We present three cases of statin-induced musculoskeletal symptoms which presented to an orthopaedic department. [ncbi.nlm.nih.gov]

• Family History of Depression

  […] information, including race/ethnicity, age, educational attainment, family history of DM, family history of depression, self-report of CVD, hormone therapy use, and smoking status. [doi.org]

• Recurrent Urinary Tract Infection

  Prior medical history includes previous myocardial infarction and recurrent urinary tract infection. 4 days prior to symptom onset, the patient developed typical urinary tract infection symptoms, treated with ciprofloxacin. [ncbi.nlm.nih.gov]

• Respiratory Insufficiency

  For other postoperative complications (cardiovascular events, stroke, renal failure, respiratory insufficiency, and thromboembolic events), there was no significant difference between the two groups (odds ratio 0.89, 95% CI 0.78-1.01, P = 0.06). [ncbi.nlm.nih.gov]

• Mononeuropathy

  Here, we report two cases of localized rhabdomyolysis associated with mononeuropathy in patients taking statins and suggest possible explanations for this uncommon association. [ncbi.nlm.nih.gov]

Sexual health for the man at midlife: in-office workup. Geriatrics 1997 ; 52 : 76 –86. 16 Shetty HGM, Routledge PA. Adverse effects of hypolipidaemic drugs. Adverse Drug Reaction Bull 1990 ; 142 : 532 –535. 17 Monk JP, Todd PA. Bezafibrate. [fampra.oxfordjournals.org]

• Glycosuria

  Protocol-specified measurements showed no significant differences between the study groups during the follow-up period with respect to the fasting blood glucose level (98 mg per deciliter [5.4 mmol per liter] in both groups, P=0.12) or newly diagnosed glycosuria [doi.org]

• Chlamydia

  Borkowski; Chlamydia/Serology Core Laboratory (Johns Hopkins University, Baltimore) — T. Quinn; C. Gaydos, B. Wood; Electrocardiographic Core Laboratory (eResearch Technology, Philadelphia) — J. [content.nejm.org]

These data, coupled with the patient findings, indicate a possible association between statin treatment, decreased ubiquinone status, and loss of complex IV activity. [ncbi.nlm.nih.gov]

In this trial, early treatment with atorvastatin 80 mg/d reduced recurrent ischemic events over a 16-week treatment period among patients with unstable angina or non–Q-wave acute MI. [jama.ama-assn.org]

Statins have been demonstrated to significantly affect the prognosis and outcome of patients with risk factors to atherosclerosis (in primary and secondary prevention trials). [ncbi.nlm.nih.gov]

The clinical prognosis of FH heterozygotes is related not only to the magnitude of the elevation in plasma LDL-C but also to the presence of other coronary risk factors ( 5 ). New insights into pathogenesis. [doi.org]

Its insidence remains high and the management has not been established yet because its etiology and pathophysiological are still poorly understood. [ncbi.nlm.nih.gov]

The etiologic role of statins in the risk of MM, however, is not well understood. [bloodjournal.org]

Rider, Trouble in Paradise: Unmeasured Confounding in Registry-based Studies of Etiologic Factors, European Urology, 69, 5, (883), (2016). [doi.org]

Ockene), Department of Medicine, University of Massachusetts Medical School, Worcester; Division of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst (Dr Balasubramanian); Department of Social and Preventive Medicine, University [web.archive.org]

The results need to be verified with observed CVD epidemiology. [hauptverband.at]

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. meta-analysis of observational studies in epidemiology [doi.org]

This article reviews the epidemiology, clinical features, risk factors and mechanisms of statin-induced myopathy and provides an evidence-based algorithm for managing patients with statin myopathy. [ncbi.nlm.nih.gov]

Its insidence remains high and the management has not been established yet because its etiology and pathophysiological are still poorly understood. [ncbi.nlm.nih.gov]

Areas covered : In this review, we summarize the role of Rho-associated coiled-coil containing kinase (ROCK) and its potential as a therapeutic target in stroke pathophysiology. [doi.org]

Rhabdomyolysis and Other Causes of Myoglobinuria In this article Pathophysiology Statins and myotoxicity Rhabdomyolysis can be defined as a clinical syndrome associated with the breakdown of skeletal muscle fibres and myocyte cell membranes, leading to [patient.co.uk]

[…] in preventing all-cause mortality. [ncbi.nlm.nih.gov]

Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS: Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 1998;279(20):1615–1622. [doi.org]