services Task Force, Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW Jr, et al. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. [emedicine.medscape.com]