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Stage IV Prostate Carcinoma

Prostate Cancer Stage IV


Presentation

  • PURPOSE: In the prostate specific antigen era most prostate cancer presents at an early stage. However, a significant number of patients have advanced disease, including those with stage IV disease.[ncbi.nlm.nih.gov]
  • […] to more than half of one lobe, but is not in both lobes T2c: the tumor is present in both lobes of the prostate T3: the tumor has grown outside of the prostate and may be present in the seminal vesicles T3a: the tumor is outside of the prostate, but[zerocancer.org]
  • In these cases a core needle biopsy is usually done because the PSA blood test result was elevated, suggesting that a cancer might be present.[roswellpark.org]
  • Cancer is present in less than 5% of the tissue removed. T1b The cancer is found after TURP but is present in more than 5% of the tissue removed. T1c The cancer is found by needle biopsy that was done because of an elevated PSA.[vasectomycolumbia.com]
  • All patients started primary androgen deprivation therapy (PADT) between 2001 and 2003, and the present study was performed using the data set from December 2011.[link.springer.com]
Chills
  • Six appointments Therapy can be completed in a little over a month with only 6 appointments Generally well tolerated safety profile The most common side effects in clinical studies were chills, fatigue, fever, back pain, nausea, joint ache, and headache[provenge.com]
  • The main side effects reported were chills, fever, and headache. 11 Treatment of Bone Complications Patients with advanced prostate cancer can have cancer cells that have spread to their bones, called bone metastases.[vacancer.com]
Weight Loss
  • If the prostate cancer has spread, become more severe and moved to a stage 4 then you might also experience the following symptoms: Bone pain, especially around the hips, thighs and lower back Swelling of the feet and legs Weight loss Fatigue Read what[naturalprostate.com]
  • Bone pain, weight loss, swelling in the legs and feet, pelvic discomfort, erectile problems, trouble urinating, and blood in the urine and/or semen are common signs of advanced prostate cancer.[healthmonitor.com]
  • Side effects include nausea, loss of appetite, and weight loss. Immunotherapy Sipuleucel-T (Provenge) is a vaccine doctors use to treat advanced prostate cancer, especially if it’s not responding to hormone therapy.[healthline.com]
  • More widespread disease often spreads to the bones and gives pain or unexplained weight loss and fatigue.[cancer.org.au]
  • Weight loss. Swelling in your legs and feet. How is prostate cancer diagnosed? A blood test called a prostate-specific antigen (PSA) test is the most common way to check for prostate cancer.[northshore.org]
Abdominal Pain
  • Contact your doctor immediately if you experience any of the following symptoms: abdominal pain, abdominal bloating, shortness of breath, dizziness, light-headedness and/or any signs of confusion In women, the most common side effects are those resulting[aboutzoladex.com]
Bone Pain
  • If the prostate cancer has spread, become more severe and moved to a stage 4 then you might also experience the following symptoms: Bone pain, especially around the hips, thighs and lower back Swelling of the feet and legs Weight loss Fatigue Read what[naturalprostate.com]
  • Bone pain, weight loss, swelling in the legs and feet, pelvic discomfort, erectile problems, trouble urinating, and blood in the urine and/or semen are common signs of advanced prostate cancer.[healthmonitor.com]
  • Once the cells settle in the bone, they start to interfere with the bone’s normal health and strength, often leading to bone pain, fracture, or other complications that can significantly impair a man’s health.[pcf.org]
  • Symptoms Signs and symptoms of stage 4 prostate cancer may include: Painful urination Decreased force in the stream of urine Blood in the semen Bone pain Swelling in the legs Fatigue When to see a doctor Make an appointment with your doctor if you have[mayoclinic.org]
  • Prostate cancer often spreads to the bones, which can cause bone pain. Your doctor can offer treatments and medications to control the pain.[drugs.com]
Back Pain
  • The story so far : he was diagnosed right-off-the-bat as Stage IV prostate cancer about six months ago, after spending the previous few months complaining of upper-back pain.[boards.straightdope.com]
