We present three cases of statin-induced musculoskeletal symptoms which presented to an orthopaedic department. [ncbi.nlm.nih.gov]

• Family History of Depression

  history of depression, self-report of CVD, hormone therapy use, and smoking status. [doi.org]

• Respiratory Insufficiency

  For other postoperative complications (cardiovascular events, stroke, renal failure, respiratory insufficiency, and thromboembolic events), there was no significant difference between the two groups (odds ratio 0.89, 95% CI 0.78-1.01, P   0.06). [ncbi.nlm.nih.gov]

• Intracranial Hemorrhage

  In contrast to the findings in a previous study of high-dose statin therapy, 23 we found no significant between-group difference in the number of subjects with intracranial hemorrhage (six in the rosuvastatin group and nine in the placebo group, P 0.44 [doi.org]

• Mononeuropathy

  Here, we report two cases of localized rhabdomyolysis associated with mononeuropathy in patients taking statins and suggest possible explanations for this uncommon association. [ncbi.nlm.nih.gov]

  Multiple mononeuropathy associated to treatment with pravastatin [in Spanish]. Rev Neurol 2006 Dec 1–15; 43(11): 659–61. PubMed Google Scholar 542. Palmucci L, Doriguzzi C, Orsi L, et al. [doi.org]

• Ataxia

  Reversible atorvastatin-associated external ophthalmoplegia, anti-acetylcholine receptor antibodies, and ataxia. Arch Ophthalmol 2000 Mar; 118(3): 427–8. PubMed Google Scholar 799. Fraunfelder FW, Richards AB. [doi.org]

Sexual health for the man at midlife: in-office workup. Geriatrics 1997 ; 52 : 76 –86. 16 Shetty HGM, Routledge PA. Adverse effects of hypolipidaemic drugs. Adverse Drug Reaction Bull 1990 ; 142 : 532 –535. 17 Monk JP, Todd PA. Bezafibrate. [fampra.oxfordjournals.org]

• Glycosuria

  Protocol-specified measurements showed no significant differences between the study groups during the follow-up period with respect to the fasting blood glucose level (98 mg per deciliter [5.4 mmol per liter] in both groups, P 0.12) or newly diagnosed glycosuria [doi.org]

These data, coupled with the patient findings, indicate a possible association between statin treatment, decreased ubiquinone status, and loss of complex IV activity. [ncbi.nlm.nih.gov]

In this trial, early treatment with atorvastatin 80 mg/d reduced recurrent ischemic events over a 16-week treatment period among patients with unstable angina or non–Q-wave acute MI. [jama.ama-assn.org]

Statins have been demonstrated to significantly affect the prognosis and outcome of patients with risk factors to atherosclerosis (in primary and secondary prevention trials). [ncbi.nlm.nih.gov]

Persistent renal damage after contrast-induced acute kidney injury: incidence, evolution, risk factors, and prognosis. Circulation. 2012 ;125 (25): 3099 – 3107. Google Scholar Crossref Medline ISI 3. Dangas, G, Iakovou, I, Nikolsky, E. [doi.org]

Its insidence remains high and the management has not been established yet because its etiology and pathophysiological are still poorly understood. [ncbi.nlm.nih.gov]

The etiologic role of statins in the risk of MM, however, is not well understood. [bloodjournal.org]

Rider, Trouble in Paradise: Unmeasured Confounding in Registry-based Studies of Etiologic Factors, European Urology, 69, 5, (883), (2016). [doi.org]

Ockene), Department of Medicine, University of Massachusetts Medical School, Worcester; Division of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst (Dr Balasubramanian); Department of Social and Preventive Medicine, University [web.archive.org]

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. meta-analysis of observational studies in epidemiology [doi.org]

This article reviews the epidemiology, clinical features, risk factors and mechanisms of statin-induced myopathy and provides an evidence-based algorithm for managing patients with statin myopathy. [ncbi.nlm.nih.gov]

Its insidence remains high and the management has not been established yet because its etiology and pathophysiological are still poorly understood. [ncbi.nlm.nih.gov]

Contrast medium-induced nephropathy: the pathophysiology. Kidney Int Suppl. 2006 ;(100): S8 – S10. Google Scholar Crossref Medline 10. Wong, PC, Li, Z, Guo, J, Zhang, A. Pathophysiology of contrast-induced nephropathy. [doi.org]

Rhabdomyolysis and Other Causes of Myoglobinuria In this article Pathophysiology Statins and myotoxicity Rhabdomyolysis can be defined as a clinical syndrome associated with the breakdown of skeletal muscle fibres and myocyte cell membranes, leading to [patient.co.uk]

[…] in preventing all-cause mortality. [ncbi.nlm.nih.gov]

Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS: Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998;279(20):1615–1622. [doi.org]