Presentation
We review the literature and present an additional case to emphasize the subtle changes that resulted in positive outcome when diagnosed and managed in a comprehensive transplant team. [ncbi.nlm.nih.gov]
Entire Body System
- Anemia
Fanconi’s anemia Thalassemia major Glanzmann’s Thrombasthenia Sickle cell anemia [texaschildrens.org]
We present a child with hepatitis-associated severe aplastic anemia who underwent an unrelated allogeneic hematopoietic stem cell transplantation and subsequently developed graft failure and an Epstein-Barr virus-positive monomorphic plasmacytoma-type [ncbi.nlm.nih.gov]
Our team is internationally known for research and treatment of blood cancers and blood disorders such as leukemia, lymphoma, multiple myeloma, myelodysplastic syndromes, aplastic anemia, sickle cell anemia and bloodless transplants. [winshipcancer.emory.edu]
In those pre-Internet days, budding journalist Keener went to Countway Library at Harvard Medical School and read everything she could about aplastic anemia. [blog.dana-farber.org]
- Pain
At average follow up of 4.2 years of the seven patients with two year followup, pain and range of motion improved with SA (p = 0.0625-0.2500). [ncbi.nlm.nih.gov]
The transplant won't be painful and you'll be awake throughout. [nhs.uk]
“Our data provide more support that this therapy is safe and effective and prevents patients from living shortened lives, condemned to pain and progressive complications.” [news.uic.edu]
I still have problems and I'm always going to have problems, but I'm not in that constant pain." [medicalxpress.com]
But Paine, a statistician herself, argues: “This is total guesswork. [theguardian.com]
- Fever
KEYWORDS: cord blood stem cell transplant; immunosuppression; vaccine; yellow fever [ncbi.nlm.nih.gov]
Minor side effects, such as fever, chills and shortness of breath, can accompany the infusion of new stem cells. [danafarberbostonchildrens.org]
- Chills
Minor side effects, such as fever, chills and shortness of breath, can accompany the infusion of new stem cells. [danafarberbostonchildrens.org]
You may also have chills, cramps in your hands, and a feeling of numbness around your lips. This is temporary and does not persist for longer than a few hours after the collection procedure is done. [verywellhealth.com]
They will check to be sure you are not developing fever, chills, hives, or a drop in blood pressure. You might have mild side effects, including headache, nausea, flushing, or shortness of breath. [webmd.com]
You'll be checked frequently for signs of fever, chills, hives, a drop in blood pressure or shortness of breath. [llscanada.org]
Common side effects can include: Infections Low blood cell counts Bleeding Low blood pressure Shortness of breath Chest pain or tightness Coughing Fever or chills Hair loss Nausea Vomiting Mouth sores Loss of appetite Diarrhea Fatigue Weakness Possible [urmc.rochester.edu]
- Asymptomatic
Sebaceous hyperplasia most commonly presents as asymptomatic papules over the face, chest, or groin. [ncbi.nlm.nih.gov]
Screening for Hepatitis C | CTFPHC Review Canadian Task Force on Preventive Health Care guideline on Hepatitis C screening REFERENCE BOOK Screening for Abdominal Aortic Aneurysm | CTFPHC REFERENCE BOOK Impaired Vision | CTFPHC REFERENCE BOOK Screening for Asymptomatic [qxmd.com]
It is also reasonable to screen for asymptomatic portal hypertension in the pretransplantation workup, since numerous factors in myelofibrosis may impair liver function. There is also the issue of managing relapses after stem cell transplant. [ascopost.com]
In some centers, sinus computed tomography (CT) is performed to determine whether asymptomatic disease is present. Chest CT is performed on pediatric patients, especially if pulmonary function testing could not be accomplished. [clinicaladvisor.com]
Gastrointestinal
- Diarrhea
Here we describe a patient who presented with hemolytic anemia, thrombocytopenia, renal and neurological impairment, who also developed significant bloody diarrhea. [ncbi.nlm.nih.gov]
This can cause symptoms such as: Skin rashes with itching Yellowing of the skin (jaundice) Severe diarrhea Damage to the liver, kidneys, or other organs Fatigue Muscle aches Making a decision It's important to discuss the procedure with your doctor to [urmc.rochester.edu]
Treat any problems that happen, such as mouth sores, vomiting, diarrhea, infections, bleeding, rejection, and graft-versus-host disease. Make sure the patient is getting good nutrition. [kidshealth.org]
Be vigilant about the possibility of rejection by observing the skin for rashes, monitoring diarrhea, and ensuring the administration of antirejection medication according to the patient's home administration schedule or the healthcare provider's order [journals.lww.com]
- Abdominal Pain