  • Six appointments Therapy can be completed in a little over a month with only 6 appointments Generally well tolerated safety profile The most common side effects in clinical studies were chills, fatigue, fever, back pain, nausea, joint ache, and headache[provenge.com]
  • Side effects may include: nausea a headache back pain joint pain Surgery While some surgery to remove tumors may be an option, your doctor is less likely to recommend it for prostate cancer that has spread to multiple areas.[healthline.com]
  • pain pain with ejaculation your doctor will diagnose prostate cancer by feeling the prostate through the wall of the rectum or doing a blood test for prostate-specific antigen (psa).[icd10data.com]
  • When symptoms occur, they include urinary complaints (retention, urgency, frequency, nocturia, dysuria, hematuria) and back pain. The physician palpates the prostate gland via a digital rectal examination (DRE).[medical-dictionary.thefreedictionary.com]
Low Back Pain
  • back pain pain with ejaculation your doctor will diagnose prostate cancer by feeling the prostate through the wall of the rectum or doing a blood test for prostate-specific antigen (psa).[icd10data.com]
  • These treatments also may reduce chronic low back pain, joint pain, headaches, and pain from cancer treatments. Before you try a complementary therapy, talk to your doctor about the possible value and potential side effects.[northshore.org]
Upper Back Pain
  • The story so far : he was diagnosed right-off-the-bat as Stage IV prostate cancer about six months ago, after spending the previous few months complaining of upper-back pain.[boards.straightdope.com]
Enlargement of the Prostate
  • prostate nodular prostate polyp of prostate Type 1 Excludes benign neoplasms of prostate (adenoma, benign) (fibroadenoma) (fibroma) (myoma) ( D29.1 ) Type 2 Excludes malignant neoplasm of prostate ( C61 ) Adenocarcinoma - see also Neoplasm, malignant[icd10data.com]
  • Indeed, most, if not all of these can occur in men with noncancerous (benign) enlargement of the prostate (BPH), which is the more common form of prostate enlargement .[emedicinehealth.com]
  • PSA levels may also be high in men who have an infection or inflammation of the prostate or BPH (an enlarged, but noncancerous, prostate).[theoncologyinstitute.com]
  • This procedure is performed to help alleviate the symptoms of BPH, a benign enlargement of the prostate. Like a biopsy, this is a definitive diagnostic method for prostate cancer.[medical-dictionary.thefreedictionary.com]
Urinary Retention
  • Adverse effects of EBRT include cystitis, proctitis, enteritis, impotence, urinary retention, and incontinence.[emedicine.medscape.com]
  • The urinary stream may be diminished (urinary retention), or it may simply dribble out and a feeling of bladder fullness after urination can appear as well. These symptoms are commonly referred to as “voiding” or “obstructive” urinary symptoms.[emedicinehealth.com]
  • Typical side effects from interstitial implants that are seen in most patients but subside with time include urinary tract frequency, urgency, and less commonly, urinary retention.[healthlinkbc.ca]
Prostatic Disease
  • What happens in the aging man’s body, however, is that testosterone converts to estrogen and DHT, and these two testosterone metabolites have been shown to be involved in benign and malignant prostate disease.[lifeextension.com]
  • Although the chance of finding prostate cancer is over 50 percent, the benign prostatic disease does produce a marked increase in serum PSA in some men. Less than 0.2 ng/mL: After the prostate is surgically removed.[emedicinehealth.com]
  • Prostate Disease Patient Outcome Research Team. Arch Fam Med 2 (5): 487-93, 1993. Adolfsson J, Steineck G, Whitmore WF Jr: Recent results of management of palpable clinically localized prostate cancer. Cancer 72 (2): 310-22, 1993.[healthlinkbc.ca]
  • Prostate Disease Patient Outcome Research Team. Arch Fam Med 2 (5): 487-93, 1993. [PUBMED Abstract] Adolfsson J, Steineck G, Whitmore WF Jr: Recent results of management of palpable clinically localized prostate cancer. Cancer 72 (2): 310-22, 1993.[cancer.gov]
Urinary Hesitancy
  • Symptoms associated with BPH include frequent urination and urinary hesitancy that can be especially troublesome at night (Gharaee-Kermani 2013).[lifeextension.com]
Pelvic Pain
  • Examples of these symptoms include: back, hip, or pelvic pain blood in the urine or semen burning or pain upon urination difficulty fully emptying the bladder difficulty starting a stream of urine experiencing sudden urge to urinate a weak urine stream[medicalnewstoday.com]

