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Stauffer Syndrome

Stauffer's Syndrome


  • […] pain Absent Absent Present Present Jaundice Present Present Present Present Pruritus Present Absent Present Present Hepatomegaly Absent Absent Present Present Splenomegaly Absent Absent Absent Present Urinary hyperpigmentation Present Present Present[ncbi.nlm.nih.gov]
  • Mayank Jain Department of Gastroenterology, Gleneagles Global Health City, Chennai - 600 100, Tamil Nadu India Source of Support: None, Conflict of Interest: None DOI: 10.4103/ijmpo.ijmpo_97_17 An elderly male patient presented with cholestatic jaundice[ijmpo.org]
Intermittent Fever
  • She reported intermittent fever, nausea, decreased appetite, and darkening of her urine for 2 weeks before admission. Past medical history included hypertension and hyperlipidemia. She had no previous surgery.[ncbi.nlm.nih.gov]
Painless Jaundice
  • He underwent right nephrectomy with complete resolution of his symptoms after surgery. 9 In 2005, Giannakos et al. 10 reported a 73-year-old male who presented with painless jaundice, pruritus, urinary hyperpigmentation, and hepatomegaly.[ncbi.nlm.nih.gov]
  • […] than 10% of patients. 5 More often, this tumor presents with systemic and paraneoplastic symptoms that may not suggest the correct diagnosis: increased erythrocyte sedimentation rate, anemia, cachexia, weight loss, fever, hypercalcemia, polycythemia, amyloidosis[ncbi.nlm.nih.gov]
  • Acknowledgments We acknowledge the help of Consultant Pathologist Dr. Mukul Vij and Dr. Deepti Sachan, Consultant – Department of Transfusion Medicine in the management of the patient. Financial support and sponsorship Nil.[ijmpo.org]
Ascitic Fluid
  • .: Acrylamid disc gel electrophoresis of alkaline phosphatase of human tissues, serum and ascites fluid using Triton X-100 in the sample and the gel matrix. Biochem. Med. 9, 309 (1974) PubMed Google Scholar 8.[link.springer.com]
Abdominal Pain
  • We report a patient who presented with abdominal pain and cholestatic jaundice in whom RCC was incidentally found during initial workup. Jaundice and liver dysfunction resolved completely after surgical resection of the tumor.[ncbi.nlm.nih.gov]
Abdominal Mass
  • The classic diagnostic triad of flank pain, palpable abdominal mass, and hematuria is present in less than 10% of patients. 5 More often, this tumor presents with systemic and paraneoplastic symptoms that may not suggest the correct diagnosis: increased[ncbi.nlm.nih.gov]
  • Computed tomographic (CT) scan of the abdomen revealed hepatosplenomegaly, and a 3.0 3.0 4.0 cm exophytic mass arising from the left kidney (see Fig. 1 ).[ncbi.nlm.nih.gov]
  • Hepatosplenomegaly may also be observed. The symptoms and signs resolve if the renal cell carcinoma (or another associated tumor) is successfully ablated. It is due to release of IL-6 from cancerous cell. [1] Eponym [ edit ] Maurice H.[en.wikipedia.org]
  • The second case was a 48-year-old male who presented with jaundice and urinary hyperpigmentation. A space-occupying lesion in the right kidney was found in a CT scan of his abdomen.[ncbi.nlm.nih.gov]
Renal Stone
  • The kidneys revealed no evidence of hydronephrosis, renal stones, or masses. Further evaluation regarding the etiology of her underlying liver disease was undertaken.[ncbi.nlm.nih.gov]


  • A metastatic workup, including a CT scan with intravenous contrast of the chest, abdomen, and pelvis, revealed no evidence of metastatic disease.[ncbi.nlm.nih.gov]
Alkaline Phosphatase Decreased
  • phosphatase, decreased albumin, and prolonged prothrombin time, in addition to cholestatic jaundice.[ncbi.nlm.nih.gov]
Liver Biopsy
  • Diagnosis of Stauffer's syndrome was confirmed based on his clinical history, biochemical evaluation, and liver biopsy. Resolution of jaundice was noted after removal of the renal mass.[ijmpo.org]


  • Lymphangiomas are associated with a high rate of local recurrence and metastasis, even after aggressive surgical treatment.[emedicine.medscape.com]
  • This case illustrates the protean manifestations of RCC, and the importance of considering Stauffer's syndrome and its variant in the differential diagnosis of anicteric and icteric cholestasis, which may allow early recognition and treatment of an underlying[ncbi.nlm.nih.gov]


  • Prognosis The prognosis is dismal. Lymphangiosarcomas are extremely aggressive tumors with a high local recurrence rate and a tendency to metastasize early to many areas. Long-term survivors are the exceptions.[emedicine.medscape.com]
  • Acute Coronary Syndrome in the Young: Clinical Characteristics, Risk Factors and Prognosis; The Open Car diovascular Medicine Journal, 2014 (8): 61-67. 5.[romanianjournalcardiology.ro]


  • Further evaluation regarding the etiology of her underlying liver disease was undertaken.[ncbi.nlm.nih.gov]
  • These cha-racteristics make it the ideal method for defi ning the etiology and anatomic location of the culprit vessel/ segment or ruling out ACS16.[romanianjournalcardiology.ro]


  • For the IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition. Lancet 2005; 366: 1059-62. Parikh RM, Joshi SR, Menon PS, Shah NS. Index of central obesity - A novel parameter.[content.sciendo.com]
  • Epidemiology Frequency Currently, approximately 400 cases of Stewart-Treves syndrome are reported in the world literature.[emedicine.medscape.com]
Sex distribution
Age distribution


  • .: Observations on the molecular biology and pathophysiology of soluble fibrin complexes. Abstr. Int. Soc. Haematol. Kyoto, p. 37, 1975 Google Scholar 3.[link.springer.com]
  • The underlying pathophysiology of this paraneoplastic manifestation is not fully understood; however, reports have suggested the possible role of interleukin-6 overexpression by the primary tumor. 8 This manifestation is not unique to renal cell carcinoma[ncbi.nlm.nih.gov]


  • Prevention of tumor progression in Stewart-Treves syndrome with a low dose of pazopanib. J Dermatol. 2019 Feb 25. [Medline].[emedicine.medscape.com]
  • The prognosis of this patient depends largely on secondary preventative measures such as smoking cessation and lifestyle improvement. The medical ma-nagement for MINOCA patients is still a matter of debate and future research is needed.[romanianjournalcardiology.ro]

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