Crohn's disease is a long-term condition that causes inflammation of the lining of the digestive system, and results in diarrhoea, abdominal pain, extreme tiredness and other symptoms that significantly affect quality of life. [medicalxpress.com]
I had a reaction to an anti-fungal drug, Ambisome, high heart rate and excruciating abdominal pains that travelled up my oesophagus, felt like an acidic burning feeling. [alexisallin.com]
This causes hematuria (blood in urine), frequent urination, abdominal pain, and thrombocytopenia.[37] Graft-versus-host disease[edit] Graft-versus-host disease (GVHD) is an inflammatory disease that is unique to allogeneic transplantation. [en.wikipedia.org]
Rarely, it could cause bradycardia, abdominal pain, encephalopathy/seizures, and renal failure. [emedicine.medscape.com]
Cardiovascular
- Hypotension
Other side effects include myalgia, hyperhidrosis, xerostomia, dyspnea, hypoxia, orthostatic hypotension, leukocytosis, and thrombocytopenia. [emedicine.medscape.com]
Skin
- Eruptions
A 37-year-old male patient presented with fever, incomplete paralysis of bilateral legs, and bullous eruptions 8 months after allogeneic transplant. [ncbi.nlm.nih.gov]
Neurologic
- Perseveration
That jersey served as an uplifting symbol throughout the season and a reminder of Leah’s strength and perseverance. The Stills will be in the minds of sports fans everywhere as Leah battles through this complication. [bleacherreport.com]
Workup
It is also reasonable to screen for asymptomatic portal hypertension in the pretransplantation workup, since numerous factors in myelofibrosis may impair liver function. There is also the issue of managing relapses after stem cell transplant. [ascopost.com]
In addition, transplant coordinators are responsible for initiating the workup of donors and performing infusions once patients are admitted. [uhhospitals.org]
Treatment
A thematic content analysis was performed, and three themes were assessed: what is oral health, why was pre-transplant dental treatment performed, and what was the relevance of dental treatment for the haematopoietic stem cell transplant. [ncbi.nlm.nih.gov]
Prognosis
Prognosis is poor, particularly after allogeneic transplantation, and literature to guide clinical decision-making is scarce. [ncbi.nlm.nih.gov]
Using this model (or an age-adjusted version), prognosis can be assessed anytime during the course of primary myelofibrosis. Source: Passamonti F, et al: Blood 115:1703-1708, 2010. [ascopost.com]
Etiology
Its etiology is related to endothelial injury accompanied by complement activation. [ncbi.nlm.nih.gov]
Epidemiology
RSV-B genomes from 16 patients and health care workers (HCWs) suspected to be involved in the outbreak were compared to RSV-B genomes that were acquired from outpatients during the same time period but epidemiologically unrelated to the outbreak. [ncbi.nlm.nih.gov]
"Future epidemiologic studies and disease prevention studies will need to include this growing patient population. [healio.com]
An exceptional outcome Keener was so thankful and invigorated by her recovery that she soon returned to Dana-Farber/Boston Children’s as a part-time researcher in Epidemiology. [blog.dana-farber.org]
Our study is reported according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines (the checklist used is included in the eAppendix in the Supplement ). [jamanetwork.com]
Pathophysiology
This observation might have important drawbacks as far as HSCT-TMA pathophysiology and treatment are concerned. [ncbi.nlm.nih.gov]
[…] require therapy.4 The cells express pan B-cell markers and are usually positive for CD5, CD20, CD10 and CD23 and are negative for CD3 and CD103.5 The 6q deletion is present in 42% of patients and is associated with an adverse prognosis.6 Waldenström pathophysiology [nature.com]
Prevention
Antibiotics, antifungal medications, and antiviral medications can help prevent and treat bacterial, fungal, and viral infections. [webmd.com]
Your healthcare provider may prescribe medication to prevent fungal infections. Scientists are still learning about which transplant patients are at highest risk and how to best prevent fungal infections. 7,8 Protect yourself from the environment. [cdc.gov]
The reason for performing prior dental treatment involves strict guidelines for transplants, and when questioned as to the importance of the dental treatment for transplants, the interviewed subjects' statements focused on the prevention of infections [ncbi.nlm.nih.gov]
Some are meant to prevent nausea from chemotherapy, some to prevent infections, others to prevent complications from the chemotherapy drugs. Many are given by mouth, some are given by vein. [franciscanhealth.org]
CAMPATH 1H stays active in the body for a long time after patients receive it, which means it may work longer at preventing graft-versus-host-disease (GvHD) symptoms. [clinicaltrials.gov]