Workup

  • What Is Prostate Cancer Workup? If cancer is present on biopsy, workup for metastasis may be indicated. Imaging studies may reveal the size and location of the tumor in the prostate as well as the extent of spread of the disease.[emedicinehealth.com]
  • Laboratory Studies In cases of suspected advanced prostate cancer, the hematologic workup should include a complete blood count (CBC), liver function tests (LFTs), and a chemistry profile, including levels of serum creatinine, acid and alkaline phosphatase[emedicine.medscape.com]

Treatment

  • Treatments that “target” cancer cells may offer the advantage of reduced treatment-related side effects and improved outcomes.[vacancer.com]

Prognosis

  • Staging helps a physician make an informed decision about treatment and provides information for a more reliable prognosis ( the likely course of this disease ).[whathealth.com]
  • Filed under: Diagnosis, Living with Prostate Cancer, Management, Risk, Treatment Tagged: advanced, Management, mortality, prognosis, survival[prostatecancerinfolink.net]
  • Prostate cancer prognosis and survival rates can help give patients an idea of their chances of surviving the disease based on the stage and time of diagnosis. While some patients may find this information helpful, others may not want to know.[protons.com]
  • A score of under 7 indicates a more favorable prognosis; a 7 indicates a moderate prognosis; a score over 7 indicates a less favorable prognosis.[cancertutor.com]
  • I've done some research and it appears that the prognosis is approx a year. :( .. I know cancer has its own mind sometimes however and there are many factors involved with prognosis assessment. Hubby has NO pain!!![cancerconnection.ca]

Etiology

  • Use Additional Use Additional Help Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10data.com]

Epidemiology

  • An interesting study based out of the Australian Oncology Radiology Department, Northern Sydney Cancer Centre, conducted a very thorough epidemiological meta-analysis, completed in 2003 and published in 2004.[naturalnews.com]
  • Muralidhar et al. used data from the Surveillance, Epidemiology, and End Results (SEER) database to identify men initially diagnosed with AJCC Stage IV prostate cancer between 1973 and 2011 and treated with.[prostatecancerinfolink.net]
  • Eur Urol 65:565–573 CrossRef PubMed Google Scholar Baade PD, Youlden DR, Cramb SM et al (2013) Epidemiology of prostate cancer in the Asia-Pacific region.[link.springer.com]
  • *SEER Surveillance, Epidemiology, and End Results[cancer.org]
  • However, a study that used the Surveillance, Epidemiology, and End Results (SEER)-Medicare data of 577 patients showed a contrasting result. 14 By using a propensity-weighting methodology, the study showed no significant difference between the two groups[gucasym.org]
Sex distribution
Age distribution

Prevention

  • Details of how to improve your diet and what steps to undertake can be found in my book: Healthy Prostate: The Extensive Guide to Prevent and Heal Prostate Problems.[naturalprostate.com]
  • ZERO — The End of Prostate Cancer recently chalked major advocacy successes, increasing the amount of funding for the Prostate Cancer Research Program (PCRP) by 10 million per year, and pressing the United States Preventative Services Task Force (USPSTF[themighty.com]
  • Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. Journal of Urology 2003; 169:2008-2012. 15 Smith MR, Saad F, Coleman R et al.[vacancer.com]

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