Symptoma

Stavudine

D4T

A male and a female, 47 and 45 years of age, respectively, presented with abdominal pain, nausea, vomiting, and weakness after 9 and 6 months, respectively, of treatment with stavudine. [ncbi.nlm.nih.gov]

  • Hypoxemia

    Evaluations for other causes of lactic acidosis, including hypoxemia, malignancy, sepsis, and cardiogenic shock, were negative. [ncbi.nlm.nih.gov]

  • Epigastric Pain

    A 36-year-old man presented with a one-week history of nausea, vomiting, epigastric pain, dyspnea associated with progressive muscle weakness and numbness in glove and stocking pattern. [ncbi.nlm.nih.gov]

  • Claustrophobia

    All of the patients had completed the process of evaluation of lipodystrophy syndrome, except for 2 patients who refused a DEXA scan because of claustrophobia. All patients had already had genotype data in HLA genes from the previous study [ 34 ]. [doi.org]

  • Facial Lipoatrophy

    There were no statistically significant differences in d4T-TP intracellular levels with respect to the presence of metabolic syndrome, the clinical form of HALS (pure lipoatrophic vs mixed), the degree of facial lipoatrophy, the presence of hepatitis [ncbi.nlm.nih.gov]

  • HLA-DR7

    […] available pharmacogenomics tests, Clin Pharmacol Ther, 2009, vol. 86 (pg. 109 - 113 ) 31 Generating genome-scale candidate gene lists for pharmacogenomics, Clin Pharmacol Ther, 2009, vol. 86 (pg. 183 - 189 ) 32 Association between presence of HLA-B*5701, HLA-DR7 [doi.org]

The Food and Drug Administration today announced the approval of stavudine, or d4T -- the fourth drug approved for the treatment of AIDS and HIV infection. [aidsinfo.nih.gov]

This is another sign of our commitment to act quickly on treatments for life threatening diseases," said FDA Commissioner David A. Kessler, M.D. [web.archive.org]

We describe the frequency of stavudine toxicity in children receiving ART at a treatment clinic in Soweto, South Africa. [ncbi.nlm.nih.gov]

Anemia at the beginning of ART is an important parameter for the short and long term prognosis [ 4 ]. ART generally improves HIV-associated anemia [ 3, 4 ], but some ARVs may cause anemia. [omicsonline.org]

Etiology has not been clearly established to date, but diverse mechanisms are proposed including inhibition of enzymes such as mitochondrial DNA gamma-polymerase (an enzyme that contributes to DNA replication), which causes decrease in energy generation [casereports.in]

DESIGN: Prospective cohort analysis (International epidemiological Databases to Evaluate AIDS-Multiregional) including ART-naive, HIV-infected patients aged at least 16 years, initiating ART between January 2005 and December 2012. [ncbi.nlm.nih.gov]

Applications of Bayesian methods to epidemiologic research. Curr Epidemiol Rep 2014. 103–109. 1.3. 33. Springer, Lash TL, Fox MP, Fink AK. Applying quantitative bias analysis to epidemiologic Data. 2009. 35. Rubin DB. [journals.lww.com]

Glossary AVLT Auditory Verbal Learning Test ; CES-D Center for Epidemiologic Studies–Depression Scale ; d-drug dideoxynucleoside antiretroviral drug ; GEE generalized estimating equation ; GP Grooved Pegboard test ; HAART highly active antiretroviral [neurology.org]

We invite comprehensive review articles and novel, pioneering work in the basic and clinical fields on all areas of HIV research, including virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and [ingentaconnect.com]

However, a recent epidemiology study reported that the HIV-1 viral load in blood is lower in women than in men at similar stages of HIV-1 infection, suggesting that there are gender effects in HIV/AIDS progression [ 5 ]. [retrovirology.biomedcentral.com]

High index of suspicion and early withdrawal of the offending drug may prevent further harm in such cases. [ncbi.nlm.nih.gov]

Viraday tablets slow down the replication of HIV within your body but does not kill the virus already incorporated in the CD4 cells or prevent the spread of the infection to others. [inhousepharmacy.vu]

RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA thus preventing HIV from multiplying. Stavudine is an analog of thymidine. [3dchem.com]

Images